Eight Weeks of Aromatase Inhibition Using the Nutritional Supplement Novedex XT: Effects in Young, Eugonadal Men

2007 ◽  
Vol 17 (1) ◽  
pp. 92-108 ◽  
Author(s):  
Darryn S. Willoughby ◽  
Colin Wilborn ◽  
Lemuel Taylor ◽  
William Campbell
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Repeated Measures ◽  
Free Testosterone ◽  
Nutritional Supplement ◽  
Total Testosterone ◽  
Aromatase Inhibition ◽  
Clinical Safety ◽  
Repeated Measures Anova ◽  
Blood And Urine Samples

This study examined the effects of an aromatase-inhibiting nutritional supplement on serum steroid hormones, body composition, and clinical safety markers. Sixteen eugonadal young men ingested either Novedex XT™ or a placebo daily for 8 wk, followed by a 3-wk washout period. Body composition was assessed and blood and urine samples obtained at weeks 0, 4, 8, and 11. Data were analyzed by 2-way repeated-measures ANOVA. Novedex XT resulted in average increases of 283%, 625%, 566%, and 438% for total testosterone (P = 0.001), free testosterone (P = 0.001), dihydrotestosterone (P = 0.001), and the testosterone:estrogen ratio (P = 0.001), respectively, whereas fat mass decreased 3.5% (P = 0.026) during supplementation. No significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones (P > 0.05). This study indicates that Novedex XT significantly increases serum androgen levels and decreases fat mass.

scholarly journals Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans

2019 ◽  
Vol 9 (1) ◽  
pp. 74 ◽  
Author(s):  
Małgorzata Chlabicz ◽  
Jacek Jamiołkowski ◽  
Marlena Paniczko ◽  
Paweł Sowa ◽  
Magda Łapińska ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Body Composition ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Fat Mass ◽  
Fat Distribution ◽  
Free Testosterone ◽  
Sodium Balance ◽  
Composition Analysis ◽  
Gynoid Fat

Background: Natriuretic peptides (NPs), including brain natriuretic peptide (BNP), are neurohormones involved in the regulation of water-sodium balance and the maintenance of cardiovascular homeostasis. A higher concentration of NPs is observed in females, but the mechanism behind this difference has not been fully elucidated. Methods: Randomly chosen 255 volunteers from the general population were examined. Overall, 196 people without severe cardiovascular disease were included (mean age 48 years, 35.7% male). A comprehensive assessment was performed, including anthropometric measurements, N-terminal pro-brain natriuretic peptide (NT-proBNP), total testosterone (TT) and sex hormone-binding globulin (SHBG) concentration, transthoracic echocardiography (ECHO), and body composition analysis by direct dual-energy X-ray absorptiometry (DEXA). The univariate analysis adjusted by the known affecting factors determined which measurements were independently associated with NT-proBNP concentration. Results: NT-proBNP concentration was positively associated with gynoid fat mass, gynoid/total fat (G/TF) mass index, SHBG and negatively with android/gynoid (A/G) fat mass index, TT and calculated free testosterone (CFT) concentrations. Furthermore, body composition parameters remained independently associated with NT-proBNP levels even after adjusting for CFT and SHBG. Conclusion: In the population without severe cardiovascular disease, the NT-proBNP concentration is independently associated with lower availability of testosterone and higher gynoid fat distribution, which may explain higher NPs levels in females.

scholarly journals Serum estradiol is associated with lean mass in elderly Swedish men

2010 ◽  
Vol 162 (4) ◽  
pp. 737-745 ◽  
Author(s):  
Liesbeth Vandenput ◽  
Dan Mellström ◽  
Magnus K Karlsson ◽  
Eric Orwoll ◽  
Fernand Labrie ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Lean Mass ◽  
Association Studies ◽  
Serum Testosterone ◽  
Fat Distribution ◽  
Free Testosterone ◽  
Elderly Men ◽  
Central Fat ◽  
Free Serum

ObjectiveAssociation studies in men have shown that androgens are inversely related to fat measures, while the relation between sex steroids and lean mass remains unclear. We, therefore, investigated the associations between serum sex steroid levels and body composition in elderly men with a main focus on lean mass measures.Design and methodsA cross-sectional survey of a population-based cohort of 3014 elderly men, aged 69–80 years (Osteoporotic Fractures in Men study, Sweden). Serum levels of testosterone and estradiol (E2) were measured by mass spectrometry, sex hormone-binding globulin (SHBG) levels were measured by IRMA, and measures of body composition were obtained by dual-energy X-ray absorptiometry.ResultsTotal as well as free serum testosterone associated independently inversely (P<0.001), while total as well as free serum E2associated independently directly (P<0.001) with total body fat mass and trunk fat mass. Serum SHBG associated independently inversely with central fat distribution. Serum E2and free E2but not serum testosterone or free testosterone levels associated positively with lean mass (P<0.01). Elderly men within the lowest quartile of free E2had 0.5 kg less lean mass in the legs than subjects within the highest quartile, while the subjects in the different quartiles of free testosterone did not differ in lean mass.ConclusionsSerum E2, but not serum testosterone, is directly associated with lean mass in this large study of elderly Swedish men. In addition, serum SHBG is associated with central fat distribution and we confirmed that serum testosterone is inversely associated with fat mass.

scholarly journals Testosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial

2020 ◽  
Vol 182 (6) ◽  
pp. 539-548 ◽  
Author(s):  
Dorte Glintborg ◽  
Henrik Bjarke Vaegter ◽  
Louise Lehmann Christensen ◽  
Emma Bendix ◽  
Thomas Graven-Nielsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Pain Perception ◽  
Adrenal Function ◽  
Total Testosterone ◽  
Double Blind

Background Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear. Purpose To measure changes in body composition, pain perception, quality of life, and adrenal function after TRT or placebo in opioid-treated men with chronic non-malignant pain. Methods Double-blind, placebo-controlled study in 41 men (>18 years) with total testosterone <12 nmol/L were randomized to 24 weeks TRT (Testosterone undecanoate injection three times/6 months, n = 20) or placebo (placebo-injections, n = 21). Outcomes Body composition (lean body mass and fat mass assessed by DXA), clinical pain intensity (numerical rating scale), and experimental pain perception (quantitative sensory assessment), quality of life (SF36), and adrenocorticotrophic hormone (ACTH) test. Data were presented as median (quartiles). Mann–Whitney tests were performed on delta values (24–0 weeks) between TRT and placebo. Results The median age was 55 years (46; 59) and total testosterone before intervention was 6.8 (5.0; 9.3) nmol/L. TRT was associated with change of testosterone levels: 12.3 (7.0; 19.9) nmol/L (P < 0.001 vs placebo), increased lean body mass: 3.6 (2.3; 5.0) kg vs 0.1 kg (−2.1; 1.5) during TRT vs placebo and decreased total fat mass: −1.2 (−3.1; 0.7) kg vs 1.2 kg (−0.9; 2.5) kg, both P < 0.003. Changed pain perception, SF36, and ACTH-stimulated cortisol levels were non-significantly changed during TRT compared with placebo. Conclusions Six months of TRT improved body composition in men with opioid-induced hypogonadism without significant changes in outcomes of pain perception, quality of life, or adrenal function.

scholarly journals High-Load Resistance Exercise Augments Androgen Receptor–DNA Binding and Wnt/β-Catenin Signaling without Increases in Serum/Muscle Androgens or Androgen Receptor Content

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3829
Author(s):  
Thomas D. Cardaci ◽  
Steven B. Machek ◽  
Dylan T. Wilburn ◽  
Jeffery L. Heileson ◽  
Darryn S. Willoughby
Keyword(s):  
Androgen Receptor ◽  
Dna Binding ◽  
Resistance Exercise ◽  
Repeated Measures ◽  
Free Testosterone ◽  
High Load ◽  
Total Testosterone ◽  
Post Exercise ◽  
Bonferroni Adjustment ◽  
Full Body

The purpose of this study was (1) to determine the effect of single bouts of volume- and intensity-equated low- (LL) and high-load (HL) full-body resistance exercise (RE) on AR-DNA binding, serum/muscle testosterone and dihydrotestosterone, muscle androgen receptor (AR), and AR-DNA binding; and, (2) to determine the effect of RE on sarcoplasmic and nucleoplasmic β-catenin concentrations in order to determine their impact on mediating AR-DNA binding in the absence/presence of serum/muscle androgen and AR protein. In a cross-over design, 10 resistance-trained males completed volume- and intensity-equated LL and HL full-body RE. Blood and muscle samples were collected at pre-, 3 h-, and 24 h post-exercise. Separate 2 × 3 factorial analyses of variance (ANOVAs) with repeated measures and pairwise comparisons with a Bonferroni adjustment were used to analyze the main effects. No significant differences were observed in muscle AR, testosterone, dihydrotestosterone, or serum total testosterone in either condition (p > 0.05). Serum-free testosterone was significantly decreased 3 h post-exercise and remained significantly less than baseline 24 h post-exercise in both conditions (p < 0.05). In response to HL, AR-DNA binding significantly increased at 3 h post-exercise (p < 0.05), whereas no significant differences were observed at any time in response to LL (p > 0.05). Moreover, sarcoplasmic β-catenin was significantly greater in HL (p < 0.05) without significant changes in nucleoplasmic β-catenin (p > 0.05). In conclusion, increases in AR-DNA binding in response to HL RE indicate AR signaling may be load-dependent. Furthermore, despite the lack of increase in serum and muscle androgens or AR content following HL RE, elevations in AR-DNA binding with elevated sarcoplasmic β-catenin suggests β-catenin may be facilitating this response.

scholarly journals Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men

1998 ◽  
pp. 517-523 ◽  
Author(s):  
CS Cooper ◽  
DR Taaffe ◽  
D Guido ◽  
E Packer ◽  
L Holloway ◽  
...  
Keyword(s):  
Body Composition ◽  
Muscle Strength ◽  
Endurance Exercise ◽  
Free Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Group Differences ◽  
Total Testosterone ◽  
Free Androgen Index ◽  
Igf I

To investigate putative abrogating effects of habitual endurance exercise on age-related changes in endocrine function and body composition, we compared insulin-like growth factor-I (IGF-I), sex hormonal status and body composition in 15 Masters runners and 15 minimally exercising men (MEM) aged 60-70 years. A higher maximal oxygen uptake (VO2 max.) in the runners (41.4+/-1.6 compared with 27.3+/-1.4 ml/kg/min, P=0.0001; mean+/-S.E.M.) reflected our group allocations. Analysis of body composition and bone mineral density (BMD) by dual energy X-ray absorptiometry showed no group differences in lean tissue mass or in regional or whole body BMD, but MEM were heavier, reflecting greater adiposity. Of nine muscle groups tested, only quadriceps strength differed significantly, being greater in runners (60.3+/-2.8 compared with 51.1+/-2.3 kg, P=0.02). Total IGF-I (129+/-10 compared with 124+/-11 ng/ml, P=0.72) and IGF-binding protein-3 (2854+/-94 compared with 2623+/-128ng/ml, P=0.16), were similarly depressed compared with young adult norms in both groups. There was no relationship between total or bioavailable IGF-I and any body composition, BMD or muscle strength variable. In the runners, concentrations of total testosterone (19.1+/-0.8 compared with 15.0+/-0.9 nmol/l, P=0.002) and sex hormone binding globulin (SHBG) (124.4+/-21.6 compared with 67.7+/-11.6 nmol/l, P=0.03) were significantly greater, but the free androgen index was significantly lower (20.7+/-2.7 compared with 31.4+/-4.1, P=0.04). Directly measured free testosterone, however, was similar between the runners and MEM (47.9+/-1.8 compared with 47.1+/-2.0 nmol/l P=0.80). Therefore the group differences in total testosterone and free androgen index were due to their different SHBG concentrations. Although estrone concentration was higher in MEM (85.1+/-5.2 compared with 108+/-6.7 pmol/l, P=0.03), estradiol concentration was similar between groups (73.0+/-6.3 compared with 81.8+/-8.0 pmol/l, P=0.18), indicating that estrogens were not responsible for the increased SHBG in runners. These results indicate that even high levels of regular endurance exercise do not prevent the decline in the somatotropic axis that occurs with aging. Furthermore, the somatic effects of exercise in older men (reduced adiposity and increased regional muscle strength) occurred independently of somatotropic or androgen status. Although habitual exercise does not influence free testosterone concentrations in older men, it appears to enhance the age-associated increase in SHBG synthesis.

scholarly journals The effects of regular step-aerobic exercises on body fat values of adult sedentary womenDüzenli step-aerobik egzersizlerinin yetişkin sedanter kadınlarda vücut yağ değerlerine etkisi

2016 ◽  
Vol 13 (3) ◽  
pp. 4973 ◽  
Author(s):  
Şeyma Kurşun ◽  
Gürhan Suna ◽  
Mahmut Alp
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Repeated Measures ◽  
Eating Habits ◽  
Repeated Measures Anova ◽  
Positive Effects ◽  
Post Test ◽  
Sedentary Women

The aim of this study was to investigate the effects of 12-week regular step aerobic exercises on body fat values of adult sedentary women. 35 female joined to the study voluntarily who work as academic and administrative staff in Isparta Süleyman Demirel University. Step aerobic exercises were applied to the participants regularly as 12 weeks, 3 days a week, 60 minutes a day. The tempo of music in the exercises was based on “Bpm≥120”. Body fat ratios and fat mass measurements were taken with TANITA BC 418 Professional Body Analysis Device. Datas were compared by using “Repeated-Measures ANOVA” at SPSS 18 Statistics Programme. Participants’ mean of age was calculated 35,20±6,26 years and mean of lenght was calculated 168,48±5,09 cm. There were no statistical differences as a result of comparison of pre, mid and post-test weight, body fat ratio, fat mass and body mass index values taken from participants (p>0,05). As a result, according to findings handled from the research and similar studies in the literature, it can be thought that short-term Step-Aerobic exercises can cause reductions in body fat ratio values; but cannot cause reductions in weight and body mass index values because of the increment in muscle mass. Planning long-term exercises can be suggested to the future studies for being seen positive effects in these values. Additionally, for optimum physical fitness, these can be suggested to the participants that they should pay attention to their eating habits and should attend the exercises with a dietician control. ÖzetBu çalışmanın amacı, 12 haftalık düzenli step aerobik egzersizlerinin yetişkin sedanter kadınlarda vücut yağ değerlerine etkisinin incelenmesidir. Araştırmaya Isparta Süleyman Demirel Üniversitesi’nde akademik ve idari personel olarak çalışan 35 kadın gönüllü katıldı.  Katılımcılara düzenli olarak 12 hafta, haftada 3 gün, günde 60 dakika step aerobik egzersizleri uygulandı. Egzersizlerde müzik temposu “Bpm≥120” olarak baz alındı. Vücut yağ yüzdesi ve yağ kütlesi ölçümleri TANİTA BC 418 Profesyonel Vücut Analiz Cihazı ile alındı. Veriler SPSS 18.0 programında “Repeated-Measures ANOVA” kullanılarak analiz edildi. Katılımcıların yaş ortalaması 35,20±6,26 yıl ve boy ortalaması 168,48±5,09 cm olarak hesaplandı.  Katılımcılardan alınan vücut ağırlığı, vücut yağ yüzdesi, yağ kütlesi ve beden kütle endeksi ön, ara, son test değerlerinin karşılaştırılması sonucunda istatistiksel olarak farka rastlanmadı (p>0,05). Sonuç olarak, araştırmada ve literatürdeki benzer çalışmalardan elde edilen bulgulara göre, kısa dönem Step-Aerobik egzersizlerinin vücut yağ yüzdesi değerlerinde azalmaya neden olabileceği; fakat vücut ağırlığı ve beden kütle endeksi değerlerinde azalmaya neden olmamasının kas kütlesindeki artıştan dolayı olduğu düşünülmektedir. İleride yapılacak araştırmalarda bu değerlerde pozitif etkilerin görülebilmesi için daha uzun süreli egzersizlerin planlanması önerilebilir. Ek olarak, optimum fiziksel uygunluk için planlanan egzersizlerin yanı sıra katılımcılara bu tip egzersizlerde beslenme alışkanlıklarına dikkat etmeleri ve bir diyetisyen kontrolünde egzersizlere katılmaları önerilebilir.

Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV

2021 ◽  
Vol 184 (1) ◽  
pp. 107-122
Author(s):  
Sara De Vincentis ◽  
Maria Chiara Decaroli ◽  
Flaminia Fanelli ◽  
Chiara Diazzi ◽  
Marco Mezzullo ◽  
...  
Keyword(s):  
Body Composition ◽  
Health Status ◽  
Body Fat ◽  
Sex Steroids ◽  
Highly Active Antiretroviral Therapy ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Cross Sectional ◽  
Highly Active

Objective Hypogonadism is common in HIV-infected men. The relationship between health status, sex steroids and body composition is poorly known in HIV. The aim was to investigate the association between health status (comorbidities/frailty), body composition, and gonadal function in young-to-middle-aged HIV-infected men. Design Prospective, cross-sectional, observational study. Methods HIV-infected men aged <50 years and ongoing Highly Active Antiretroviral Therapy were enrolled. Serum total testosterone (TT), estradiol (E2), estrone (E1) were measured by liquid chromatography-tandem mass spectrometry, LH and FSH by immunoassay. Free testosterone (cFT) was calculated by Vermeulen equation. Body composition was assessed by dual-energy X-ray absorptiometry and abdominal CT scan. Multimorbidity (MM) and frailty were defined as ≥3 comorbidities and by a 37-item index, respectively. Results A total of 316 HIV-infected men aged 45.3 ± 5.3 years were enrolled. Body fat parameters were inversely related to cFT and TT, and directly related to E1 and E2/testosterone (TS) ratio. Patients with MM had lower cFT (P < 0.0001) and TT (P = 0.036), and higher E1 (P < 0.0001) and E2/TS ratio (P = 0.002). Frailty was inversely related to cFT (R2 = 0.057, P < 0.0001) and TT (R2 = 0.013, P = 0.043), and directly related to E1 (R2 = 0.171, P < 0.0001), E2 (R2 = 0.041, P = 0.004) and E2/TS ratio (R2 = 0.104, P < 0.0001). Conclusions Lower TT and cFT, higher E1, E2/TS ratio and visceral fat were independently associated to poor health status and frailty, being possible hallmarks of unhealthy conditions in adult HIV-infected men. Overall, MM, frailty and body fat mass are strictly associated to each other and to sex steroids, concurring together to functional male hypogonadism in HIV.

Effects of Seasonal Vitamin D3 Supplementation on Strength, Power, and Body Composition in College Swimmers

2020 ◽  
Vol 30 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Michelle S. Rockwell ◽  
Madlyn I. Frisard ◽  
Janet W. Rankin ◽  
Jennifer S. Zabinsky ◽  
Ryan P. Mcmillan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Vertical Jump ◽  
Free Testosterone ◽  
Fat Free Mass ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Anabolic Hormones ◽  
Fall Season

The purpose of this study was to evaluate the impact of fall season vitamin D3 supplementation on strength/power, body composition, and anabolic hormones in swimmers with optimal vitamin D status at summer’s end. Male and female National Collegiate Athletic Association Division I swimmers (N = 19) with optimal 25-hydroxyvitamin D [25(OH)D] randomly received 5,000 IU of vitamin D3 (VITD) or placebo (PLA) daily for 12 weeks while participating in swimming and strength and conditioning training (August–November). Before and after the intervention, the participants underwent blood sampling for analysis of serum 25(OH)D, parathyroid hormone, total testosterone, free testosterone, sex hormone-binding globulin, and insulin-like growth factor 1, dual-energy X-ray absorptiometry, and strength/power testing (bench press, squat, dead lift, standing broad jump, vertical jump, and dips and pull-ups). Sex was used as a covariate for analyses. The 25(OH)D was decreased by 44% in PLA (p < .05) and increased by 8% in VITD over the 12 weeks. Fat-free mass increased in VITD (56.4–59.1 kg; p < .05), but not PLA (59.4–59.7 kg; p < .01). Significant Group × Time interaction effects were observed for dead lift (F = 21.577, p < .01) and vertical jump (F = 11.219, p < .01), but no other strength/power tests. Total testosterone decreased similarly in both groups, but free testosterone decreased and sex hormone-binding globulin increased only in PLA (p < .01). There were no group differences or changes in insulin-like growth factor 1 with the intervention. The findings suggest that vitamin D supplementation is an efficacious strategy to maintain 25(OH)D during the fall season training and to enhance some aspects of strength/power and fat-free mass in swimmers. Further research on the relationship between vitamin D and anabolic hormones is needed.

scholarly journals Relationship between body composition and eating disorder risk in adolescents. UP& DOWN follow-up substudy

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
J.A. Rodriguez-Laprast ◽  
S. Gomez-Martinez ◽  
A. Hernandez ◽  
V. Cabanas-Sanchez ◽  
O.L. Veiga ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Repeated Measures ◽  
Mental Health Problems ◽  
Female Adolescent ◽  
Categorical Variables ◽  
Hydration Status ◽  
Chi Square ◽  
Binary Model

AbstractAdolescence is a decisive and characteristic period for overall development throughout the life-span in which Eating Disorders (ED) are among the most common mental health problems in young population. Different factors might be related to the risk of ED such as sex and body composition, but literature about hydration status is still very scarce. This study was aimed to assess possible relationships between ED risk and body composition, including hydration status. A 2-year follow-up substudy from the UP&DOWN Study was performed in a sample of 77 adolescents at baseline (n = 74 after the follow-up; 13.87 ± 1.54 years old at baseline). Subjects were grouped by sex. ED risk was measured by the SCOFF questionnaire, a validated screening tool for ED. Risk of ED criterion is considered when SCOFF score is equal or higher than 2.0. Body composition, particularly Fat Mass (FM%) and hydration [Total Body Water (TBW in liters) regarding the weight of individuals and its range (low, within, high)] were determined by bioimpedance. Data analysis was conducted using version 25.0; SPSS Inc., Chicago, IL, USA, software. A logistic regression was made to select the variables [sex, TBW (L), FM%] that could be more related to ED risk, considered as a dependent variable. Crosstabs and chi-square test were used to establish the relationships between the categorical variables. Almost 30% girls and 10% boys were at risk of ED at baseline (P = 0.036). Furthermore, almost 39% girls and none of the boys were at ED risk after the follow-up (P = 0.000). All the subjects at ED risk showed a low TBW range at both points (baseline, P = 0.04; after the follow-up, P = 0.039). A probit binary model of repeated measures (151 healthy adolescent values were obtained considering every subject in both points of the study) was made to study the influence of sex, TBW (L), FM% on the ED risk. Positive associations between Sex-TBW interaction and ED risk (P = 0.000) as well as between FM% and ED risk (P = 0.020) were observed. These findings show that body composition, not only fat mass but also hydration status is related to ED risk, although it is well known that boys and girls show different hydration and fat patterns. The fact of being a female adolescent with low TBW and FM% values may predispose to a high ED risk. Therefore, sex-hydration interaction together with body composition should be further investigated for ED in adolescence.

The effects of pre-sleep consumption of casein protein on next-morning measures of RMR and appetite compared between sedentary pre- and postmenopausal women

2020 ◽  
Vol 125 (2) ◽  
pp. 121-128
Author(s):  
Christopher M. Schattinger ◽  
J. T. Leonard ◽  
C. L. Pappas ◽  
M. J. Ormsbee ◽  
L. B. Panton
Keyword(s):  
Body Composition ◽  
Postmenopausal Women ◽  
Repeated Measures ◽  
Analogue Scale ◽  
Controlled Trial ◽  
Premenopausal Women ◽  
Double Blind ◽  
Repeated Measures Anova ◽  
Casein Protein ◽  
One Way Anova

AbstractThe purpose of the present study was to compare next-morning responses of RMR and appetite to pre-sleep consumption of casein protein (CP) in pre- and postmenopausal women. The study was a randomised, crossover, double-blind, placebo-controlled trial. Seven sedentary premenopausal (age: 19·9 (sd 1·2) years; BMI: 23·1 (sd 2·6) kg/m2) and seven sedentary postmenopausal (age: 56·4 (sd 4·9) years; BMI: 26·3 (sd 3·5) kg/m2) women participated. During visit one, anthropometrics and body composition were measured. Following visit one, subjects consumed either CP (25 g) or placebo (PL) ≥2 h after their last meal and ≤30 min prior to sleep on the night before visits two and three. Visits two and three occurred ≥1 week after visit one and were 48 h apart. During visits two and three, RMR (VO2), RER and appetite were measured via indirect calorimetry and visual analogue scale, respectively. Anthropometrics and body composition were analysed by one-way ANOVA. RMR and measures of appetite were analysed using a 2 × 2 (menopause status × CP/PL) repeated-measures ANOVA. Significance was accepted at P ≤ 0·05. RMR was significantly lower in postmenopausal compared with premenopausal women under both conditions (P = 0·003). When consumed pre-sleep CP did not alter RMR, RER or appetite compared with PL when assessed next morning in pre- and postmenopausal women. These data contribute to growing evidence that pre-sleep consumption of protein is not harmful to next-morning metabolism or appetite. In addition, these data demonstrate that menopause may not alter next-morning RMR, RER or appetite after pre-sleep consumption of CP.

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