The Influence of Supplementation with Rhodiola rosea L. Extract on Selected Redox Parameters in Professional Rowers

2009 ◽  
Vol 19 (2) ◽  
pp. 186-199 ◽  
Author(s):  
Anna Skarpanska-Stejnborn ◽  
Lucja Pilaczynska-Szczesniak ◽  
Piotr Basta ◽  
Ewa Deskur-Smielecka
Keyword(s):  
Superoxide Dismutase ◽  
Placebo Group ◽  
Antioxidant Capacity ◽  
Thiobarbituric Acid ◽  
Creatine Kinase Activity ◽  
Superoxide Dismutase Activity ◽  
Rhodiola Rosea ◽  
Blood Samples ◽  
Plasma Antioxidant Capacity ◽  
Lactate Levels

The aim of this study was to investigate the effect of Rhodiola rosea supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. This double-blinded study included 22 members of the Polish Rowing Team who were participating in a preparatory camp. Participants were randomly assigned to the supplemented group (n = 11), who received 100 mg of R. rosea extract twice daily for 4 wk, or the placebo group (n = 11). At the beginning and end of the study, participants performed a 2,000-m maximum test on a rowing ergometer. Blood samples were taken from the antecubital vein before each exercise test, 1 min after completing the test, and after a 24-hr restitution period. The following redox parameters were assessed in erythrocytes: superoxide dismutase activity, glutathione peroxidase activity, and thiobarbituric-acid-reactive substances concentrations. In addition, creatine kinase activity and total antioxidant capacity were measured in plasma samples, lactate levels were determined in capillary blood samples, and uric acid concentrations were measured in serum. After supplementation, the total plasma antioxidant capacity was significantly higher (p = .0002) in the supplemented group than in the placebo group, and superoxide dismutase activity in erythrocytes directly after and 24 hr after the ergometry was significantly (p = .0461) lower in athletes receiving R. rosea extracts than in the placebo group. In conclusion, supplementation with R. rosea increased antioxidant levels in the plasma of professional rowers but had no effect on oxidative damage induced by exhaustive exercise.

Effects of Oral Supplementation With Plant Superoxide Dismutase Extract on Selected Redox Parameters and an Inflammatory Marker in a 2,000-m Rowing-Ergometer Test

2011 ◽  
Vol 21 (2) ◽  
pp. 124-134 ◽  
Author(s):  
Anna Skarpanska-Stejnborn ◽  
Lucja Pilaczynska-Szczesniak ◽  
Piotr Basta ◽  
Ewa Deskur-Smielecka ◽  
Donata Woitas-Slubowska ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Placebo Group ◽  
Inflammatory Marker ◽  
Thiobarbituric Acid ◽  
Creatine Kinase Activity ◽  
C Reactive Protein ◽  
Sod Activity ◽  
Blood Samples ◽  
Reactive Protein ◽  
Rowing Ergometer

The aim of this study was to investigate the effect of plant superoxide dismutase extract (GliSODin) supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. The double-blinded study included 19 members of the Polish rowing team who were participating in a preparatory camp. Subjects were randomly assigned to the supplemented group (n = 10), who received 2 capsules (500 mg) of GliSODin extract once daily for 6 weeks, or the placebo group (n = 9). At the beginning and end of the study, subjects performed a 2,000-m maximum-effort test on a rowing ergometer. Blood samples were taken from the antecubital vein before each exercise test, 1 min after completing the test, and after a 24-hr restitution period. The following redox parameters were assessed in erythrocytes: superoxide dismutase (SOD) activity, glutathione peroxidase activity, and concentrations of thiobarbituric-acid-reactive substances. In addition, creatine kinase activity and total antioxidant capacity were measured in plasma samples, lactate levels were determined in capillary blood samples, and C-reactive protein and lactate dehydrogenase concentrations were measured in serum. After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise.

The Influence of Supplementation with Artichoke (Cynara scolymus L.) Extract on Selected Redox Parameters in Rowers

2008 ◽  
Vol 18 (3) ◽  
pp. 313-327 ◽  
Author(s):  
Anna Skarpañska-Stejnborn ◽  
Lucia Pilaczynska-Szczesniak ◽  
Piotr Basta ◽  
Ewa Deskur-Smielecka ◽  
Magorzata Horoszkiewicz-Hassan
Keyword(s):  
Placebo Group ◽  
Leaf Extract ◽  
Reductase Activity ◽  
Thiobarbituric Acid ◽  
Antioxidant Defense System ◽  
Creatine Kinase Activity ◽  
Antioxidant Potential ◽  
Blood Samples ◽  
Lactate Levels ◽  
Artichoke Leaf Extract

High-intensity physical exercise decreases intracellular antioxidant potential. An enhanced antioxidant defense system is desirable in people subjected to exhaustive exercise. The aim of this study was to investigate the influence of supplementation with artichoke-leaf extract on parameters describing balance between oxidants and antioxidants in competitive rowers. This double-blinded study was carried out in 22 members of the Polish rowing team who were randomly assigned to a supplemented group (n = 12), receiving 1 gelatin capsule containing 400 mg of artichoke-leaf extract 3 times a day for 5 wk, or a placebo group (n = 10). At the beginning and end of the study participants performed a 2,000-m maximal test on a rowing ergometer. Before each exercise test, 1 min after the test completion, and after a 24-hr restitution period blood samples were taken from antecubital vein. The following redox parameters were assessed in red blood cells: superoxide dismutase activity, glutathione peroxidase activity, glutathione reductase activity, reduced glutathione levels, and thiobarbituric-acid-reactive-substances concentrations. Creatine kinase activity and total antioxidant capacity (TAC) were measured in plasma samples, lactate levels were determined in capillary blood samples, and serum lipid profiles were assessed. During restitution, plasma TAC was significantly higher (p < .05) in the supplemented group than in the placebo group. Serum total cholesterol levels at the end of the study were significantly (p < .05) lower in the supplemented group than in the placebo group. In conclusion, consuming artichoke-leaf extract, a natural vegetable preparation of high antioxidant potential, resulted in higher plasma TAC than placebo but did not limit oxidative damage to erythrocytes in competitive rowers subjected to strenuous training.

scholarly journals Antioxidant Capacity and Superoxide Dismutase Activity in Adrenoleukodystrophy

2017 ◽  
Vol 74 (5) ◽  
pp. 519 ◽  
Author(s):  
Bela R. Turk ◽  
Benjamin E. Theisen ◽  
Christina L. Nemeth ◽  
Joel S. Marx ◽  
Xiaohai Shi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Superoxide Dismutase Activity

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

2007 ◽  
Vol 20 (3) ◽  
pp. 585-593 ◽  
Author(s):  
G. Cinnella ◽  
G. Vendemiale ◽  
M. Dambrosio ◽  
G. Serviddio ◽  
P.L. Pugliese ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Antioxidant Properties ◽  
Redox Balance ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Sodium Thiopental ◽  
Blood Samples ◽  
Plasma Antioxidant Capacity ◽  
Trolox Equivalent ◽  
Plasma Antioxidant ◽  
Group D

We studied the effects of Propofol, Desflurane, and Sevoflurane on the systemic redox balance in patients undergoing laparohysterectomy. We measured blood concentration of glutathione (GSH), plasma antioxidant capacity (Trolox Equivalent Antioxidant Capacity-TEAC), and lipid peroxidation products (malondialdehyde (aMDA) and 4-hydroxynonenal (aHNE) protein adducts). Sixty patients were randomly placed into three groups of twenty people each. In Group P anesthesia was induced with Propofol 2 mg/kg and maintained with 12–10–8 mg/kg/min; in Groups S and D anesthesia was induced with 3 mg/kg Sodium Thiopental and maintained with 2% Sevoflurane and 6% Desflurane, respectively. Blood samples were collected prior to induction (T0bas), 60min and 24h postoperatively (T160' and T224 h). In Group P, GSH increased on T160' (p<0.02) and returned to baseline on T24h, while TEAC remained unmodified; in Groups S, GSH and TEAC decreased on T160' (p<0.01 vs. T0bas, p<0.03 vs. T0bas, respectively); in Group D, on T160' there was a slight decrease of GSH and TEAC. The levels of aMDA slightly decreased throughout the study periods in Group P, increased in Group D, and remained stable in Group S. Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

scholarly journals 97 The effects of excess iron on growth performance, intestinal and liver morphology and antioxidant capacity in weaned piglets

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 80-80
Author(s):  
Xiaonan Yu ◽  
Jianan Han ◽  
Jie Feng
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Superoxide Dismutase Activity ◽  
Weaned Piglets ◽  
Protein Carbonyl Content ◽  
Excess Iron ◽  
Liver Morphology ◽  
Iron Excretion

Abstract Iron is one of the essential trace elements for animals and involved in many important physiological processes, thus exogenous iron is often supplemented as feed additive. However, the addition of excess iron may have adverse effects on animals and the environment. To investigate the effects of excess iron on growth performance, intestinal and liver morphology and antioxidant capacity in weaned piglets, in this study, forty 23-day-old weaned piglets were allotted to 4 treatments，respectively received the basal diet containing 100, 400, 3000 or 10000 mg Fe/kg as FeSO4. The experiment lasted for 28 days and then the piglets were euthanized and sampled. Lower average daily gain and higher diarrhea rate were detected in the piglets received the diet with 3000 or 10000 mg Fe/kg. Iron excretion in piglets’ feces was dependent on the iron concentration in the diet. In addition, iron overload induced mitochondrial swelling and cell death in the duodenum and liver of piglets. Excessive iron also increased piglets’ serum malondialdehyde content and reduced glutathione peroxidase and superoxide dismutase activity. Furthermore, significant increase of malondialdehydecontent and protein carbonyl content in the intestine and decrease of total antioxidant capacity, glutathione peroxidase activity and superoxide dismutase activity in the liver were observed in the piglets received diet containing high concentrations of iron. In conclusion, the results indicated that excess iron would reduce the growth performance of weaned piglets and increase the iron excretion in feces which adversely affect the environment. It may also negatively affect intestine and liver morphology and reduce the antioxidant capacity of piglets.

Influence of Aloe Arborescens Mill. Extract on Selected Parameters of Pro-oxidant-Antioxidant Equilibrium and Cytokine Synthesis in Rowers

2013 ◽  
Vol 23 (4) ◽  
pp. 388-398 ◽  
Author(s):  
Piotr Basta ◽  
Łucja Pilaczyńska-Szczȩśniak ◽  
Donata Woitas-Ślubowska ◽  
Anna Skarpańska-Stejnborn
Keyword(s):  
Placebo Group ◽  
Recovery Period ◽  
Thiobarbituric Acid ◽  
Creatine Kinase Activity ◽  
Double Blind Study ◽  
Double Blind ◽  
Maximum Test ◽  
Before And After ◽  
Total Antioxidant ◽  
Aloe Arborescens

This investigation examined the effect of supplementation with Biostimine, extract from aloe arborescens Mill. leaves, on the levels of pro-oxidant–antioxidant equilibrium markers and anti- and proinflammatory cytokines in rowers subjected to exhaustive exercise. This double-blind study included 18 members of the Polish Rowing Team. Subjects were randomly assigned to the supplemented group (n = 9), which received one ampoule of Biostimine once daily for 4 weeks, or to the placebo group (n = 9). Subjects performed a 2,000-meter-maximum test on a rowing ergometer at the beginning and end of the preparatory camp. Blood samples were obtained from the antecubital vein before each exercise test, 1 min after completing the test and after a 24-hr recovery period. Superoxide dismutase and glutathione peroxidase activity as well as the concentration of thiobarbituric acid reactive substances (TBARS) were assessed in erythrocytes. In addition, total antioxidant capacity (TAC) and creatine kinase activity were measured in plasma samples, and cytokine (IL-6, IL-10) concentrations were determined in the serum. Before and after Biostimine supplementation, exercise significantly increased the values of SOD, IL-6, IL-10, and TBARS in both groups. However, postexercise and recovery levels of TBARS were significantly lower in athletes receiving Biostimine than in controls. After supplementation, TAC was the only variable with the level being significantly higher in the supplemented group than in the placebo group. Consequently, we can conclude that Biostimine supplementation reduces the postexercise level of TBARS by increasing the antioxidant activity of plasma but has no effect on inflammatory markers.

Vitamin C and E supplementation prevents mitochondrial damage of ileum myocytes caused by intense and exhaustive exercise training

2009 ◽  
Vol 107 (5) ◽  
pp. 1532-1538 ◽  
Author(s):  
Eloi F. Rosa ◽  
Rafael Ferreira Ribeiro ◽  
Felipe M. T. Pereira ◽  
Edna Freymüller ◽  
Jeannine Aboulafia ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Citrate Synthase ◽  
Redox Status ◽  
Superoxide Dismutase Activity ◽  
Treadmill Running ◽  
Exhaustive Exercise ◽  
Control Group ◽  
Carbonyl Content ◽  
Oxidative Markers

Intense and exhaustive exercise (IEE) is associated with oxidative stress in skeletal muscle, and we recently reported that intestine is sensitive to IEE. In the present study, we investigated the possible relationship between the effects of IEE on morphology and oxidative markers in the ileum and isolated mitochondria. C57BL/6 mice were ascribed either to a control group comprising two subgroups, one sedentary and another exercised for 10 days (E10), or to a corresponding supplemented control group again comprising two subgroups, one sedentary and another exercised for 10 days (E10-V). The IEE program consisted of a single daily treadmill running session at 85% of Vmax, until animal exhaustion. Vitamins C (10 mg/kg) and E (10 mg/kg) were concurrently intraperitoneally administered 2 h before the exercise sessions. IEE was shown to cause 1) impairment of ileum internal membrane mitochondria verified by ultramicrography analysis; 2) increase in ileum carbonyl content (117%) and reduction in antioxidant capacity (36%); 3) increase in mitochondria carbonyl content (38%), increase in the percentage of ruptured mitochondria (25.3%), increase in superoxide dismutase activity (186%), and reduction in citrate synthase activity (40.4%) compared with control animals. Observations in the vitamin-supplemented exercised animals (E10-V) were 1) healthy appearance of myocyte mitochondria; 2) decrease in ileum carbonyl content (66%) and increase in antioxidant capacity (53%); 3) decrease in mitochondria carbonyl content (43%), decrease in the percentage of ruptured mitochondria (30%), slight increase in superoxide dismutase activity (7%), and significant increase in citrate synthase activity (121%) compared with E10 animals. Therefore, the present results strongly corroborate the hypothesis that IEE leads to marked disturbances in intestinal mitochondria, mainly in redox status, and affects whole intestinal redox status.

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