scholarly journals Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study

2002 ◽  
Vol 2 ◽  
pp. 1070-1078 ◽  
Author(s):  
Nicolas Padilla ◽  
Rosalinda Diaz ◽  
Alfonso Alarcon ◽  
Roberto Barreda
Keyword(s):  
Primary Schools ◽  
Personal Hygiene ◽  
Study Group ◽  
Three Samples ◽  
Stool Samples ◽  
Group 3 ◽  
Group 2 ◽  
Study Participants ◽  
Prospective Longitudinal ◽  
Group 1

This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency ofEntamoeba histolyticacysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence ofE. histolyticacysts after a parasitoscopic analysis by concentration (PSC) in three samples over consecutive days using Faust’s method. Those included in the study received a single 4.3-g/kg dose of quinfamide, and we performed PSC on days 5, 6, and 7 following dose administration to examine whether quinfamide had affected the presence of the cysts. The study participants who tested negative for cysts were divided into three groups: Group 1 had 102 patients who underwent quinfamide treatment and three CPS analyses after the 12 months of the study; Group 2 had 98 subjects who underwent the quinfamide treatment and three CPS analyses at months 3, 6, 9, and 12 after their entrance into the study; and Group 3 had 102 patients, who underwent the quinfamide treatment and series of three CPS analyses at months 6 and 12 of the study. All participants received the dose of quinfamide after providing stool samples and after a clinical gastrointestinal history was obtained. Further clinical gastrointestinal data were collected 5 days after the quintamide dose was administered. We used EpiInfo 6.0 for statistical analysis, calculatingX2andpvalues for the clinical data and the CPS data after the 12 months concluded. Of the initial samples of 1,524 subjects, 308 (20.2%) had Entamoebic cysts. Of these, six were further eliminated because they did not meet the inclusion requirements. At the conclusion of the study, Group 1 presented with 37.6% of subjects still testing positive for cysts; of Group 2, 12.5% tested positive; and in Group 3, 23.5% of participants tested positive for cysts (X2= 16.8; df = 2;p= 0.0002). For comparisons of groups 1 and 2 and 1 and 3,p> 0.05. We conclude that antiamoebic chemoprophylaxis can be a choice for control of amoebic infection where personal hygiene and food consumption habits are not improving.

scholarly journals Plasma fatty acids in de novo lipogenesis pathway are associated with diabetogenic indicators among adults: NHANES 2003–2004

2018 ◽  
Vol 108 (3) ◽  
pp. 622-632 ◽  
Author(s):  
Elaine A Yu ◽  
Peter J Hu ◽  
Saurabh Mehta
Keyword(s):  
Fatty Acids ◽  
De Novo ◽  
Plasma Concentrations ◽  
The United States ◽  
Structure Study ◽  
De Novo Lipogenesis ◽  
Group 3 ◽  
Group 2 ◽  
Study Participants ◽  
Group 1

ABSTRACT Background Insulin regulates fatty acids (FAs) in the blood; conversely, FAs may mediate insulin sensitivity and are potentially modifiable risk factors of the diabetogenic state. Objective The objective of our study was to examine the associations between plasma concentrations of FAs, fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) among individuals (n = 1433) in the NHANES (2003–2004). Design Plasma concentrations of 24 individual FAs were considered individually and in subgroups, per chemical structure. Study participants were categorized in diabetogenic groups: Group 1 (HbA1c ≥6.5% or FPG ≥126 mg/dL), Group 2 (HbA1c 5.7% to <6.5% or FPG 100 to <126 mg/dL), and Group 3 (HbA1c <5.7% and FPG <100 mg/dL). We assessed associations between diabetogenic groups and plasma FAs in multivariate multinomial regressions (with Group 3 as the reference). Results Overall, 7.0% of study participants were in Group 1; 33.3% were in Group 2. Plasma concentrations of several individual FAs, including even-chain saturated FAs (SFAs; myristic, palmitic, stearic acids) and monounsaturated FAs (MUFAs; cis-vaccenic, oleic acids), were respectively associated with greater odds of Groups 1 and 2 status, adjusting for covariates. Higher concentrations of SFA and MUFA subgroups (highest compared with lowest quartile) were associated with increased odds of Group 2 status [SFAs adjusted OR (aOR): 1.51 (95% CI: 1.05, 2.18); MUFAs aOR: 1.78 (95% CI: 1.11, 2.85)]. Higher eicosapentaenoic acid plasma concentration was associated with decreased odds of Group 1 status [quartile 4 aOR: 0.41 (95% CI: 0.17, 0.95)]. Conclusions Higher plasma concentrations of SFAs and MUFAs, primary de novo lipogenesis products, were associated with elevated FPG and HbA1c in a nationally representative study population in the United States. Additional studies are necessary to elucidate potential causal relationships between FAs (from endogenous production and dietary consumption) and diabetogenic indicators, as well as clinical implications for managing diabetes and prediabetes.

scholarly journals Congenital pes metatarsus varus: Role of arterial abnormalities in feet and treatment duration and outcome in children

2019 ◽  
Vol 147 (1-2) ◽  
pp. 65-69
Author(s):  
Dragana Cirovic ◽  
Dejan Nikolic ◽  
Tatjana Knezevic ◽  
Vesna Bokan-Mirkovic ◽  
Polina Pavicevic ◽  
...  
Keyword(s):  
Physical Therapy ◽  
Treatment Duration ◽  
Significant Difference ◽  
Group A ◽  
Group 3 ◽  
Group 2 ◽  
Group B ◽  
Prospective Longitudinal ◽  
Group 1 ◽  
Severity Degree

Introduction/Objective. The aim of this paper was to examine proportion of patients with arterial abnormalities of feet due to age and severity degree of pes metatarsus varus (PMV), and to evaluate the treatment duration and outcome. Methods. The prospective longitudinal study included 240 patients with congenital PMV classified into three age groups: group < 3 months of life (Group 1), group 3?9 months (Group 2), and group 9?12 months (Group 3). Three categories of PMV were analyzed: mild/moderate/severe. Groups with arterial anomalies (Group A) and without (Group B) were analyzed. Clinical outcome was graded as: good/satisfactory/poor. Results. There is statistically significant difference in distribution of children regarding age and severity degree on first visit and presence of feet arterial abnormalities (p < 0.01). For Group A, younger children had longer physical therapy, while for Group B, older children had longer duration of physical therapy. Same trend applies as severity degree of foot deformity increase. In Group A, the most frequent treatment outcome was poor (for Group 1 ? 46.7%; Group 2 ? 60%; Group 3 ? 62%), while in Group B for Group 1 and Group 2 it was frequently good (Group 1 ? 90%; Group 2 ? 40%), and for Group 3 frequently satisfactory (Group 3 ? 53.3%). Conclusion. In children with PMV it might be advisable to perform ultrasound evaluation of arterial structure of feet, and particularly in cases were such deformity is more severe.

scholarly journals Contemporary Concepts and Techniques of Teaching Posterior Palatal Seal among Dental Colleges of Karnataka: A Cross-sectional Survey

2020 ◽  
Author(s):  
Sweekriti Mishra ◽  
BM Rashmi ◽  
K Ravishankar ◽  
Sanober Khan ◽  
Anoop Sharma ◽  
...  
Keyword(s):  
Conventional Method ◽  
Goodness Of Fit ◽  
Teaching Experience ◽  
Faculty Members ◽  
Goodness Of Fit Test ◽  
Chi Square ◽  
Group 3 ◽  
Group 2 ◽  
Study Participants ◽  
Group 1

Introduction: Since literature provides various schools of thought to achieve Posterior Palatal Seal (PPS) in a maxillary denture, it becomes essential to know the techniques dominating in our curriculum presently. Aim: To determine the prevalence of concepts and also the need for standardisation in establishing PPS among dental colleges of Karnataka. Materials and Methods: A descriptive survey was conducted among teaching faculty of Department of Prosthodontics with varied teaching experience across the dental colleges of Karnataka. A pre-tested questionnaire containing ten close ended questions was distributed to 230 faculty members with MDS qualification in Prosthodontics via e-mail. The faculty responses were divided into three groups based on teaching experience: Group 1 (2-7 years), Group 2 (7-12 years) and Group 3 with more than 12 years of teaching experience. The Chi-Square Goodness of Fit test was used to compare the overall differences in the responses by the study participants; and Independent Chi-Square test to compare the differences in the responses based on teaching experience of the study participants. A value of p<0.05 was considered as statistically significant. Results: The most common method taught for locating vibrating line was Phonation-Nose Blowing-Fovea Palatini (46.0%). Two-line concept of vibrating line was taught (77%) more commonly, where the termination of maxillary denture is on posterior vibrating line (58%). Currently, Boucher’s conventional method without master cast scoring (63%) was the most favoured method to record the seal. This was true mainly with Group 1 (81.9%) and Group 2 (66.7%). In contrast, Group 3 faculty largely advocated Boucher’s conventional technique along with master cast scoring (70%). Overall most of the faculty members (66.5%) did not make the students score the postpalatal area. This was mainly seen in faculty belonging to Group 1 (81.9%) and Group 2 (69.7%). Bulk of Group 3 faculty (75%) taught scoring of the master cast. A large portion of the faculty (60.0%) recommended standardisation in the methods of teaching PPS which was mainly backed by Group 2 (77.3%) and Group 1 (61.7%). Conclusion: This survey indicates that among dental colleges of Karnataka, a majority of faculty of Prosthodontics prefer Boucher’s conventional method without master cast scoring (63%) to achieve maxillary PPS. Nevertheless, teaching concepts differed based on faculty experience. It is emphasised that teaching methods should be standardised and include unambiguous techniques.

scholarly journals Intestinal carriage ofBacillus cereus: faecal isolation studies in three population groups

1985 ◽  
Vol 95 (3) ◽  
pp. 629-638 ◽  
Author(s):  
P. C. B. Turnbull ◽  
J. M. Kramer
Keyword(s):  
South Africa ◽  
Food Samples ◽  
Microbiology Laboratory ◽  
Rural Region ◽  
Four Seasons ◽  
Stool Samples ◽  
Group 3 ◽  
Group 2 ◽  
Ofbacillus Cereus ◽  
Group 1

SUMMARYThe results of examinations of stools forBacillus cereusamong three unrelated groups of individuals are presented. The groups consisted of (1) healthy schoolchildren aged 6–11 years in a rural region of South Africa examined during each of the four seasons of the year; (2) 15 healthy volunteers comprising staff of a London microbiology laboratory and their families examined on each of 3 consecutive weeks; (3) 75 unrelated young children, 2 months to 5 years of age, in a second rural region of South Africa examined during a pilot study of 1 week's duration on the aetiology of rural gastroenteritis. The stools of the last group were submitted as being related to present or recent diarrhoea in the respective children.In group 1,B. cereusisolation rates ranged from 24·3% at the autumn visit to 43% at the summer visit with a significantly higher rate of isolation in the summer than at other seasons of the year(P <0·05).B. cereuswas isolated from 40% of group 2 volunteers on week 1, none on week 2 and 20% on week 3. The organism was detected in the 12 positive specimens at levels of approximately 102/g and constituted 2·5–30% of the total aerobic spore-forming bacillus population in the stools. In group 3,B. cereuswas recovered from 18·7% of the stool samples and was isolated consecutively with other pathogens (entcropathogenicEscherichia coliand rotavirus) on only five occasions. In groups 1 and 3, < 5% of the stools had ‘3+ ‘levels ofB. cereus(> 10 colonies per direct plate culture).B. cereuswas readily isolated from all of 10 food samples, representative of the typical diet of the group 1 individuals, and was present in substantial numbers (104to 5·5 × 106/g) in half of them.The isolation results, supported by serotyping, indicated that carriage ofB. cereusin stools is transient and its presence at any one time reflects solely its intake with foods.

scholarly journals Heparin Effects on Serum Gonadotropins

2021 ◽  
Author(s):  
Sarah A Kohn ◽  
Angela J Fought ◽  
Katherine Kuhn ◽  
Kelsey Jones Slogett ◽  
Andrew P Bradford ◽  
...  
Keyword(s):  
Secondary Analysis ◽  
Normal Weight ◽  
Heparin Infusion ◽  
Early Follicular Phase ◽  
Membrane Bound ◽  
Group 3 ◽  
Group 2 ◽  
Study Participants ◽  
Combined Data ◽  
Group 1

Abstract Introduction Studies using lipid infusions to raise fatty acid levels require heparin to release lipoprotein lipase (LPL), thus calling into question the appropriate control infusion for this type of study: saline alone or saline plus heparin. We aimed to evaluate whether the addition of heparin alone, in doses needed to release LPL, would alter circulating free fatty acids (FFA) and/or affect gonadotropins. Materials and Methods This was a secondary analysis using combined data from eumenorrheic normal-weight women subjected to ‘control’ conditions in one of two separate studies. In one study, participants received saline alone (Group 1) as a control, and in the other study participants received saline alone and/or saline plus heparin (Groups 2-3) as a control. Both studies performed early follicular phase, frequent blood sampling. FSH and LH were compared across groups and in conditions with and without heparin. Linear mixed models were used to analyze the data. Results LH did not differ across any of the 3 groups. Estimated means (SE) for FSH differed between groups but this difference was marginal (p=0.05) after adjusting for AMH and unrelated to heparin infusion [Group 1: 4.47IU/L (SE 1.19), Group 2: 8.01IU/L (SE 1.14), Group 3: 7.94IU/L (SE 1.13)]. Conclusions Heparin does not exert major effects on gonadotropins when infused in quantities sufficient to release LPL. However, because it can release other vascular membrane bound proteins, heparin should be considered part of the control infusions in lipid infusion studies where increased FFA levels are the goal.

scholarly journals THE USING OF POLYPRENOL-CONTAINING DRUG IN PATIENTS WITH ACUTE CORONARY SYNDROME

2018 ◽  
Vol 33 (2) ◽  
pp. 21-25
Author(s):  
E. I. Tsoi ◽  
E. V. Vyshlov ◽  
V. B. Trusov
Keyword(s):  
Acute Coronary Syndrome ◽  
Standard Therapy ◽  
Control Group ◽  
Study Group ◽  
Double Blind ◽  
Coronary Syndrome ◽  
Group 3 ◽  
Group 2 ◽  
The Right ◽  
Group 1

The article shows the results of the study using drug Ropren in the patients with acute coronary syndrome. Ropren is  a plant drug containing polyprenols — dolichol precursors which take part in dolichol phosphate pathway. The pathology in this pathway leads to disbalance and glycoprotein deficiency. This is the reason of large group of diseases. This study is randomized double blind placebo controlled (No. NCT03122340 at ClinicalTrials.gov). Patients (n=68) with ACS taking standard therapy including atorvastatin 40 mg/day were randomized into to 2 groups: group 1 (n=34) took Ropren  8 drops 3 times per day for 3 week, then 5 drops 3 times per day for 5 weeks; group 2 (n=34) took placebo in the same dose regimen. After two — month therapy there was a positive dynamic (decreasing) in the level of interleukin-6 in the study group whereas in the control group there was no statistically significant change: 4.36 (2.61, 8.95) and 5.5 (3.3; 8.4) pg/ml, respectively (p<0.05). In the group of patients taking Ropren the reduction or cessation of statin was required significantly less than in the placebo group: 3 (8.8%) vs 9 (26.5%), respectively. One patient from the first group had a side effect in the form of gravity in the right hypochondrium. That is why the administration of Ropren in addition to standard therapy is reasonable in patients with ACS.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Abnormal Haemostasis and Blood Viscosity in Malignant Hypertension

1984 ◽  
Vol 52 (03) ◽  
pp. 253-255 ◽  
Author(s):  
C Isles ◽  
G D O Lowe ◽  
B M Rankin ◽  
C D Forbes ◽  
N Lucie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Viscosity ◽  
Renal Damage ◽  
Antithrombin Iii ◽  
Plasma Viscosity ◽  
Malignant Hypertension ◽  
Fibrin Deposition ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

SummaryWe have previously shown abnormalities of haemostasis suggestive of intravascular coagulation in patients with malignant hypertension, a condition associated with retinopathy and renal fibrin deposition. To determine whether such abnormalities are specific to malignant hypertension, we have measured several haemostatic and haemorheological variables in 18 patients with malignant hypertension (Group 1), 18 matched healthy controls (Group 2), and 18 patients with non-malignant hypertension (Group 3) matched for renal pathology, blood pressure and serum creatinine with Group 1. Both Groups 1 and 3 had increased mean levels of fibrinogen, factor VIIIc, beta-thrombo- globulin, plasma viscosity and blood viscosity (corrected for haematocrit); and decreased mean levels of haematocrit, antithrombin III and platelet count. Mean levels of fast antiplasmin and alpha2-macroglobulin were elevated in Group 1 but not in Group 3. We conclude that most blood abnormalities are not specific to malignant hypertension; are also present in patients with non-malignant hypertension who have similar levels of blood pressure and renal damage; and might result from renal damage as well as promoting further renal damage by enhancing fibrin deposition. However increased levels of fibrinolytic inhibitors in malignant hypertension merit further investigation in relation to removal of renal fibrin.

Features of postoperative period in patients with chronic venous insufficiency: phlebectomy versus thermal ablation

2020 ◽  
pp. 64-75
Author(s):  
E. Burleva ◽  
O. Smirnov ◽  
S. Tyurin
Keyword(s):  
Postoperative Period ◽  
Chronic Venous Insufficiency ◽  
Thermal Ablation ◽  
Venous Insufficiency ◽  
Clinical Symptoms ◽  
Varicose Veins ◽  
Statistical Processing ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The purpose of the study was to conduct a comparative assessment of the course of the postoperative period after phlebectomy and thermal ablation in patients with varicose veins of the lower extremities in the system of the great saphenous vein (GSV) with class C2 of chronic venous insufficiency (CVI) — CEAP class C2. Materials and methods: 455 patients (455 limbs) with CEAP class C2. Group 1 (n = 154) received stripping + minimally invasive phlebectomy; Group 2 — endovenous laser ablation (EVLA) of GSV trunk + sclerotherapy of varicose veins; 3 group (n = 150) — radiofrequency ablation (RFA) of the GSV + sclerotherapy. All patients were united by a single tactical solution — the elimination of pathological vertical reflux in GSV. In each group, patients were with similar hemodynamic profile were selected (Group 1 = 63; Group 2 = 61; Group 3 = 61). The course of the postoperative period (from 2 days to 2 months) was compared for pain (visual analog scale — VAS), clinical symptoms of chronic venous insufficiency, degree of satisfaction (Darvall questionnaire), and duration of disability. Statistical processing was carried out using Excel programs for Windows XP, MedCalc® (version 11.4.2.0., Mariakerke, Belgium). Results: Postoperative pain is more pronounced (during day 1 for Group 1–4.0, Group 2–3.0, Group 3–2.0) and more prolonged (up to 4 days) after open surgeries (p < 0.05). The dynamics of the clinical symptoms of CVI (including varicose syndrome and use of compression therapy) could not be fully evaluated in connection with the ongoing sclerotherapy procedures for patients of Groups 2 and 3. Satisfaction of patients with aesthetic aspects was higher than expected in all groups. Reliable statistical differences proved decrease in days of disability (Group 1–14; Group 2–4; Group 3–3) and earlier return to physical activities and work in patients after thermal ablation in comparison with phlebectomy. Conclusion: The study shows that all three methods for eliminating vertical reflux in the GSV can be proposed for a large category of patients with CEAP of class C3 and C2. Medical and social rehabilitation of patients using endovascular thermal ablation technologies proceeds faster, which is beneficial both for the patients and for society.

Analysis of the quality of early diagnostics of cardiovascular diseases in students of educational institutions of Khabarovsk (according to the data of preventive examinations)

2020 ◽  
pp. 13-16
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Sinus Tachycardia ◽  
Blood Pressure Level ◽  
Educational Institutions ◽  
Conduction Disturbances ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

To identify the prevalence of early pathology of cardiovascular diseases, a survey of 400 200 girls) in the age group 15 and 17 years old was conducted as a part of routine medical of the level of blood pressure (BP) was carried out, with the calculation of the average level pressure on the basis of three separate measurements estimated by percentile tables for a registration of a standard resting ECG in 12 leads. According to the results of the survey, into 3 groups: with an increase in blood pressure above 95 ‰ (group 1 – 16 people), which recorded in males (p<0,05); Group 2 (67 people) – adolescents with a normal blood pressure level and group 3 of adolescents with a decrease in blood pressure below 5 ‰ changes in the form of rhythm and conduction disturbances were noted in almost every a predominance of sinus tachycardia in the first group. In the third group of adolescents, form of ectopic rhythm and pacemaker migration were significantly more frequently only 78 % of adolescents were referred for consultation and in-depth examination by a pediatric cardiologist.

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