scholarly journals Voxelated three-dimensional miniature magnetic soft machines via multimaterial heterogeneous assembly

2021 ◽  
Vol 6 (53) ◽  
pp. eabf0112
Author(s):  
Jiachen Zhang ◽  
Ziyu Ren ◽  
Wenqi Hu ◽  
Ren Hao Soon ◽  
Immihan Ceren Yasa ◽  
...  
Keyword(s):  
Biological Fluids ◽  
Three Dimensional ◽  
Fluid Flows ◽  
Small Scale ◽  
Surface Anchoring ◽  
Shape Morphing ◽  
Biomedical Device ◽  
Peristaltic Pumping ◽  
Solid Objects ◽  
Stiffness Distribution

Small-scale soft-bodied machines that respond to externally applied magnetic field have attracted wide research interest because of their unique capabilities and promising potential in a variety of fields, especially for biomedical applications. When the size of such machines approach the sub-millimeter scale, their designs and functionalities are severely constrained by the available fabrication methods, which only work with limited materials, geometries, and magnetization profiles. To free such constraints, here, we propose a bottom-up assembly-based 3D microfabrication approach to create complex 3D miniature wireless magnetic soft machines at the milli- and sub-millimeter scale with arbitrary multimaterial compositions, arbitrary 3D geometries, and arbitrary programmable 3D magnetization profiles at high spatial resolution. This approach helps us concurrently realize diverse characteristics on the machines, including programmable shape morphing, negative Poisson’s ratio, complex stiffness distribution, directional joint bending, and remagnetization for shape reconfiguration. It enlarges the design space and enables biomedical device-related functionalities that are previously difficult to achieve, including peristaltic pumping of biological fluids and transport of solid objects, active targeted cargo transport and delivery, liquid biopsy, and reversible surface anchoring in tortuous tubular environments withstanding fluid flows, all at the sub-millimeter scale. This work improves the achievable complexity of 3D magnetic soft machines and boosts their future capabilities for applications in robotics and biomedical engineering.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

scholarly journals Quantification of Measurement and Model Effects in Monopile Foundation Scour Protection Experiments

2021 ◽  
Vol 9 (6) ◽  
pp. 585
Author(s):  
Minghao Wu ◽  
Leen De Vos ◽  
Carlos Emilio Arboleda Chavez ◽  
Vasiliki Stratigaki ◽  
Maximilian Streicher ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Flow Field ◽  
Three Dimensional ◽  
Small Scale ◽  
Maximum Wave Height ◽  
Chaotic Flow ◽  
The Mean ◽  
Scour Protection ◽  
Damage Number ◽  
Measurement Effects

The present work introduces an analysis of the measurement and model effects that exist in monopile scour protection experiments with repeated small scale tests. The damage erosion is calculated using the three dimensional global damage number S3D and subarea damage number S3D,i. Results show that the standard deviation of the global damage number σ(S3D)=0.257 and is approximately 20% of the mean S3D, and the standard deviation of the subarea damage number σ(S3D,i)=0.42 which can be up to 33% of the mean S3D. The irreproducible maximum wave height, chaotic flow field and non-repeatable armour layer construction are regarded as the main reasons for the occurrence of strong model effects. The measurement effects are limited to σ(S3D)=0.039 and σ(S3D,i)=0.083, which are minor compared to the model effects.

Visualizing Fluid Flows With X-Rays

2007 ◽  
Author(s):  
Theodore J. Heindel ◽  
Terrence C. Jensen ◽  
Joseph N. Gray
Keyword(s):  
Computed Tomography ◽  
Flow Visualization ◽  
Three Dimensional ◽  
Fluid Flows ◽  
X Rays ◽  
Radiographic Images ◽  
Optical Access ◽  
X Ray ◽  
X Ray Computed ◽  
Density Map

There are several methods available to visualize fluid flows when one has optical access. However, when optical access is limited to near the boundaries or not available at all, alternative visualization methods are required. This paper will describe flow visualization using an X-ray system that is capable of digital X-ray radiography, digital X-ray stereography, and digital X-ray computed tomography (CT). The unique X-ray flow visualization facility will be briefly described, and then flow visualization of various systems will be shown. Radiographs provide a two-dimensional density map of a three dimensional process or object. Radiographic images of various multiphase flows will be presented. When two X-ray sources and detectors simultaneously acquire images of the same process or object from different orientations, stereographic imaging can be completed; this type of imaging will be demonstrated by trickling water through packed columns and by absorbing water in a porous medium. Finally, local time-averaged phase distributions can be determined from X-ray computed tomography (CT) imaging, and this will be shown by comparing CT images from two different gas-liquid sparged columns.

scholarly journals Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct

2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110136
Author(s):  
Safia Akram ◽  
Najma Saleem ◽  
Mir Yasir Umair ◽  
Sufian Munawar
Keyword(s):  
Couple Stress ◽  
Three Dimensional ◽  
Pressure Rise ◽  
Partial Slip ◽  
Couple Stress Fluid ◽  
Rectangular Duct ◽  
Peristaltic Pumping ◽  
Current Article ◽  
The Impact ◽  
Lateral Walls

The impact of lateral walls and partial slip with different waveforms on peristaltic pumping of couple stress fluid in a rectangular duct with different waveforms has been discussed in the current article. By means of a wave frame of reference the flow is explored travelling away from a fixed frame with velocity c. Peristaltic waves generated on horizontal surface walls of rectangular duct are considered using lubrication technique. Mathematical modelling of couple fluid for three-dimensional flow are first discussed in detail. Lubrication approaches are used to simplify the proposed problem. Exact solutions of pressure gradient, pressure rise, velocity and stream function have been calculated. Numerical and graphical descriptions are displayed to look at the behaviour of diverse emerging parameters.

scholarly journals Experimental and Numerical Investigation about Small Clearance Journal Bearings under Static Load Conditions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Carlo Alberto Niccolini Marmont Du Haut Champ ◽  
Fabrizio Stefani ◽  
Paolo Silvestri
Keyword(s):  
Three Dimensional ◽  
Journal Bearings ◽  
Radial Clearance ◽  
Small Scale ◽  
Test Rig ◽  
Small Clearance ◽  
Dimensional Simulation ◽  
Dynamic Loading Conditions ◽  
Static And Dynamic Loading ◽  
Good Agreement

The aim of the present research is to characterize both experimentally and numerically journal bearings with low radial clearances for rotors in small-scale applications (e.g., microgas turbines); their diameter is in the order of ten millimetres, leading to very small dimensional clearances when the typical relative ones (order of 1/1000) are employed; investigating this particular class of journal bearings under static and dynamic loading conditions represents something unexplored. To this goal, a suitable test rig was designed and the performance of its bearings was investigated under steady load. For the sake of comparison, numerical simulations of the lubrication were also performed by means of a simplified model. The original test rig adopted is a commercial rotor kit (RK), but substantial modifications were carried out in order to allow significant measurements. Indeed, the relative radial clearance of RK4 RK bearings is about 2/100, while it is around 1/1000 in industrial bearings. Therefore, the same original RK bearings are employed in this new test rig, but a new shaft was designed to reduce their original clearance. The new custom shaft allows to study bearing behaviour for different clearances, since it is equipped with interchangeable journals. Experimental data obtained by this test rig are then compared with further results of more sophisticated simulations. They were carried out by means of an in-house developed finite element (FEM) code, suitable for thermoelasto-hydrodynamic (TEHD) analysis of journal bearings both in static and dynamic conditions. In this paper, bearing static performances are studied to assess the reliability of the experimental journal location predictions by comparing them with the ones coming from already validated numerical codes. Such comparisons are presented both for large and small clearance bearings of original and modified RKs, respectively. Good agreement is found only for the modified RK equipped with small clearance bearings (relative radial clearance 8/1000), as expected. In comparison with two-dimensional lubrication analysis, three-dimensional simulation improves prediction of journal location and correlation with experimental results.

scholarly journals Nonlinear effects of locally heterogeneous hydraulic conductivity fields on regional stream–aquifer exchanges

2015 ◽  
Vol 19 (11) ◽  
pp. 4531-4545 ◽  
Author(s):  
J. Zhu ◽  
C. L. Winter ◽  
Z. Wang
Keyword(s):  
Groundwater Flow ◽  
Effective Conductivity ◽  
Model Simulation ◽  
Three Dimensional ◽  
Small Scale ◽  
Heihe River ◽  
Effective Parameters ◽  
Aquifer Systems ◽  
Basin Scale ◽  
Local Grid

Abstract. Computational experiments are performed to evaluate the effects of locally heterogeneous conductivity fields on regional exchanges of water between stream and aquifer systems in the Middle Heihe River basin (MHRB) of northwestern China. The effects are found to be nonlinear in the sense that simulated discharges from aquifers to streams are systematically lower than discharges produced by a base model parameterized with relatively coarse effective conductivity. A similar, but weaker, effect is observed for stream leakage. The study is organized around three hypotheses: (H1) small-scale spatial variations of conductivity significantly affect regional exchanges of water between streams and aquifers in river basins, (H2) aggregating small-scale heterogeneities into regional effective parameters systematically biases estimates of stream–aquifer exchanges, and (H3) the biases result from slow paths in groundwater flow that emerge due to small-scale heterogeneities. The hypotheses are evaluated by comparing stream–aquifer fluxes produced by the base model to fluxes simulated using realizations of the MHRB characterized by local (grid-scale) heterogeneity. Levels of local heterogeneity are manipulated as control variables by adjusting coefficients of variation. All models are implemented using the MODFLOW (Modular Three-dimensional Finite-difference Groundwater Flow Model) simulation environment, and the PEST (parameter estimation) tool is used to calibrate effective conductivities defined over 16 zones within the MHRB. The effective parameters are also used as expected values to develop lognormally distributed conductivity (K) fields on local grid scales. Stream–aquifer exchanges are simulated with K fields at both scales and then compared. Results show that the effects of small-scale heterogeneities significantly influence exchanges with simulations based on local-scale heterogeneities always producing discharges that are less than those produced by the base model. Although aquifer heterogeneities are uncorrelated at local scales, they appear to induce coherent slow paths in groundwater fluxes that in turn reduce aquifer–stream exchanges. Since surface water–groundwater exchanges are critical hydrologic processes in basin-scale water budgets, these results also have implications for water resources management.

Three-dimensional wake transition

1996 ◽  
Vol 328 ◽  
pp. 345-407 ◽  
Author(s):  
C. H. K. Williamson
Keyword(s):  
Shear Layer ◽  
Three Dimensional ◽  
Streamwise Vortex ◽  
Physical Structure ◽  
Small Scale ◽  
Half Cycle ◽  
Vortex Loops ◽  
Wake Transition ◽  
Mode A ◽  
Flow States

It is now well-known that the wake transition regime for a circular cylinder involves two modes of small-scale three-dimensional instability (modes A and B), depending on the regime of Reynolds number (Re), although almost no understanding of the physical origins of these instabilities, or indeed their effects on near-wake formation, have hitherto been made clear. We address these questions in this paper. In particular, it is found that the two different modes A and B scale on different physical features of the flow. Mode A has a larger spanwise wavelength of around 3–4 diameters, and scales on the larger physical structure in the flow, namely the primary vortex core. The wavelength for mode A is shown to be the result of an ‘elliptic instability’ in the nearwake vortex cores. The subsequent nonlinear growth of vortex loops is due to a feedback from one vortex to the next, involving spanwise-periodic deformation of core vorticity, which is then subject to streamwise stretching in the braid regios. This mode gives an out-of-phase streamwise vortex pattern.In contrast, mode-B instability has a distinctly smaller wavelength (1 diameter) which scales on the smaller physical structure in the flow, the braid shear layer. It is a manifestation of an instability in a region of hyperbolic flow. It is quite distinct from other shear flows, in that it depends on the reverse flow of the bluff-body wake; the presence of a fully formed streamwise vortex system, brought upstream from a previous half-cycle, in proximity to the newly evolving braid shear layer, leads to an in-phase stream-wise vortex array, in strong analogy with the ‘Mode 1’ of Meiburg & Lasheras (1988) for a forced unseparated wake. In mode B, we also observe amalgamation of streamwise vortices from a previous braid with like-sign vortices in the subsequent braid.It is deduced that the large scatter in previous measurements concerning mode A is due to the presence of vortex dislocations. Dislocations are triggered at the sites of some vortex loops of mode A, and represent a natural breakdown of the periodicity of mode A instability. By minimizing or avoiding the dislocations which occur from end contamination or which occur during wake transition, we find an excellent agreement of both critical Re and spanwise wavelength of mode A with the recent secondary stability analysis of Barkley & Henderson (1996).Wake transition is further characterized by velocity and pressure measurements. It is consistent that, when mode-A instability and large-scale dislocations appear, one finds a reduction of base suction, a reduction of (two-dimensional) Reynolds stress level, a growth in size of the formation region, and a corresponding drop in Strouhal frequency. Finally, the present work leads us to a new clarification of the possible flow states through transition. Right through this regime of Re, there exist two distinct and continuous Strouhal frequency curves: the upper one corresponds with purley small- scale instabilities (e.g. denoted as mode A), while the lower curve corresponds with a combination of small-scale plus dislocation structures (e.g. mode A*). However, some of the flow states are transient or ‘unstable’, and the natural transitioning wake appears to follow the scenario: (2D→A*→B).

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