Physical and chemical stability of sweet walnut oil emulsion: Influence of homogenization conditions and stabilizer ratio

ABSTRACTZirconolite is a potential inorganic matrix that is currently investigated in France, in the framework of the 1991 radioactive waste management law, with a view to provide durable containment of the trivalent and tetravalent minor actinides like neptunium, curium, americium and small quantities of unrecyclable plutonium separated from other nuclear waste. To confirm the actinide loading capacity of the zirconolite calcium site and to study the physical and chemical stability of this type of ceramic when subjected to alpha self-irradiation, zirconolite ceramic pellets were fabricated with 10 wt% plutonium oxide (isotope 239 or 238). The 55 pellets are dense (> 93.3% of the theoretical density on average) and free of cracks. They are characterized by a grain size of between 10 and 20 micrometers. X-ray diffraction analyses confirmed the presence of the zirconolite 2M crystalline structure.

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Light-induced crosslinkable semiconducting polymer dots

Chemical Science ◽

10.1039/c4sc03959a ◽

2015 ◽

Vol 6 (3) ◽

pp. 2102-2109 ◽

Cited By ~ 15

Author(s):

Yue Zhang ◽

Fangmao Ye ◽

Wei Sun ◽

Jiangbo Yu ◽

I-Che Wu ◽

...

Keyword(s):

Small Molecules ◽

Chemical Stability ◽

Semiconducting Polymer ◽

Polymer Dots ◽

Semiconducting Polymer Dots ◽

Physical And Chemical

This paper describes photocrosslinkable Pdots with enhanced colloidal, physical, and chemical stability, and excellent encapsulating ability of functional small molecules.

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Physical and chemical stability of ceftaroline in an elastomeric infusion device

European Journal of Hospital Pharmacy ◽

10.1136/ejhpharm-2017-001221 ◽

2017 ◽

Vol 25 (e2) ◽

pp. e115-e119 ◽

Cited By ~ 2

Author(s):

Farah Al Madfai ◽

Syed Tabish R Zaidi ◽

Long Chiau Ming ◽

Troy Wanandy ◽

Rahul P Patel

Keyword(s):

Chemical Stability ◽

Infusion Device ◽

Physical And Chemical

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Formulation, Physical and Chemical Stability of Ocimum gratissimum L. Leaf Oil Nanoemulsion

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.901.117 ◽

2021 ◽

Vol 901 ◽

pp. 117-122

Author(s):

Netnapa Ontao ◽

Sirivan Athikomkulchai ◽

Sarin Tadtong ◽

Phuriwat Leesawat ◽

Chuda Chittasupho

Keyword(s):

Essential Oil ◽

Zeta Potential ◽

Chemical Stability ◽

Polydispersity Index ◽

Hydrodynamic Diameter ◽

Potential Value ◽

Yellow Color ◽

Leaf Oil ◽

The Stability ◽

Physical And Chemical

Ocimum gratissimum L. leaf oil exhibited many pharmacological properties. This study aimed to formulate and evaluate the physical and chemical stability of O.gratissimum leaf oil nanoemulsion. O.gratissimum leaf oil was extracted by hydrodistillation. The major component of the essential oil eugenol, was analyzed by UV-Vis spectrophotometry. Nanoemulsions of O.gratissimum leaf oil were formulated using polysorbate 80, hyaluronic acid, poloxamer 188, and deionized water by phase inversion composition method. The hydrodynamic diameter, polydispersity index, and zeta potential value of O.gratissimum leaf oil nanoemulsion was evaluated by a dynamic light scattering technique. The %remaining of eugenol in the nanoemulsion was analyzed by UV-Vis spectrophotometry. The essential oil extracted from of O. gratissimum leaf oil was a clear, pale yellow color. The %yield of the essential oil was 0.15 ± 0.03% v/w. The size of the nanoemulsion was less than 106 nm. The polydispersity index of the nanoemulsion was ranging from 0.303 - 0.586 and the zeta potential value of the nanoemulsion was closely to zero, depending on the formulation component. O. gratissimum leaf oil at concentrations ranging from 0.002 - 0.012% v/v contained 35 - 41% of eugenol. The size of nanoemulsion was significantly decreased after storage at 4 °C, while significantly increased upon storage at 45 °C. The size of nanoemulsion stored at 30 °C did not significantly change. The %remaining of eugenol in the nanoemulsion was more than 90% after storage at 4 °C and 30 °C for 28 days. The percentage of eugenol remaining in the nanoemulsion stored at 45 °C was more than 85 - 90%, suggesting that the temperature affected the stability of eugenol in the nanoemulsion.

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Physical and Chemical Stability Considerations in the Development and Stress Testing of Freeze-Dried Pharmaceuticals

Pharmaceutical Stress Testing ◽

10.1201/9780849359194-12 ◽

2005 ◽

pp. 283-314

Keyword(s):

Chemical Stability ◽

Stress Testing ◽

Freeze Dried ◽

Physical And Chemical

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AMPHOTERICIN B TOPICAL EXTEMPORANEOUS PREPARATIONS FOR THE TREATMENT OF NON-DERMATOPHYTIC ONYCHOMYCOSIS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.39645 ◽

2020 ◽

pp. 135-139

Author(s):

KOMESMUNEEBORIRAK PHOJANA ◽

WERAWATGANONE PORNPEN ◽

MUANGSIRI WALAISIRI

Keyword(s):

Amphotericin B ◽

Chemical Stability ◽

High Performance ◽

Sodium Lauryl Sulfate ◽

Physical Stability ◽

Lauryl Sulfate ◽

Physical And Chemical ◽

Injection Product

Objective: At present, the nail preparation to cure onychomycosis, caused by non-dermatophyte molds, is not commercially available in Thailand. The physical and chemical stability of amphotericin B (AmB) extemporaneous preparations in the presence of 30% dimethyl sulfoxide (DMSO) and their in vitro nail permeation was evaluated. Methods: AmB extemporaneous preparations in the presence of 30% DMSO were prepared from a commercial sterile injection product, and cream or hydrophilic ointment. Physical stability was tested at 30°C for 2 months, or using 6 heating-cooling cycles. The chemical stability and in vitro nail permeation of AmB content were analyzed using high-performance liquid chromatography (HPLC). In vitro nail permeation was performed by applying 3.5 mg/mm2 of the tested formulation on nail clippings for 5 consecutive days. Results: The AmB cream and ointment extemporaneous preparations containing 30% DMSO, a permeation enhancer, were homogeneous and pale yellow to yellow cream or ointment. The AmB ointment was stable for up to 60 days. The ointment preparation allows in vitro penetration through nails up to 14.17 μg/cm2. The ointment preparation allows significantly better penetration through than the cream preparation due to the presence of DMSO, sodium lauryl sulfate (SLS), and water in the ointment preparation. Conclusion: The AmB extemporaneous ointment was successfully compounded from a commercial sterile injection product with a beyond-use date of 60 days. The ointment preparation is currently under further investigation for in vivo efficacy.

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Physical and chemical stability of triethylenetetramine dihydrochloride, an API against Wilson’s disease

MATEC Web of Conferences ◽

10.1051/matecconf/20130301050 ◽

2013 ◽

Vol 3 ◽

pp. 01050

Author(s):

T. Henriet ◽

R. Rotival ◽

C. Ghaddar ◽

M. Choquet ◽

Y. Cartigny ◽

...

Keyword(s):

Chemical Stability ◽

Wilson’S Disease ◽

Wilson's Disease ◽

Physical And Chemical

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Palonosetron HCl Compatibility and Stability with Doxorubicin HCl and Epirubicin HCl During Simulated Y-Site Administration

Annals of Pharmacotherapy ◽

10.1345/aph.1e408 ◽

2005 ◽

Vol 39 (2) ◽

pp. 280-283 ◽

Cited By ~ 5

Author(s):

Lawrence A Trissel ◽

Yanping Zhang

Keyword(s):

Receptor Antagonist ◽

Chemical Stability ◽

Drug Concentration ◽

Room Temperature ◽

Visual Inspection ◽

Physical Stability ◽

Chemotherapy Drugs ◽

Ambient Room Temperature ◽

Physical And Chemical ◽

Anthracycline Chemotherapy

BACKGROUND: Palonosetron HCl is a selective 5-HT3 receptor antagonist used for the prevention of chemotherapy-induced nausea and vomiting. Palonosetron HCl may be administered with other drugs by Y-site administration, including doxorubicin HCI and epirubicin HCI. Consequently, stability and compatability information are needed to verify the acceptability of such Y-site administration. OBJECTIVE: To evaluate the physical and chemical stability of undiluted palonosetron HCl 50 μg/mL with doxorubicin HCl 1 mg/mL and epirubicin HCl 0.5 mg/mL during simulated Y-site administration. METHODS: Triplicate samples of palonosetron HCl with each of the anthracycline chemotherapy drugs were tested. Samples were stored and evaluated for up to 4 hours at room temperature near 23°C. Physical stability was assessed using turbidimetric and particulate measurement, as well as visual inspection. Chemical stability was assessed by HPLC. RESULTS: All of the admixtures were clear and red—orange when viewed in normal fluorescent room light and with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in any of the samples throughout the study. CONCLUSIONS: Palonosetron HCl is physically and chemically stable with doxorubicin HCl and epirubicin HCl during simulated Y-site administration of these drugs over 4 hours at ambient room temperature.

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