Acute Effects of Resistance-Exercise Intensity in Depressed Black/African Americans Living With HIV: A Randomized Pilot Study

2019 ◽  
Vol 41 (5) ◽  
pp. 261-270
Author(s):  
Sanaz Nosrat ◽  
James W. Whitworth ◽  
Nicholas J. SantaBarbara ◽  
Shira I. Dunsiger ◽  
Joseph T. Ciccolo

Depressive symptoms and fatigue are prevalent among people living with human immunodeficiency virus. Resistance exercise is known to stimulate a positive affective response. Objective: To examine the acute psychological effects of resistance-exercise intensity among Black/African-American people living with human immunodeficiency virus and experiencing depressive symptoms. Methods: A total of 42 participants were randomized into a moderate- (n = 21) or high-intensity (n = 21) group. Assessments were collected before exercise (PRE), at the midpoint (MID), immediately following (POST) exercise, and 15 (DELAY 15) and 30 (DELAY 30) min after. Results: In the moderate-intensity group, affect improved PRE to POST, PRE to DELAY 15 and DELAY 30, and perceived distress decreased from PRE to all time points. In the high-intensity group, affect declined PRE to MID, and perceived distress decreased PRE to DELAY 15 and DELAY 30. Perceived activation increased PRE to MID, and POST in both groups (ps < .01). Conclusions: The moderate-intensity group compared with the high-intensity group is more effective at improving affect and energy and at reducing distress.

2020 ◽  
Vol 106 (1) ◽  
pp. e83-e93
Author(s):  
Vinutha B Shetty ◽  
Paul A Fournier ◽  
Nirubasini Paramalingam ◽  
Wayne Soon ◽  
Heather C Roby ◽  
...  

Abstract Context Under basal insulin levels, there is an inverted U relationship between exercise intensity and exogenous glucose requirements to maintain stable blood glucose levels in type 1 diabetes (T1D), with no glucose required for intense exercise (80% V̇O2 peak), implying that high-intensity exercise is not conducive to hypoglycemia. Objective This work aimed to test the hypothesis that a similar inverted U relationship exists under hyperinsulinemic conditions, with high-intensity aerobic exercise not being conducive to hypoglycemia. Methods Nine young adults with T1D (mean ± SD age, 22.6 ± 4.7 years; glycated hemoglobin, 61 ± 14 mmol/mol; body mass index, 24.0 ± 3.3 kg/m2, V̇O2 peak, 36.6 ± 8.0 mL·kg–1 min–1) underwent a hyperinsulinemic-euglycemic clamp to maintain stable glycemia (5-6 mmol·L−1), and exercised for 40 minutes at 4 intensities (35%, 50%, 65%, and 80% V̇O2peak) on separate days following a randomized counterbalanced study design. Main Outcome Measures Glucose infusion rates (GIR) and glucoregulatory hormones levels were measured. Results The GIR (± SEM) to maintain euglycemia was 4.4 ± 0.4 mg·kg–1 min–1 prior to exercise, and increased significantly by 1.8 ± 0.4, 3.0 ± 0.4, 4.2 ± 0.7, and 3.5 ± 0.7 mg·kg–1 min–1 during exercise at 35%, 50%, 65%, and 80% V̇O2 peak, respectively, with no significant differences between the 2 highest exercise intensities (P &gt; .05), despite differences in catecholamine levels (P &lt; .05). During the 2-hour period after exercise at 65% and 80% V̇O2 peak, GIRs did not differ from those during exercise (P &gt; .05). Conclusions Under hyperinsulinemic conditions, the exogenous glucose requirements to maintain stable glycemia during and after exercise increase with exercise intensity then plateau with exercise performed at above moderate intensity ( &gt; 65% V̇O2 peak). High-intensity exercise confers no protection against hypoglycemia.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
T. W. Jones ◽  
L. Eddens ◽  
J. Kupusarevic ◽  
D. C. M. Simoes ◽  
M. J. W. Furber ◽  
...  

AbstractThis study examined whether intensity of endurance stimulus within a concurrent training paradigm influenced the phosphorylation of signaling proteins associated with the mTOR and AMPK networks. Eight male cyclists completed (1) resistance exercise (RES), 6 × 8 squats at 80% 1-RM; (2) resistance exercise and moderate intensity cycling of 40 min at 65% V̇O2peak, (RES + MIC); (3) resistance exercise and high intensity interval cycling of 40 min with 6 alternating 3 min intervals of 85 and 45% V̇O2peak (RES + HIIC), in a cross-over design. Muscle biopsies were collected at rest and 3 h post-RES. There was a main effect of condition for mTORS2448 (p = 0.043), with a greater response in the RES + MIC relative to RES condition (p = 0.033). There was a main effect of condition for AMPKα2T172 (p = 0.041), with a greater response in RES + MIC, relative to both RES + HIIC (p = 0.026) and RES (p = 0.046). There were no other condition effects for the remaining protein kinases assessed (p > 0.05). These data do not support a molecular interference effect in cyclists under controlled conditions. There was no intensity-dependent regulation of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise intensity.


2011 ◽  
Vol 33 (6) ◽  
pp. 866-883 ◽  
Author(s):  
Yu-Kai Chang ◽  
I-Hua Chu ◽  
Feng-Tzu Chen ◽  
Chun-Chih Wang

The present research attempts to evaluate the dose-response relationship between acute resistance exercise and planning. Seventeen participants performed the Tower of London (TOL) in control condition and three different exercise intensity conditions (40%, 70%, and 100% 10-repetition maximal) in a counterbalanced order. The results revealed positive effects of an acute bout of resistance exercise on the TOL. Specifically, a curvilinear trend was observed between exercise intensity and TOL scores that measured performances of “correct” and “move,” where moderate intensity demonstrated the most optimal performance compared with the other conditions. None of these differences were found in TOL scores that measure performances of “violation” and “planning speed.” These results suggest that acute moderate intensity resistance exercise could facilitate planning-related executive functions in middle-aged adults.


AIDS Care ◽  
2015 ◽  
Vol 27 (9) ◽  
pp. 1174-1182 ◽  
Author(s):  
Mee-Kyung Kee ◽  
Sae-Young Lee ◽  
Na-Young Kim ◽  
Joo-Shil Lee ◽  
June Myung Kim ◽  
...  

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Belinda M. Brown ◽  
Natalie Frost ◽  
Stephanie R. Rainey-Smith ◽  
James Doecke ◽  
Shaun Markovic ◽  
...  

Abstract Background Physical inactivity has been consistently linked to increased risk of cognitive decline; however, studies examining the impact of exercise interventions on cognition have produced inconsistent findings. Some observational studies suggest exercise intensity may be important for inducing cognitive improvements; however, this has yet to be thoroughly examined in older adult cohorts. The objective of the current study was to evaluate the effect of systematically manipulated high-intensity and moderate-intensity exercise interventions on cognition. Methods This multi-arm pilot randomised clinical trial investigated the effects of 6 months of high-intensity exercise and moderate-intensity exercise, compared with an inactive control, on cognition. Outcome measures were assessed at pre- (baseline), post- (6 months), and 12 months post-intervention. Ninety-nine cognitively normal men and women (aged 60–80 years) were enrolled from October 2016 to November 2017. Participants that were allocated to an exercise group (i.e. high-intensity or moderate-intensity) engaged in cycle-based exercise two times per week for 6 months. Cognition was assessed using a comprehensive neuropsychological test battery. Cardiorespiratory fitness was evaluated by a graded exercise test. Results There was a dose-dependent effect of exercise intensity on cardiorespiratory fitness, whereby the high-intensity group experienced greater increases in fitness than the moderate-intensity and control groups. However, there was no direct effect of exercise on cognition. Conclusions We did not observe a direct effect of exercise on cognition. Future work in this field should be appropriately designed and powered to examine factors that may contribute to individual variability in response to intervention. Trial registration This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000643370). Registered on 3 May 2017—retrospectively registered. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372780


1996 ◽  
Vol 168 (S30) ◽  
pp. 117-122 ◽  
Author(s):  
Mario Maj

The association between the infection produced by the human immunodeficiency virus (HIV) and syndromal or subsyndromal depression has been the topic of several studies in recent years. The results of the WHO Neuropsychiatric AIDS Study, conducted in the five geographical areas predominantly affected by the HIV epidemic, suggest that the symptomatic stages of HIV infection are associated with an increased prevalence of depressive symptoms, and, at least in some contexts in which the spreading of the infection is more recent and the social rejection of HIV-seropositive subjects is harsher, may also be associated with an increased prevalence of a syndromal diagnosis of depression.


2015 ◽  
Vol 21 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Luciano Antonacci Condessa ◽  
Christian Emmanuel Torres Cabido ◽  
André Maia Lima ◽  
Daniel Barbosa Coelho ◽  
Vinicius M. Rodrigues ◽  
...  

This study compared the exercise intensity of four specific soccer training sessions (friendly and training match, tactical and technical workouts). Ten professional soccer players (24.2 ± 3.7 years, 177.9 ± 7.3 cm, 63.2 ± 4.6 mLO2•kg-1•min-l) were recruited. A treadmill progressive interval test was performed to determine the players' VO2max, maximal heart rate (HRmax), HR-VO2 curve, and the heart rate corresponding to blood lactate concentrations of 2 and 4 mmol/L. The heart rate during the training sessions was used to estimate the exercise intensity and to classify them into intensity zones (low-intensity: <2 mmol/L; moderate-intensity: between 2 and 4 mmol/L; high-intensity: >4 mmol/L). Exercise intensities were different among training sessions (friendly match: 86.0 ± 5.1% HRmax; training match: 81.2 ± 4.1% HRmax; tactical workout: 70.4 ± 5.3% HRmax; technical workout: 62.1 ± 3.6% HRmax). The friendly match presented the highest percentage of time performed in the high-intensity zone.


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