A Mendelian randomization study of telomere length and blood-cell traits

Corpuscular Hemoglobin ◽

Standard Deviation Increase ◽

Mean Cell Volume ◽

Distribution Width

AbstractWhether telomere attrition reducing proliferative reserve in blood-cell progenitors is causal has important public-health implications. Mendelian randomization (MR) is an analytic technique using germline genetic variants as instrumental variables. If certain assumptions are met, estimates from MR should be free from most environmental sources of confounding and reverse causation. Here, two-sample MR is performed to test whether longer telomeres cause changes to hematological traits. Summary statistics for genetic variants strongly associated with telomere length were extracted from a genome-wide association (GWA) study for telomere length in individuals of European ancestry (n=9190) and from GWA studies of blood-cell traits, also in those of European ancestry (n∼173,000 participants). A standard deviation increase in genetically influenced telomere length increased red blood cell (RBC) and white blood cell (WBC) counts, decreased mean corpuscular hemoglobin (MCH) and mean cell volume (MCV), and had no observable impact on mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), hematocrit, or hemoglobin. Sensitivity tests for pleiotropic distortion were mostly inconsistent with glaring violations to the MR assumptions. Similar to how germline mutations in TERT can lead to bone-marrow failure, these data provide evidence that genetically influenced common variation in telomere length impacts hematologic traits in the population.

Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study

Nutrients ◽

10.3390/nu13061940 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1940

Author(s):

Karl Michaëlsson ◽

Susanna C. Larsson

Keyword(s):

Bone Mineral Density ◽

Confidence Interval ◽

Bone Mineral ◽

Genetic Variants ◽

Mendelian Randomization ◽

Alpha Tocopherol ◽

European Ancestry ◽

Mineral Density ◽

Standard Deviation Increase ◽

A Genome

Recent cohort studies indicate a potential role of the antioxidant α-tocopherol in reducing bone loss and risk of fractures, especially hip fractures. We performed a Mendelian randomization investigation of the associations of circulating α-tocopherol with estimated bone mineral density (eBMD) using heel ultrasound and fractures, identified from hospital records or by self-reports and excluding minor fractures. Circulating α-tocopherol was instrumented by three genetic variants associated with α-tocopherol levels at p < 5 × 10−8 in a genome-wide association meta-analysis of 7781 participants of European ancestry. Summary-level data for the genetic associations with eBMD in 426,824 individuals and with fracture (53,184 cases and 373,611 non-cases) were acquired from the UK Biobank. Two of the three genetic variants were strongly associated with eBMD. In inverse-variance weighted analysis, a genetically predicted one-standard-deviation increase of circulating α-tocopherol was associated with 0.07 (95% confidence interval, 0.05 to 0.09) g/cm2 increase in BMD, which corresponds to a >10% higher BMD. Genetically predicted circulating α-tocopherol was not associated with odds of any fracture (odds ratio 0.97, 95% confidence interval, 0.91 to 1.05). In conclusion, our results strongly strengthen a causal link between increased circulating α-tocopherol and greater BMD. Both an intervention study in those with a low dietary intake of α-tocopherol is warranted and a Mendelian randomization study with fragility fractures as an outcome.

Impacts of Mycoplasma loads and lung lesions on immune and hematological statuses of pigs in an eight-breed cross heterogeneous population

Journal of Animal Science ◽

10.1093/jas/skaa235 ◽

2020 ◽

Vol 98 (8) ◽

Author(s):

Qing Zhang ◽

Jing Li ◽

Tao Huang ◽

Yifeng Zhang ◽

Wenwu Xu ◽

...

Keyword(s):

Blood Cell ◽

Neutrophil Count ◽

Lymphocyte Count ◽

Volume Distribution ◽

Mean Corpuscular Hemoglobin Concentration ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Lung Lesions

Abstract Developments of pulmonary diseases, often accompanied by infections of bacteria, severely affect the meat production and welfare of pigs. This study investigated 307 pigs at age of 240 d from an eight-breed cross reared under standardized housing conditions for associations among the extent of lung lesions, bacteria load inferred from 16S rRNA sequencing of bronchoalveolar lavage fluid, as well as 57 immune cells and 25 hematological traits. We showed that the pigs under study suffered substantial and varied lung lesions, and the Mycoplasma is the most associated bacteria genera. At a false discovery rate of 0.05 (FDR < 0.05), the severity of lung lesions were significantly associated with greater CD8+ to CD3+ cell ratio, neutrophil-to-lymphocyte ratio (NLR), and standard deviation of red blood cell volume distribution width (RDW-SD), and lower CD4−CD8−/CD3+, CD3+CD4−CD8−/PBMCs (peripheral blood mononuclear cells) and CD14−CD16−/PBMCs cell ratios, mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage, reflecting an status of inflammation, immune suppression, and hypoxia of the pigs accompanying the progression of the lung lesions. The Mycoplasma abundance showed positive correlations with neutrophil count, neutrophil count percentage, NLR, monocyte count, coefficient of variation in red blood cell volume distribution width , and RDW-SD, and negative correlations with mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage; these correlations are largely consistent with those of lung lesions, supporting the comorbidity of lung lesions and Mycoplasma infection. We also observed nonlinear associations that sharp increases in neutrophil count and neutrophil count percentage occurred only when Mycoplasma abundance raised above the population-average level. The results provide helpful insights into the changes of host immune status in response to Mycoplasma relevant lung diseases in pigs.

Genome Wide Scan of Complete Blood Count (CBC) Measures Suggests Strong Linkage of Red Blood Cell (RBC) Count to Chromosome 4q25.

Blood ◽

10.1182/blood.v110.11.1729.1729 ◽

2007 ◽

Vol 110 (11) ◽

pp. 1729-1729 ◽

Cited By ~ 1

Author(s):

Diana Abbott ◽

Kai Wang ◽

Amy Shapiro ◽

Trudy Burns ◽

Jorge Di Paola

Keyword(s):

Linkage Analysis ◽

Blood Cell ◽

Complete Analysis ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Large Pedigree ◽

Strong Linkage ◽

Significant Heritability ◽

Von Willebrand

Abstract Previous reports suggest that peripheral blood counts are strongly influenced by environmental and genetic determinants; however few of the genetic factors that regulate these quantitative traits have been discovered. We analyzed CBC data from 395 samples collected from an 854-member Amish pedigree with von Willebrand disease. 71 individuals of the pedigree are heterozygous for a missense mutation at position 4120, represented by a single base substitution (C>T) that predicts an arginine to cysteine change at position 1374 (R1374C) in the A1 domain of the mature von Willebrand factor molecule. The detection of genetic signals is likely to be enhanced in groups that live in a more homogeneous environment like the Amish. Linear and quadratic age effect accounted for varying proportions of the gender-specific variation in the CBC measures (from 1% to 70%). The variance component associated with additive polygenic effects was estimated for each CBC phenotype using MENDEL to obtain estimates of heritability. Significant heritability was found for platelet (h2= 0.518, p <0.0005), white blood cell (WBC) (h2=0.395, p <0.0001), RBC counts (h2= 0.358, p <0.0025) and mean corpuscular hemoglobin concentration (MCHC) (h2= 0.547, p <0.0005). Lower heritability was found for red cell distribution width (RDW) (h2= 0.217, p <0.001) and mean corpuscular hemoglobin (MCH) (h2= 0.231, p < 0.02) hematocrit (Hct) (h2= 0.126, p <0.10) and hemoglobin (Hb) (h2= 0.055, p > 0.2). Interestingly since significant heritability for Hct and Hb was reported in other studies, and to rule out the significant effect of bleeding due to the VWF mutation, we estimated heritability of Hb excluding all members of the pedigree that exhibited the 4120 C>T mutation, h2= 0. 21 (p < 0.05). A primary genetic screen at a 10 cM average interval was performed on the entire Amish pedigree in collaboration with the Marshfield genotyping center. Standard Screening Set 16 with 400 short tandem repeat polymorphic (STRP) markers was utilized generating a total of approximately 160,000 genotypes on the 395 samples. Due to data complexity, the Markov Chain Monte Carlo (MCMC)-based program LOKI was used to conduct multipoint linkage analysis for eight CBC measures that were adjusted for age, sex and mutation status to control for potential confounding. The outcome of interest from the MCMC analysis is represented by the Bayes factor (BF) which examines the probability of linkage in complex pedigrees at every centimorgan (cM). A complete analysis of the genome scan with 1,000,000 iterations was performed. A quantitative trait locus (QTL) suggesting strong linkage was identified for the RBC measure at position 4q25 with a BF of 58.17 at 114.5 cM. This result was confirmed by splitting the pedigree into several smaller subsets and conducting traditional linkage analysis using MERLIN (all individuals in the pedigree were included in at least one subset) with a LOD score of 0.66 (p < 0.05). Interestingly, a previous twin study found evidence for linkage for RBC to 4q32. Similar to animal studies, no evidence of linkage was observed in chromosomal regions known to contain the genes that encode for the hemoglobin chains, erythropoietin or erythropoietin receptor. This analysis in a very large pedigree identified a region of strong linkage for RBC that will be analyzed at higher resolution for the presence of novel modifying genes and alleles that may potentially be important for our understanding of the control of erythropoiesis.

Association of haplotypes for SNPs in the LTR regions of bovine leukemia virus with hematological indices of cattle

Vavilov Journal of Genetics and Breeding ◽

10.18699/vj19.491 ◽

2019 ◽

Vol 23 (3) ◽

pp. 262-269 ◽

Cited By ~ 2

Author(s):

N. V. Blazhko ◽

S. Kh. Vyshegurov ◽

A. S. Donchenko ◽

K. S. Shatokhin ◽

T. I. Krytsyna ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Leukemia Virus ◽

White Blood Cells ◽

Biological Species ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Hematological Indices ◽

Blood Indices

Molecular typing of BLV samples isolated from Holsteinized Russian Black Pied cattle was carried out, and various cytofluorometric and morphological blood indices were examined. We performed the total count of white blood cells (WBC), lymphocyte (lymf), granulocyte (gran), monocyte (mon), red blood cell (RBC), hemoglobin (HGB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit count (PCT). The LTR-region of BLV was haplotyped. Only viruses of haplotypes I (0.33±0.03) and III (0.67±0.03) of the eight possible were detected. The ratio of hematologically sick, healthy, and suspected carriers of BLV of haplotypes I and II was comparable with the results of other researchers. The numbers of leukocytes, erythrocytes and platelets in the blood of carriers of haplotype III exceeded the corresponding parameters of cattle affected by the virus of haplotype I. It is interesting to note that the difference in the hemolytic status of animals was manifested not only by the concentration of leukocytes as direct immune agents but also by the count of erythrocytes and platelets, which are not directly involved in the immune response. The number of particles of haplotype III of the BLV circulating in the blood of infected individuals exceeded that of the carriers of haplotype I. In this connection, an assumption was made about the evolutionary advantage of the more virulent haplotype III. However, the results of our own research in conjunction with the data of other scientists indicate that the high virulence of individual virus strains is a consequence of the tendency to implement the maximum possible intensity of the synthesis of virus particles but not of the high damaging effect alone. It is shown that high lethality is evolutionarily disadvantageous for viruses, since the extinction of the carrier as a biological species is fraught with the disappearance of the virus itself.

Comparative Clinical and Haematological Investigations in Lactating Cows with Subclinical and Clinical Ketosis

Macedonian Veterinary Review ◽

10.14432/j.macvetrev.2015.04.042 ◽

2015 ◽

Vol 38 (2) ◽

pp. 159-166 ◽

Cited By ~ 2

Author(s):

Vania Marutsova ◽

Rumen Binev ◽

Plamen Marutsov

Keyword(s):

Weight Loss ◽

Body Weight ◽

Blood Cell ◽

Body Weight Loss ◽

Control Group ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Subclinical Ketosis ◽

Lactating Cows

Abstract Ketosis of lactating cows is among the most common metabolic diseases in modern dairy farms. The economic importance of the disease is caused by the reduced milk yield and body weight loss, poor feed conversion, lower conception rates, culling and increased mortality of affected animals. In the present study, a total of 47 high-yielding dairy cows up to 45 days in milk (DIM) are included. All animals were submitted to physical examination wich included checking the rectal body temperature, heart rate, respiratory and rumen contraction rates, and inspection of visible mucous coats. The body condition was scored, and blood β-hydroxybutyrate (BHBA) concentrations were assayed. The cows were divided into 3 groups: first group (control) (n=24) with blood β-hydroxybutyrate level <1.2 mmol/l, second group (n=15) with blood β-hydroxybutyrate between 1.2-2.6 mmol/l (subclinical ketosis) and third group (n=8) with blood β-hydroxybutyrate >2.6 mmol/l (clinical ketosis). Whole blood samples were obtained and analyzed for Red Blood Cell (RBC, 1012/l), Hemoglobin (HGB, g/l), Hematocrit (HCT, %), Mean Corpuscular Volume (MCV, fl), Mean Corpuscular Hemoglobin (MCH, pg), Mean Corpuscular Hemoglobin Concentration (MCHC, g/l), White Blood Cell (WBC, 109/l), Lymphocytes (LYM, 109/l), Monocytes (MON, 109/l), Granulocytes (GRA, 109/l), Red Blood Distribution Width (RDW, %), Red Blood Cell Distribution Width Absolute (RDWa, fl), Platelets (PLT, 109/l) and Mean Platelet Volume (MPV, fl). In this study, deviations in the clinical parameters in the control group and in those with subclinical ketosis were not identified. The cows from the third group (clinical ketosis) exhibited hypotonia, anorexia and body weight loss vs. control group. Hematological analysis showed leukocytosis and lymphocytosis in cows with subclinical ketosis vs. control group. In cows with clinical ketosis WBC counts decreased (leukopenia), while hemoglobin content and hematocrit values are higher vs. control group. Blood BHBA values are higher in both groups of ketotic cows vs. the control group. The other analyzed parameters (RBC, MCH, MCHC, MCV, RDW, RDWa, MON, GRA, PLT and MPV) were close to control values.

Comparison of Hematological and Biochemical Profiles of Late Pregnant and Non-Pregnant Mares

jurnal veteriner ◽

10.19087/jveteriner.2021.22.1.1 ◽

2021 ◽

Vol 22 (1) ◽

pp. 1-7

Author(s):

Murat Onur Yazlik ◽

Ezgi Dikmeoglu ◽

Arzu Esen ◽

Ufuk Kaya ◽

Özgenur Kafkas ◽

...

Keyword(s):

Blood Cell ◽

Cell Count ◽

Biochemical Parameters ◽

Clinical Practices ◽

Blood Cell Count ◽

Corpuscular Hemoglobin ◽

Mean Cell Volume ◽

Pregnancy Status

The maternal body must adapt to fetal growth and development during the state of pregnancy for successful foal and mother. Pregnancy status as in other mammals is related to physiology and hematology. This study aimed to compare the hematology profiles and biochemical parameters of late pregnant and non-pregnant mares. Twenty-two mares were included in the study. Mares were divided into two groups according to the pregnancy status. Hematology profile and biochemical parameters were analyzed from blood samples collected from the jugular vein. All data were analyzed using Stata 12/MP4. White blood cell count, lymphocyte, red blood cell count, hemoglobin concentration, hematocrit, monocyte and percentage of monocyte were significantly lower in non-pregnant mares compared to late pregnant mares (P<0.05). No significant differences were noted in values of neutrophil, eosinophil, mean cell volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, platelet, mean platelet volume, red cell distribution width in both groups (P>0.05). On the other hand, biochemical parameters analysis showed that calcium, total bilirubin, and triglyceride concentrations were greater in late pregnant mares (P<0.05). However, urea, albumin, cholesterol, and magnesium concentrations were similar among groups (P>0.05). In conclusion, the present study showed hematology profile and biochemical parameters differences in late pregnant and non-pregnant mares. These values could be useful in clinical practices to assess the situation of late pregnant mares.

Complete Blood Count Peculiarities in Pregnant SARS-CoV-2-Infected Patients at Term: A Cohort Study

Diagnostics ◽

10.3390/diagnostics12010080 ◽

2021 ◽

Vol 12 (1) ◽

pp. 80

Author(s):

Roxana Covali ◽

Demetra Socolov ◽

Razvan Socolov ◽

Ioana Pavaleanu ◽

Alexandru Carauleanu ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Blood Count ◽

Complete Blood Count ◽

Mean Corpuscular Hemoglobin Concentration ◽

Blood Cell Count ◽

Corpuscular Hemoglobin ◽

Distribution Width

Background: During viral outbreaks, pregnancy poses an increased risk of infection for women. Methods: In a prospective study, all patients admitted for delivery at term to Elena Doamna Obstetrics and Gynecology University Hospital in Iasi, Romania, between 1 April 2020 and 31 December 2020 were included. There were 457 patients, divided into two groups: group 1, SARS-CoV-2-positive patients (n = 46) and group 2, SARS-CoV-2-negative patients (n = 411). Among other tests, complete blood count was determined upon admittance, and the following values were studied: white blood cell count, lymphocytes, neutrophils, red blood cell count, hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, red blood cell distribution width, hematocrit, platelet count, mean platelet volume, platelet distribution width, plateletcrit, and platelet large cell ratio. Results: in pregnant SARS-CoV-2-infected patients at term, there was a significant decrease in white blood cell, neutrophil, and lymphocyte count, and an increase in mean corpuscular hemoglobin concentration, compared to healthy pregnant women at term, although all still within normal limits. None of the other components of the complete blood count or fetal outcomes studied was significantly influenced by SARS-CoV-2 infection in pregnant patients at term.

Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

10.21203/rs.3.rs-504669/v1 ◽

2021 ◽

Author(s):

Misganaw Asmamaw ◽

Tariku Sime ◽

Kumsa Kene ◽

Minale Fekadie ◽

Muluken Teshome ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Cell Parameters

Abstract Background: Type 2 Diabetes Mellitus (T2 DM) is a common type of DM characterized by hyperglycemia. Glycation of hemoglobin and related proteins in DM can affect the physiological and structural properties of red blood cells. Although glycated hemoglobin (HbA1c) test continues to be the gold standard for the assessment of long-term glycemic control accessibility and affordability of the test in routine diagnosing service are still limited in developing countries. Hence, this study was aimed to assess red blood cell parameters as a biomarker for long-term glycemic monitoring among T2 DM patients.Methods: Facility-based cross-sectional study through a consecutive sampling technique was conducted among 124 T2 DM patients at the chronic illness follow-up clinic of Jimma Medical Center (JMC) from July 27 to August 31, 2020. A structured questionnaire was used to collect socio-demographic and clinical-related data. Five milliliters of the blood specimen was collected from each eligible T2 DM patient. HbA1c and red blood cell parameters were determined by Cobas 6000 and DxH 800 fully automated analyzers respectively. Data were entered into Epi-data software version 3.1 and exported to SPSS 25 version for analysis. Independent t-test and Pearson’s correlation coefficient were used to address the research questions. A P-value < 0.05 was considered statistically significant. Results: The mean age of study participants was 51.84± 11.6 years. 60.5% of T2 DM patients were in poor glycemic control. There was a significant mean difference between good and poor glycemic controlled T2 DM patients in red blood cell count (4.79±0.5 vs 4.38±0.8), hemoglobin (14.13±1.4 vs 13.60±1.6), mean corpuscular volume (89.52±4.7 vs 92.62±7.5), mean corpuscular hemoglobin (29.63±1.6 vs 30.77±2.9), and red cell distribution width (13.68±1.1 vs 14.63±1.2) respectively. Red blood cell count was inversely correlated (r=-0.280, p=0.002) with HbA1c while mean corpuscular volume (r=0.267, p=0.003), mean corpuscular hemoglobin (r=0.231, p=0.010), and red cell distribution width (r= 0.496, p=0.000) were positively correlated with level of HbA1c. Conclusion: Red cell count, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width could be useful indicators to monitor the glycemic status of T2 DM patients instead of HbA1c, though large prospective studies should be considered.

Impact of weight loss on inflammation and red blood cell biomarkers after laparoscopic gastric banding surgery

Journal of Investigative Medicine ◽

10.1136/jim-2017-000528 ◽

2017 ◽

Vol 66 (2) ◽

pp. 304-308 ◽

Cited By ~ 5

Author(s):

Susana Coimbra ◽

Cátia Ferreira ◽

Luís Belo ◽

Petronila Rocha-Pereira ◽

Alice Catarino ◽

...

Keyword(s):

Weight Loss ◽

Blood Cell ◽

Gastric Banding ◽

Iron Metabolism ◽

Red Blood Cell ◽

Obese Patients ◽

Corpuscular Hemoglobin ◽

Distribution Width

Adipose tissue produces several adipokines that are enrolled in different metabolic and inflammatory pathways that may disturb iron metabolism and erythropoiesis. Considering that laparoscopic adjustable gastric banding (LAGB) has not been associated with a long-term risk of malabsorption, we performed a 13-month follow-up study in severe obese patients submitted to LAGB in order to clarify its impact on inflammation, iron metabolism and on red blood cell (RBC) biomarkers. Twenty obese patients were enrolled in the study, being clinical and analytically assessed before (T0) and 13 months after LAGB intervention (T1). Inflammation, iron bioavailability and RBC biomarkers were evaluated at T0 and T1. At T1, weight and anthropometric indices decreased significantly; patients showed a significant increase in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (MCHC), and a reduction in red cell distribution width, ferritin, hepcidin, tumor necrosis factor-α, interleukin-6 (IL-6) and C-reactive protein. Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.

The Effect of One Bout of Intensive Judo Exercise on Select Hematological and Immunological Parameters in Adolescent Elite Judo Athletes

Asian Journal of Sports Medicine ◽

10.5812/asjsm.101364 ◽

2020 ◽

Vol 11 (2) ◽

Author(s):

Mohammad-Reza Hazratian ◽

Hossein Taheri-Chadorneshin ◽

Asmat Rashidi

Keyword(s):

Blood Cell ◽

Blood Parameters ◽

Adolescent Male ◽

Corpuscular Hemoglobin ◽

Immunological Parameters ◽

Distribution Width ◽

Humoral Immune ◽

Paired Samples

Background: Exercise-related studies do not agree on changes in blood parameters regarding anemia and serum immunoglobulin concentration as adaptive immunity. Objectives: The current study aimed to investigate exercise-induced variations in hematological and immunological parameters in response to one bout of intensive judo exercise in adolescent elite judoka. Methods: Venipuncture was performed on ten adolescent male Iranian elite judoka (age: 15.60 ± 0.69 years; body mass index: 24.15 ± 2.80 kg/m2) before and immediately after one bout of intensive judo protocol. Erythrocyte variables [red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), red distribution width (RDW), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC)], platelets variables [platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT)], cellular immune variables [white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM)], and humoral immune variables (IgM, IgA, IgG, IgE) were measured. Data were analyzed using Wilcoxon and paired-samples t-test, and P < 0.05 was considered significant. Results: After the plasma volume was corrected using the Dill and Costill equation, the results showed that RBC, HGB, HCT, MCHC, IgA, and IgM decreased significantly immediately after exercise. However, MCH, RDW, PLT, PDW, MPV, PCT, WBC, LYM, NEU, IgG, and IgE did not change significantly. Conclusions: According to the findings, it can be concluded that intensive judo exercise results in transient anemia and suppression of humoral immune response among adolescent elite judoka.