scholarly journals Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

Materials ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1096 ◽  
Author(s):  
Bashayer H. Baras ◽  
Mary Anne S. Melo ◽  
Vivek Thumbigere-Math ◽  
Franklin R. Tay ◽  
Ashraf F. Fouad ◽  
...  
Keyword(s):  
Root Canal ◽  
Dynamic Environment ◽  
Long Term Effects ◽  
Dental Services ◽  
Positive Role ◽  
Complex Anatomy ◽  
Treatment Procedures ◽  
New Generation ◽  
Root Canal Sealers

According to the American Dental Association Survey of Dental Services Rendered (published in 2007), 15 million root canal treatment procedures are performed annually. Endodontic therapy relies mainly on biomechanical preparation, chemical irrigation and intracanal medicaments which play an important role in eliminating bacteria in the root canal. Furthermore, adequate obturation is essential to confine any residual bacteria within the root canal and deprive them of nutrients. However, numerous studies have shown that complete elimination of bacteria is not achieved due to the complex anatomy of the root canal system. There are several conventional antibiotic materials available in the market for endodontic use. However, the majority of these antibiotics and antiseptics provide short-term antibacterial effects, and they impose a risk of developing antibacterial resistance. The root canal is a dynamic environment, and antibacterial and antibiofilm materials with long-term effects and nonspecific mechanisms of action are highly desirable in such environments. In addition, the application of acidic solutions to the root canal wall can alter the dentin structure, resulting in a weaker and more brittle dentin. Root canal sealers with bioactive properties come in direct contact with the dentin wall and can play a positive role in bacterial elimination and strengthening of the root structure. The new generation of nanostructured, bioactive, antibacterial and remineralizing additives into polymeric resin-based root canal sealers are discussed in this review. The effects of these novel bioactive additives on the physical and sealing properties, as well as their biocompatibility, are all important factors that are presented in this article.

scholarly journals The Long-term Effects of Instruction on EFL Learners' Use of Complaining Formulas

10.29007/5xsb ◽  
2018 ◽  
Author(s):  
Alicia Martínez-Flor ◽  
Esther Usó-Juan
Keyword(s):  
Foreign Language ◽  
Language Learners ◽  
Future Research ◽  
Long Term Effects ◽  
Positive Role ◽  
Efl Learners ◽  
Foreign Language Learners ◽  
Over Time

Studies analysing the positive role of pragmatic instruction in formal settings have increased over the last decades. Within this area of interventional pragmatics, some studies have particularly examined whether the effectiveness of the instruction implemented is sustained over time. In order to shed more light on the long-term effects of instruction, this research investigates English as a Foreign Language learners’ use of complaining formulas not only after immediately receiving instruction, but also two months later. Results show that learners keep using a variety of appropriate complaining formulas two months after having participated in the instructional period. These findings are discussed and directions for future research suggested.

scholarly journals Long Term Results Regarding the Clinical Applicability of Two Root Canal Sealers

2017 ◽  
Vol 54 (2) ◽  
pp. 308-311
Author(s):  
Oana Andreea Diaconu ◽  
Ionela Teodora Dascalu ◽  
Marina Amarascu ◽  
Horia Octavian Manolea ◽  
Radu Rica ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Root Canal ◽  
Long Term Results ◽  
Filling Material ◽  
Clinical Protocol ◽  
Clinical Applicability ◽  
Ah Plus ◽  
Endodontic Disease ◽  
Root Canal Sealers

The aim of this study was the evaluation of the long term results in the clinical applicability of two root canal sealers, Sealapex Xpress - Kerr Endodontics (non-eugenol, calcium hydroxide polymeric root canal sealant) and AH Plus Jet - Dentsply Maillefer (epoxy resin-based sealant). 225 teeth of 159 patients included in this study, were endodontic treated and filled with the previously mentioned root canal sealers, in accordance with a standard clinical protocol. The long term results regarding the evaluation of the used two root sealers were realized clinically and radiologically, after annually monitoring conducted during three years. Long-term results of the study showed that, although their different chemical composition, the two root filling material showed good results in the treatment of various types of endodontic disease.

A Carbon Fiber Based Sensor for Measurement of Serotonin From Platelets

2002 ◽  
Author(s):  
Clifton F. Frilot ◽  
Stephen R. Patton ◽  
Steven A. Jones
Keyword(s):  
Endothelial Cells ◽  
Calcium Release ◽  
Morphological Changes ◽  
Fluid Dynamic ◽  
Dynamic Environment ◽  
Shear Stresses ◽  
Long Term Effects ◽  
Enhanced Diffusion ◽  
And Diffusion

The fluid dynamic environment within an artery is an important contributor to haemostasis. Fluid mechanics can alter the biochemical environment through convection and diffusion of reactive substances. It can bring the platelets close to the wall through convection and enhanced diffusion, cause platelet activation through hemodynamic shear stresses, and alter the substrate for platelet adhesion through shear effects on endothelial cells. Shear produces long-term effects on endothelial cells, such as morphological changes in the cells and adaptation of the size of the artery. It can also affect endothelial cells in the short term by increasing calcium release or release of nitric oxide.

The concept of monobloc in Endodontic - A review

2014 ◽  
Vol 6 (2) ◽  
pp. 83-89
Author(s):  
BS Deepak ◽  
T Sophia ◽  
J Deepa ◽  
GK Mallikarjun
Keyword(s):  
Root Canal ◽  
Fracture Resistance ◽  
Canal Wall ◽  
Recent Past ◽  
User Friendliness ◽  
Root Canal Filling ◽  
Filling Materials ◽  
Root Canal Filling Materials ◽  
New Generation ◽  
Root Canal Sealers

Abstract The creation of a homogenous filling within the root canal has always been one of the most sought after objectives in the field of Endodontics. While conventional root canal filling materials have given predictable results, the pursuit of developing alternative sealers or techniques that bond simultaneously to canal wall dentin as well as filling materials has continued. Breakthroughs in dentin adhesive technology in the recent past have built a new generation of bondable root canal sealers and post systems. Thus arose the concept of monoblocs, with its purported advantages of simultaneously improving the seal and fracture resistance of the filled canals. The added advantages of reduced application steps and overall improvements in their user friendliness led to the aggressive marketing of materials claiming to achieve the ‘monobloc effect’. On the other hand the credibility of this concept in practice has launched controversial discussions. This review attempts to throw light on the various dimensions of the concept of monoblocs as well as to scrutinize the potential of various root canal filling materials to create monoblocs. How to cite this article Sophia T, Deepak BS, Deepa J, Mallikarjun GK. The concept of monobloc in Endodontics - A review. CODS J Dent 2014;6;83-89

scholarly journals Long-term cytotoxic effects of contemporary root canal sealers

2013 ◽  
Vol 21 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Emmanuel João Nogueira Leal da SILVA ◽  
Carolina Carvalho SANTOS ◽  
Alexandre Augusto ZAIA
Keyword(s):  
Root Canal ◽  
Cytotoxic Effects ◽  
Root Canal Sealers

Solubility and pH Value of 3 Different Root Canal Sealers: A Long-term Investigation

2018 ◽  
Vol 44 (11) ◽  
pp. 1736-1740 ◽  
Author(s):  
Kent Urban ◽  
Julian Neuhaus ◽  
David Donnermeyer ◽  
Edgar Schäfer ◽  
Till Dammaschke
Keyword(s):  
Root Canal ◽  
Ph Value ◽  
Root Canal Sealers

scholarly journals Longitudinal craze line propagation in human root dentin after instrumentation with NiTi rotary files of different instrument tapers after long-term chewing simulation

2021 ◽  
Author(s):  
Marie-Therese Heberer ◽  
Hubert C. Roggendorf ◽  
Franz-Josef Faber ◽  
Nicolai-Alexander Lawrenz ◽  
Roland Frankenberger ◽  
...  
Keyword(s):  
Root Canal ◽  
Cutting Edge ◽  
Long Term Effects ◽  
Tooth Structure ◽  
Group Iii ◽  
Chewing Simulation ◽  
Root Canals ◽  
Edge Angle ◽  
Group I

Abstract Objectives The aim of this study was to investigate whether file design and taper significantly influence microcrack initiation during machine preparation. Materials and methods Sixty extracted teeth with straight single canals were selected. The teeth were randomly assigned to four groups based on their root canal anatomy and the corresponding NiTi rotary file system (I, Mtwo; II, ProTaper Universal; III, F6 SkyTaper; control, no preparation and filling). The root canals of the experimental groups were filled using the single-cone technique. The tested teeth were all subjected to a mechanical chewing simulation with flat lead loading over a period of 3 years (corresponding to 150,000 cycles). The teeth were checked for dentinal defects (accumulative crack growth in length) under the digital microscope (Keyence VHX-5000) at time 0 (baseline prior to chewing simulation) and after 3, 6, 12, 24, and 36 months of loading. The cumulative crack increase was statistically analyzed using the Kruskal–Wallis test, Jonckheere–Terpstra test, and the Wilcoxon rank-sum test. The significance was set at p < 0.05. Results In contrast to preparation with greater-tapered instruments, ProTaper Universal (group II) and F6 SkyTaper (group III) instrumentation with the smaller tapered Mtwo files (group I) showed less accumulative propagation of craze lines (p < 0.05) at all time points. Conclusion Instruments with greater taper for root canal instrumentation should be used with care to avoid negative long-term effects in the form of propagation of dentinal defects over time. A positive cutting-edge angle and a smaller taper have a positive effect on a lower craze line development. Clinical relevance Instruments with a positive cutting-edge angle and a smaller taper are beneficial for the long-term preservation of dentinal tooth structure.

scholarly journals Laser Watch—New Generation 2021: Modern Integrative Photomedicine Equipment for Photobiomodulation

2021 ◽  
Vol 06 (04) ◽  
pp. 1-1
Author(s):  
Gerhard Litscher ◽  
Keyword(s):  
Near Infrared ◽  
Laser Light ◽  
Ulnar Artery ◽  
Mitochondrial Activity ◽  
Recent Past ◽  
Long Term Effects ◽  
Light Stimulation ◽  
Preliminary Measurement ◽  
New Generation

In the recent past, laser therapy has made immense progress as it is known to change microcirculation, modulate vegetative parameters, and stimulate mitochondrial activity in the human body. This editorial briefly describes a new laser watch prototype (generation 2021), which can be used to perform continuous and simultaneous blood irradiation at the radial and/or ulnar artery of the wrist with different wavelengths of laser light. In a preliminary measurement, the increase in regional oxygen saturation at the crook of the elbow during laser light stimulation with the watch was observed using near-infrared spectroscopy. Apart from this, laser stimulation applied via a newly designed laser watch can modulate biological parameters (photobiomodulation). However, presently, the possible long-term effects are not known, as there are no studies on this topic available to date.

scholarly journals Calcium Silicate-Based Root Canal Sealers: A Narrative Review and Clinical Perspectives

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 3965
Author(s):  
Germain Sfeir ◽  
Carla Zogheib ◽  
Shanon Patel ◽  
Thomas Giraud ◽  
Venkateshbabu Nagendrababu ◽  
...  
Keyword(s):  
Root Canal ◽  
Calcium Silicate ◽  
Current Knowledge ◽  
Antimicrobial Properties ◽  
Narrative Review ◽  
Current Evidence ◽  
Short Term ◽  
Root Canal Sealers

Over the last two decades, calcium silicate-based materials have grown in popularity. As root canal sealers, these formulations have been extensively investigated and compared with conventional sealers, such as zinc oxide–eugenol and epoxy resin-based sealers, in in vitro studies that showed their promising properties, especially their biocompatibility, antimicrobial properties, and certain bioactivity. However, the consequence of their higher solubility is a matter of debate and still needs to be clarified, because it may affect their long-term sealing ability. Unlike conventional sealers, those sealers are hydraulic, and their setting is conditioned by the presence of humidity. Current evidence reveals that the properties of calcium silicate-based sealers vary depending on their formulation. To date, only a few short-term investigations addressed the clinical outcome of calcium silicate-based root canal sealers. Their use has been showed to be mainly based on practitioners’ clinical habits rather than manufacturers’ recommendations or available evidence. However, their particular behavior implies modifications of the clinical protocol used for conventional sealers. This narrative review aimed to discuss the properties of calcium silicate-based sealers and their clinical implications, and to propose rational indications for these sealers based on the current knowledge.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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