Significance of Kinetotherapy in Rehabilitation Treatment of Osteoporosis

2013 ◽  
Author(s):  
Petru A. Pop ◽  
Liviu Lazar ◽  
Florin M. Marcu
Keyword(s):  
Conservative Treatment ◽  
Physical Inactivity ◽  
Fragility Fractures ◽  
Future Research ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Rehabilitation Treatment ◽  
Quality Life ◽  
Recovery Treatment ◽  
Support Devices

Osteoporosis is a systemic skeleton disease, characterized by a low bone mass and micro-architectural deterioration of bone tissue with consecutive increasing of fragile bones and susceptibility of fractures. Risk facture, advanced ages, family history, rheumatoid arthritis, low calcium intake, physical inactivity, and low body weight can lead to this condition. The aim of treatment in osteoporosis is to grow-up the bone mineral density of the skeleton and to increase resorption of formed bone, used diverse methods as medications, conservative measures, weight reduction, physical and occupational therapy, mechanical support devices and surgery. This paper presents a balneal-conservative treatment applied to 82 patients diagnosed with osteoporosis from Rehabilitation Clinical Hospital of Felix Spa in 2011–2012, which has combined with a kinetotherapy and medication treatment. The complex rehabilitation treatment involves balneal-physical-kinetic recovery treatment that must be periodical repeated every six months, while the subjects themselves at home followed the kinetotherapy with drugs between balneal-treatments at hospital. The significance of rehabilitation treatment for the osteoporosis patients is to rise both functional and independence level, and improving their quality life. DEXA, Qualeffo-41 Test, fragility fractures, difference of height patients, using the statistical analysis have performed the evaluation of trial. These results emphasized the efficiency of balneal-rehabilitation treatment with main accent on respect the kinetotherapy applied the osteoporosis patients. The future research will be focused upon the implementation of vibration therapy with balneal-conservative treatment on patients with osteoporosis to reduce the therapy time and improving the quality patients life.

Benefic Effect of Conservative Treatments on Patients Diagnosed With Osteoporosis

2012 ◽  
Author(s):  
Petru A. Pop ◽  
Liviu Lazar ◽  
Florin M. Marcu
Keyword(s):  
Conservative Treatment ◽  
Fragility Fractures ◽  
Future Research ◽  
Mineral Density ◽  
Rehabilitation Treatment ◽  
Physical Kinetic ◽  
Metabolic Bone ◽  
Quality Life ◽  
Sf 36 ◽  
Recovery Treatment

Osteoporosis (OP) represents the most common metabolic bone disease, characterized by the shrinkage in bone mass and the destruction of bone quality, thus conferring a higher risk for micro-fractures and injuries. The goal of treatment in OP is to grow-up the bone mineral density of the skeleton and to increase resorption of formed bone, due to improving the quality life of patients. The methods are diverse, such as medications, conservative measures, weight reduction, physical and occupational therapy, mechanical support devices and surgery. This paper presents a balneal-conservative treatment of patients diagnosed with OP from Rehabilitation Clinical Hospital of Felix Spa. The treatment is complex and involves balneal-physical-kinetic therapy or balneal-physical-kinetic recovery treatment, which must be periodical repeated every six months to obtain good results. The study has been applied to two separate groups of patients with OP between 2009–2011. The first group of 100 subjects, presented clinical symptomatology, as pain of variable types like backaches, fragility fractures or deformation of bone shape that resulted from fractures or alterations of weakens bones. A second group of 80 subjects, received the balneal-rehabilitation treatment combined, or not with physical exercises. DEXA and SF-36 scores, using statistical analysis, performed the evaluation of OP treatment. The results of experiment emphasized the efficiency of balneal-rehabilitation treatment applied patients with OP. The future research will be focused upon the implementation of vibration therapy with balneal-conservative treatment on patients with osteoporosis and osteoarthritis to reduce the therapy time and improving the quality life of patients.

Specific Treatments for Improving the Quality of Life in Rheumatologic Affections and Osteoporosis

2011 ◽  
Author(s):  
Petru A. Pop ◽  
Liviu Lazar ◽  
Florin M. Marcu
Keyword(s):  
Conservative Treatment ◽  
Wistar Rats ◽  
Vibration System ◽  
Mineral Density ◽  
Digital Frequency ◽  
Quality Life ◽  
Sf 36 ◽  
Life Scale ◽  
Circulatory Disorders

The analysis and implementation of modern treatments for the patients diagnosed with osteoporosis, degenerative rheumatic affections and peripheral circulatory disorders have become a healthy priority for the society. These treatments have the goal to raise the bone mineral density of the skeleton, reducing joints pain and inflammation while improving and maintaining joints function. This paper presents a conservative treatment of patients from Recovery Clinical Hospital of Felix Spa, diagnosed with degenerative and rheumatoid affections. The treatment is complex and involves balneal-physical-kinetic recovery therapy that must be periodical repeated at every six months to perform. Ankylosing spondylitis was been evaluated by BASFI-BASDAI scores, while the gonarthrosis with Artroflex by SF-36 of quality life scale and Lequesne index. In addition, a vibration treatment combined with balneal-conservative treatment was been proposed to reduce the therapy time and improved the quality live of patients. The vibration system comprises a vibration bed with adjusting control of signal by a digital frequency convertor, and a command panel system for measuring and processing of data. Because the vibration trial is in incipient experiment stage, it was been applied first on Wistar rats, due to increase the calcium mass of bones. The results of all treatments were emphasized the efficiency of balneal cure in rheumatic affections.

scholarly journals Diagnosis, Screening and Treatment of Osteoporosis –A Review

2021 ◽  
Vol 14 (2) ◽  
pp. 567-575
Author(s):  
V. Chitra ◽  
Evelyn Sharon.S
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Previous History ◽  
Fragility Fractures ◽  
Prevention Measures ◽  
Lifestyle Modifications ◽  
Mineral Density ◽  
Treatment Of Osteoporosis

Osteoporosis is the multifactorial skeletal disease that leads to fracture risk in individuals. It is characterized by a decrease in bone mineral density leading to increased fracture risk. It is often silent and only known when fractures occur in the elderly leading to death. The reason is that the disease is always underdiagnosed and not treated properly. It affects men and women, but women are more susceptible to it due to estrogen deficiency. Osteoporosis is diagnosed based on the fragility fractures, low bone mineral density assessed by DEXA scan. Pharmacological (anti-resorptive and anabolic drugs) and lifestyle modifications (dietary intake, weight-bearing exercise, hip protectors, and fall prevention measures) are helpful in the prevention and treatment of Osteoporosis. Clinicians must take proper measures in finding out the patients who are at higher risk of Osteoporosis and providing treatment by either diagnosing or by screening the previous history of fracture risk in the patients. This article provides an overview of the diagnosis, screening, and treatment of Osteoporosis.

scholarly journals Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhengbo Tao ◽  
Jinpeng Wang ◽  
Kaicheng Wen ◽  
Renqi Yao ◽  
Wacili Da ◽  
...  
Keyword(s):  
Fragility Fractures ◽  
Bone Architecture ◽  
Inflammatory Factors ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Extracellular Milieu ◽  
Cellular Effects ◽  
Programmed Death ◽  
Increased Risk ◽  
First Time

Osteoporosis has become a worldwide disease characterized by a reduction in bone mineral density and the alteration of bone architecture leading to an increased risk of fragility fractures. And an increasing number of studies have indicated that osteoblasts undergo a large number of programmed death events by many different causes in osteoporosis and release NLRP3 and interleukin (e.g., inflammatory factors), which play pivotal roles in contributing to excessive differentiation of osteoclasts and result in exaggerated bone resorption. NLRP3 is activated during pyroptosis and processes the precursors of IL-1β and IL-18 into mature forms, which are released into the extracellular milieu accompanied by cell rupture. All of these compounds are the classical factors of pyroptosis. The cellular effects of pyroptosis are commonly observed in osteoporosis. Although many previous studies have focused on the pathogenesis of these inflammatory factors in osteoporosis, pyroptosis has not been previously evaluated. In this review, pyroptosis is proposed as a novel hypothesis of osteoporosis pathogenesis for the first time, thus providing a new direction for the treatment of osteoporosis in the future.

scholarly journals Calcium supplementation in osteoporosis: useful or harmful?

2018 ◽  
Vol 178 (4) ◽  
pp. D13-D25 ◽  
Author(s):  
Iacopo Chiodini ◽  
Mark J Bolland
Keyword(s):  
Vitamin D ◽  
Calcium Supplementation ◽  
Fragility Fractures ◽  
Cardiovascular Effects ◽  
Vitamin D Supplementation ◽  
Calcium Balance ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Gastrointestinal Side Effects ◽  
Vitamin D Supplements

Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism, and for many years, calcium and vitamin D have been considered crucial in the prevention and treatment of osteoporosis. However, recently, the usefulness of calcium supplementation (alone or with concomitant vitamin D) has been questioned, since some studies reported only weak efficacy of these supplementations in reducing fragility fracture risk. On the other hand, besides the gastrointestinal side effects of calcium supplements and the risk of kidney stones related to use of co-administered calcium and vitamin D supplements, other recent data suggested potential adverse cardiovascular effects from calcium supplementation. This debate article is focused on the evidence regarding both the possible usefulness for bone health and the potential harmful effects of calcium and/or calcium with vitamin D supplementation.

Sclerostin and Bone Aging: A Mini-Review

Gerontology ◽  
2016 ◽  
Vol 62 (6) ◽  
pp. 618-623 ◽  
Author(s):  
Eric Hay ◽  
Wafa Bouaziz ◽  
Thomas Funck-Brentano ◽  
Martine Cohen-Solal
Keyword(s):  
Bone Formation ◽  
Fragility Fractures ◽  
Bone Fragility ◽  
High Bone Mineral Density ◽  
Mineral Density ◽  
Necrosis Factor Alpha ◽  
Treatment Of Osteoporosis ◽  
Bone Aging ◽  
High Bone ◽  
Factor Alpha

Sclerostin, mainly produced by osteocytes, is now considered a major regulator of bone formation. Identified from patients with a low bone mass, sclerostin inhibits the Wnt pathway by binding to LRP5/6 and subsequently increases bone formation. Sclerostin may also play a role in the mediation of systemic and local factors such as calcitriol, PTH, glucocorticoids and tumor necrosis factor-alpha. Circulating sclerostin levels increase with age and with the decline of kidney function. However, they are surprisingly higher in patients with a high bone mineral density, suggesting that sclerostin may be a relevant marker of the pool of mature osteocytes. The anti-anabolic properties lead to the development of anti-sclerostin biotherapies that are under current evaluation. The results of these clinical trials will open new promising opportunities for the treatment of osteoporosis and bone fragility fractures.

scholarly journals Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making

2021 ◽  
Vol 10 (5) ◽  
pp. 1140
Author(s):  
Kaleen N. Hayes ◽  
Elizabeth M. Winter ◽  
Suzanne M. Cadarette ◽  
Andrea M. Burden
Keyword(s):  
Surrogate Marker ◽  
Femoral Fractures ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Therapy ◽  
Narrative Review ◽  
Drug Holiday ◽  
Future Research ◽  
Mineral Density ◽  
First Line Therapy

Bisphosphonates are first-line therapy for osteoporosis, with alendronate, risedronate, and zoledronate as the main treatments used globally. After one year of therapy, bisphosphonates are retained in bone for extended periods with extended anti-fracture effects after discontinuation. Due to this continued fracture protection and the potential for rare adverse events associated with long-term use (atypical femoral fractures and osteonecrosis of the jaw), a drug holiday of two to three years is recommended for most patients after long-term bisphosphonate therapy. The recommendation for a drug holiday up to three years is derived primarily from extensions of pivotal trials with alendronate and zoledronate and select surrogate marker studies. However, certain factors may modify the duration of bisphosphonate effects on a drug holiday and warrant consideration when determining an appropriate time off-therapy. In this narrative review, we recall what is currently known about drug holidays and discuss what we believe to be the primary considerations and areas for future research regarding drug holiday duration: total bisphosphonate exposure, type of bisphosphonate used, bone mineral density and falls risk, and patient sex and body weight.

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

scholarly journals Management of primary and secondary osteoporosis in children

2020 ◽  
Vol 12 ◽  
pp. 1759720X2096926
Author(s):  
Sophia D. Sakka ◽  
Moira S. Cheung
Keyword(s):  
Bone Fractures ◽  
Bone Biopsy ◽  
Treatment Options ◽  
Quantitative Computed Tomography ◽  
Fragility Fractures ◽  
Secondary Osteoporosis ◽  
Long Bone ◽  
Vertebral Fracture Assessment ◽  
Primary Osteoporosis ◽  
Mineral Density

Osteoporosis in children differs from adults in terms of definition, diagnosis, monitoring and treatment options. Primary osteoporosis comprises primarily of osteogenesis imperfecta (OI), but there are significant other causes of bone fragility in children that require treatment. Secondary osteoporosis can be a result of muscle disuse, iatrogenic causes, such as steroids, chronic inflammation, delayed or arrested puberty and thalassaemia major. Investigations involve bone biochemistry, dual-energy X-ray absorptiometry scan for bone densitometry and vertebral fracture assessment, radiographic assessment of the spine and, in some cases, quantitative computed tomography (QCT) or peripheral QCT. It is important that bone mineral density (BMD) results are adjusted based on age, gender and height, in order to reflect size corrections in children. Genetics are being used increasingly for the diagnosis and classification of various cases of primary osteoporosis. Bone turnover markers are used less frequently in children, but can be helpful in monitoring treatment and transiliac bone biopsy can assist in the diagnosis of atypical cases of osteoporosis. The management of children with osteoporosis requires a multidisciplinary team of health professionals with expertise in paediatric bone disease. The prevention and treatment of fragility fractures and improvement of the quality of life of patients are important aims of a specialised service. The drugs used most commonly in children are bisphosphonates, that, with timely treatment, can give good results in improving BMD and reshaping vertebral fractures. The data regarding their effect on reducing long bone fractures are equivocal. Denosumab is being used increasingly for various conditions with mixed results. There are more drugs trialled in adults, but these are not yet licenced for children. Increasing awareness of risk factors for paediatric osteoporosis, screening and referral to a specialist team for appropriate management can lead to early detection and treatment of asymptomatic fractures and prevention of further bone damage.

Risk Factors for the Development of Osteoporosis and Osteoporotic Fractures Among Older Men

2009 ◽  
Vol 36 (9) ◽  
pp. 1947-1952 ◽  
Author(s):  
MARIA THOMAS-JOHN ◽  
MARY B. CODD ◽  
SIALAJA MANNE ◽  
NELSON B. WATTS ◽  
ANNE-BARBARA MONGEY
Keyword(s):  
Risk Factors ◽  
African American ◽  
Dairy Products ◽  
African American Men ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
Older Men ◽  
Current Treatment ◽  
Androgen Deprivation ◽  
Mineral Density

Objective.Osteoporotic fractures are associated with significant morbidity and mortality particularly among older men. However, there is little information regarding risk factors among this population. The aims of our study were to determine risk factors for osteoporosis and fragility fractures and the predictive value of bone mineral density (BMD) measurements for development of fragility fractures in a cohort of elderly Caucasian and African American men.Methods.We evaluated 257 men aged 70 years or older for risk factors for osteoporosis and fragility fractures using a detailed questionnaire and BMD assessment. Exclusion criteria included conditions known to cause osteoporosis such as hypogonadism and chronic steroid use, current treatment with bisphosphonates, bilateral hip arthroplasties, and inability to ambulate independently.Results.Age, weight, weight loss, androgen deprivation treatment, duration of use of dairy products, exercise, and fracture within 10 years prior to study entry were associated with osteoporosis (p ≤ 0.05). Fragility fractures were associated with duration of use of dairy products, androgen deprivation treatment, osteoporosis, and history of fracture within 10 years prior to BMD assessment (p ≤ 0.05). There were some differences in risk factors between the Caucasian and African American populations, suggesting that risk factors may vary between ethnic groups.Conclusion.Although men with osteoporosis had a higher rate of fractures, the majority of fractures occurred in men with T-scores > −2.5 standard deviations below the mean, suggesting that factors other than BMD are also important in determining risk.

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