Structure of anchorless RML prion reveals motif variation between strains
Keyword(s):
Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of brain-derived fibrils of the mouse anchorless RML scrapie strain which, like the recently determined hamster 263K strain, has a parallel in-register β-sheet-based core. However, detailed comparisons reveal that variations in shared structural motifs provide a basis for prion strain determination.
2018 ◽
Keyword(s):
2019 ◽
Vol 48
(1)
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pp. 45-61
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2017 ◽