Reproductive and toxic effects of methanol extract ofAlchornea cordifolialeaf in male rats

Andrologia ◽  
2014 ◽  
Vol 47 (9) ◽  
pp. 1034-1040 ◽  
Author(s):  
T. O. Ajibade ◽  
F. O. Olayemi
Keyword(s):  
Methanol Extract ◽  
Toxic Effects ◽  
Male Rats

scholarly journals Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Oluwatosin Adekunle Adaramoye ◽  
Olubukola Oyebimpe Akanni
Keyword(s):  
Methanol Extract ◽  
Dietary Cholesterol ◽  
Relative Weight ◽  
Redox Status ◽  
Cellular System ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Protective Effects ◽  
Artocarpus Altilis ◽  
Atherogenic Indices

We investigated the effects of methanol extract ofArtocarpus altilis(AA) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while Questran (QUE) served as standard. Biochemical indices such as total cholesterol (TC), triglycerides (TG), low- and high-density lipoproteins-cholesterol (LDL-C and HDL-C), aspartate and alanine aminotransferases (AST and ALT), lactate dehydrogenase (LDH), reduced glutathione, glutathione-s-transferase, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and lipid peroxidation (LPO) were assessed. Hypercholesterolemic (HC) rats had significantly increased relative weight of liver and heart. Dietary cholesterol caused a significant increase (P<0.05) in the levels of serum, hepatic, and cardiac TC by 110%, 70%, and 85%, LDL-C by 79%, 82%, and 176%, and TG by 68%, 96%, and 62%, respectively. Treatment with AA significantly reduced the relative weight of the organs and lipid parameters. There were beneficial increases in serum and cardiac HDL-C levels in HC rats treated with AA. In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced. All biochemical and histological alterations were ameliorated upon treatment with AA. Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.

Effects of Myrtus communis leaf extracts on CdCl2-induced metabolic disturbance in male wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 185-192
Author(s):  
Hafsa Dellaoui ◽  
Abdelkrim Berroukche ◽  
Bakhta Bouzouira ◽  
Narimen Taibi ◽  
Mohamed Zouidi ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Methanol Extract ◽  
Cadmium Accumulation ◽  
Male Rats ◽  
Myrtus Communis ◽  
Leaf Extracts ◽  
Male Wistar Rats ◽  
Sugar Levels ◽  
Induced Changes ◽  
Preventive Effects

Cadmium (Cd) is widespread in the environment. Cd toxicity targets liver and renal tissues and generates oxidative stress. Medicinal plants produce antioxidants scavenging reactive oxygen species (ROS) and chelate heavy metals. This study aimed to investigate the preventive effects of Myrtus communis leaves hydro-methanol extract (HME) and aqueous extract (AE) on Cdinduced toxicity. The experiments were carried out, during 30 days, on male rats; GR1 (controls), GR2 treated with CdCl2 (18 mg/kg), GR3 co-treated with HME (1 g/kg) and Cd (18 mg/kg), GR4 co-treated with AE (1 g/kg) and Cd (18 mg/kg), GR5 with HME and GR6 with AE. Cd induced changes in biochemical parameters (transaminases, urea, creatinine and blood sugar)related to hepato renal function, increased tissue mortification and decreased animals’ body weight. While the treatment animals, with M. communis leaves (HME) or (AE), regulated blood sugar levels. Hepatic steatosis and loss of glomeruli were particularly induced either by Cd or a co-treatment with Cd and plant extracts. M. communis extracts (HME and EA) can regulate blood sugar levels and prevent cadmium accumulation.

Potential toxic effects produced by L-mimosine in the thyroid and reproductive systems. Evaluation in male rats.

Toxicon ◽  
2021 ◽  
Author(s):  
André Tadeu Gotardo ◽  
Vânius Vinicius Dipe ◽  
Elaine Renata Motta de Almeida ◽  
Isis Machado Hueza ◽  
James Alan Pfister ◽  
...  
Keyword(s):  
Toxic Effects ◽  
Male Rats ◽  
Reproductive Systems

scholarly journals Assessment of Toxic Effects of the Methanol Extract of Citrus macroptera Montr. Fruit via Biochemical and Hematological Evaluation in Female Sprague-Dawley Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e111101 ◽  
Author(s):  
Nizam Uddin ◽  
Md. Rakib Hasan ◽  
Md. Mahadi Hasan ◽  
Md. Monir Hossain ◽  
Md. Robiul Alam ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Toxic Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Hematological Evaluation

scholarly journals Toxic effects of carbendazim at low dose levels in male rats

2008 ◽  
Vol 33 (1) ◽  
pp. 25-30 ◽  
Author(s):  
V. Muthuviveganandavel ◽  
P. Muthuraman ◽  
S. Muthu ◽  
K. Srikumar
Keyword(s):  
Low Dose ◽  
Toxic Effects ◽  
Male Rats ◽  
Dose Levels

Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats

2005 ◽  
Vol 155 (1) ◽  
pp. 87-96 ◽  
Author(s):  
A. Lafuente ◽  
A. González-Carracedo ◽  
A. Romero ◽  
T. Cabaleiro ◽  
A.I. Esquifino
Keyword(s):  
Adult Male ◽  
Regulatory Mechanism ◽  
Prolactin Secretion ◽  
Toxic Effects ◽  
Male Rats

scholarly journals Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Sinem Ilgın ◽  
Gözde Aydoğan-Kılıç ◽  
Merve Baysal ◽  
Volkan Kılıç ◽  
Mina Ardıç ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Reproductive Toxicity ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Toxic Effects ◽  
Male Rats ◽  
Hormonal Changes ◽  
Depression And Anxiety ◽  
Sperm Dna Damage

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Drugs used in repeated doses also play a role in the etiology of infertility. In our study, it was aimed to identify the possible toxic effects of trazodone on male rats and elucidate the underlying mechanisms. Vehicle or trazodone (5, 10, and 20 mg/kg/day) was administered to rats for 28 consecutive days (n=8 per group). At the end of that period, sperm concentration, motility, morphology, and DNA damage were determined and testicular morphology was assessed histopathologically in rats. Additionally, we investigated hormonal status by determining serum testosterone, FSH, and LH levels and oxidative stress by determining glutathione and malondialdehyde levels in testicular tissue to elucidate mechanisms of possible reproductive toxicity. According to our results, sperm concentration, sperm motility, and normal sperm morphology were decreased; sperm DNA damage was increased in trazodone-administered groups. Degenerative findings on the testicular structure were observed after trazodone administration in rats. Additionally, serum FSH, LH, and testosterone levels were elevated in the trazodone-administered groups. Increased MDA levels were the signs of enhanced oxidative stress after trazodone administration in testis tissues. Thus, we concluded that trazodone induced reproductive toxicity in male rats; this reproductive toxicity was accompanied by oxidative stress and hormonal changes, which are considered as important causes of reproductive disorders.

scholarly journals ANTI-OBESITY EFFECTS OF THE METHANOL EXTRACT OF MOMORDICA FOETIDA (CUCURBITACEAE) IN MALE WISTAR RATS

2021 ◽  
pp. 31-35
Author(s):  
CHOUMESSI T. APHRODITE ◽  
CHI H. A. NKWENTI ◽  
SOH DESIRE ◽  
MBOUH MARIAM ◽  
ATSAMO A. DONATIEN
Keyword(s):  
Methanol Extract ◽  
Risk Index ◽  
Normal Diet ◽  
Low Density Lipoproteins ◽  
The Body ◽  
Atherogenic Index ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Reference Drug

Objective: This study was designed to evaluate the effect of the methanol extract of M. foetida (MEMf) on high fat diet-induced obese male rats. Results: HFD induced an increase (P<0.05) in the body and liver weights and the relative abdominal fat pad of the animals in the experimental groups as compared to those in the normal diet group. Also, HFD in the experimental groups reduced (P<0.05) superoxide dismutase and catalase activities, glutathione levels and increased lipid peroxidation in the liver, heart and kidney as well as altered lipid profile (increased serum triglycerides, total cholesterol, low-density lipoproteins (LDL-C), very low-density lipoproteins (VLDL-C), decreased high-density lipoproteins (HDL-C), increased atherogenic index and coronary risk index), when compared to the normal diet animals. All altered parameters were subsequently normalized when obese rats received either MEMf (50 or100 mg/kg) or the reference drug Atorvastatin. Conclusion: This study demonstrates the potential of MEMf to normalize hyperlipidemia, oxidative stress and animal visceral organ weights increased by HFD in rats. Thus, M. foetida is an interesting medicinal plant that could be exploited as sources of anti-obesity agents.

Beetroot Extracts as Haematopoietic Agents on Rats

2021 ◽  
pp. 175-178
Author(s):  
Ni Putu Ermi Hikmawanti ◽  
Lusi Putri Dwita ◽  
Dinitia Az Zahra
Keyword(s):  
Methanol Extract ◽  
Ethanolic Extract ◽  
Blood Parameters ◽  
Normal Group ◽  
Male Rats ◽  
Test Results ◽  
Tukey Test ◽  
White Rats ◽  
One Way Anova ◽  
Number Of Cells

Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent.

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