scholarly journals A Cortico-Basal Ganglia Model for choosing an optimal rehabilitation strategy in Hemiparetic Stroke

2018 ◽  
Author(s):  
Rukhmani Narayanamurthy ◽  
Samyukta Jayakumar ◽  
Sundari Elango ◽  
Vignesh Muralidharan ◽  
V. Srinivasa Chakravarthy
Keyword(s):  
Basal Ganglia ◽  
Lesion Size ◽  
Constraint Induced Movement Therapy ◽  
Reaching Tasks ◽  
Optimal Rehabilitation ◽  
Simulation Results ◽  
Hemiparetic Stroke ◽  
Rehabilitation Strategy ◽  
Bimanual Reaching ◽  
Selection Of

AbstractTo facilitate the selection of an optimal therapy for a stroke patient with upper extremity hemiparesis, we propose a cortico-basal ganglia model capable of performing reaching tasks under normal and stroke conditions. The model contains two hemispherical systems, each organized into an outer sensory-motor cortical loop and an inner basal ganglia (BG) loop, controlling their respective hands. In addition to constraint induced movement therapy (CIMT), the model performs both unimanual and bimanual reaching tasks and the simulation results are in congruence with the experiment conducted by Rose et al (2004). Based on our study on the effect of lesion size on arm performance, we hypothesize that the effectiveness of a therapy could greatly depend on this factor. By virtue of the model’s ability to capture the experimental results effectively, we believe that it can serve as a benchmark for the development and testing of various rehabilitation strategies for stroke.

scholarly journals A Cortico- Basal Ganglia Model for choosing an optimal rehabilitation strategy in Hemiparetic Stroke

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rukhmani Narayanamurthy ◽  
Samyukta Jayakumar ◽  
Sundari Elango ◽  
Vignesh Muralidharan ◽  
V. Srinivasa Chakravarthy
Keyword(s):  
Basal Ganglia ◽  
Lesion Size ◽  
Therapeutic Approaches ◽  
Constraint Induced Movement Therapy ◽  
Sensory Motor ◽  
Optimal Rehabilitation ◽  
Hemiparetic Stroke ◽  
Rehabilitation Strategy ◽  
Bimanual Reaching ◽  
Selection Of

Abstract To facilitate the selection of an optimal therapy for a stroke patient with upper extremity hemiparesis, we propose a cortico-basal ganglia model capable of performing reaching tasks under normal and stroke conditions. The model contains two hemispherical systems, each organized into an outer sensory-motor cortical loop and an inner basal ganglia (BG) loop, controlling their respective hands. The model is trained to simulate two therapeutic approaches: the constraint induced movement therapy (CIMT) in which the intact is arrested, and Bimanual Reaching in which the movements of the intact arm are found to aid the affected arm. Which of these apparently mutually conflicting approaches is right for a given patient? Based on our study on the effect of lesion size on arm performance, we hypothesize that the choice of the therapy depends on the lesion size. Whereas bimanual reaching is more suitable for smaller lesion size, CIMT is preferred in case of larger lesion sizes. By virtue of the model’s ability to capture the experimental results effectively, we believe that it can serve as a benchmark for the development and testing of various rehabilitation strategies for stroke.

scholarly journals The Lamprey Forebrain – Evolutionary Implications

2021 ◽  
pp. 1-16
Author(s):  
Shreyas M. Suryanarayana ◽  
Juan Pérez-Fernández ◽  
Brita Robertson ◽  
Sten Grillner
Keyword(s):  
Basal Ganglia ◽  
Sensory Integration ◽  
Critical Role ◽  
Detailed Comparison ◽  
Common Ancestry ◽  
Dopamine System ◽  
Cortical Areas ◽  
Neural Processes ◽  
Living Group ◽  
Selection Of

The forebrain plays a critical role in a broad range of neural processes encompassing sensory integration and initiation/selection of behaviour. The forebrain functions through an interaction between different cortical areas, the thalamus, the basal ganglia with the dopamine system, and the habenulae. The ambition here is to compare the mammalian forebrain with that of the lamprey representing the oldest now living group of vertebrates, by a review of earlier studies. We show that the lamprey dorsal pallium has a motor, a somatosensory, and a visual area with retinotopic representation. The lamprey pallium was previously thought to be largely olfactory. There is also a detailed similarity between the lamprey and mammals with regard to other forebrain structures like the basal ganglia in which the general organisation, connectivity, transmitters and their receptors, neuropeptides, and expression of ion channels are virtually identical. These initially unexpected results allow for the possibility that many aspects of the basic design of the vertebrate forebrain had evolved before the lamprey diverged from the evolutionary line leading to mammals. Based on a detailed comparison between the mammalian forebrain and that of the lamprey and with due consideration of data from other vertebrate groups, we propose a compelling account of a pan-vertebrate schema for basic forebrain structures, suggesting a common ancestry of over half a billion years of vertebrate evolution.

An Analysis on the Forming Load of AA 2024 Aluminium Alloy in Combined and Sequence Operation Process

2006 ◽  
Vol 519-521 ◽  
pp. 949-954 ◽  
Author(s):  
Beong Bok Hwang ◽  
J.H. Shim ◽  
Jung Min Seo ◽  
H.S. Koo ◽  
J.H. Ok ◽  
...  
Keyword(s):  
Finite Element ◽  
Load Capacity ◽  
Low Cost ◽  
Forming Load ◽  
Mechanical Press ◽  
Combined Operation ◽  
Aa 2024 ◽  
Load Characteristics ◽  
Simulation Results ◽  
Selection Of

This paper is concerned with the analysis of the forming load characteristics of a forward-backward can extrusion in both combined and sequence operation. A commercially available finite element program, which is coded in the rigid-plastic finite element method, has been employed to investigate the forming load characteristics. AA 2024 aluminum alloy is selected as a model material. The analysis in the present study is extended to the selection of press frame capacity for producing efficiently final product at low cost. The possible extrusion processes to shape a forward-backward can component with different outer diameters are categorized to estimate quantitatively the force requirement for forming forward-backward can part, forming energy, and maximum pressure exerted on the die-material interfaces, respectively. The categorized processes are composed of combined and/or some basic extrusion processes such as sequence operation. Based on the simulation results about forming load characteristics, the frame capacity of a mechanical press of crank-drive type suitable for a selected process could be determined along with securing the load capacity and with considering productivity. In addition, it is suggested that different load capacities be selected for different dimensions of a part such as wall thickness in forward direction and etc. It is concluded quantitatively from the simulation results that the combined operation is superior to sequence operation in terms of relatively low forming load and thus it leads to low cost for forming equipments. However, it is also known from the simulation results that the precise control of dimensional accuracy is not so easy in combined operation. The results in this paper could be a good reference for analysis of forming process for complex parts and selection of proper frame capacity of a mechanical press to achieve low production cost and thus high productivity.

Matching area selection of an underwater terrain navigation database with fuzzy multi-attribute decision making method

2018 ◽  
Vol 233 (4) ◽  
pp. 1133-1140 ◽  
Author(s):  
Lihui Wang ◽  
Desheng Sun ◽  
Qingya Liu ◽  
Le Yu
Keyword(s):  
Set Theory ◽  
Membership Functions ◽  
Vague Set ◽  
Topographic Factor ◽  
Vague Sets ◽  
Multi Attribute Decision Making ◽  
Matching Performance ◽  
Simulation Results ◽  
Terrain Matching ◽  
Selection Of

Selecting suitable underwater terrain navigation matching areas is a prerequisite for building an underwater terrain navigation database, which is important for vehicles operating underwater. By using information features to evaluate underwater terrain matching areas, vague sets are proposed to evaluate matching performance. Mathematical models of matching area features are built and topographic factor eigenvalues are obtained. With the topographic factor eigenvalues, fuzzy relationships between factor sets and judge sets are calculated. Vague set uses membership functions and non-membership functions to define the influence of topographic factor eigenvalues on matching suitability. Simulation results demonstrate that vague set theory can overcome the deficiency of single value in fuzzy sets and define the effect of geographic characteristics for matching performance. Based on vague set method, selection rules for terrain navigation matching areas in underwater terrain database are put forward.

scholarly journals Algoritma Elephant Herding Optimization: Permasalahan Multiple Constraints Knapsack 0-1

2018 ◽  
Vol 18 (1) ◽  
pp. 13
Author(s):  
Yulia Dewi Regita ◽  
Kiswara Agung Santoso ◽  
Ahmad Kamsyakawuni
Keyword(s):  
Knapsack Problem ◽  
Simplex Method ◽  
Optimization Problems ◽  
Optimal Solution ◽  
Secondary Data ◽  
Multiple Constraints ◽  
Microsoft Excel ◽  
Storage Media ◽  
Simulation Results ◽  
Selection Of

Optimization problems are often found in everyday life, such as when determining goods to be a limited storage media. This causes the need for the selection of goods in order to obtain profits with the requirements met. This problem in mathematics is usually called a knapsack. Knapsack problem itself has several variations, in this study knapsack type used is multiple constraints knapsack 0-1 which is solved using the Elephant Herding Optimization (EHO) algorithm. The aim of this study is to obtain an optimal solution and study the effectiveness of the algorithm comparing it to the Simplex method in Microsoft Excel. This study uses two data, consisting of primary and secondary data. Based on the results of parameter testing, the proven parameters are nClan, nCi,α,β and MaxGen have a significant effect. The final simulation results have also shown a comparison of the EHO algorithm with the Simplex method having a very small percentage deviation. This shows that the EHO algorithm is effective for completing optimization multiple constraints knapsack 0-1. Keywords: EHO Algorithm, Multiple Constraints Knapsack 0-1 Problem.

Contralesional plasticity following constraint-induced movement therapy benefits outcome: contributions of the intact hemisphere to functional recovery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Abigail L. Kerr
Keyword(s):  
Functional Recovery ◽  
Daily Living ◽  
Animal Studies ◽  
Movement Therapy ◽  
Lesion Size ◽  
Neural Mechanisms ◽  
Constraint Induced Movement Therapy ◽  
Current Review ◽  
Paretic Limb

Abstract Stroke is a leading cause of death and disability worldwide. A common, chronic deficit after stroke is upper limb impairment, which can be exacerbated by compensatory use of the nonparetic limb. Resulting in learned nonuse of the paretic limb, compensatory reliance on the nonparetic limb can be discouraged with constraint-induced movement therapy (CIMT). CIMT is a rehabilitative strategy that may promote functional recovery of the paretic limb in both acute and chronic stroke patients through intensive practice of the paretic limb combined with binding, or otherwise preventing activation of, the nonparetic limb during daily living exercises. The neural mechanisms that support CIMT have been described in the lesioned hemisphere, but there is a less thorough understanding of the contralesional changes that support improved functional outcome following CIMT. Using both human and non-human animal studies, the current review explores the role of the contralesional hemisphere in functional recovery of stroke as it relates to CIMT. Current findings point to a need for a better understanding of the functional significance of contralesional changes, which may be determined by lesion size, location, and severity as well stroke chronicity.

Brain Imaging and Treatment Response in Spasmodic Torticollis

1988 ◽  
Vol 153 (3) ◽  
pp. 399-402 ◽  
Author(s):  
J. A. O. Besson ◽  
K. P. Ebmeier ◽  
H. G. Gemmell ◽  
P. F. Sharp ◽  
M. McFadyen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Basal Ganglia ◽  
Drug Treatment ◽  
Corpus Striatum ◽  
Spasmodic Torticollis ◽  
Flow Imaging ◽  
Blood Flow Imaging ◽  
The Right ◽  
Selection Of

A patient with spasms of the neck, occurring when he turned his head to the left, responded to treatment with benzhexol. Cerebral blood flow imaging demonstrated reduced uptake in the right corpus striatum compared with the left. The study demonstrates the presence of an abnormality in the basal ganglia; it also illustrates response to drug treatment. Cerebral blood flow imaging may be useful in the detection of basal ganglia abnormalities in spasmodic torticollis and assist in the selection of cases which should be targeted for treatment with drugs.

Comparison of Molecular Simulation and Pseudo-Rigid-Body Model Predictions for a Carbon Nanotube–Based Compliant Parallel-Guiding Mechanism

2008 ◽  
Vol 130 (4) ◽  
Author(s):  
Christopher M. DiBiasio ◽  
Martin L. Culpepper ◽  
Robert Panas ◽  
Larry L. Howell ◽  
Spencer P. Magleby
Keyword(s):  
Rigid Body ◽  
Molecular Simulation ◽  
Moment Of Inertia ◽  
Bulk Deformation ◽  
Body Model ◽  
Kinematic Behavior ◽  
Model Predictions ◽  
Rigid Body Model ◽  
Simulation Results ◽  
Selection Of

We report on the accuracy of the pseudo-rigid-body model (PRBM) in predicting the behavior of a nanoscale parallel-guiding mechanism (nPGM) that uses two single-walled (5,5) carbon nanotubes (CNTs) as the flexural guiding elements. The nPGM has two regions of behavior: region 1 is governed by the bulk deformation of the nanotubes, and region 2 is characterized by hingelike flexing of four “kinks” that occur due to buckling of the nanotube walls. PRBM parameters for (5,5) CNTs are proposed. Molecular simulation results of region 1 behavior match PRBM predictions of (1) kinematic behavior with less than 7.3% error and (2) elastomechanic behavior with less than 5.7% error. Although region 1 is of more interest because of its well-defined and stable nature, region 2 motion is also investigated. We show that the PRBM parameters are dependent on the selection of the effective tube thickness and moment of inertia, the lesson being that designers must take care to consider the thickness and moment of inertia values when deriving PRBM constants.

FINITE ELEMENT ANALYSIS OF FULL-LAYER REPAIR BASED ON IMPROVED ARTICULAR CARTILAGE MODEL

2019 ◽  
Vol 19 (08) ◽  
pp. 1940066
Author(s):  
MONAN WANG ◽  
YUANXIN JI ◽  
JIAN WANG ◽  
JUNTONG JING
Keyword(s):  
Elastic Modulus ◽  
Articular Cartilage ◽  
Stress Concentration ◽  
Mechanical Behavior ◽  
Theoretical Basis ◽  
Clinical Pathology ◽  
Mechanical State ◽  
Element Analysis ◽  
Simulation Results ◽  
Selection Of

In this paper, the tangential zone of cartilage is introduced into the fiber-reinforced model of articular cartilage. Considering the distribution content of the main fiber and the secondary fiber in the tangential layer of cartilage, the permeability and fiber stiffness of the layer are set in parallel and perpendicular directions, respectively, to more accurately reflect the mechanical behavior of cartilage. The parameters are set to reflect the mechanical behavior of the cartilage more realistically. We use a modified articular cartilage model to simulate the mechanical properties of implanted cartilage with different elastic modulus. The simulation results show that the selection of implants with different elastic modulus will affect the repair of cartilage. Appropriately increasing the elastic modulus of implanted cartilage, can increase the bearing capacity of the repaired area and reduce the stress concentration at the junction. The elastic modulus of the implant should be moderate, not too large or too small, and the damage of stress concentration on the repair surface should be considered. Through simulation, the mechanical state of the repaired cartilage under pressure can be obtained comprehensively, which provides a theoretical basis for clinical pathology.

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