Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort

2009 ◽  
Vol 39 (1) ◽  
pp. 62-71 ◽  
Author(s):  
I. A. Laing ◽  
N. H. de Klerk ◽  
S. W. Turner ◽  
P. K. Judge ◽  
C. M. Hayden ◽  
...  
Keyword(s):  
Cross Sectional ◽  
Asthma Phenotype ◽  
Longitudinal Association

scholarly journals Normalized grip strength is inversely associated with DNAm age in middle age and older adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 984-984
Author(s):  
Mark Peterson ◽  
Stacey Collins ◽  
Helen Meier ◽  
Jessica Faul
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Middle Age ◽  
Large Body ◽  
Future Research ◽  
Cross Sectional ◽  
Longitudinal Association ◽  
Retirement Study ◽  
Biomarker Of Aging

Abstract There is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative aging-related health outcomes. Given these links, grip strength has been labeled a “biomarker of aging”; and yet, this metric provides no biological plausibility. The objective of this study was to determine the association between grip strength and DNA methylation (DNAm) age acceleration. Middle age and older adults from the 2006-2008 waves of the Health and Retirement Study with 8-years of follow-up were included. Cross sectional and longitudinal modeling were performed to examine the association between grip strength (normalized to body mass: NGS) and DNAm age acceleration, adjusting for cell composition, sociodemographic variables, and smoking. Three DNAm clocks were incorporated for estimating age acceleration including the established DunedinPoAm, Levine, and GrimAge clocks. There was a robust and independent cross sectional association between NGS and DNAm age for men (β:-0.36; p<0.001) and women (β:-0.36; p<0.001) using the DunedinPoAm clock, and for men only using the Levine (β:-8.04; p=0.01) and GrimAge (β:-4.76; p=0.01) clocks. There was also an independent longitudinal association between baseline NGS and DNAm age for men (β:-0.27; p<0.001) and women (β:-0.36; p<0.001) using the DunedinPoAm clock, and for women only using the Levine (β:-8.20; p<0.001) and GrimAge (β:-6.04; p<0.001) clocks. Our findings provide some evidence of age acceleration among men and women with lower NGS. Future research is needed to understand the extent to which DNAm age mediates the association between grip strength and chronic disease, disability, and mortality.

Longitudinal associations of energy balance-related behaviours and cross-sectional associations of clusters and body mass index in Norwegian adolescents

2010 ◽  
Vol 13 (10A) ◽  
pp. 1716-1721 ◽  
Author(s):  
Maria E van der Sluis ◽  
Nanna Lien ◽  
Jos WR Twisk ◽  
Ingrid HM Steenhuis ◽  
Elling Bere ◽  
...  
Keyword(s):  
Energy Balance ◽  
Fruits And Vegetables ◽  
Vegetable Intake ◽  
Health Behaviours ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Longitudinal Association ◽  
Longitudinal Associations

AbstractBackgroundInsight into the role of energy balance-related behaviours (EBRB) is of great importance when it comes to prevention of weight gain and design of interventions tailored to target these behaviours.ObjectivesFirst, the present study examines the longitudinal association of four EBRB in Norwegian adolescents. Second, it aims to examine whether clusters of EBRB are cross-sectionally associated with being overweight.DesignThe present study is part of the ‘Fruits and Vegetables Make the Marks’ project. The study sample consists of twenty control schools in two Norwegian counties.MethodsSurvey questionnaires were completed by 884 pupils with an average age at baseline, September 2001, of 11·8 years. In the follow-up surveys in May 2002 and May 2005, a total of 809 and 724 adolescents participated, respectively. Four EBRB were measured: habitual fruit and vegetable intake, snacking and soda consumption, television and computer use and physical activity.ResultsResults of the associations between EBRB were similar for boys and girls. The odds, ranging from 1·14 to 12·06, were mostly significant. One out of four clusters, the unhealthy cluster, was significantly and cross-sectionally associated with overweight and obesity.ConclusionsLongitudinal associations of EBRB show that it is important to start early with interventions that aim to prevent unhealthy behaviours becoming habitual. These behaviours should be targeted at the same time as they tend to co-occur. More research, preferably longitudinal and more objective, is needed to investigate associations between health behaviours and body weight among adolescents.

Association between diabetic retinopathy and incident cognitive impairment

2019 ◽  
Vol 103 (11) ◽  
pp. 1605-1609 ◽  
Author(s):  
Preeti Gupta ◽  
Alfred Tau Liang Gan ◽  
Ryan Eyn Kidd Man ◽  
Eva K Fenwick ◽  
Charumathi Sabanayagam ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Cognitive Impairment ◽  
Formal Education ◽  
Population Based ◽  
Cross Sectional ◽  
Increased Risk ◽  
Longitudinal Association ◽  
Disease Study

Background/AimThe relationship between diabetic retinopathy (DR) and cognitive impairment (CI) is unclear due to equivocal findings from cross-sectional studies and a lack of long-term data. In this population-based cohort study, we investigated the longitudinal association between the severity of DR and the incidence of CI.Methods682 participants with diabetes, gradable retinal photographs and no CI at baseline 2004–2011) and complete relevant data at follow-up 2010–2016 from the Singapore Epidemiology of Eye Disease Study were included. CI was assessed using the validated Abbreviated Mental Test (AMT), defined as scores of ≤6 and ≤8 for those with 0–6 and >6 years of formal education, respectively. Six-year incident CI was defined as having no CI at baseline but present at the follow-up visit.ResultsOf the 682 included participants, 483 (70.8%) had no DR and 199 (29.2%) had any DR. Of those with DR, 142 (20.8%) had minimal/mild DR and 57 (8.4%) had moderate or worse DR at baseline. At the follow-up visit, 40 (5.9%) participants had incident CI based on AMT. In multivariate analysis compared with participants without DR, those with any DR had more than twofold increased odds of incident CI (OR (95% CI): 2.32 (1.07 to 5.03)). Participants with moderate or worse DR had threefold increased odds of developing CI (3.41 (1.06 to 11.00)), compared with those with no DR.ConclusionsDR, particularly at the more severe stages, is associated with increased risk of developing CI, independent of vision and other risk factors.

Association of alcohol intake with incidence and progression of diabetic retinopathy

2020 ◽  
pp. bjophthalmol-2020-316360
Author(s):  
Preeti Gupta ◽  
Eva K Fenwick ◽  
Charumathi Sabanayagam ◽  
Alfred Tau Liang Gan ◽  
Yih-Chung Tham ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Alcohol Intake ◽  
Population Based ◽  
Cross Sectional ◽  
Longitudinal Association ◽  
One Step ◽  
Multivariable Analyses ◽  
The Mean ◽  
Retinal Photographs

PurposeWe examined the longitudinal association of baseline alcohol intake and frequency with the 6-year incidence and progression of diabetic retinopathy (DR) in a population-based cohort of Singaporean Indians.MethodsWe included 656 participants with diabetes mellitus, gradable retinal photographs from baseline (2007–2009) and follow-up (2013–2015) examinations, information on alcohol intake and other relevant data from the Singapore Indian Eye Study were included. Incident DR was defined using the Modified Airlie House Classification as no DR at baseline and at least minimal non-proliferative DR at follow-up; and DR progression as at least a one-step worsening in DR at follow-up from minimal or worse status at baseline, excluding those with proliferative DR.ResultsThe mean age (SD) of our participants (n=656) was 58.8 (9.2) years, and 54.4% were male. At follow-up, 82 of 510 (16%) participants developed DR, and 45 of 146 (30.8%) had DR progression. 65 (12.7%) and 28 (19.1%) participants consumed alcohol in incident DR and progression categories, respectively. In multivariable analyses, those who consumed alcohol had nearly two-thirds reduced odds of incident DR (OR (95% CI): 0.36 (0.13 to 0.98)) compared with those who did not. Participants with infrequent consumption of alcohol also had a reduction in odds of incident DR (0.17 (0.04 to 0.69)), compared with non-drinkers. No association was found between alcohol consumption and DR progression.Conclusions and relevanceIn our longitudinal population of Singapore Indians, baseline alcohol intake, particularly infrequent consumption, was associated with lower risk of developing DR, compared with non-drinkers, in line with previous cross-sectional findings.

State-of-the-art aortic imaging: Part II - applications in transcatheter aortic valve replacement and endovascular aortic aneurysm repair

VASA ◽  
2014 ◽  
Vol 43 (1) ◽  
pp. 6-26 ◽  
Author(s):  
Fabian Rengier ◽  
Philipp Geisbüsch ◽  
Paul Schoenhagen ◽  
Matthias Müller-Eschner ◽  
Rolf Vosshenrich ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Replacement ◽  
Surgical Repair ◽  
Imaging Modality ◽  
Open Surgical Repair ◽  
Cross Sectional ◽  
Transcatheter Aortic Valve ◽  
Cross Sectional Imaging ◽  
Sectional Imaging

Transcatheter aortic valve replacement (TAVR) as well as thoracic and abdominal endovascular aortic repair (TEVAR and EVAR) rely on accurate pre- and postprocedural imaging. This review article discusses the application of imaging, including preprocedural assessment and measurements as well as postprocedural imaging of complications. Furthermore, the exciting perspective of computational fluid dynamics (CFD) based on cross-sectional imaging is presented. TAVR is a minimally invasive alternative for treatment of aortic valve stenosis in patients with high age and multiple comorbidities who cannot undergo traditional open surgical repair. Given the lack of direct visualization during the procedure, pre- and peri-procedural imaging forms an essential part of the intervention. Computed tomography angiography (CTA) is the imaging modality of choice for preprocedural planning. Routine postprocedural follow-up is performed by echocardiography to confirm treatment success and detect complications. EVAR and TEVAR are minimally invasive alternatives to open surgical repair of aortic pathologies. CTA constitutes the preferred imaging modality for both preoperative planning and postoperative follow-up including detection of endoleaks. Magnetic resonance imaging is an excellent alternative to CT for postoperative follow-up, and is especially beneficial for younger patients given the lack of radiation. Ultrasound is applied in screening and postoperative follow-up of abdominal aortic aneurysms, but cross-sectional imaging is required once abnormalities are detected. Contrast-enhanced ultrasound may be as sensitive as CTA in detecting endoleaks.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

Theoretical and Methodological Problems of a 10-Year Follow-Up Program Evaluation Study

2002 ◽  
Vol 18 (3) ◽  
pp. 229-241 ◽  
Author(s):  
Kurt A. Heller ◽  
Ralph Reimann
Keyword(s):  
Program Evaluation ◽  
Evaluation Studies ◽  
Evaluation Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Long Term Study ◽  
Partial Inclusion ◽  
Methodological Problems

Summary In this paper, conceptual and methodological problems of school program evaluation are discussed. The data were collected in conjunction with a 10 year cross-sectional/longitudinal investigation with partial inclusion of control groups. The experiences and conclusions resulting from this long-term study are revealing not only from the vantage point of the scientific evaluation of new scholastic models, but are also valuable for program evaluation studies in general, particularly in the field of gifted education.

Hearing Outcome of Stapes Surgery in NIENT, Bangladesh

2020 ◽  
Vol 26 (1) ◽  
pp. 31-36
Author(s):  
Md Zakaria Sarkar ◽  
AHM Ferdows Nur ◽  
Utpal Kumar Dutta ◽  
Muhammad Rafiqul Islam ◽  
Debabrota Roy ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cross Sectional Study ◽  
Surgical Trauma ◽  
Group 14 ◽  
Progressive Hearing Loss ◽  
Cross Sectional ◽  
Hearing Gain ◽  
Hearing Outcome

Objective: The aim of this study was to evaluate hearing outcome after stapedotomy in patients with Otosclerosis. Methods: This cross sectional study was carried out from July 2017 to January 2019 in National Institute of ENT, Unit V. About 22 patients with Otosclerosis were included in this study. Diagnosis of Otosclerosis was based on the history, medical status with Otoscopy, Tuning fork tests and Audiometric tests. We compiled data on the pre and post operative air-bone gap (ABG) at 0.5, 1, 2 KHZ. The ABG was Calculated using AC and BC thresholds on the same audiogram. Post operative hearing gain was then Calculated from the ABG before the operation minus the ABG of the last follow up examination Results: In this study most of the cases were age group 14-30 years (72.7%), female (54.5%). Most common symptoms was progressive hearing loss, tinnitus (77.8%).The average preoperative hearing loss in this study was (AC) was 48.31±7.68. The average post opt. hearing (AC) at follow up was 28.95±10.30 with an average hearing gain of 15.40±8.53 dB which was significant. The average pre-operative ABG was 28.99 dB ± 8.10. The average post opt. ABG was analyzed at 1 follow up showed ABG 13.18±8.09 dB which was found to be significant. Conclusion: Stapedotomy is an effective surgical procedure for the treatment of otosclerosis which leads to improvement in patient’s quality of life. A favorable hearing outcome can be obtained by the combination of experienced hands with minimal surgical trauma and appropriate surgical technique. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 31-36

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

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