scholarly journals Multilayer fabrication of durable catheter-deployable soft robotic sensor arrays for efficient left atrial mapping

2020 ◽  
Vol 6 (46) ◽  
pp. eabc6800
Author(s):  
Varun Kashyap ◽  
Alexandre Caprio ◽  
Tejas Doshi ◽  
Sun-Joo Jang ◽  
Christopher F. Liu ◽  
...  
Keyword(s):  
Effective Means ◽  
Sensor Arrays ◽  
Stretchable Electronics ◽  
Cardiac Chamber ◽  
Point Mapping ◽  
Complex Anatomy ◽  
Voltage Mapping ◽  
Robotic Sensor ◽  
New Generation ◽  
Electronic Sensors

Devices that perform cardiac mapping and ablation to treat atrial fibrillation provide an effective means of treatment. Current devices, however, have limitations that either require tedious point-by-point mapping of a cardiac chamber or have limited ability to conform to the complex anatomy of a patient’s cardiac chamber. In this work, a detailed, scalable, and manufacturable technique is reported for fabrication of a multielectrode, soft robotic sensor array. These devices exhibit high conformability (~85 to 90%) and are equipped with an array of stretchable electronic sensors for voltage mapping. The form factor of the device is intended to match that of the entire left atrium and has a hydraulically actuated soft robotic structure whose profile facilitates deployment from a 13.5-Fr catheter. We anticipate that the methods described in this paper will serve a new generation of conformable medical devices that leverage the unique characteristics of stretchable electronics and soft robotics.

New approaches to pharmacotherapy of allergic eye diseases

2015 ◽  
pp. 18-26
Author(s):  
Zoya Veselovska ◽  
Nataliia Veselovska
Keyword(s):  
Effective Means ◽  
Experimental Studies ◽  
Tear Film ◽  
Eye Diseases ◽  
Eye Drops ◽  
Lipid Layer ◽  
Ophthalmic Surgery ◽  
Promising Alternative ◽  
New Approaches ◽  
New Generation

The problem of studying the prеvalencе of allergic diseases of the eye and the search for new approaches and effective means to correct this condition does not lose its relevance. The presented data on the state of profound biochemical studies of the tear film in allergic conditions justify the expediency of the use of eye drops of a new generation. As a result of experimental studies on the effect on the lipid layer ectoine was discovered the mechanism of its therapeutic action. This paper presents compelling evidence that new eye drops based on natural molecules ectoine which are able to restore and maintain the functional state of the lipid layer of the tear film in the pharmacotherapy of аllergic diseases of anterior surface of the eye. The analyzes of multiple experimental data revealed the clear evidence of mechanisms of action on the eye and the first clinical experience with a new pharmacological agent testifies to its strong anti-inflammatory and regenerative effect due to the stabilization of the lipid layer of the tear film and the protection of the front surface of the eye tissue from the hyperosmolarity. It was confirmed by the subjective and objective reducing eye irritation and dryness in reducing itching and burning from the conjunctiva, to improve the moisture level of the surface of the eye, to reduce discomfort of the eyes. The drug can be used in children older than 2 years and adults, when wearing contact lenses, ophthalmic surgery and after an eye injury. Based on this, it can be conclude that the appearance in the arsenal of new-generation antiallergic eye drops (EYE-t) with sufficient efficacy and safety profile can be regarded as a promising alternative approach to the treatment of allergic and inflammatory eye diseases.

scholarly journals NEW GENERATION OF ADAPTABLE MOBILE MEANS OF ORGANISATIONAL REPAIR

2018 ◽  
pp. 32-34 ◽  
Author(s):  
V. L. Krivolapov ◽  
A. F. Strakhov
Keyword(s):  
Effective Means ◽  
Key Factors ◽  
Time Period ◽  
Foreign Countries ◽  
Repair Systems ◽  
New Generation ◽  
Technological Opportunities ◽  
Technical Readiness ◽  
Further Development ◽  
Intended Use

One of the key factors of ensuring the required level of the AD WME technical readiness for the intended use is minimisation of the time period necessary for restoration of the AD WME systems after their failures. Over the years, JSC Principle Production and Technical Company Granit has per-formed a cycle of R&D activities aimed at creating effective means of the AD WME maintenance and organisational repair at their deployment sites as well as at developing innovative maintenance and organisational repair technologies. Following the results of these activities, a set of adaptable unified mobile repair and diagnostic equipment (RDE)was created and then exported in order to ensure the maintenance and organisational repair of the AD WME pieces delivered within military technical cooperation with foreign countries. Further development of this focus area resulted in creation of a set of unified mobile organisational repair systems. This article considers main functional and technical as well as technological opportunities of the unified mobile organisational repair systems. Their prototypes are previously developed RDE for export.

Individual Work as Means of Professional Competence Development in Physiotherapy Assistant Students

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Donka Nikolova ◽  
Marinella Grudeva
Keyword(s):  
Working Conditions ◽  
Healthcare Professionals ◽  
Professional Competence ◽  
Effective Means ◽  
Modern Society ◽  
Self Employment ◽  
Individual Work ◽  
Labor Market Dynamics ◽  
Educational Paradigm ◽  
New Generation

Modern society requires medical schools to prepare a new generation of healthcare professionals who possess the knowledge, the skills and the competencies to adequately and quickly adapt to the changes in public health and labor market dynamics. In the transition toward the establishment of a new educational paradigm, an emphasis is placed on the purposeful, well-planned and organized individual work of the students, which is accepted and considered as an effective means for the formation of their professional competence. As such, self-employment increases choice, increases adaptability to changing living and working conditions, makes people more social, more mobile, more competitive and more motivated.

scholarly journals New generation of optical robotic sensor applied to small notch detection

2011 ◽  
Author(s):  
A. Lay-Ekuakille ◽  
N.I. Giannoccaro ◽  
L. Spedicato ◽  
P. Vergallo ◽  
A. Massaro ◽  
...  
Keyword(s):  
Robotic Sensor ◽  
New Generation

scholarly journals Starting Fire with Gunpowder revisited: Inuktitut New Media content creation in the Canadian Arctic

2011 ◽  
Vol 34 (2) ◽  
pp. 61-80 ◽  
Author(s):  
Timothy J. Pasch
Keyword(s):  
New Media ◽  
Effective Means ◽  
Canadian Arctic ◽  
Cultural Preservation ◽  
Media Content ◽  
Content Creation ◽  
Critical Approaches ◽  
History Of ◽  
Edible Roots ◽  
New Generation

In 1991, the Canadian documentary Starting Fire with Gunpowder was produced, focusing in part on the history of early media productions by the Inuit Broadcasting Corporation (IBC). It examined how the creation of Inuktitut media content could be an effective means of creative improvisation, linguistic and cultural preservation, and transmission of traditional knowledge. Almost 20 years later, the Internet serves as one of the primary communicative methods for young Inuit in the Canadian Arctic. However, it remains to be seen whether the quality of Inuktitut media online can compare with the example of linguistic and cultural preservation set by the visionaries of the early IBC. This article challenges prevailing critical approaches to the Inuit as linguistically and culturally vulnerable. It views Inuktitut New Media content as an embodiment of the word airaq (‘edible roots’), used here as a model of strength, resilience, and adaptability. It concludes that the creativity and prolificacy of the early IBC productions should set the standard for a new generation of Inuktitut content creators online.

Novel Defect Location Method for Pressure Vessel by Using L (0, 2) Mode Guided Wave

2018 ◽  
Vol 141 (1) ◽  
Author(s):  
Shuangmiao Zhai ◽  
Shaoping Zhou ◽  
Shaojie Chen ◽  
Bin Yang ◽  
Yong Li
Keyword(s):  
Pressure Vessel ◽  
Clustering Algorithm ◽  
Guided Waves ◽  
Effective Means ◽  
Sensor Arrays ◽  
Cost Effective ◽  
Guided Wave ◽  
Economic Losses ◽  
Process Industries ◽  
Direct Wave

Pressure vessel plays an increasingly important role in process industries, in which its performance degradation, such as crack and corrosion, may lead to serious accidents and significant economic losses. Guided wave-based method is a cost-effective means for pressure vessel rapid interrogation. In this paper, the method based on direct-wave and fuzzy C-means clustering algorithm (FCM) is proposed to locate defect for pressure vessel. Finite element (FE) simulation is applied to analyze the propagation characteristics of guided waves. The experiment using the method based on direct-wave and FCM has been conducted on the barrel and head with different sensor arrays, respectively. The variation rule of the direct-wave difference with different distance coefficients has been studied. By combining FCM with the direct-wave difference, the defects on barrel and head can be detected accurately. The defect inspection experiment for pressure vessel using ellipse imaging algorithm is conducted as well. The experimental results show that the method based on direct-wave and FCM can locate the defects on barrel and head of the pressure vessel effectively and accurately.

scholarly journals Applications and integration of chromogenic culture media in clinical microbiology

2010 ◽  
Vol 31 (3) ◽  
pp. 127
Author(s):  
John Merlino
Keyword(s):  
Culture Media ◽  
Effective Means ◽  
Traditional Culture ◽  
Cost Effective ◽  
Conventional Culture ◽  
Chromogenic Agar ◽  
Isolation Media ◽  
Species Specific ◽  
Micro Organisms ◽  
New Generation

The ability to rapidly detect and identify micro-organisms is of paramount importance for many microbiology laboratories. The application of new classes of enzymatic-based chromogenic compounds has revolutionised traditional culture media, leading to the developments of a new generation of chromogenic media. Many studies have shown that the chromogenic agar has become more than an isolation media when compared to conventional culture media. A newer, faster, more cost-effective means in the presumptive identification or screening of microorganisms which are either genus, or in some cases species-specific, and allows superior differentiation of mixed micro-organisms in cultures. When supplemented with antibiotics or other agents, chromogenic media allows the screening for multidrug resistance and virulence in many micro-organisms and can be easily integrated with other automated and/or molecular-based methods.

Estimating Segment Inertial Parameters Using Fan-Beam DXA

2008 ◽  
Vol 24 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Jason Wicke ◽  
Genevieve A. Dumas
Keyword(s):  
Data Reduction ◽  
Effective Means ◽  
Center Of Mass ◽  
Reduction Process ◽  
Human Motion ◽  
End Point ◽  
Inertial Parameters ◽  
Animal Specimen ◽  
New Generation ◽  
Data Reduction Process

Body segment inertial parameters are required as input parameters when the kinetics of human motion is to be analyzed. However, owing to interindividual differences in body composition, noninvasive inertial estimates are problematic. Dual-energy x-ray absorptiometry (DXA) is a relatively new imaging approach that can provide cost- and time-effective means for estimating these parameters with minimal exposure to radiation. With the introduction of a new generation of DXA machines, utilizing a fan-beam configuration, this study examined their accuracy as well as a new interpolative data-reduction process for estimating inertial parameters. Specifically, the inertial estimates of two objects (an ultra-high molecular density plastic rod and an animal specimen) and 50 participants were obtained. Results showed that the fan-beam DXA, along with the new interpolative data-reduction process, provided highly accurate estimates (0.10–0.39%). A greater variance was observed in the center of mass location and moment of inertia estimates, likely as a result of the course end-point location (1.31 cm). However, using a midpoint interpolation of the end-point locations, errors in the estimates were greatly reduced for the center of mass location (0.64–0.92%) and moments of inertia (–0.23 to –0.48%).

scholarly journals Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

Materials ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1096 ◽  
Author(s):  
Bashayer H. Baras ◽  
Mary Anne S. Melo ◽  
Vivek Thumbigere-Math ◽  
Franklin R. Tay ◽  
Ashraf F. Fouad ◽  
...  
Keyword(s):  
Root Canal ◽  
Dynamic Environment ◽  
Long Term Effects ◽  
Dental Services ◽  
Positive Role ◽  
Complex Anatomy ◽  
Treatment Procedures ◽  
New Generation ◽  
Root Canal Sealers

According to the American Dental Association Survey of Dental Services Rendered (published in 2007), 15 million root canal treatment procedures are performed annually. Endodontic therapy relies mainly on biomechanical preparation, chemical irrigation and intracanal medicaments which play an important role in eliminating bacteria in the root canal. Furthermore, adequate obturation is essential to confine any residual bacteria within the root canal and deprive them of nutrients. However, numerous studies have shown that complete elimination of bacteria is not achieved due to the complex anatomy of the root canal system. There are several conventional antibiotic materials available in the market for endodontic use. However, the majority of these antibiotics and antiseptics provide short-term antibacterial effects, and they impose a risk of developing antibacterial resistance. The root canal is a dynamic environment, and antibacterial and antibiofilm materials with long-term effects and nonspecific mechanisms of action are highly desirable in such environments. In addition, the application of acidic solutions to the root canal wall can alter the dentin structure, resulting in a weaker and more brittle dentin. Root canal sealers with bioactive properties come in direct contact with the dentin wall and can play a positive role in bacterial elimination and strengthening of the root structure. The new generation of nanostructured, bioactive, antibacterial and remineralizing additives into polymeric resin-based root canal sealers are discussed in this review. The effects of these novel bioactive additives on the physical and sealing properties, as well as their biocompatibility, are all important factors that are presented in this article.

S243 – An Interactive 3D Game of the Pterygopalatine Fossa

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P156-P157
Author(s):  
Ramin Javan ◽  
Jeun Bryan ◽  
Spencer C Payne
Keyword(s):  
Head And Neck ◽  
Virtual Environment ◽  
Effective Means ◽  
Simulated Environment ◽  
Complex Anatomy ◽  
Gaming Environment ◽  
Interactive 3D ◽  
Complex Relationships ◽  
Entertainment Value ◽  
The Cost

Objectives Develop an interactive computer simulation of complex structures of the head and neck that would assist the teaching of relevant anatomy. Methods Areas of the head and neck with complex spatial relationships were selected and their anatomical relationships were confirmed. Graphical representations of these areas were created, performed, and integrated into a virtual gaming environment through various software components. A variety of adjunctive teaching materials were also developed and laid over this virtual environment to reinforce the complex relationships. Results A 3D simulation was successfully created which allows users to freely move throughout a virtual environment framed by key and complex anatomy of the head and neck. Both this movement and visualization of the environment in all directions is provided through simultaneous use of the mouse and keyboard. Navigation through the game-space is assisted by a dynamically updated ‘anatomical’ compass. A combination of accurate structural depictions and conceptual representations of cavities and spaces with rooms, hallways, doors and/or windows was employed. Structures can be identified and educational information through adjunctive media can be displayed with simple point-and-click techniques. Gaming features were also employed to provide entertainment value, with the expectation that this would reinforce the anatomical concepts. Conclusions Virtual simulation of the complex anatomy of the head and neck may be an effective means to offset the cost and limited availability of cadaveric dissection. We describe here the development of such a simulated environment employing an interactive gaming construct which, to our knowledge, has not been previously described elsewhere.

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