Predictive value of family history of allergy and cord blood IgE level for allergic diseases up to adulthood

2015 ◽  
Vol 26 (4) ◽  
pp. 383-383 ◽  
Author(s):  
Qun Ui Lee
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Predictive Value ◽  
Allergic Diseases ◽  
History Of

scholarly journals Three Characterisctics of Atopy to Diagnose Allergy in Children with Respiratory Symptomps

2020 ◽  
Vol 31 (2) ◽  
pp. 116
Author(s):  
Imanuel Far-Far ◽  
Anang Endaryanto ◽  
Retno Asih Setyoningrum ◽  
Gatot Soegiarto
Keyword(s):  
Family History ◽  
Sensitivity And Specificity ◽  
Predictive Value ◽  
Respiratory Symptoms ◽  
Daily Practice ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Pediatric Allergy ◽  
History Of

<p class="Englishversionofabstract">The prevalence of allergic diseases has increased in the last decade. Therefore, precise and reliable in predicting allergy in children were needed. However, in daily practice, most misdiagnosis occurs because it is only based on a family history of allergy. This study aims to evaluate the chronicity, recurrence of symptoms with similar exposure, and family history of allergy to be used as a predictor of allergy in children with respiratory symptoms. Cross sectional study was conducted in children who referred to the Pediatric Allergy and Immunology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 1st - July 31st 2019. Children with a suspected allergy who developed respiratory symptoms was included. The data was taken from standardized medical record. The sensitivity and specificity of the 3 characteristics of atopic with positive SPT were calculated. A total of 115 children were admitted and 109 children fulfill the inclusion criteria. Gender 60% male and 40% female. The most common group of age founded was age 5-&lt;10 years 39.4%, followed by 1-&lt;3 years (25.8%), 3-&lt;5 years (22.9%), 10 years 8.3%, and &lt;1 year (3.6%). Fifty-four patients (49.5%) fulfilled 3 characteristics of atopy and there were 64 patients (58.7%) with positive SPT results. The sensitivity, specificity, positive predictive value and negative predictive value were 81.3%, 95.6%, 96.3%, and 78.2%, respectively. The 3 characteristics of atopy have good sensitivity and specificity to predict allergy in children.</p>

Identification of Features Associated with Flying Phobia in Aircrew

1981 ◽  
Vol 139 (1) ◽  
pp. 38-42 ◽  
Author(s):  
R. C. B. Aitken ◽  
J. A. Lister ◽  
C. J. Main
Keyword(s):  
Family History ◽  
Skin Conductance ◽  
Predictive Value ◽  
Matched Control ◽  
Anxiety Symptoms ◽  
Control Group ◽  
Psychometric Tests ◽  
Matched Control Group ◽  
Spontaneous Fluctuation ◽  
History Of

SummaryThe psychological and physiological features of 20 aircrew consecutively referred for treatment of anxiety symptoms when flying were compared with a matched control group of uncomplaining aircrew. There were no significant differences between the two groups on psychometric tests of personality, though there were differences in skin conductance; the phobics had a higher rate of spontaneous fluctuation, and habituated less to a repeated auditory tone. More of the phobic group worried about their wives and acknowledged childhood and other adulthood phobias; more had a family history of an episode perhaps best described as flying trauma. Many were on an overseas posting when symptoms presented. These few features could correctly classify 85 per cent of the subjects into the phobic or control group. This type of ‘phobic aircrew index’ now requires to be validated prospectively for its predictive value.

scholarly journals The effect of breastfeeding on lung function at 12 and 18 years: a prospective cohort study

2016 ◽  
Vol 48 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Nilakshi T. Waidyatillake ◽  
Julie A. Simpson ◽  
Katrina J. Allen ◽  
Caroline J. Lodge ◽  
Shyamali C. Dharmage ◽  
...  
Keyword(s):  
Cohort Study ◽  
Family History ◽  
Lung Function ◽  
Linear Regression ◽  
Exclusive Breastfeeding ◽  
Allergic Diseases ◽  
P Values ◽  
Mediating Factors ◽  
History Of ◽  
Duration Of Breastfeeding

The objective was to assess associations between duration of total and exclusive breastfeeding and lung function up to adolescence.A birth cohort (Melbourne Atopy Cohort Study) of 620 infants with a family history of allergic disease was recruited. Mothers were encouraged to breastfeed exclusively for 6 months. Lung function was assessed at 12 and 18 years of age. Associations between breastfeeding and lung function were investigated using multivariable linear regression and path analysis was used to assess the potential mediating factors.Duration of breastfeeding (total and exclusive) was not associated with most assessed lung function outcomes. However, there was a trend for increased pre-bronchodilator mid-expiratory flow (MEF) at both 12 (adjusted mean difference (95% CI) per week of breastfeeding of 10 (−1–20) mL·s−1) and 18 years (11 (−1–22) mL·s−1) (p-values of 0.07 and 0.08, respectively). There was a strong indirect effect of height on these observed associations.Duration of breastfeeding does not appear to greatly influence lung function outcomes in children with a family history of allergic diseases. Longer duration of exclusive breastfeeding may be associated with an increase in MEF, partly due to greater attained height of the child.

scholarly journals A Longitudinal Study of a Panel of Adipokines and Gestational Diabetes Risk (OR36-01-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ellen Francis ◽  
Mengying Li ◽  
Stefanie Hinkle ◽  
Jinbo Chen ◽  
Liwei Chen ◽  
...  
Keyword(s):  
Family History ◽  
Gestational Diabetes ◽  
Early Pregnancy ◽  
Predictive Value ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Blood Draw ◽  
Fatty Acid Binding ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objectives Prospective studies with measurement of a comprehensive panel of adipokines in early pregnancy and gestational diabetes (GDM) risk are sparse, and studies of adipokines for prediction of GDM are limited. We aimed to prospectively investigate a comprehensive panel of adipokines in relation to GDM risk. Methods We investigated a panel of adipokines in relation to GDM risk. In a nested case-control study within the NICHD Fetal Growth Studies-Singleton cohort (2009–2013), we identified 107 GDM cases and selected 214 controls matched on age, race/ethnicity, and gestational week (GW) at blood draw. Plasma Leptin, Soluble Leptin Receptor (sOB-R), Free Leptin, Chemerin, Fatty Acid Binding Protein 4 (FABP4), Retinol Binding Protein 4, Adiponectin, Omentin1, and Vaspin were measured prior to GDM at GWs 10–14, 15–26. Adjusting for maternal age, GW of blood collection, nulliparity, and family history of diabetes, conditional logistic analysis was performed to estimate adjusted odds ratios (aOR) for associations of adipokines with GDM. Receiver-operating-characteristic (ROC) curves assessed the predictive value of adipokines for GDM diagnosis. Results Before GDM diagnosis, Leptin, Free Leptin, Chemerin, and FABP4 concentrations were significantly higher, and Adiponectin, and sOB-R were lower among cases than controls. At GW 10–14, Adiponectin, and sOB-R were significantly and inversely related to GDM risk. For example, across increasing quartiles of sOB-R the aOR were 1.00 (ref), 0.37 (0.19, 0.74), 0.28 (0.13, 0.59), and 0.24 (0.11, 0.52) (Ptrend ≤ .0001). In contrast, Leptin, Free Leptin, Chemerin, and FABP4 were significantly and positively associated with GDM risk; Ptrend ≤ .0001, ≤.0001, 0.005, 0.004, respectively. In general, associations of adipokines with GDM were stronger at GW 15–26. In addition, at GW 15–26, sOB-R significantly improved GDM prediction over conventional risk factors (age, GW, race, nulliparity, family history of diabetes, prepregnancy BMI) and glucose (P = 0.02). Conclusions A panel of adipokines may be implicated in the pathogenesis of GDM with significant associations and incremental predictive value detected in early pregnancy before GDM is usually screened for. Funding Sources Ellen Francis was supported by the Graduate Partnership Program in the Office of Intramural Training & Education, a component of the National Institutes of Health. Supporting Tables, Images and/or Graphs  

Reduced membrane bound CD14 expression in the cord blood of infants with a family history of allergic disease

2009 ◽  
Vol 39 (7) ◽  
pp. 982-990 ◽  
Author(s):  
R. J. Boyle ◽  
R Morley ◽  
L-J Mah ◽  
S. Kivivuori ◽  
M. L-K Tang
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Allergic Disease ◽  
History Of ◽  
Membrane Bound

scholarly journals Relationship between atopic manifestations, family history of atopic disease and cord blood IgE levels in children

2007 ◽  
Vol 47 (6) ◽  
pp. 278
Author(s):  
Tisnasari Hafsah ◽  
Myrna Soepriadi ◽  
Budi Setiabudiawan ◽  
Herry Garna
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Atopic Disease ◽  
Mean Value ◽  
Inclusion Criteria ◽  
Chi Square ◽  
The Past ◽  
History Of ◽  
The Mean ◽  
The Relationship

Background The incidence of atopic disease tends to increaseover the past few decades and its morbidity interferes with thequality of life and health. Prediction of the disease is importantfor early prevention.Objective To evaluate the relationship between atopicmanifestations, family history (FH) of atopic disease and cordblood IgE (CB-IgE) levels.Methods We conducted an analytic observational study withcohort retrospective design on children with an average age of 3years whose CB-IgE had been measured at delivery inKiaracondong Primary Health Care during October–December2004. Manifestations of atopic disease were recorded using ISAACquestionaire for allergy. Chi-square, Mann-Whitney test, andlogistic regression analysis were used for analysis.Results Cord blood IgE was measured on 124 children after birth.Only 94 children (76%) fulfilled the inclusion criteria. Atopicdisease was found in 17 children (18%), consisting of 8 childrenwith atopic dermatitis, 4 with allergic rhinitis, and 5 suffered fromboth. There were significant differences in the mean value of CB-IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)between atopic and non atopic children. Cut off point of the CB-IgE concentration was 1.4 IU/mL (77.7%). The highest probabilityfor atopic manifestations was found in children who had highCB-IgE and positive FH (P=45%). Relative risk of children withhigh CB-IgE level in positive FH group was 3.636 (95% CI0.943;14.016).Conclusion CB-IgE level and family history of atopic disease arerisk factors for the development of atopic manifestation.

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