scholarly journals Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Jordan Morrison-Ham ◽  
Gillian M Clark ◽  
Elizabeth G Ellis ◽  
Andris Cerins ◽  
Juho Joutsa ◽  
...  
Keyword(s):  
Brain Stimulation ◽  
Effect Size ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Future Research ◽  
Motor Training ◽  
Intraoperative Bleeding ◽  
Non Invasive ◽  
Small Effect Size ◽  
Deep Brain

Background. Deep brain stimulation is a highly effective treatment of dystonia, but is invasive and associated with risks, such as intraoperative bleeding and infections. Previous research has used non-invasive brain stimulation (NIBS) in an attempt to alleviate symptoms of dystonia. The results of these studies, however, have been variable, leaving efficacy unclear. This study aimed to evaluate the effects of NIBS on symptoms of dystonia and determine whether methodological characteristics are associated with variability in effect size. Methods. Embase and MEDLINE Complete databases were searched for articles using any type of NIBS as an intervention in dystonia patients, with changes in dystonia symptoms the primary outcome of interest. Results. Meta-analysis of 26 studies demonstrated a small effect size for NIBS in reducing symptoms of dystonia (random-effects Hedges' g = 0.21, p = .002). Differences in the type of NIBS, type of dystonia, and brain region stimulated had a significant effect on dystonia symptoms. Meta-regression revealed that 10 sessions of active stimulation, and the application of concurrent motor training programs resulted in significantly larger mean effect sizes. Conclusion. NIBS has yielded small improvements to dystonic symptoms, but effect sizes depended on methodological characteristics, with more sessions of stimulation producing a larger response. Future research should further investigate the application of NIBS parallel to motor training, in addition to providing a greater quantity of sessions, to help define optimal parameters for NIBS protocols in dystonia. Registration. PROSPERO 2020, CRD42020175944

A Meta-Analysis of Facebook-Assisted Learning Outcomes and Their Gender Differences

2021 ◽  
Vol 13 (4) ◽  
pp. 63-82
Author(s):  
*Zhonggen Yu ◽  
Liheng Yu
Keyword(s):  
Gender Differences ◽  
Social Media ◽  
Learning Outcomes ◽  
Effect Size ◽  
Meta Analysis ◽  
Medium Effect ◽  
Future Research ◽  
Small Effect Size ◽  
Medium Effect Size ◽  
Media Applications

Social media applications such as Facebook have received wide attention in their use in education. However, it is still hard to arrive at a conclusion regarding whether a Facebook-assisted approach is effective in education and whether there are any significant gender differences in the learning outcomes. Based on rigid inclusion criteria, this study included 21 peer-reviewed high-quality journal articles. Through a meta-analysis using Reviewer Manager 5.3, the authors concluded that a Facebook-assisted approach could obtain significantly higher learning outcomes than the non-Facebook-assisted one with a medium effect size (d = 0.42) and that females could achieve significantly better learning outcomes than males with a very small effect size (d = -0.21) in the Facebook-assisted education. Future research could examine the effect of educational use of other social media applications, as well as in sociological, psychological, or educational dimensions.

scholarly journals The Effects of Psychological Skills Training for Archery Players in Korea: Research Synthesis Using Meta-Analysis

2021 ◽  
Vol 18 (5) ◽  
pp. 2272
Author(s):  
Eui Jae Kim ◽  
Hyun Wook Kang ◽  
Seong Man Park
Keyword(s):  
Effect Size ◽  
Meta Analysis ◽  
Skills Training ◽  
Training Period ◽  
Future Research ◽  
Psychological Skills ◽  
Psychological Skills Training ◽  
Training Interventions ◽  
Small Effect Size ◽  
And Training

The purpose of this meta-analysis study was to investigate the effectiveness of psychological skills training interventions for archery players in Korea. A total of 17 research papers examining the effects of psychological skills training interventions were selected for data analysis. To analyze the data, the Comprehensive Meta-Analysis (CMA) software program was used. The results of this study were as follows: The overall effect size of psychological skills training interventions for archery players was ES = 0.469 (Hedges’ g), which was a small effect size. The major factors that influenced the effects of psychological skills training interventions for archery players appeared to be the player level and training period. In particular, adult players and longer periods of training had bigger effect sizes. The results of this study demonstrate that psychological skills training for archery players is effective and show that the player level and training period are crucial factors in the psychological skills training design. Based on these findings, some implications for future research are discussed.

Quality of life outcomes after globus pallidus internus deep brain stimulation in idiopathic or inherited isolated dystonia: a meta-analysis

2020 ◽  
Vol 91 (9) ◽  
pp. 938-944 ◽  
Author(s):  
Takashi Tsuboi ◽  
James H Cauraugh ◽  
Joshua K Wong ◽  
Michael S Okun ◽  
Adolfo Ramirez-Zamora
Keyword(s):  
Quality Of Life ◽  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Effect Size ◽  
Meta Analysis ◽  
Sf 36 ◽  
Over Time ◽  
Deep Brain

BackgroundSeveral studies reported the beneficial effects of globus pallidus internus deep brain stimulation (GPi DBS) on health-related quality of life (HRQoL) in patients with inherited or idiopathic isolated dystonia. However, the impact of this intervention on physical and mental/psychological domains and the effects over time remain unclear.MethodsWe conducted a systematic literature review from January 2000 to May 2019 and performed a meta-analysis of HRQoL outcomes based on the Short Form Health Survey-36 (SF-36) after GPi DBS in patients with inherited or idiopathic isolated dystonia to evaluate the effects of DBS on physical and mental QoL.ResultsSeven studies comprising 144 patients with dystonia (78, generalised; 34, segmental; and 32, focal cervical) were included in this comprehensive analysis. The mean (SD) age at DBS implantation was 41.0 (11.4) years, and the follow-up period after implantation was 3.2 (3.8) years. The random effects model meta-analysis revealed that both physical and mental domains of SF-36 improved following DBS with a significantly larger effect size for the physical domains (effect size=0.781; p<0.0001) compared with the mental domains (effect size=0.533; p<0.0001). A moderator variable analysis demonstrated that effect sizes for HRQoL improvement were maintained over time.ConclusionsThis is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with inherited or idiopathic isolated dystonia. The benefits are greater for physical QoL domains compared with mental/psychological QoL. These findings highlight the importance of a comprehensive multidisciplinary approach to improve mental/psychological QoL.

scholarly journals Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Cathy K. Cui ◽  
Simon J. G. Lewis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Freezing Of Gait ◽  
Surgical Approaches ◽  
Future Research ◽  
Non Invasive ◽  
Dual Site ◽  
Deep Brain

Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson’s disease. In this review, we summarise the recent insights into freezing of gait and highlight the strategies that should be considered to improve future treatment. There is a need to develop individualised and on-demand therapies, through improved detection and wearable technologies. Whilst there already exist a number of pharmacological (e.g., dopaminergic and beyond dopamine), non-pharmacological (physiotherapy and cueing, cognitive training, and non-invasive brain stimulation) and surgical approaches to freezing (i.e., dual-site deep brain stimulation, closed-loop programming), an integrated collaborative approach to future research in this complex area will be necessary to systematically investigate new therapeutic avenues. A review of the literature suggests standardising how gait freezing is measured, enriching patient cohorts for preventative studies, and harnessing the power of existing data, could help lead to more effective treatments for freezing of gait and offer relief to many patients.

scholarly journals A meta-analysis of effects of Internet CBT for anxiety disorders: open community versus clinical service recruitment (Preprint)

2018 ◽  
Author(s):  
Geke Romijn ◽  
Neeltje Batelaan ◽  
Robin Kok ◽  
Jeroen Koning ◽  
Anton van Balkom ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Effect Size ◽  
Meta Analysis ◽  
Behavioural Therapy ◽  
Routine Care ◽  
Clinical Service ◽  
Effect Sizes ◽  
Current Evidence ◽  
Significant Difference ◽  
Small Effect Size

BACKGROUND Ample studies show the high potential of Internet-delivered cognitive behavioural therapy (iCBT) for anxiety disorders. However, evidence for its effectiveness in routine care is scarce. We conducted a meta-analysis to compare results obtained in trials with open recruitment to results obtained in trials with clinical service recruitment and updated previous findings. OBJECTIVE The present study thus aims 1) to update the current evidence on iCBT for anxiety disorders by assessing overall efficacy and 2) to assess whether open recruitment results are comparable to those with recruitment in a routine care context. METHODS Randomised controlled trials were included in which the effects of iCBT for anxiety disorders were compared to wait-list controls (WLC) or face-to-face (f2f) CBT controls. Pooled effect sizes based on anxiety measures (primary outcome), depression and quality of life measures (secondary outcomes) were computed. RESULTS We included 42 studies with 53 comparisons (43 open recruitment comparisons and 10 clinical recruitment comparisons). Overall effect size of (1) iCBT versus WLC was g=0.72 (p<.001) and (2) iCBT versus f2f CBT g=0.12 (p=0.11). Subgroup analyses revealed (3) iCBT clinical recruitment studies with WLC as comparator: g=0.29 (p<0.01), while iCBT open recruitment studies with WLC comparators showed a higher significant effect of g=0.76 (p<0.001). (4) Clinical recruitment studies comparing iCBT to f2f CBT revealed a non-significant and small effect size g=0.06 (p=0.51) while open recruitment studies comparing iCBT to f2f CBT showed an effect of g=0.19 (p=0.09). Comparing clinical recruitment trials with open recruitment trials showed a significant difference in effect size (p<.001) based on WLC comparators, and no significant difference (p=0.38) based on f2f CBT comparators. CONCLUSIONS iCBT is effective in samples recruited in routine clinical practice, but effect sizes are smaller than those found in open recruitment trials. More studies with routine care populations are needed to further validate these findings.

scholarly journals Non-Invasive Brain Stimulation to Investigate Language Production in Healthy Speakers: A Meta-Analysis

2017 ◽  
Author(s):  
Jana Klaus ◽  
Dennis J.L.G. Schutter
Keyword(s):  
Healthy Volunteers ◽  
Brain Stimulation ◽  
Language Production ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Language Functioning ◽  
Non Invasive ◽  
Control Target ◽  
The Brain ◽  
Healthy Participants

Non-invasive brain stimulation (NIBS) has become a common method to study the interrelations between the brain and language functioning. This meta-analysis examined the efficacy of transcranial magnetic stimulation (TMS) and direct current stimulation (tDCS) in the study of language production in healthy volunteers. Forty-five effect sizes from 30 studies which investigated the effects of NIBS on picture naming or verbal fluency in healthy participants were meta-analysed. Further sub-analyses investigated potential influences of stimulation type, control, target site, task, online vs. offline application, and current density of the target electrode. Random effects modelling showed a small, but reliable effect of NIBS on language production. Subsequent analyses indicated larger weighted mean effect sizes for TMS as compared to tDCS studies. No statistical differences for the other sub-analyses were observed. We conclude that NIBS is a useful method for neuroscientific studies on language production in healthy volunteers.

scholarly journals Updated systematic review and meta-analysis of studies examining the relationship between reported racism and health and well-being for children and youth: a protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e043722
Author(s):  
Naomi Priest ◽  
Kate Doery ◽  
Mandy Truong ◽  
Shuaijun Guo ◽  
Ryan Perry ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Research Policy ◽  
Meta Analysis ◽  
Well Being ◽  
Children And Youth ◽  
Effect Sizes ◽  
Future Research ◽  
Critical Determinant ◽  
Health And Well Being

IntroductionRacism is a critical determinant of health and health inequities for children and youth. This protocol aims to update the first systematic review conducted by Priest et al (2013), including a meta-analysis of findings. Based on previous empirical data, it is anticipated that child and youth health will be negatively impacted by racism. Findings from this review will provide updated evidence of effect sizes across outcomes and identify moderators and mediators of relationships between racism and health.Methods and analysisThis systematic review and meta-analysis will include studies that examine associations between experiences of racism and racial discrimination with health outcomes of children and youth aged 0–24 years. Exposure measures include self-reported or proxy reported systemic, interpersonal and intrapersonal racism. Outcome measures include general health and well-being, physical health, mental health, biological markers, healthcare utilisation and health behaviours. A comprehensive search of studies from the earliest time available to October 2020 will be conducted. A random effects meta-analysis will examine the average effect of racism on a range of health outcomes. Study-level moderation will test the difference in effect sizes with regard to various sample and exposure characteristics. This review has been registered with the International Prospective Register of Systematic Reviews.Ethics and disseminationThis review will provide evidence for future research within the field and help to support policy and practice development. Results will be widely disseminated to both academic and non-academic audiences through peer-review publications, community summaries and presentations to research, policy, practice and community audiences.PROSPERO registration numberCRD42020184055.

Macro-level Criminological Perspectives and School Delinquency: A Meta-analysis

2021 ◽  
pp. 0044118X2110223
Author(s):  
Natasha Pusch
Keyword(s):  
Social Cohesion ◽  
Meta Analysis ◽  
School Level ◽  
Effect Sizes ◽  
Macro Level ◽  
Future Research ◽  
Concentrated Disadvantage ◽  
Individual Level ◽  
School Differences ◽  
Academic Implications

School delinquency in public elementary, middle, and high schools has decreased in recent years, but is still a major issue that has negative mental health and academic implications for adolescents. Although research has focused on both individual-level and school-level explanations of school delinquency, it is not yet clear which macro-level criminological perspectives best explains it. Using 656 effect sizes nested within 75 studies and 30 unique datasets, this study addresses two questions using meta-analytic methods: Which macro-level criminological perspectives explain between-school differences in delinquency? Are effect sizes invariant across samples and research design? Results indicate that only concentrated disadvantage and social cohesion are significantly related to school delinquency. With the exception of concentrated disadvantage, effects are homogenous. This suggests that some school-level explanations are useful and future research should not exclude these factors. Practical implications suggest that improving social cohesion in schools may be more effective at preventing violence than target-hardening efforts.

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