scholarly journals ANTI-OBESITY EFFECTS OF THE METHANOL EXTRACT OF MOMORDICA FOETIDA (CUCURBITACEAE) IN MALE WISTAR RATS

2021 ◽  
pp. 31-35
Author(s):  
CHOUMESSI T. APHRODITE ◽  
CHI H. A. NKWENTI ◽  
SOH DESIRE ◽  
MBOUH MARIAM ◽  
ATSAMO A. DONATIEN
Keyword(s):  
Methanol Extract ◽  
Risk Index ◽  
Normal Diet ◽  
Low Density Lipoproteins ◽  
The Body ◽  
Atherogenic Index ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Reference Drug

Objective: This study was designed to evaluate the effect of the methanol extract of M. foetida (MEMf) on high fat diet-induced obese male rats. Results: HFD induced an increase (P<0.05) in the body and liver weights and the relative abdominal fat pad of the animals in the experimental groups as compared to those in the normal diet group. Also, HFD in the experimental groups reduced (P<0.05) superoxide dismutase and catalase activities, glutathione levels and increased lipid peroxidation in the liver, heart and kidney as well as altered lipid profile (increased serum triglycerides, total cholesterol, low-density lipoproteins (LDL-C), very low-density lipoproteins (VLDL-C), decreased high-density lipoproteins (HDL-C), increased atherogenic index and coronary risk index), when compared to the normal diet animals. All altered parameters were subsequently normalized when obese rats received either MEMf (50 or100 mg/kg) or the reference drug Atorvastatin. Conclusion: This study demonstrates the potential of MEMf to normalize hyperlipidemia, oxidative stress and animal visceral organ weights increased by HFD in rats. Thus, M. foetida is an interesting medicinal plant that could be exploited as sources of anti-obesity agents.

scholarly journals Influence of Functional Sweet White Lupin Biscuits on Lipid Profile and Food Efficiency of Induced Hyperlipidemia Rats

2015 ◽  
Vol 4 (3) ◽  
pp. 14 ◽  
Author(s):  
Rasha Mousa Ahmed Mousa
Keyword(s):  
Weight Gain ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
High Density ◽  
The Body ◽  
Atherogenic Index ◽  
White Lupin ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Food Efficiency

<p>In recent years, functional foods have attracted much interest to prevent nutrition-related diseases such as hyperlipidemia and weight gain. In this regard, this study was designed to examine the effect of use sweet white lupin (SWL) oil and flour with/without germination as a source of active healthy components to prepare functional biscuits for lowering blood lipids and growth. Functional biscuits were formulated by replacing wheat flour and butter in biscuit formulae by SWL extracted flour and SWL oil in the range of 20-30% (w/w) and 30-40% (v/w), respectively. Results indicated that the feed of hyperlipidemic rats on diets supplemented with different functional SWL biscuits for 6 weeks significantly (P &lt; 0.05) reduced serum total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, ratio of total cholesterol/high density lipoproteins cholesterol, ratio of low density lipoproteins/high density lipoproteins cholesterol and atherogenic index. Furthermore, the feed of functional SWL biscuits significantly reduced the body weight gain of rats and their food efficiency compared to that of rats fed on hyperlipidemic diet. On the other hand, there was an increase in the value of high density lipoproteins cholesterol and its ratio with total cholesterol. All these findings supported that the addition of 25% germinated SWL flour and 35% or 40% germinated SWL oil in biscuits gave interested results compared to the common wheat biscuits. Therefore, the proposed functional SWL biscuits could be able to regulate the blood cholesterol and the body growth levels of individuals and patients.</p>

scholarly journals Blood cells and their effect on the lipid profile in women with essential hypertension

2020 ◽  
Vol 25 (3) ◽  
pp. 3349
Author(s):  
B. I. Kuznik ◽  
E. S. Guseva ◽  
S. O. Davydov ◽  
Yu. N. Smolyakov ◽  
E. V. Roitman ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Lipid Metabolism ◽  
Antihypertensive Therapy ◽  
Blood Cells ◽  
Low Density Lipoproteins ◽  
Negative Association ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Healthy Women

Aim. To find out the relationship of particular blood cells (BC) and their ratios with lipid metabolism in patients with essential hypertension (EH), with (EH-1) and without kinesiotherapy (EH-2).Material and methods. The study included 30 healthy women (control group) and 72 women with EH, which were divided into 2 groups: group 1 (EH-1) — 37 women with stage II (target organ damage classification) hypertension who receive antihypertensive therapy; group 2 (EH-2) — 35 women who underwent antihypertensive therapy and kinesiotherapy (3-4 courses for 2-3 years).Results. Correlation analysis revealed that the studied relationships in healthy women, EH-1 and EH-2 women can be either direct or inverse. In healthy women, we observed negative association of monocytes (MON) with atherogenic index (AI), a positive association of basophils (BAS) with high density lipoproteins (HDL) and its negative association with low density lipoproteins (LDL), very low density lipoproteins (VLDL) and AI and red blood cells/platelets (RBC/PLT ratio) with HDL. Negative associations of lymphocytes (LYM)/BAS ratio with triglyceride (TG) and eosinophils (EOS)/BAS ratio with LDL were also detected. Patients with EH-1 had a direct relationship between LYM/EOS ratio and TG. In patients with EH-2, a negative relationship was found between PLT and HDL, MON and HDL, neutrophils (NEU)/MON ratio and TAG, and a positive — between white blood cells (WBC), NEU, MON and AI, LYM and TAG, MON and TAG, as well as AI.Conclusion. The obtained data indicate that all BC and their ratios in women with/without EH and with/without kinesiotherapy affect the lipid metabolism.

scholarly journals Changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy

2021 ◽  
Vol 17 (1) ◽  
pp. 55-58
Author(s):  
A.O. Maisuradze ◽  
I.V. Chubuk
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Obese Patients ◽  
Obese People ◽  
Group 1

Background. Changes in lipid metabolism indicators in the pre- and postoperative periods are due to frequent metabolic disorders in obese people and particular difficulties with the selection of appropriate therapy. In turn, the cause for metabolic changes in the body is the influence of a certain extreme situation — surgical intervention. Objective: to study the changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy. Materials and methods. The study involved 50 individuals (mean age — 47.0 ± 1.5 years), who underwent surgery for acute cholecystitis by laparoscopic cholecystectomy. The patients were divided into 2 groups: 1 — obese, 2 — non-obese. The level of triglycerides, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL) was assessed in all patients and compared in the preoperative period and on days 1 and 5 after surgery. Results. The parameters of lipid metabolism in the pre- and postoperative periods in all groups had permissible fluctuations, given the fact that in obese patients lipids were initially increased compared to patients without obesity. In the postoperative period in group 1 on the first day, there was a decrease in triglycerides (1.1 ± 0.6 mmol/L) from the baseline, in total cholesterol (4.5 ± 0.3 mmol/L), an increase in HDL cholesterol (1.5 ± 0.2 mmol/L), a decrease in LDL (2.9 ± 0.2 mmol/L) and VLDL (1.0 ± 0.2 mmol/L). In group 2, indicators of triglyceri­des (0.6 ± 0.2 mmol/L), total cholesterol (3.4 ± 0.1 mmol/L), LDL (1.9 ± 0.3 mmol/L) and VLDL (0.8 ± 0.2 mmol/L) also tended to decrease and there was an increase in HDL (1.6 ± 0.1 mmol/L), but these values, regardless of their variation, were within the normal range. In group 1, three patients showed cognitive impairment, which was due to a significant increase in LDL over HDL and the possible development of atherosclerosis, which could lead to cerebrovascular accident. Conclusions. After conducting a study between two groups in which the lipids were studied, a variation in parame­ters was revealed in both groups, which is due to the characteristics of metabolism in such patients and the influence of surgical stress. Based on this, control and regulation of lipid values should be carried out in all patients with dyslipidemia, and in obese patients, additional consideration should be given to risk factors, concomitant diseases and possible complications.

scholarly journals Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Haddad A. El Rabey ◽  
Madeha N. Al-Seeni ◽  
Habibah B. Al-Ghamdi
Keyword(s):  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Albino Rats ◽  
Low Density ◽  
Creatine Kinase Mb ◽  
Liver Tissues

Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups (n=6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.

Changes in plasma lipids after a non-lethal dose of cycloheximide in rats

2003 ◽  
Vol 22 (5) ◽  
pp. 245-248
Author(s):  
A Lucić ◽  
V Bradamante ◽  
M Peraica ◽  
B Radić ◽  
A-M Domijan ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Lethal Dose ◽  
Hdl Cholesterol ◽  
Low Density Lipoproteins ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Apo B

This paper describes a study of the effect of a single intraperitoneal non-lethal dose of cycloheximide (CHM; 2.0 mg/kg body weight) on the concentration of plasma lipids and lipoproteins in male rats killed one, two, three, four and nine days after receiving the dose. The concentration of triglycerides, total cholesterol, high-density lipoproteins (HDL)-cholesterol and low-density lipoproteins (LDL)-cholesterol was measured in treated and control animals. The effect of CHM on the concentration of triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol was visible in rat plasma throughout the study. Total cholesterol and HDL-cholesterol concentrations showed the same pattern of changes, probably due to the reversible inhibition of apolipoprotein apo A-I synthesis by CHM. The concentration of triglycerides decreased after a lag period of three days when the reserves of apolipoprotein apo B, the main apolipoprotein of very low-density lipoproteins (VLDL)-cholesterols produced in the liver, were consumed.

scholarly journals EVALUATION OF LIPID PROFILE COMPONENTS IN FOREIGN STUDENTS STUDYING AT THE IRKUTSK STATE MEDICAL UNIVERSITY

2018 ◽  
Vol 3 (5) ◽  
pp. 22-26
Author(s):  
M. A. Darenskaya ◽  
Ya. L. Danchinova ◽  
Adjitha Aaromal ◽  
L. I. Grebenkina ◽  
S. G. Aleksandrov ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Foreign Students ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Full Time ◽  
Very Low Density Lipoproteins ◽  
Functional Changes ◽  
Medical University

Background. A socially significant order for the training of foreign specialists, including the promotion of Russian education on the international market, certainly requires the organization of the process of students’ adaptation to the educational and information environment of the university. Particular attention deserves the components of the lipid profile, which are part of the overall adaptation syndrome.Aim: to study the features of the lipid profile in foreign students studying at the Irkutsk State Medical University.Methods. In total, 100 students of the medical profile of the Irkutsk State Medical University were enrolled in full-time study: 58 students (36 males and 22 females) were students of Russian nationality and 42 students (32 males and 11 females) – Indian students. Levels of lipid status indicators were determined with the help of Cormay kits on the automatic analyzer BTS-330 using the photometry method.Results. Hindu young men had statistically significantly higher values of triacylglycerols, very low-density lipoproteins and lower levels of high-density lipoproteins in comparison with young Russians. In the groups of girls of Indian origin, the changes concerned increased levels of triacylglycerols and very low-density lipoproteins in comparison with Russians. Gender differences were found only among Russian students – in the form of increased values of cholesterol and low-density lipoproteins in the group of girls compared to boys.Conclusion. The established functional changes in lipid metabolism in foreign students characterize the stress of the adaptive resources of the body, which, probably, can be due to the irrationality of nutrition.

scholarly journals The Effect of Infection by Toxocariasis on Some Biochemical Parameters in Some Areas of Salah Al-Din Governorate

2020 ◽  
Vol 1 (3) ◽  
pp. 89-92
Author(s):  
Enas Ermeith ◽  
Ashraf Jamal Mahmoud ◽  
Buthaina Jassim Yousef
Keyword(s):  
Fatty Acids ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Age Group ◽  
Very Low Density Lipoproteins ◽  
Large Numbers ◽  
Rate Of Increase ◽  
Group 15

The current study examined 277 blood samples of people, from both sexes of different ages, living in different areas of Salah Al-Din Governorate (Tikrit, Al-Alam and Baiji districts). The study was conducted from November, 2018 to June, 2019. All participants were secrened to investigate the incidence of toxocariasis using IgG TES-ELISA technique. The results showed that the rate of infection with toxocariasis was 22%. It was found an increase in cholesterol concentrations within age group 48-58 years and amounted to 185.8 mg/dl, and highest rate of increase in triglycerides was recorded within age group 15-25 years (168.1 mg/dl). The highest percentage of total protein was recorded within age group 26- 36 years (6.67 mg/dl). As for lipoprotein tests, highest percentage of high-density lipoproteins in age group 48-58 years was recorded (53 mg/dl), while low-density lipoproteins were highest in age group 48-58 years (100.8 mg/dl), and in very low-density lipoproteins the highest percentage within age group 15-25 years (33.5 mg/dl). The highest percentage of AST liver enzymes was recorded in age group 15-25 years and the percentage was 20.6 u/l. The highest percentage of ALT was recorded in age group 26-36 years (20.1 u/l) and 15-25 years (20 u/l). It is concluded that This age group continues to be exposed to infection with toxocariasis, which leads to presence large numbers of live larvae which secrete their antigens in the body and thus spread of toxoplasmosis, and the increase in proportion of fats is caused by poor oxidation of fatty acids and increased production of hepatic fatty acids Which leads to a delay in breakdown of lipoproteins, and the increase in level of AST, ALT enzyme occurs in cases of hepatitis and cirrhosis and may be associated with advanced cases of toxocariasis.

The Saponin-Rich Fraction of a Gymnema sylvestre R. Br. Aqueous Leaf Extract Reduces Cafeteria and High-Fat Diet-Induced Obesity

2012 ◽  
Vol 67 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
Rama Manohar I. Reddy ◽  
Pushpa B. Latha ◽  
Tartte Vijaya ◽  
Dattatreya S. Rao
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Leaf Extract ◽  
Low Density Lipoproteins ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Gymnema Sylvestre ◽  
Low Density ◽  
High Fat ◽  
Aqueous Leaf Extract

We examined the antiobesity effect of a saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract (SGE) using cafeteria and high-fat diet-induced obese rats for a period of eight weeks. SGE was orally administered at a dose of 100 mg/kg body weight once a day to the treatment group. It significantly decreased the body weight, food consumption, visceral organs weight, and the levels of triglycerides, total cholesterol, low-density lipoproteins, very low-density lipoproteins, atherogenic index, glucose, and increased the levels of high-density lipoproteins. There was no significant difference with respect to all parameters of the study in case of normal (N) diet and N diet + SGE rats. In vitro, SGE inhibited the pancreatic lipase activity. The present study gave clear evidence that the SGE has a significant antiobese action, supporting its use in traditional medicine, and can be used as a substitute for synthetic drugs.

scholarly journals Anti-atherogenic properties of a functional herbal mixture

2016 ◽  
pp. 205-218
Author(s):  
Stevan Miletic ◽  
Jaroslava Svarc-Gajic ◽  
Ivan Milovanovic ◽  
Maja Djurendic-Brenesel ◽  
Anamarija Mandic ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Bile Acids ◽  
Low Density Lipoproteins ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Experimental Animals ◽  
Herbal Mixture ◽  
Fatty Food ◽  
Feeding Regimes

In this work, anti-atherogenic and anti-hyperlipidemic effects of a herbal mixture, rich in polyphenols, and composed of 35% of buckthorn bark (Frangulae cortex), 20% of mint leaves (Menthae piperita folium), 20% of caraway fruit (Carvi fructus) and 25% of parsley fruit (Petroselinum fructus) were studied by monitoring biochemical parameters in experimental animals. Experimental animals (Wistar rats) were subjected to five different feeding regimes. Plasma levels of total cholesterol, triglycerides, cholesterol bound to high-density lipoproteins (HDL) and cholesterol linked to low-density lipoproteins (LDL) were monitored in different time periods. The feces of experimental animals was analysed for seven bile acids, as well as for total cholesterol. Simultaneously, the activities of alanine aminotranferase (ALT) and aspartate aminotransferase (AST) were measured. The introduction of herbal mixture into fatty food did not have significant influence on enzyme activities; however, the effect on induced hyperlipidemia was significant. Total atherogenic index was reduced by 43.3%, whereas total cholesterol and cholesterol bound to low density lipoproteins were reduced by 18.2% and 18.8%, respectively. Total bile acids concentrations dropped by 13.2%, whereas cholesterol was reduced by 33%.

scholarly journals Lipid and lipoprotein profile changes in dairy cows in response to late pregnancy and the early postpartum period

2016 ◽  
Vol 59 (4) ◽  
pp. 429-434 ◽  
Author(s):  
Francesca Arfuso ◽  
Francesco Fazio ◽  
Maria Levanti ◽  
Maria Rizzo ◽  
Simona Di Pietro ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Repeated Measures ◽  
Serum Lipid ◽  
Well Being ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Lactation Period ◽  
Peripartum Period

Abstract. In dairy cows the peripartum period involves endocrine and metabolic changes to compensate for the increased energy requirement aggravated by reduced feed intake. Cows adjust to the resulting negative energy balance with the mobilization of lipids from adipose tissue that, if excessive, could lead to many transition disorders compromising the offspring's growth and well-being. The aim of this study was to evaluate the dynamic changes in serum lipid and lipoprotein profiles in five dairy cows during the peripartum period. For each cow body condition score (BCS) and body weight (BW) measurements as well as blood sampling was carried out 60, 30 and 15 days before calving (−60, −30 and −15 BC), at calving day (C) and on days 15, 30 and 60 after calving (+15, +30 and +60 AC). Blood samples were tested for serum total lipids, phospholipids, triglycerides, very low-density lipoproteins (VLDLs), total cholesterol (Total-Chol), high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). One-way repeated measures analysis of variance (ANOVA) was applied to determine the effect of the peripartum period on the studied parameters in cows. A statistically significant effect of the peripartum period (P < 0.05) was found in the values of BCS, BW and all serum lipid and lipoprotein indices measured in cows. The changes observed in lipid indices of peripartum cows could be due to the start of milking and the increase in energy consumption in the body, confirming that metabolic adjustments occur as cows move from the gestation to the lactation period.

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