scholarly journals Heparin-based ELISA reduces background reactivity in virus-like particle-based papillomavirus serology

2005 ◽  
Vol 86 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Xiaohong Wang ◽  
Martin Sapp ◽  
Neil D. Christensen ◽  
Joakim Dillner
Keyword(s):  
Quality Control ◽  
Human Papillomavirus ◽  
Poor Quality ◽  
Cross Reactivity ◽  
Heparin Binding ◽  
Binding Ability ◽  
Capture Elisa ◽  
Virus Like Particle ◽  
Variable Quality

The interaction between human papillomavirus (HPV) particles and cell surface heparan sulfate requires intact conformation of the HPV particles. Type-specific HPV serology is currently based on virus-like particles (VLPs) with intact conformation. Presence of incorrectly folded VLPs in VLP preparations is recognized as an important cause of cross-reactivity in HPV serology. Heparin-coated microtitre plates were evaluated for capturing conformationally correct VLPs and improving the type specificity of HPV serology. Hybrid VLPs between HPV16 and HPV11, which had been found to have significant reactivity with children's sera and a batch of HPV18 VLPs that had failed the quality control because of significant reactivity with sera from virginal women, were tested in parallel with heparin ELISA, ordinary ELISA and type-specific mAb capture ELISA. Control sera from children that had detectable reactivity with HPV16/11 hybrid VLPs in ordinary ELISA did not react in heparin-based ELISA, but some hybrid VLPs also had background reactivity in capture ELISAs. Control sera from virginal women that had some reactivity with a poor quality HPV18 VLP preparation in ordinary ELISA had no reactivity in heparin or capture ELISA, suggesting that certain VLP preparations expose cross-reactive epitopes that are not exposed on VLPs with heparin-binding ability. As the sensitivity was similar or only marginally affected by the use of heparin plates, use of heparin-coated plates may improve the type specificity of VLP-based ELISAs and reduce interassay variability attributable to variable quality of different VLP batches.

Quality of life of young patients with recurrent respiratory papillomatosis

2017 ◽  
Vol 131 (5) ◽  
pp. 425-428 ◽  
Author(s):  
B B Montaño-Velázquez ◽  
J Nolasco-Renero ◽  
J E Parada-Bañuelos ◽  
F Garcia-Vázquez ◽  
S Flores-Medina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Human Papillomavirus ◽  
Otitis Media ◽  
Young Patients ◽  
Chronic Otitis Media ◽  
Poor Quality ◽  
Recurrent Respiratory Papillomatosis ◽  
Assess Quality ◽  
The Impact

AbstractObjective:To assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media.Method:Participants and their parents completed the Pediatric Quality of Life Inventory 4.0.Results:Patients with recurrent respiratory papillomatosis and their parents reported lower quality of life than healthy subjects (p < 0.01), but similar quality of life to patients with chronic otitis media. Those with human papillomavirus type 11 showed the lowest scores among all participants (p < 0.05).Conclusion:Young Mexican patients with recurrent respiratory papillomatosis and their parents perceive a poor quality of life, and they may experience limitations in interactions with their peers. Infection by human papillomavirus type 11 may increase the impact of the disease on quality of life.

PENGENDALIAN KUALITAS PROSES PRODUKSI PAKAN IKAN DENGAN MENERAPKAN QUALITY CONTROL PRODUKSI (QCP) DI PT CENTRAL PERTIWI BAHARI

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Putri Endah Suwarni ◽  
Keyword(s):  
Quality Control ◽  
Control Chart ◽  
Poor Quality ◽  
Fish Feed ◽  
Feed Production ◽  
Machine Productivity ◽  
Fish Feeds ◽  
Product Defect ◽  
Major Defect

Abstract The research method used is P-Chart method, with diagram of upper and lower control chart, check sheet, pareto diagram, and cause and effect diagram. The result of analysis using Pareto Diagram can be seen that from 199,880 kg or 0.6097% defective product, it is dominant defect 0.4282% in Size, 0.0981% in Floating, 0.0633% in Moisture, 0.0150% in Belang, and Others 0.0051%. Occurrence of fish feeds product defect caused by material factors, machine, methods, and man. Based on these factors that affect the quality of fish feeds are lack of training and lack of skill, exhaustion and negligence, lack of socialization of SOP (Standard Operating Procedures) and techniques in improper mixing, poor quality materials and material storage is too long , decreased machine productivity and lack of maintenance or maintenance of machinery. Application of quality control of fish feed production process at PT Central Pertiwi Bahari has been running well, this is proved by the percentage of major defect that does not exceed the maximum standards specified by the company. Keywords: quality control, check sheet, pareto diagram, cause-effect diagram, control chart (p-chart).

The Non-Destructive Test Method as A Simple Way to Evaluate the Quality Of Metal Core Pcbs for High Power Micro-Assemblies

2017 ◽  
Vol 8 (2) ◽  
pp. 281
Author(s):  
A.V. Sukhanov ◽  
A.I Artemova ◽  
R.S Litvinenko
Keyword(s):  
Quality Control ◽  
Heat Sink ◽  
Poor Quality ◽  
Test Method ◽  
Joint Interface ◽  
Layer By Layer ◽  
Metal Core ◽  
Before And After ◽  
Non Destructive

<p>The article describes the necessity of an incoming quality control of the delivered power electronics elements especially at the stage of choosing a reliable supplier. In particular, in the field of the metal core PCBs production, there is a need to control not only its heat sink parameters, but also to control the quality of the joint interface of the metal core PCBs. Since the use of poor-quality materials or the violation of the technological process by the manufacturer can lead to the defects in the PCBs structure. Thus it can affect the heat sink efficiency and the reliability of the entire assembly. The article proposes and describes the method of nondestructive incoming quality control of metal core PCBs. This method is based on the use of ultrasonic layer-by-layer scanning for obtaining the internal structure of PCBs. The article presents the results of applying this method for the PCBs of various manufacturers. The data of the structure visualization and the influence of environment temperatures changes were also obtained. The result pictures of the tested samples before and after the thermal circling were obtained to study the possible degradation of the PCBs structure and its parameters.</p>

scholarly journals Qoala-T: A supervised-learning tool for quality control of automatic segmented MRI data

2018 ◽  
Author(s):  
Eduard T. Klapwijk ◽  
Ferdi van de Kamp ◽  
Mara van der Meulen ◽  
Sabine Peters ◽  
Lara M. Wierenga
Keyword(s):  
Quality Control ◽  
Supervised Learning ◽  
Area Under The Curve ◽  
High Sensitivity ◽  
Poor Quality ◽  
Developmental Studies ◽  
Quality Ratings ◽  
Control Procedures ◽  
Processing Errors

AbstractPerforming quality control to detect image artifacts and data-processing errors is crucial in structural magnetic resonance imaging, especially in developmental studies. Currently, many studies rely on visual inspection by trained raters for quality control. The subjectivity of these manual procedures lessens comparability between studies, and with growing study sizes quality control is increasingly time consuming. In addition, both inter-rater as well as intra-rater variability of manual quality control is high and may lead to inclusion of poor quality scans and exclusion of scans of usable quality. In the current study we present the Qoala-T tool, which is an easy and free to use supervised-learning model to reduce rater bias and misclassification in manual quality control procedures. First, we manually rated quality of N = 784 FreeSurfer-processed T1-weighted scans. Different supervised-learning models were then compared to predict manual quality ratings. Results show that the Qoala-T tool using random forests is able to predict scan quality with both high sensitivity and specificity (mean area under the curve (AUC) = 0.98). In addition, the Qoala-T tool was also able to adequately predict the quality of a novel unseen dataset (N = 112; mean AUC = 0.95). These outcomes indicate that using Qoala-T in other datasets could greatly reduce the time needed for quality control. More importantly, this procedure could further help to reduce variability related to manual quality control, thereby benefiting the comparability of data quality between studies.

CHALLENGES IN THE IMPLEMENTATION OF QUALITY CONTROL TECHNIQUES DURING SITE INSPECTION

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Nur Nabihah Abd Razak ◽  
Intan Rohani Endut ◽  
Siti Akmar Abu Samah ◽  
Ahmad Ruslan Mohd Ridzuan ◽  
Sabihah Saaidin
Keyword(s):  
Quality Control ◽  
Construction Projects ◽  
Poor Quality ◽  
Construction Process ◽  
Test Plan ◽  
Negative Effects ◽  
Control Techniques ◽  
Project Outcomes ◽  
Quality Control Techniques

Quality has been the main issue in construction projects. In handling it, the quality control techniques during construction process are required to thoroughly carry out in order to avoid any mistakes which lead to bigger problem such as poor quality of project outcomes. The implementation of quality control techniques during site inspection is able to discard all possible negative effects towards construction projects. There are three quality control techniques that have been used during site inspection known as Project Quality Plan (PQP), Inspection Test Plan (ITP) and Checklist. In order to implement these techniques, there are some matters that need to be identified and overcome. Therefore, this study has been carried out to identify the challenges in implementation of quality control techniques during site inspection. To achieve the objective, the survey questionnaire was distributed among G5, G6 and G7 contractors’ in Malaysia. A total of 82 useable questionnaires were received and analysed using factor analysis. The challenges were clumped and categorized into respective groups. The seven groups were renamed, namely: (1) attitude, (2) documents, (3) operations, (4) management, (5) workers, (6) information and (7) methods. This study helps to improve the quality control techniques especially during site inspection among Malaysian contractors.

Development and Application of Quality Control System for Highway Subgrade Construction

2019 ◽  
Vol 2 (5) ◽  
Author(s):  
Tong Wang
Keyword(s):  
Quality Control ◽  
Real Time ◽  
Detection Method ◽  
System Development ◽  
Effective Control ◽  
Construction Process ◽  
Development Mode ◽  
The Road ◽  
Whole Process

The compaction quality of the subgrade is directly related to the service life of the road. Effective control of the subgrade construction process is the key to ensuring the compaction quality of the subgrade. Therefore, real-time, comprehensive, rapid and accurate prediction of construction compaction quality through informatization detection method is an important guarantee for speeding up construction progress and ensuring subgrade compaction quality. Based on the function of the system, this paper puts forward the principle of system development and the development mode used in system development, and displays the development system in real-time to achieve the whole process control of subgrade construction quality.

Construction Control As A Strategy For Improving The Quality Of Buildings And Structures

2020 ◽  
Keyword(s):  
Quality Control ◽  
Life Cycle ◽  
Construction Control ◽  
Construction Sites ◽  
Actual Problem ◽  
Construction Market ◽  
Construction Products ◽  
Underlying Causes ◽  
Required Quality

In construction production, the safety of constructing buildings and structures is achieved by ensuring the required quality as a result of systematic construction control based on the implementation of a complex of technical, economic and organizational measures at all stages of the object's life cycle. The article deals with the actual problem of improving the quality of construction products-buildings and structures in conjunction with the activities of construction control bodies. The article presents the advanced foreign and domestic experience of ensuring the quality control at the construction sites, providing for the prevention of the underlying causes of defects and increasing the interest of the contractors directly. On the basis of the analysis of the current situation with quality control at the construction market, ways to improve its efficiency by developing a unified system of technological implementation of relevant requirements for the quality of construction products, determining the rational number and business load of construction control engineers, as well as the active activities of self-regulatory organizations in this area are offered.

An experience of performing spirometry by trained general practitioners

2020 ◽  
pp. 34-36
Author(s):  
M. A. Pokhaznikova ◽  
E. A. Andreeva ◽  
O. Yu. Kuznetsova
Keyword(s):  
General Practitioners ◽  
Quality Criteria ◽  
Poor Quality ◽  
Male Gender ◽  
Study Research ◽  
The Poor ◽  
Quality Of Research ◽  
Forced Expiratory Maneuver ◽  
Maximal Effort

The article discusses the experience of teaching and conducting spirometry of general practitioners as part of the RESPECT study (RESearch on the PrEvalence and the diagnosis of COPD and its Tobacco-related aetiology). A total of 33 trained in spirometry general practitioners performed a study of 3119 patients. Quality criteria met 84.1% of spirometric studies. The analysis of the most common mistakes made by doctors during the forced expiratory maneuver is included. The most frequent errors were expiration exhalation of less than 6s (54%), non-maximal effort throughout the test and lack of reproducibility (11.3%). Independent predictors of poor spirogram quality were male gender, obstruction (FEV1 /FVC<0.7), and the center where the study was performed. The number of good-quality spirograms ranged from 96.1% (95% CI 83.2–110.4) to 59.8% (95% CI 49.6–71.4) depending on the center. Subsequently, an analysis of the reasons behind the poor quality of research in individual centers was conducted and the identified shortcomings were eliminated. The poor quality of the spirograms was associated either with the errors of the doctors who undertook the study or with the technical malfunctions of the spirometer.

68. The resident experience in a large urban teaching setting: Results of the 2005-2006 resident exit survey, University of Torontos

2007 ◽  
Vol 30 (4) ◽  
pp. 66
Author(s):  
N. Tenn-Lyn ◽  
S. Verma ◽  
R. Zulla
Keyword(s):  
Quality Control ◽  
Residency Training ◽  
Royal College ◽  
Online Survey ◽  
Career Guidance ◽  
Training Programs ◽  
Program Planning ◽  
Educational Experience ◽  
Care Experience

We developed and implemented an annual online survey to administer to residents exiting residency training in order to (1) assess the quality of the residency experience and (2) identify areas of strength and areas requiring improvement. Long-term goals include program planning, policy-making and maintenance of quality control. Survey content was developed from an environmental scan, pre-existing survey instruments, examination of training criteria established by the CFPC and the CanMEDS criteria established by the RCPSC. The survey included evaluation benchmarks and satisfaction ratings of program director and faculty, preparation for certification and practice, quality of life, quality of education, and work environment. The response rate was 28%. Seventy-five percent of respondents were exiting from Royal College training programs. Results of descriptive statistics determined that the overall educational experience was rated highly, with 98.9% of respondents satisfied or very satisfied with their overall patient care experience. Ninety-six percent of respondents were satisfied or very satisfied with the overall quality of teaching. Preparation for practice was identified as needing improvement, with 26% and 34% of respondents giving an unsatisfactory rating to career guidance and assistance with finding employment, respectively. Although 80% of respondents reported receiving ongoing feedback and 84% discussed their evaluations with their supervisors, only 38% of evaluations were completed by the end of the rotation. The results indicate that residents are generally satisfied with their experiences during residency training, especially with their overall educational experience. Areas of improvement include preparation for practice and timeliness of evaluations. Further iterations of this survey are needed to refine the instrument, identify data trends and maintain quality control in residency training programs. Frank JR (ed.). The CanMEDS competency framework: better standards, better physicians, better care. Ottawa: The Royal College of Physicians and Surgeons of Canada, 2005. Merritt, Hawkins and Associates. Summary Report: 2003 Survey of final-year medical residents. http://www.merritthawkins.com/pdf/MHA2003residentsurv.pdf. Accessed May 1, 2006. Regnier K, Kopelow M, Lane D, Alden A. Accreditation for learning and change: Quality and improvement as the outcome. The Journal of Continuing Education in the Health Professions 2005; 25:174-182.

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