Specific inhibition of response to purified protein antigens

1956 ◽  
Vol 146 (922) ◽  
pp. 18-33 ◽  
Keyword(s):  
Antibody Formation ◽  
The Body ◽  
Specific Inhibition ◽  
Protein Antigens ◽  
Bovine Albumin ◽  
Adult Mice ◽  
Immune Paralysis ◽  
Small Doses ◽  
Long Time ◽  
Stimulate Antibody

The injection of large doses of pneumococcus polysaccharides into adult mice fails to stimulate antibody formation and prevents subsequent small doses from stimulating antibody formation. This inhibition—termed immune paralysis (Felton 1949; Felton, Cameron & Prather 1941; Felton, Kauffmann, Prescott & Ottinger 1955) persists for at least 15 to 18 months. It is not possible to produce a similar effect with protein antigens. Dixon & Maurer (1953, I955 a,b ) injected very large quantities of bovine serum albumin into adult rabbits, 18 g/kg rabbit over a period of 6 weeks. Within 6 weeks of these injections four of the five animals produced antibody in response to injections of bovine albumin. It is not surprising that a long time elapsed before antibody could be detected, since during the persistence of antigen in the body, all antibody released would have combined with that vast excess of antigen.

scholarly journals Development of Novel Oral Formulations of Disulfide Antioxidants Based on Porous Silica for Controlled Release of the Drugs

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 963
Author(s):  
Ekaterina S. Dolinina ◽  
Elena V. Parfenyuk
Keyword(s):  
Antioxidant Activity ◽  
Surface Chemistry ◽  
Sol Gel ◽  
Porous Silica ◽  
The Body ◽  
Oral Drug ◽  
Therapeutic Concentration ◽  
Release Process ◽  
Zero Order Kinetics ◽  
Long Time

Powerful antioxidant α-lipoic acid (LA) exhibits limited therapeutic efficiency due to its pharmacokinetic properties. Therefore, the purpose of this work was to evaluate the ability of silica-based composites of LA as well as its amide (lipoamide, LM), as new oral drug formulations, to control their release and maintain their therapeutic concentration and antioxidant activity in the body over a long time. The composites synthesized at different sol–gel synthesis pH and based on silica matrixes with various surface chemistry were investigated. The release behavior of the composites in media mimicking pH of digestive fluids (pH 1.6, 6.8, and 7.4) was revealed. The effects of chemical structure of the antioxidants, synthesis pH, surface chemistry of the silica matrixes in the composites as well as the pH of release medium on kinetic parameters of the drug release and mechanisms of the process were discussed. The comparative analysis of the obtained data allowed the determination of the most promising composites. Using these composites, modeling of the release process of the antioxidants in accordance with transit conditions of the drugs in stomach, proximal, and distal parts of small intestine and colon was carried out. The composites exhibited the release close to the zero order kinetics and maintained the therapeutic concentration of the drugs and antioxidant effect in all parts of the intestine for up to 24 h. The obtained results showed that encapsulation of LA and LM in the silica matrixes is a promising way to improve their bioavailability and antioxidant activity.

scholarly journals Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 79
Author(s):  
Svetlana N. Morozkina ◽  
Thi Hong Nhung Vu ◽  
Yuliya E. Generalova ◽  
Petr P. Snetkov ◽  
Mayya V. Uspenskaya
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Research Direction ◽  
Biological Action ◽  
The Body ◽  
Biologically Active ◽  
Polymer Systems ◽  
Anti Cancer ◽  
Long Time ◽  
Cancer Agent

For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

VI. The glucoside constitution of proteid matter

1894 ◽  
Vol 54 (326-330) ◽  
pp. 53-57 ◽  
Keyword(s):  
Sulphuric Acid ◽  
Cupric Oxide ◽  
The Body ◽  
Long Time

For a long time I have adopted a process for separating the glycogen of the liver consisting in boiling with potash, pouring into alcohol, and collecting the precipitate. For the purpose of estimation, the precipitated glycogen was converted by means of sulphuric acid into glucose, the determination of which gave the information required. I afterwards applied the process to blood, and the various organs and tissues of the body, with the result that a more or less notable amount of cupric oxide reducing product was obtained, which I at the time looked upon as taking origin, as in the case of the liver, from glycogen.

ABRAHAM JACOBI ON JUVENILE DIABETES MELLITUS-1896

PEDIATRICS ◽  
1977 ◽  
Vol 60 (6) ◽  
pp. 830-830
Author(s):  
T. E. C.
Keyword(s):  
Diabetes Mellitus ◽  
New York ◽  
Juvenile Diabetes ◽  
The United States ◽  
Mineral Waters ◽  
Juvenile Diabetes Mellitus ◽  
Pediatric Clinic ◽  
Medicinal Treatment ◽  
Small Doses ◽  
Long Time

Abraham Jacobi (1830-1919) was the first in the United States to specialize in the teaching of pediatrics. In 1862 he founded the first pediatric clinic in New York City. Probably no other pediatrician in America had a greater influence than Jacobi on the development of American pediatrics. This is how Jacobi treated juvenile diabetes mellitus 80 years ago and 26 years before Banting and Best had isolated insulin. ... The disease runs a more rapid course in infants and children than in adults, and terminates more readily in coma and death. Therefore the treatment must be enforced. Fortunately, the young, with very rare exceptions, are apt to live on milk mostly. Thus less difficulties are encountered in them than in adults. For these also milk, skimmed or not, forms a principal and beneficial part of their nutriment. The medicinal treatment of the young requires some modifications. The facility with which cerebral symptoms ("coma") are developed, renders the persistent use of alkalies advisable (mineral waters), and forbids the use of opium. lodoform, which I have seen to render fair service in adults, in daily doses of from ten to twenty grains internally, is seldom tolerated by the young, even in proportionately small doses. Arsenic may be given in increasing doses a long time, the bromide as well as other preparations, one drop and more of Fowler's solution [potassium arsenite], largely diluted, after meals, three times daily, the dose to be increased gradually until doses of from two to four drops are taken.

CHRONIC ATYPICAL NEUTROPHILIC DERMATOSIS WITH LIPODYSTROPHY AND FEVER (CANDLE SYNDROME) IN PEDIATRIC PRACTICE

2021 ◽  
Vol 100 (2) ◽  
pp. 254-261
Author(s):  
O.G. Sukhovjova ◽  
◽  
I.A. Ivanova ◽  
N.A. Kalugina ◽  
E.S. Zholobova ◽  
...  
Keyword(s):  
Clinical Observation ◽  
Clinical Manifestations ◽  
Maculopapular Rash ◽  
The Body ◽  
Neutrophilic Dermatosis ◽  
Inherited Disease ◽  
Laboratory Activity ◽  
Ubiquitinated Proteins ◽  
Systemic Inflammatory Reaction ◽  
Long Time

The purpose of this publication is to describe the CANDLE syndrome (its etiology, pathogenesis, clinical manifestations) and present a clinical observation. CANDLE syndrome is a rare genetically inherited disease caused by impaired assembly by of the protease, which leads to the accumulation of abnormal (ubiquitinated) proteins in B-lymphocytes, fibroblasts, macrophages and some other cells of the body. As a result, an excessive activation of interferon synthesis occurs and a systemic inflammatory reaction develops with symptoms such as febrile fever, skin syndrome, represented by nodules and maculopapular rash, hepatosplenomegaly, lipodystrophy, amyotrophy, delayed physical development, as well as high laboratory activity. The article describes a clinical observation of a female patient with typical symptoms of CANDLE syndrome. However, due to the rarity of the disease and lack of publications describing it, it has not been possible to diagnose the child for a long time.

The Role of Spices with reference Novel Coronavirus Covid 19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1655-1661
Author(s):  
Roshna Sukheoji Bhutada ◽  
Kritika Umate
Keyword(s):  
Viral Infections ◽  
The Body ◽  
Common People ◽  
Supplementary Food ◽  
Long Time ◽  
Novel Coronavirus ◽  
The Right ◽  
Common Spices ◽  
Physiological Reactions

The need of the day is a brisk lift to the resistant framework to keep it fit, battling today pandemic infections, for example, Covid — 19. One should get the right amount of nutrients from the diet, supplementation regimen to boost the immune system. These spices are always there to make tasty food as well as to protect the body from infectious diseases by building the immunity strong Ayurveda approaches to develop physiological reactions to facilitate immunity. Planning of diet is most important to boost immunity. As per many types of research to provide supplementary food which contains Zinc, Vitamin C, Vitamin D and immunity boosting food such as dealing with plenty of spices for a very long time. These spices include some rare to very common spices which we can found near us. The concern is that these viral infections are very prone to attack weak immunity and take the chance to affect the country to the globe. So the very common spices available will be always helpful to get through this Regular use of a few spices in the very simple form proves its importance as a medicine. In this article a review of spices is done which we are available near us, we are using it in our daily life and we are getting the benefit of these which a common people might not be fully aware of about role of immunity building of the body. 

A Liberating Experience. On Becoming a Work of Art

2020 ◽  
Vol 7 (2) ◽  
pp. 411-430
Author(s):  
Maja Tabea Jerrentrup
Keyword(s):  
Three Dimensional ◽  
The Body ◽  
The Other ◽  
Work Of Art ◽  
Other Hand ◽  
Film Clips ◽  
Long Time ◽  
The One ◽  
Body Painting ◽  
Dimensional Surface

Abstract The art of bodypainting that is fairly unknown to a wider public turns the body into a canvas - it is a frequently used phrase in the field of bodypainting that illustrates the challenge it faces: it uses a three-dimensional surface and has to cope with its irregularities, but also with the model’s abilities and characteristics. This paper looks at individuals who are turned into art by bodypainting. Although body painting can be very challenging for them - they have to expose their bodies and to stand still for a long time while getting transformed - models report that they enjoy both the process and the result, even if they are not confident about their own bodies. Among the reasons there are physical aspects like the sensual enjoyment, but also the feeling of being part of something artistic. This is enhanced and preserved through double staging - becoming a threedimentional work of art and then being staged for photography or film clips. This process gives the model the chance to experience their own body in a detached way. On the one hand, bodypainting closely relates to the body and on the other hand, it can help to over-come the body.

New Light on the Grylli

1935 ◽  
Vol 55 (2) ◽  
pp. 232-235
Author(s):  
Anne Roes
Keyword(s):  
The Body ◽  
The Other ◽  
Hellenistic Period ◽  
Other Hand ◽  
Long Time ◽  
Greek Art

Well known though the grylli are, we have still very little to say about their meaning and about their origin.Our knowledge of them, which has hardly increased since the days of Furtwangler, amounts to the following facts. Grylli were one of the most popular motives for the decoration of gems in Roman times; they remained in favour during more than three centuries. Several indications lead us to believe that some pro-phylactic value was ascribed to them; this may also account for their long popularity. In appearance they can as a rule be divided into two classes. Either they are a composition of various human and animal heads, sometimes with birds added to them, or else they consist of the body of a bird, generally a cock, to which heads and masks are attached in different ways. As the cock often is provided with a horse's head, we are reminded of the Attic hippalectryon; it is, however, impossible to trace their descent from Greek art, for we do not know of any more complicated Greek design that may have inspired Roman gem-cutters; the hippalectryon itself even does not seem to have lived down to the Hellenistic period. On the other hand, it is equally impossible to regard them as an original Roman fantasy. In the first place, their connexion with the hippalectryon, though distant, is unmistakable; secondly and chiefly, we know there were grylli before the days of Roman glyptic art. In the necropolis of Tharros in Sardinia have been found several scarabs decorated with motives closely resembling the Roman grylli. Now the necropolis seems to have been in use for a very long time, but Furtwangler believed, no doubt rightly, that the bulk of the objects found in it, and especially the grylli, must be dated rather early as they still show some of the traditions of archaic art. Our Fig. 3a is a good example.

scholarly journals The Body of Sound: Sounding out the History of Science

2012 ◽  
Vol 2 (1) ◽  
pp. 197-209 ◽  
Author(s):  
Holger Schulze
Keyword(s):  
History Of Science ◽  
The Body ◽  
Western History ◽  
Science History ◽  
Hermann Von Helmholtz ◽  
Material Appearance ◽  
Long Time ◽  
History Of ◽  
Anthropology Of The Senses ◽  
Lower Material

Sound affects and pervades our body in a physical as well as a phenomenological sense: a notion that may sound fairly trivial today. But for a long time in Western history ‘sound’ was no scientific entity. It was looked upon merely as the lower, material appearance of truly higher forces: of more ephemeral, angel-, spirit- or godlike structures – and later of compositional knowledge. To be interested in sound was to be defamed as being unscientific, noncompositional, unmanly. Which steps were taken historically that gradually gave sound the character of a scientific entity? This article moves along recent science history: since the nineteenth century when the physicality of sound and later the corporeality of sonic experiences were first discovered and tentatively described. Exemplary studies from the science history of acoustics, musicology and anthropology of the senses are analysed and restudied – from Hermann von Helmholtz to Michel Serres. Even today, we may ask ourselves: What would an auditorily-founded research be like? Could there be a field of sensory research – via sensing sound?

scholarly journals Contamination of food with cadmium and dioxins – influence on the human body

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Aleksandra Słojewska ◽  
Izabela Gutowska
Keyword(s):  
General Population ◽  
Health Effects ◽  
Human Body ◽  
Bone Mineralization ◽  
The Body ◽  
Food Sources ◽  
Hormonal Balance ◽  
Small Doses ◽  
Contaminated Food

Introduction: Food is a carrier of many pollutants nowadays. For cadmium and dioxins, it is the main source of these compounds in the general population. Hence, the aim of this work was to collect data on the health effects associated with exposure to cadmium and dioxins which get into the human body through food.Materials and methods: A literature review was conducted by searching the scientific Medline database (PubMed) and Google Scholar.Results: Health effects associated with a long-term exposure to low doses of cadmium and dioxins may be nonspecific and are rarely attributed to food sources. These may cause disorders affecting hormonal balance, kidney function, lipid metabolism, fertility, cognitive function, bone mineralization, and susceptibility to diseases and allergies. These compounds may also lead to cancer development.Conclusions: The general population faces the problem of longterm exposure to small doses of these substances due to their accumulation in the body, even if their amounts do not exceed the relevant standards. The health effects of this type of exposure may be significantly delayed and are not likely to be attributed to the consumption of contaminated food. Consumers wishing to reduce the amounts of these compounds delivered to the body should limit the consumption of grilled and smoked products, and should also opt for organic food.

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