Serum Adiponectin Levels and Cardiorespiratory Fitness in Nonoverweight and Overweight Portuguese Adolescents: The LabMed Physical Activity Study

2017 ◽  
Vol 29 (2) ◽  
pp. 237-244 ◽  
Author(s):  
César Agostinis-Sobrinho ◽  
Carla Moreira ◽  
Sandra Abreu ◽  
Luís Lopes ◽  
José Oliveira-Santos ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Hdl Cholesterol ◽  
Analysis Of Covariance ◽  
Serum Adiponectin ◽  
Inverse Association ◽  
C Reactive Protein ◽  
Pubertal Stage ◽  
Reactive Protein ◽  
Significant Difference ◽  
Portuguese Adolescents

Purpose:This study examined the independent associations between cardiorespiratory fitness and circulating adiponectin concentration in adolescents, controlling for several potential covariates.Methods:This is a cross-sectional study in Portuguese adolescents. A sample of 529 (267 girls) aged 12–18 years were included and categorized as overweight and nonoverweight. Cardiorespiratory fitness was assessed by 20 meters shuttle run test. We measured serum adiponectin, high-sensitivity C-reactive protein, fasting glucose, insulin and HDL-cholesterol.Results:After adjustment for age, sex, pubertal stage, adherence to the Mediterranean diet, socioeconomic status, body fat percentage, insulin resistance, HDL-cholesterol and C-reactive protein, regression analysis showed a significant inverse association between adiponectin and cardiorespiratory fitness in nonoverweight participants (B=-0.359; p < .042). Analysis of covariance showed a significant difference between the highest cardiorespiratory fitness Healthy zone (above healthy zone) and the Under and the Healthy cardiorespiratory fitness zones in nonoverweight adolescents (p = .03) (F (2, 339) = 3.156, p < .001).Conclusion:Paradoxically, serum adiponectin levels are inversely associated with cardiorespiratory fitness in nonoverweight, but not in overweight adolescents. In nonoverweight adolescents, those with highest levels of cardiorespiratory fitness (above healthy zone) presented lower levels of adiponectin compared with those in Under and Healthy cardiorespiratory fitness zones.

scholarly journals Higher Cardiorespiratory Fitness Levels May Attenuate the Detrimental Association between Weight Status, Metabolic Phenotype and C-Reactive Protein in Adolescents—A Multi-Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1461
Author(s):  
Cesar Agostinis-Sobrinho ◽  
Rafaela Rosário ◽  
Rute Santos ◽  
Sigute Norkiene ◽  
Jorge Mota ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Weight Status ◽  
Analysis Of Covariance ◽  
Metabolic Phenotype ◽  
C Reactive Protein ◽  
Protein Z ◽  
Pubertal Stage ◽  
Metabolic Phenotypes ◽  
Protein Levels ◽  
Reactive Protein

Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age- and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy non-overweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.

scholarly journals The Inverse Association between Cardiorespiratory Fitness and C-Reactive Protein Is Mediated by Autonomic Function: A Possible Role of the Cholinergic Antiinflammatory Pathway

2009 ◽  
Vol 15 (9-10) ◽  
pp. 291-296 ◽  
Author(s):  
Sae Young Jae ◽  
Kevin S. Heffernan ◽  
Eun Sun Yoon ◽  
Moon-Kyu Lee ◽  
Bo Fernhall ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Autonomic Function ◽  
Inverse Association ◽  
C Reactive Protein ◽  
Reactive Protein

C-Reactive Protein and the Framingham Coronary Risk Score in Patients Newly Diagnosed With Intermittent Claudication

2012 ◽  
Vol 46 (3) ◽  
pp. 242-245
Author(s):  
Yousef Shahin ◽  
Josie Hatfield ◽  
Ian Chetter
Keyword(s):  
Intermittent Claudication ◽  
Risk Score ◽  
Analysis Of Covariance ◽  
Newly Diagnosed ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Framingham Risk ◽  
Significant Difference ◽  
Post Hoc ◽  
Serum Crp

Objective: To investigate the relationship between serum C-reactive protein (CRP) levels and the calculated 10-year Framingham risk score (FRS) in patients newly diagnosed with intermittent claudication. Methods: Serum CRP levels were measured in 90 patients newly diagnosed with intermittent claudication over a 12-month period. In all, 76 patients (53 males [70%], mean age 63.3 ± 9.3) were included in the analysis. Results: Log-transformed CRP levels significantly correlated with total FRS ( r = .34, P = .002). Participants were divided into 4 groups according to log-CRP levels. Analysis of variance showed a statistically significant difference between the 4 groups in terms of mean FRS, P = .003. Post hoc comparisons indicated that group 1 was significantly different from group 4, P = .002. Analysis of covariance showed a significant difference between the 4 groups of log-CRP levels in terms of mean FRS, P = .008. Conclusion: There is an increased 10-year risk of coronary heart disease associated with increased plasma concentration of CRP in patients newly diagnosed with intermittent claudication.

scholarly journals The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals

2011 ◽  
Vol 9 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Renato Laks ◽  
Lara Miguel Quirino Araújo ◽  
Clineu de Mello Almada Filho ◽  
Maysa Seabra Cendoroglo
Keyword(s):  
Cardiovascular Risk ◽  
Cardiovascular Mortality ◽  
Total Mortality ◽  
Hdl Cholesterol ◽  
Elderly Persons ◽  
Inverse Association ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Impact

ABSTRACT The association between total mortality, lipoproteinS, and inflammatory markers, and their implications with aging and longevity are often controversial. Among the most often studied markers are low HDL cholesterol and high C-reactive protein. Particularly in octogenarians, it is expected that the impact of the inclusion of HDL cholesterol and C-reactive protein will improve the stratification of absolute cardiovascular risk. In the present study, we performed a literature review in PubMed about the relation between HDL cholesterol, inflammation and longevity. Applying the inclusion and exclusion criteria adopted, we selected 30 studies, among which one systematic review on the relation between HDL cholesterol and stroke, one meta-analysis on the relation between total cholesterol and HDL cholesterol with mortality, 22 longitudinal studies, and six cross-sectional studies. The results show an inverse association between HDL cholesterol and total mortality, and between cardiovascular mortality and C-reactive protein, as well as a positive association between C-reactive protein and mortality in longevous individuals. C-reactive protein and HDL cholesterol displayed promising characteristics as predictors of cardiovascular mortality in longevous elderly persons.

scholarly journals Correlation between C-reactive protein levels with leading risk factors for cardiovascular disease in men

2008 ◽  
Vol 61 (3-4) ◽  
pp. 164-168 ◽  
Author(s):  
Bosa Mirjanic-Azaric ◽  
Mirjana Djeric ◽  
Maja Vrhovac ◽  
Ljiljana Males-Bilic
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Total Cholesterol ◽  
Body Mass ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Significant Difference

Introduction The aim of this study was to estimate the correlation between C-reactive protein levels and leading risk factors for cardiovascular disease in men. Material and methods The study included 183 working capable men chosen randomly from the regular systematical check-up in Health Centre Banja Luka in 2006. Standard laboratory methods were used to establish the following: total cholesterol, triglyceride and HDL-cholesterol level and LDL-cholesterol level was calculated. . High sensitive C-reactive protein level was measured by immunuturbidimetric method CRP (Latex) HS Roche Diagnostic. Results Average values of high sensitive C-reactive protein for the whole group was 1.69 mg/L, total cholesterol 5.73 mmol/L, HDL-cholesterol 1.38 mmol/L, LDL-cholesterol 3.40 mmol/L. The average value for the systolic blood pressure was 132.9 mmHg, dyastolic blood pressure 85.4 mmHg, and body mass index 28.47 kg/m2. Out of the overall number of examinees, 74 were smokers (40.4%) and 109 (59.6%) nonsmokers. The statistical analysis showed that there was a statistically significant difference between C-reactive protein level in the group with dyastolic blood pressure below 90 mmHg and above (p<0.05); as well as statistically significant difference between the group with desirable body mass index and the group with increased BMI(p<0.05). Discussion The results of our study show that there is a significant correlation between CRP levels and high blood pressure, and in persons with increased body mass index. However, there was no correlation between CRP levels and total cholesterol HDL and LDL cholesterol levels. Conclusion High sensitive CRP screening is useful in early detection and prevention of cardiovascular diseases.

scholarly journals Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

2021 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Ahmet Dönder
Keyword(s):  
Systemic Inflammation ◽  
Tension Type Headache ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

scholarly journals Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kenji Yamagata ◽  
Satoshi Fukuzawa ◽  
Naomi Ishibashi-Kanno ◽  
Fumihiko Uchida ◽  
Hiroki Bukawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prognostic Marker ◽  
Squamous Cell ◽  
Inflammatory Markers ◽  
Outcome Variable ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference

AbstractThe systemic inflammatory response is known to be associated with poor outcomes in patients with various types of cancer. The C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the prognostic value of inflammatory markers for patients with oral squamous cell carcinoma (OSCC). The study population included 205 patients treated with OSCC between 2013 and 2018. The primary predictor variable was the inflammatory markers. The primary outcome variable was overall survival (OS). Univariate and multivariate analyses were performed using a Cox proportional hazards model to identify independent prognostic factors. The CAR had the highest area under the curve (AUC) values compared with other markers in the receiver operating characteristic (ROC) curve analysis. The cutoff value for CAR was 0.032 (AUC 0.693, P < 0.001). There was a significant difference in OS when patients were stratified according to CAR, with 79.1% for CAR < 0.032 and 35% for CAR ≥ 0.032 (P < 0.001). Cox multivariate analysis identified independent predictive factors for OS: age (hazard ratio [HR] 2.155, 95% confidence interval [CI] 1.262–3.682; P = 0.005), stage (HR 3.031, 95% CI 1.576–5.827; P = 0.001), and CAR (HR 2.859, 95% CI 1.667–4.904; P < 0.001). CAR (≥ 0.032 vs. < 0.032) is a good prognostic marker in patients with OSCC in terms of age and stage.

scholarly journals Diagnostic Value of C-Reactive Protein in Discrimination between Uncomplicated and Complicated Parapneumonic Effusion

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 829
Author(s):  
Yana Kogan ◽  
Edmond Sabo ◽  
Majed Odeh
Keyword(s):  
Area Under The Curve ◽  
Diagnostic Value ◽  
Parapneumonic Effusion ◽  
C Reactive Protein ◽  
Diagnostic Efficacy ◽  
Reactive Protein ◽  
Significant Difference ◽  
Study Population ◽  
Complicated Parapneumonic Effusion

Objectives: The role of serum C-reactive protein (CRPs) and pleural fluid CRP (CRPpf) in discriminating uncomplicated parapneumonic effusion (UCPPE) from complicated parapneumonic effusion (CPPE) is yet to be validated since most of the previous studies were on small cohorts and with variable results. The role of CRPs and CRPpf gradient (CRPg) and of their ratio (CRPr) in this discrimination has not been previously reported. The study aims to assess the diagnostic efficacy of CRPs, CRPpf, CRPr, and CRPg in discriminating UCPPE from CPPE in a relatively large cohort. Methods: The study population included 146 patients with PPE, 86 with UCPPE and 60 with CPPE. Levels of CRPs and CRPpf were measured, and the CRPg and CRPr were calculated. The values are presented as mean ± SD. Results: Mean levels of CRPs, CRPpf, CRPg, and CRPr of the UCPPE group were 145.3 ± 67.6 mg/L, 58.5 ± 38.5 mg/L, 86.8 ± 37.3 mg/L, and 0.39 ± 0.11, respectively, and for the CPPE group were 302.2 ± 75.6 mg/L, 112 ± 65 mg/L, 188.3 ± 62.3 mg/L, and 0.36 ± 0.19, respectively. Levels of CRPs, CRPpf, and CRPg were significantly higher in the CPPE than in the UCPPE group (p < 0.0001). No significant difference was found between the two groups for levels of CRPr (p = 0.26). The best cut-off value calculated by the receiver operating characteristic (ROC) analysis for discriminating UCPPE from CPPE was for CRPs, 211.5 mg/L with area under the curve (AUC) = 94% and p < 0.0001, for CRPpf, 90.5 mg/L with AUC = 76.3% and p < 0.0001, and for CRPg, 142 mg/L with AUC = 91% and p < 0.0001. Conclusions: CRPs, CRPpf, and CRPg are strong markers for discrimination between UCPPE and CPPE, while CRPr has no role in this discrimination.

Pancreaticogastrostomy after Pancreaticoduodenectomy Using Twin Square Wrapping with Duct-to-Mucosa Anastomosis

2015 ◽  
Vol 55 (1-2) ◽  
pp. 109-118 ◽  
Author(s):  
Kosei Maemura ◽  
Yuko Mataki ◽  
Hiroshi Kurahara ◽  
Shinichiro Mori ◽  
Naotomo Higo ◽  
...  
Keyword(s):  
Operating Time ◽  
Conventional Group ◽  
C Reactive Protein ◽  
Pancreatic Anastomosis ◽  
Pancreatic Stump ◽  
Reactive Protein ◽  
Significant Difference ◽  
Pancreatic Fistulas ◽  
Hospital Stays ◽  
Blood Loss Volume

Background/Purpose: This study aimed to evaluate the feasibility and safety of a novel pancreaticogastrostomy technique for diminishing pancreatic fistulas after pancreaticoduodenectomy using gastric wrapping of the pancreatic stump with a twin square-shaped horizontal mattress and a suture fixing the main pancreatic duct to the gastric mucosa anastomosis [twin square wrapping (TSW) method]. Methods: Fifty-three patients undergoing pancreaticogastrostomy after pancreaticoduodenectomy were included in the study and chronologically divided into a conventional group (n = 32) and a TSW group (n = 21). The perioperative factors and the postoperative outcomes were retrospectively analyzed. Results: The operating time for the pancreatic anastomosis, the total operating time, and the blood loss volume in the TSW group were lower than in the conventional group, but without a statistically significant difference. The TSW group had a significantly lower postoperative white blood cell count and C-reactive protein level, with a reduced intra-abdominal fluid accumulation as assessed by computed tomography on postoperative day 7, had a lower incidence of postoperative complications and pancreatic fistulas, and achieved a shorter duration of drain placement and shorter postoperative hospital stays as compared to the conventional group. Conclusions: The TSW technique should be considered for reducing pancreatic fistulas by diminishing the postoperative inflammatory response and improving patient outcomes without increasing the operating time.

scholarly journals Associations Between Cardiorespiratory Fitness and C-Reactive Protein in Men

2002 ◽  
Vol 22 (11) ◽  
pp. 1869-1876 ◽  
Author(s):  
T.S. Church ◽  
C.E. Barlow ◽  
C.P. Earnest ◽  
J.B. Kampert ◽  
E.L. Priest ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
C Reactive Protein ◽  
Reactive Protein
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