scholarly journals Temporal contiguity and ageing: The role of memory organization in cognitive decline

2020 ◽  
Author(s):  
Deborah Talamonti ◽  
Rebecca Koscik ◽  
Sterling Johnson ◽  
Davide Bruno
Keyword(s):  
Cognitive Decline ◽  
Temporal Contiguity ◽  
Memory Organization

scholarly journals P1-474: MEMORY ORGANIZATION AND AGEING: PREDICTING COGNITIVE DECLINE WITH TEMPORAL CONTIGUITY

2019 ◽  
Vol 15 ◽  
pp. P450-P450
Author(s):  
Deborah Talamonti ◽  
Rebecca L. Koscik ◽  
Sterling C. Johnson ◽  
Davide Bruno
Keyword(s):  
Cognitive Decline ◽  
Temporal Contiguity ◽  
Memory Organization

Role of Nut Consumption in the Management of Cognitive Decline - A Mini-Review

2018 ◽  
Vol 15 (9) ◽  
pp. 877-882 ◽  
Author(s):  
Blanka Klimova ◽  
Kamil Kuca ◽  
Martin Valis ◽  
Jakub Hort
Keyword(s):  
Cognitive Decline ◽  
Cognitive Functions ◽  
Dietary Intervention ◽  
Social Issues ◽  
Older Individuals ◽  
Active Life ◽  
Healthy Nutrition ◽  
Health Aging ◽  
Review Study

Background: Currently, there is a significant increase in the number of older generation groups, which may result in serious economic and social issues. Therefore, there is a need to prolong the active life of these older individuals, especially by focusing on modifying lifestyle factors such as healthy nutrition. In fact, recent research has shown that, for example, nuts are an important part of people’s healthy diet because they have appeared to be neuroprotective compounds which might maintain or in some cases even improve people’s cognitive functions. Objective: The purpose of this review study is to explore the role of the nut nutrition in the maintenance and delay of cognitive decline among older individuals. Results: The findings indicate that the nut consumption may contribute to the delay of cognitive decline in aging. However, this nut diet is just one component of the multi-nutrient dietary intervention for health aging. Conclusion: More longitudinal controlled randomized studies have to be performed in this field to prove the efficacy of the nut nutrition for the delay of cognitive decline.

The Therapeutic Role of Lamotrigine and Topiramate in A Depressive Patient with Anxiety Symptoms and Cognitive Decline: Neurometabolic Correlates

2016 ◽  
Vol 11 (4) ◽  
pp. 282-285
Author(s):  
Lutfu Hanoglu ◽  
Burak Yulug ◽  
Tansel Cakır ◽  
Kubra Sogukkanli ◽  
Ozge Duz ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Anxiety Symptoms ◽  
Depressive Patient ◽  
Therapeutic Role

scholarly journals The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2118
Author(s):  
Alina Mihaela Dimache ◽  
Delia Lidia Șalaru ◽  
Radu Sascău ◽  
Cristian Stătescu
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Lifestyle Modification ◽  
Cognitive Disorders ◽  
Current Evidence ◽  
Barrier Dysfunction ◽  
Serum Triglycerides ◽  
Cerebral Amyloidosis ◽  
The Relationship

The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels in cognitive function through putative mechanisms such as brain blood barrier dysfunction or amyloid metabolism imbalance, but not all research in the field found this association. Several clinical studies evaluated the relationship between different forms of cognitive decline and levels of serum triglycerides, independent of other cardiovascular risk factors. This review focuses on the role of triglycerides in cognitive decline, cerebral amyloidosis and vascular impairment. Considering that the management of hypertriglyceridemia benefits from lifestyle modification, diet, and specific drug therapy, future studies are requested to appraise the triglycerides–cognitive impairment relationship.

scholarly journals The Role of Vitamin D as a Biomarker in Alzheimer’s Disease

2021 ◽  
Vol 11 (3) ◽  
pp. 334
Author(s):  
Giulia Bivona ◽  
Bruna Lo Sasso ◽  
Caterina Maria Gambino ◽  
Rosaria Vincenza Giglio ◽  
Concetta Scazzone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Cognitive Decline ◽  
Immune Cell ◽  
Response To Treatment ◽  
Cellular Processes ◽  
Vitamin D Levels ◽  
The Brain ◽  
Key Questions

Vitamin D and cognition is a popular association, which led to a remarkable body of literature data in the past 50 years. The brain can synthesize, catabolize, and receive Vitamin D, which has been proved to regulate many cellular processes in neurons and microglia. Vitamin D helps synaptic plasticity and neurotransmission in dopaminergic neural circuits and exerts anti-inflammatory and neuroprotective activities within the brain by reducing the synthesis of pro-inflammatory cytokines and the oxidative stress load. Further, Vitamin D action in the brain has been related to the clearance of amyloid plaques, which represent a feature of Alzheimer Disease (AD), by the immune cell. Based on these considerations, many studies have investigated the role of circulating Vitamin D levels in patients affected by a cognitive decline to assess Vitamin D’s eventual role as a biomarker or a risk factor in AD. An association between low Vitamin D levels and the onset and progression of AD has been reported, and some interventional studies to evaluate the role of Vitamin D in preventing AD onset have been performed. However, many pitfalls affected the studies available, including substantial discrepancies in the methods used and the lack of standardized data. Despite many studies, it remains unclear whether Vitamin D can have a role in cognitive decline and AD. This narrative review aims to answer two key questions: whether Vitamin D can be used as a reliable tool for diagnosing, predicting prognosis and response to treatment in AD patients, and whether it is a modifiable risk factor for preventing AD onset.

Role of neuroendocrine pathways in cognitive decline during aging

2008 ◽  
Vol 7 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Ettore Ferrari ◽  
Flavia Magri
Keyword(s):  
Cognitive Decline

Role of Temporal Contiguity in Subjective Prediction

1985 ◽  
Vol 57 (3) ◽  
pp. 793-794 ◽  
Author(s):  
Leroy Matthews ◽  
Julie Hunt
Keyword(s):  
Linear Model ◽  
The Other ◽  
Temporal Contiguity

46 subjects were presented with 25 pairs of grades representing students' performance over the last two semesters. One group was asked to predict the grade for the following semester and another group was asked to predict the grade which occurred preceding the last two semesters. A linear model applied to the data indicated that both groups of subjects weighted the temporally contiguous grade more heavily than the other grade.

scholarly journals Likelihood of Participation in Home-Based Cognitive Assessment: The Role of Subjective Cognitive Decline and Age

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 293-294
Author(s):  
Moriah Splonskowski ◽  
Holly Cooke ◽  
Claudia Jacova
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Old Age ◽  
Cognitive Assessment ◽  
Community Dwelling ◽  
Subjective Cognitive Decline ◽  
Cognitive State ◽  
Home Based ◽  
Increased Risk

Abstract Home-based cognitive assessment (HBCA) services are emerging as a convenient alternative to in-clinic cognitive assessment and may aid in mitigating barriers to detecting cognitive impairment (CI). It is unknown which older adults would be likely to participate in HBCA. Here we investigated the role of age and Subjective Cognitive Decline (SCD). SCD has demonstrated an increased risk for progression to CI/dementia. A nation-wide community-dwelling sample of 494 adults age 50+ were recruited via Amazon Mechanical Turk to complete an online survey assessing perceptions around HBCA and SCD. Our sample was 91.9% White and 66.8% female. It consisted of 174 respondents aged 50-60, 265 aged 61- 70, and 55 aged 71-79. Age groups were comparable with respect to their acceptance of cognitive assessment (Range 4-20, higher score=higher acceptance, 7.9±3.3, 8.15±3.2, 8.05±3.43) and SCD-Q total (43.1±5.8, 43.2±5.7, 43.3±5.7). Correlation analysis revealed a relationship between SCD-QSCD total and perceived likelihood of participation in HBCA for those ages 61-70 (r(263) = .222 p = .000), but not for ages 50-60 or 71-79 (r(172) = .102 p = .152; r(53) = -.102 p = .458). Our findings suggest that SCD influences the likelihood of participation in HBCA for older adults’ transitioning to old age (61-70). Findings show that for adults transitioning into old age (61-70), perceived cognitive state influences their likelihood of participation in HBCA. Importantly, concerns about CI/dementia may generate more favorable perceptions of HBCA for this group.

Indicators of rapid cognitive decline in amnestic mild cognitive impairment: The role of plasma biomarkers using magnetically labeled immunoassays

2020 ◽  
Vol 129 ◽  
pp. 66-72 ◽  
Author(s):  
Chia-Lin Tsai ◽  
Chih-Sung Liang ◽  
Chun-Pai Yang ◽  
Jiunn-Tay Lee ◽  
Tsung-Han Ho ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Amnestic Mild Cognitive Impairment ◽  
Plasma Biomarkers ◽  
Rapid Cognitive Decline

scholarly journals Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

2018 ◽  
Vol 215 (12) ◽  
pp. 3038-3056 ◽  
Author(s):  
Zhi-Hao Wang ◽  
Pai Liu ◽  
Xia Liu ◽  
Shan Ping Yu ◽  
Jian-Zhi Wang ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Kinase Activity ◽  
Nuclear Translocation ◽  
Memory Deficits ◽  
Mrna Splicing ◽  
Splicing Factors ◽  
Synaptic Functions ◽  
Tau Isoforms ◽  
Exon 10

SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodegeneration; however, the role of SRPK2 in these processes remains unclear. Here we show that delta-secretase (also known as asparagine endopeptidase; AEP), which is activated in AD, cleaves SRPK2 and increases its nuclear translocation as well as kinase activity, augmenting exon 10 inclusion. Conversely, AEP-uncleavable SRPK2 N342A mutant increases exon 10 exclusion. Lentiviral expression of truncated SRPK2 increases 4R-tau isoforms and accelerates cognitive decline in htau mice. Uncleavable SRPK2 N342A expression improves synaptic functions and prevents spatial memory deficits in tau intronic mutant FTDP-17 transgenic mice. Hence, AEP mediates tau-splicing imbalance in tauopathies via cleaving SRPK2.

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