Insulin-Sensitivity Response to a Single Bout of Resistive Exercise in Type 1 Diabetes Mellitus

2009 ◽  
Vol 18 (4) ◽  
pp. 564-571 ◽  
Author(s):  
Carolyn Jimenez ◽  
Mayra Santiago ◽  
Michael Sitler ◽  
Guenther Boden ◽  
Carol Homko
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Resistance Exercise ◽  
Outcome Measures ◽  
Repeated Measures ◽  
University Hospital ◽  
Control Group ◽  
Repeated Measures Design ◽  
Single Bout

Context:Little is known about the acute effects of resistance exercise on insulin sensitivity in people with type 1 diabetes.Design:Repeated-measures design with 2 independent variables: group (exercise and nonexercise control) and time (preexercise and 12 and 36 h postexercise).Setting:General Clinical Research Center, Temple University Hospital, Philadelphia, PA.Patients:14 physically active subjects (11 men and 3 women) with type 1 diabetes.Intervention:The exercise group completed 5 sets of 6 repetitions of strenuous (80% 1-RM) quadriceps and hamstring exercises while the control group performed only activities of daily Living.Main Outcome Measures:Insulin sensitivity was assessed with the euglycemic-hyperinsulinemic-clamp technique preexercise and 12 and 36 h postexercise.Results:Insulin-sensitivity values were not significantly different between the exercise and control groups (P = .92) or over time (P = .67).Conclusions:A single bout of strenuous resistance exercise does not alter insulin sensitivity in people with type 1 diabetes.

Analysis of glycemic safety of a moderate-intensity resistance exercise session in patients with diabetes type 1

2020 ◽  
Vol 19 (1) ◽  
pp. 16
Author(s):  
Leandro Paim Da Cruz Carvalho ◽  
Samira Socorro Nunes De Souza ◽  
Djenane Cristovam Souza ◽  
Flávio De Souza Araujo ◽  
Ferdinando Oliveira Carvalho ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Physical Exercise ◽  
Resistance Exercise ◽  
Repeated Measures ◽  
Pancreatic Beta Cells ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Resistance Exercise Session

 Introduction: Type 1 diabetes is an autoimmune disease that results in the destruction of pancreatic beta cells, implying the use of insulin therapy to maintain adequate blood glucose levels. When stimulated by physical exercise, glycemic homeostasis becomes impaired, providing complications in the daily lives of this population, constituting a barrier to physical exercise practice. Objective: To evaluate the glycemic safety of a resistance exercise session of moderate intensity in people with type 1 diabetes. Methods: 12 people with type 1 diabetes (7 men), performed a resistance exercise session of moderate intensity at 60% of 1 RM consisting of 7 exercises. Capillary blood glucose was assessed at the pre-session (GP), immediately after (G IA) and 20 minutes after (G 20). ANOVA for repeated measures was performed (p <0.05). Results: In the absolute values of glycemia, no significant differences were found (P = 0.061). However, when checking the delta blood glucose variation, a difference was found between G IA and G20 vs GP (P <0.05). Clinically important reductions above 20mg / dl (PI: ~ 37mg / dl; 20P: ~ 45mg / dl) without providing hypoglycemia. Conclusion: A moderate-intensity resistance exercise session proved to be safe from a glycemic point of view in people with type 1 diabetes.Keywords: diabetes mellitus type 1, resistance training, exercise. 

Once-weekly supervised combined training improves neurocognitive and psychobehavioral outcomes in young patients with type 1 diabetes mellitus

2019 ◽  
Vol 32 (12) ◽  
pp. 1341-1350 ◽  
Author(s):  
Junghwan Suh ◽  
Han Saem Choi ◽  
Ahreum Kwon ◽  
Hyun Wook Chae ◽  
Soyong Eom ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Resistance Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Exercise Program ◽  
Exercise Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Beneficial Effects

Abstract Background Previous studies investigating the beneficial effects of exercise in type 1 diabetes mellitus (T1DM) are relatively insufficient compared to studies on type 2 diabetes mellitus (T2DM), due to the fear of hypoglycemia. Recently, several researchers have reported that combined aerobic and resistance exercise prevents hypoglycemia during and after exercise. Furthermore, exercise has been shown to have beneficial effects on the psychological status of patients with various diseases. The aim of this study was to evaluate the effect of combined aerobic and resistance exercise in adolescents with T1DM. Methods Thirty-five type 1 diabetic patients were enrolled, and subjects were divided into either an exercise group or a control group. Thirty patients (20 patients in the exercise group, 10 patients in the control group) completed the study. The exercise program was performed for 1 h at a time, once a week, for 12 weeks. Study parameters were evaluated at baseline and 3 months after baseline evaluation. Results Combined aerobic and resistance exercise better controlled the body mass index (BMI), and also improved maximum muscular strength and maximum exercise intensity. On psychological tests, subjects’ attention and quality of life showed improving tendency, while their stress and behavioral problems diminished. The number of exercise events increased in the training group, while the daily total insulin dose and glycated hemoglobin (HbA1c) level showed no significant changes. Conclusions A 12-week structured exercise program consisting of aerobic and resistance exercises improves cardiovascular, neurocognitive and psychobehavioral functions, and positively helps lifestyle modification in patients with T1DM.

Prepubertal IGF-1 and Possible Relation with Physical Features of Growth and Type 1 Diabetes Mellitus

2019 ◽  
Vol 15 (5) ◽  
pp. 420-428
Author(s):  
Mohamed Saad Hamed ◽  
Alyaa Ahmed El-Sherbeny ◽  
Ahmed Mohamed Bahaa El-din
Keyword(s):  
Type 1 Diabetes ◽  
Fasting Blood Glucose ◽  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Childhood And Adolescence ◽  
Body Segment ◽  
Arm Span ◽  
Physical Features

Background: T1DM is considered as the most common chronic metabolic autoimmune disorder in childhood and adolescence as well as in the early adulthood. It appears frequently during 12- 13 years of age with distinctive features like immune-mediated chronic damage of pancreatic β-cells, leading eventually to partial, or mostly, absolute insulin deficiency. Insulin-like growth factor 1 (IGF-1) is a polypeptide consisting of 70 amino acids with insulin-like chemical structure. In most cases, IGF-1 is a reliable growth marker and an anabolic one in adults. It plays an important role in the regulation of various physiological functions, e.g., glucose metabolism, cell survival and proliferation. Objective: To compare the levels of IGF-1 in children having type-1 diabetes with that of healthy controls and also to determine whether there is a relationship between IGF-1 and physical features in T1DM. Patients and Methods: The current study was conducted on 85 children of both sexes. Seventy patients were less than 12 years old with T1DMselected according to ADA 2014 criteria for diagnosis of diabetes from pediatric diabetes clinic at Ain Shams University hospital. All patients were divided into 2 groups based on the duration of diabetes to T1DM>1year duration and T1DM < 1year duration and they were compared with fifteen normal children, attending the pediatric general clinics as a control group. Measurements of height, weight, and arm span, upper body segment, lower body segment, and body mass index, parents’ height beside Fasting blood glucose, HbA1C, IGF-1, FSH, and LH were noted. Results: Height percentile significantly higher inT1DM less than 1 year median 50 (10 to 75) than T1DM more than one year (median10 (3 to 44) p-value 0.007). IGF-1 level in the group of T1DM less than 1year median 90 (70 to 110) (ng/ml) was significantly lower than other groups (p-value 0.0008). IGF1 has a significant positive relation with Aram span in group T1DM more than 1year (p-value 0.024), positive significant relationship between mother height and IGF-1 level in group T1DM less than 1 year (p-value 0.013). Conclusion: IGF-1 level is reduced by the recent onset of T1DM but still it has some effect on the somatic features even in the presence of longstanding diabetes.

scholarly journals Glucose control in home-isolated adults with type 1 diabetes affected by COVID-19 using continuous glucose monitoring

2021 ◽  
Author(s):  
M. Longo ◽  
L. Scappaticcio ◽  
M. Petrizzo ◽  
F. Castaldo ◽  
A. Sarnataro ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Continuous Glucose Monitoring ◽  
Glucose Control ◽  
Glucose Monitoring ◽  
University Hospital ◽  
Control Group ◽  
Time Points ◽  
Mean Glucose ◽  
Level 2

Abstract Purpose This study is aimed at evaluating changes in metrics of glucose control in home-isolated patients with type 1 diabetes and COVID-19 using a continuous glucose monitoring (CGM) system. Methods We included adults aged 18–45 years with type 1 diabetes, using CGM, followed by telemedicine at a Southern Italian University Hospital. Thirty-two home-quarantined subjects with SARS-CoV-2 positive swab constituted the COVID-19 group. Thirty age-matched diabetic individuals without COVID-19 formed the control group. The effects of COVID-19 on glycemic control in patients infected were assessed at different time points [2 weeks before-COVID-19 (Time 1), 2 weeks during-COVID-19 (Time 2) and 2 weeks after COVID-19 (Time 3)] and compared with those without infection. Results A significant reduction of TIR (Time 1 vs Time 2, %, 60.1 ± 16.6 vs 55.4 ± 19.2, P = 0.03), associated with a significant increase of TAR level 2 (10.1 ± 7.3 vs 16.7 ± 12.9, P < 0.001), GMI (7.1 ± 0.6 vs 7.5 ± 0.8, P < 0.001), CV (37.3 ± 7.1 vs 39.6 ± 7.0, P = 0.04), mean glucose values (mg/dL, 160.2 ± 26.5 vs 175.5 ± 32.6, P = 0.001) and standard deviation (59.2 ± 13.1 vs 68.6 ± 17.7, P = 0.001) was observed in patients with COVID-19. No significant change of glycemic metrics was found in the NO COVID-19 group across the time. Conclusion Young home-isolated patients with type 1 diabetes and COVID-19 showed a worsening of glucose control during COVID-19, as compared with age-matched diabetic subjects without the infection.

Characteristics of pre-school children diagnosed with type 1 diabetes at University Hospital of Leicester

2018 ◽  
Author(s):  
Ayman Elhomoudi ◽  
V Tziaferi ◽  
James Greening ◽  
Prem Sundaram
Keyword(s):  
Type 1 Diabetes ◽  
School Children ◽  
University Hospital

1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1054-P
Author(s):  
MICHELE SCHIAVON ◽  
ALFONSO GALDERISI ◽  
KRISTEN A. KRAEMER ◽  
CLAUDIO COBELLI ◽  
CHIARA DALLA MAN ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Closed Loop

Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 27-30
Author(s):  
Elena N. Andreeva ◽  
Olga R. Grigoryan ◽  
Yulia S. Absatarova ◽  
Irina S. Yarovaya ◽  
Robert K. Mikheev
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Gland ◽  
Autoimmune Diseases ◽  
Ovarian Reserve ◽  
Reproductive Potential ◽  
Reproductive Age ◽  
Control Group ◽  
Antithyroid Antibodies ◽  
Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

scholarly journals One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jing Lu ◽  
Shan-mei Shen ◽  
Qing Ling ◽  
Bin Wang ◽  
Li-rong Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stromal Cells ◽  
Treated Group ◽  
Control Group ◽  
Adult Onset ◽  
Β Cell ◽  
Juvenile Onset ◽  
C Peptide

Abstract Background The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent cells with high capacity of immunoregulation, which emerged as a promising cell-based therapy for many immune disorders. The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. Methods This was a nonrandomized, open-label, parallel-armed prospective study. MSCs were isolated from umbilical cord (UC) of healthy donors. Fifty-three participants including 33 adult-onset (≥ 18 years) and 20 juvenile-onset T1D were enrolled. Twenty-seven subjects (MSC-treated group) received an initial systemic infusion of allogeneic UC-MSCs, followed by a repeat course at 3 months, whereas the control group (n = 26) only received standard care based on intensive insulin therapy. Data at 1-year follow-up was reported in this study. The primary endpoint was clinical remission defined as a 10% increase from baseline in the level of fasting and/or postprandial C-peptide. The secondary endpoints included side effects, serum levels of HbA1c, changes in fasting and postprandial C-peptide, and daily insulin doses. Results After 1-year follow-up, 40.7% subjects in MSC-treated group achieved the primary endpoint, significantly higher than that in the control arm. Three subjects in MSC-treated group, in contrast to none in control group, achieved insulin independence and maintained insulin free for 3 to 12 months. Among the adult-onset T1D, the percent change of postprandial C-peptide was significantly increased in MSC-treated group than in the control group. However, changes in fasting or postprandial C-peptide were not significantly different between groups among the juvenile-onset T1D. Multivariable logistic regression assay indicated that lower fasting C-peptide and higher dose of UC-MSC correlated with achievement of clinical remission after transplantation. No severe side effects were observed. Conclusion One repeated intravenous dose of allogeneic UC-MSCs is safe in people with recent-onset T1D and may result in better islet β cell preservation during the first year after diagnosis compared to standard treatment alone. Trial registration ChiCTR2100045434. Registered on April 15, 2021—retrospectively registered, http://www.chictr.org.cn/

scholarly journals The potential effect of metabolic alkalosis on insulin sensitivity in an adolescent with new‐onset type 1 diabetes

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
William E. Novotny ◽  
Irma Fiordalisi ◽  
Cynthia P. Keel ◽  
Glenn D. Harris
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Metabolic Alkalosis ◽  
Potential Effect ◽  
Onset Type ◽  
New Onset

Sex hormones and insulin sensitivity in adolescent girls with type 1 diabetes

2020 ◽  
Vol 46 (1) ◽  
pp. 75-77
Author(s):  
Beata Mianowska ◽  
Iwona Pietrzak ◽  
Małgorzata Perenc ◽  
Anna Baranowska-Jaźwiecka ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Sex Hormones ◽  
Adolescent Girls
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