Effects of zearalenone on liver development, antioxidant capacity and inflammatory factors of prepubertal gilts

Objective A series of experiments were conducted to explore the changes of some serum indexes in obese adolescents induced by closed weight loss summer camp. Methods The 12 to 18 year old obese adolescents (BMI ≥ 28), who volunteered to participate in the Haoqian summer camp, were selected for 4 weeks of closed summer camp. The main activities of the summer camp included compound exercise (aerobic exercise + resistance exercise, 3 times / day, 6 days / week), Dietary intervention, fun activities and health knowledge lectures. In order to explore the changes of serum indexes of obese adolescents, glycolipid metabolism index, fatty acid components, inflammatory factors and oxidative stress markers were analyzed before and after 4 weeks. Results (1) The 4 week weight loss summer camp had no significant effect on blood sugar, but it can obviously reduce the level of serum total cholesterol, triglyceride and low density lipoprotein cholesterol, and significantly improve the abnormal lipid metabolism. (2) The level of serum total saturated fatty acid (P < 0.05), total monounsaturated fatty acid (P < 0.01) and total polyunsaturated fatty acid (P < 0.05) in obese adolescents were decreased significantly in the 4 week weight loss summer camp. (3) The 4 week weight loss summer camp significantly reduced serum inflammatory factors IL-6 and TN F- alpha in obese adolescents, increased the level of adiponectin per body fat mass (P < 0.05), and relieved the inflammatory state of the body. (4) After 4 weeks weight loss summer camp, the serum total antioxidant capacity T-AOC, antioxidant enzyme catalase CAT, superoxide dismutase SOD and glutathione peroxidase GPx activity in obese adolescents were significantly enhanced (P < 0.05); oxidative damage markers 8-iso-PGF2α, 8-OHdG, and MDA levels were not significantly changed (P > 0.05), while protein oxidation product protein carbohydrate PC content decreased significantly (P < 0.05). Conclusions 4 weeks weight loss summer camp can significantly alleviate the body's lipid metabolism abnormalities, change the serum fatty acid components, reduce the body's inflammatory state, enhance the body's antioxidant capacity, and reduce the body's oxidative damage.

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Effects of dietary eucommia ulmoides leaf extract (ELE) on growth performance, expression of feeding-related genes, activities of digestive enzymes, antioxidant capacity, immunity and cytokines expression of large yellow croaker (Larimichthys crocea) larvae

British Journal Of Nutrition ◽

10.1017/s0007114521004621 ◽

2021 ◽

pp. 1-29

Author(s):

Wenxing Huang ◽

Chuanwei Yao ◽

Yongtao Liu ◽

Ning Xu ◽

Zhaoyang Yin ◽

...

Keyword(s):

Nitric Oxide ◽

Antioxidant Capacity ◽

Growth Performance ◽

Digestive Enzymes ◽

Leaf Extract ◽

Inflammatory Factors ◽

Large Yellow Croaker ◽

Oxide Content ◽

Eucommia Ulmoides ◽

Total Antioxidant

Abstract A 30-day feeding trial was conducted to investigate effects of dietary eucommia ulmoides leaf extract (ELE) on growth performance, activities of digestive enzymes, antioxidant capacity, immunity, expression of inflammatory factors and feeding-related genes of large yellow croaker larvae. Five micro-diets were formulated with supplementation of 0g Kg−1 (the control), 5g Kg−1 (0.5%), 10g Kg−1 (1.0%), and 20g Kg−1 (2.0%) of ELE, respectively. Results showed that the best growth performance was found in larvae fed the diet with 1.0% ELE. Furthermore, ELE supplementation significantly increased the npy expression at 1.0% dosage, while increased ghrelin in larvae at 0.5% dosages. The activity of leucine aminopeptidase in larvae fed the diet with 1.0% ELE was significantly higher than the control, while alkaline phosphatase was significantly up-regulated in larvae fed the diet with 2.0% ELE. A clear increase in total antioxidant capacity in larvae fed the diet with 1.0% ELE was observed, whereas catalase activity was significantly higher in 1.0% and 2.0% ELE supplementation compared to the control. Larvae fed the diet with 1.0% ELE had a significantly higher activities of lysozyme, total nitric oxide synthase and nitric oxide content than the control. Moreover, transcriptional levels of cox-2, il-1β and il-6 were remarkably down-regulated by supplementation of 0.5-1.0% ELE. This study demonstrated that the supplementation of 1.0% ELE in diet could increase the growth performance of large yellow croaker larvae probably by promoting expression of feeding-related genes, enhancing antioxidant capacity and immunity, and inhibiting expression of inflammatory factors.

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Probiotic Effects on Sperm Parameters, Oxidative Stress index, Inflammatory Factors and Sex Hormones in Infertile Men

10.21203/rs.2.18581/v1 ◽

2019 ◽

Author(s):

Bijan Helli ◽

Maria Kavianpour ◽

Ehsan Ghaedi ◽

Mohammadreza Dadfar ◽

Hossein Khadem haghighian

Keyword(s):

Oxidative Stress ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Inflammatory Markers ◽

Intervention Group ◽

Reproductive Hormones ◽

Semen Parameters ◽

Inflammatory Factors ◽

Infertile Men ◽

Total Antioxidant

Abstract Background: Impaired sperm production, decreased sperm motility, and increased oxidative stress levels are the main causes of male infertility. To evaluate effects of supplementation with probiotic on the spermatogram, seminal oxidative stress biomarkers, inflammatory factors and reproductive hormones.Methods: In this randomized, double-blind controlled clinical trial, 52 idiopathic asthenozoospermia men, attending urology clinic, were randomly assigned to one of intervention and placebo (n =26) groups. Participants in the intervention group took daily 500 mg Probiotic and those in the placebo group took daily placebo for 10 wk. Semen parameters, total antioxidant capacity, malondialdehyde, inflammatory factors, reproductive hormones, anthropometric and physical activity assessments were measured at the baseline and at the end of the study. Statistical analysis was performed using SPSS software.Results: Out of 52 who participated in this study, 25 men in the intervention group and 25 men in the control group completed the protocol of the study. After the intervention, ejaculate volume, number, concentration and the percentage of motile sperm, total antioxidant capacity of plasma significantly increased in the intervention group and the concentration of plasma malondialdehyde and inflammatory markers significantly decreased in the intervention group.Conclusion: Probiotic supplementation in infertile men, leading to significant increase in concentration and motility and significant reduce in oxidative stress and inflammatory markers. Possibly oral intake of probiotic has the potential to be one of the ways to deal with oxidative damage sperm of infertile men.

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W01.97 Correlation between positive family history of cardiovascular disease and inflammatory factors for children and adolescents

Atherosclerosis ◽

10.1016/s0021-9150(04)90097-4 ◽

2004 ◽

Vol 5 (1) ◽

pp. 22-23

Author(s):

M WOSIKERENBEK

Keyword(s):

Cardiovascular Disease ◽

Family History ◽

Children And Adolescents ◽

Positive Family History ◽

Inflammatory Factors ◽

History Of

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Hepatocyte Growth Factor (HGF) concentration in matched samples of maternal venous blood and fetal cord venous and arterial blood: Evidence for control of fetal liver development

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86417-9 ◽

1998 ◽

Vol 5 (1) ◽

pp. 122A-122A

Author(s):

D SOMERSET ◽

E JAUNIAUX ◽

A STRAIN ◽

S AFFORD ◽

M KILBY

Keyword(s):

Growth Factor ◽

Hepatocyte Growth Factor ◽

Fetal Liver ◽

Venous Blood ◽

Liver Development ◽

Arterial Blood ◽

Matched Samples ◽

Hepatocyte Growth

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Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000654 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Masoud Nasiri ◽

Saja Ahmadizad ◽

Mehdi Hedayati ◽

Tayebe Zarekar ◽

Mehdi Seydyousefi ◽

...

Keyword(s):

Lipid Peroxidation ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Wistar Rats ◽

Enzymatic Antioxidants ◽

Acute Response ◽

Total Antioxidant ◽

Male Wistar Rats ◽

Exercise Induced ◽

And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

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The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000116 ◽

2012 ◽

Vol 82 (3) ◽

pp. 228-232 ◽

Cited By ~ 7

Author(s):

Mauro Serafini ◽

Giuseppa Morabito

Keyword(s):

Antioxidant Capacity ◽

Dietary Intervention ◽

Ex Vivo ◽

The Body ◽

Dietary Polyphenols ◽

Enzymatic Antioxidant ◽

Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

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