Present-day G-6-PD deficit in Sardinia with respect to malarial morbidity and mortality in the past

Central line–associated bloodstream infections cause morbidity and mortality in children. We explore the evidence for prevention of central line–associated bloodstream infections in children, assess current practices, and propose research topics to improve prevention strategies.

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Adjuvant treatment of colorectal cancer

Acta chirurgica iugoslavica ◽

10.2298/aci0202015w ◽

2002 ◽

Vol 49 (2) ◽

pp. 15-18

Author(s):

J.A. Wils

Keyword(s):

Colorectal Cancer ◽

Adjuvant Treatment ◽

Large Scale ◽

New Drugs ◽

Morbidity And Mortality ◽

The Past ◽

The Future ◽

The Usa

Colorectal cancer is a leading cause of morbidity and mortality, with approximately 300,000 new cases and 200,000 related deaths in Europe and the USA each year. Adjuvant treatment of colorectal cancer is now widely accepted and can reduce mortality with approximately 10%. This can be considered as one of the major achievements in oncology from the past decade. Current results will be discussed and strategies for the future will be outlined, including on-going or planned large-scale trials with new drugs and approaches.

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IMMUNIZATION ACTION MONTH, OCTOBER 1973

PEDIATRICS ◽

10.1542/peds.52.4.483 ◽

1973 ◽

Vol 52 (4) ◽

pp. 483-484

Author(s):

Samuel L. Katz

Keyword(s):

Infectious Diseases ◽

Preventive Medicine ◽

Infants And Children ◽

The Other ◽

Morbidity And Mortality ◽

Major Aspect ◽

Beneficial Effects ◽

The Past ◽

Childhood Morbidity

The pediatrician has always been among those physicians most sensitive and attentive to the principles and practice of preventive medicine. For the past three decades immunization against infectious diseases has constituted a major aspect of his activities. Many of the vaccines utilized today are the products of research and of investigators fostered by pediatric institutions. The success of these immunizing agents has had profound, beneficial effects on childhood morbidity and mortality. This same success has enabled the pediatrician in his practice and in his research to focus greater energies on many of the other challenges to the health of infants and children.

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Measles (Rubeola) and Rubella: (1) Dangers of the Layman's Confusion (2) Mass Measles Immunization

PEDIATRICS ◽

10.1542/peds.46.6.978 ◽

1970 ◽

Vol 46 (6) ◽

pp. 978-978

Author(s):

Norman Lewak

Keyword(s):

Medical Profession ◽

Morbidity And Mortality ◽

Routine Immunization ◽

The Public ◽

The Past ◽

Mass Immunization ◽

Immunization Campaign

The apathy of the public (including the medical profession) in regard to the fact that measles can be a dangerous disease has been a concern of mine for the past few years (Pediatrics, 34:438, 1964). Because of that apathy, a mass immunization campaign never occurred and we had unnecessary morbidity and mortality. Routine immunization is now with us; the incidence of measles has finally declined. But the apathy has continued, and since immunity is far from universal, new epidemics are being forecast.

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Geriatric assessment of older adults with cancer: Baseline data from a 500 patient multicenter study

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.9546 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 9546-9546 ◽

Cited By ~ 1

Author(s):

A. Hurria ◽

S. Mohile ◽

S. Lichtman ◽

C. Owusu ◽

H. Klepin ◽

...

Keyword(s):

Older Adults ◽

Geriatric Assessment ◽

Stage Iv ◽

Morbidity And Mortality ◽

Psychological Status ◽

The Past ◽

Stage Iv Disease ◽

Oncology Practice ◽

Practice Methods ◽

Tumor Types

9546 Background: As the cancer population ages, a brief, comprehensive measure is needed to characterize the “functional age” of a patient, in order to optimize treatment decisions and evaluate outcomes based on factors other than chronological age. A geriatric assessment (GA) evaluates factors other than age that predict morbidity and mortality in older adults. The goals of this study are to describe the results of a GA performed in 500 older adults with cancer from 7 participating institutions and to evaluate the feasibility of completing this assessment in oncology practice. Methods: The GA is comprised of validated measures of functional status, comorbidity, cognition, psychological status, social functioning and support, and nutritional status (Hurria et al, Cancer 2005). The GA was completed prior to the start of a new chemotherapy regimen in patients age ≥ 65 with a solid tumor or lymphoma. Results: 500 patients (mean age 73; range 65–91) completed the GA. The most common tumor types were lung (29%), GI (29%) and breast/gyn (22%) cancer; 57% had stage IV disease. The GA revealed that 41% of patients needed assistance with instrumental activities of daily living despite a mean physician-reported KPS of 85 (range 50–100), 92% had ≥1 comorbid medical conditions (mean 2.5; range 0–9), 95% took ≥ 1 medications (mean 5; range 0–23), 16% had ≥ 1 falls in the past 6 months, 6% had gross cognitive impairment on the Blessed Orientation-Memory-Concentration Test, and 39% had > 5% weight loss in the past 6 months. The mean time to complete the GA was 27 minutes (range 10–80); 94% were satisfied with the GA length and 70% were able to complete the GA without assistance. Multivariate logistic regression identified the following sociodemiographic and disease variables predict the need for assistance with completion of the GA: age ≥ 80 (p=0.02), high school education or less (p<0.01), non-white race (p<0.01), and the presence of metastatic disease (p=0.01). Conclusions: This brief GA is largely self-administered, can be completed by the majority of older patients without assistance, and identifies important deficits and problems that may impact morbidity and mortality. Prospective data are being acquired to identify factors in the GA that predict chemotherapy toxicity in older adults with cancer. No significant financial relationships to disclose.

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How To Become a Top Model: Impact of Animal Experimentation on Human Salmonella Disease Research

Infection and Immunity ◽

10.1128/iai.01369-10 ◽

2011 ◽

Vol 79 (5) ◽

pp. 1806-1814 ◽

Cited By ~ 89

Author(s):

Renée M. Tsolis ◽

Mariana N. Xavier ◽

Renato L. Santos ◽

Andreas J. Bäumler

Keyword(s):

Animal Models ◽

Vaccine Development ◽

Animal Experimentation ◽

Morbidity And Mortality ◽

Research Needs ◽

Content Type ◽

Disease Research ◽

The Past ◽

Future Work

ABSTRACTSalmonellaserotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of humanSalmonelladisease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects ofSalmonelladisease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research onSalmonellaserotypes. This article reviews important milestones in the use of animal models to study humanSalmonelladisease and identify research needs to guide future work.

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Review on immunosenescence

Reviews in Clinical Gerontology ◽

10.1017/s0959259808002487 ◽

2007 ◽

Vol 17 (3) ◽

pp. 161-169 ◽

Cited By ~ 2

Author(s):

Lia Ginaldi ◽

Lucia Paola Mengoli ◽

Massimo De Martinis

Keyword(s):

Quality Of Life ◽

Morbidity And Mortality ◽

Old People ◽

The Past ◽

Human Lifespan ◽

Age Related ◽

Consequent Reduction ◽

General Improvement

The improvements of socio-environmental conditions, medical care and quality of life have caused a general improvement in the health status of the population and a consequent reduction of morbidity and mortality, resulting in an overall increased life-expectancy. The role of immunosenescence was negligible in the past, when the human lifespan was 40–50 years, and its impact on morbidity and mortality has emerged in combination with the extension of lifespan. Immunosenescence results from multifactorial processes that act on all components of the immune system. The changes associated with immunosenescence are playing an increasingly important role in the emergence of a series of age-related pathologies, conditioning the present epidemiology of old people.

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Path of infectious diseases in Brazil in the last 50 years: an ongoing challenge

Revista de Saúde Pública ◽

10.1590/s1518-8787.2016050000232 ◽

2016 ◽

Vol 50 (0) ◽

Cited By ~ 1

Author(s):

Eliseu Alves Waldman ◽

Ana Paula Sayuri Sato

Keyword(s):

Public Health ◽

Infectious Diseases ◽

Brazilian Population ◽

Health Interventions ◽

Morbidity And Mortality ◽

Strong Impact ◽

Public Health Interventions ◽

The Past ◽

Analysis Strategies ◽

Great Development

ABSTRACT In this article, we comment on the main features of infectious diseases in Brazil in the last 50 years, highlighting how much of this path Revista de Saúde Pública could portray. From 1967 to 2016, 1,335 articles focusing on infectious diseases were published in Revista de Saúde Pública. Although the proportion of articles on the topic have decreased from about 50.0% to 15.0%, its notability remained and reflected the growing complexity of the research required for its control. It is noteworthy that studies design and analysis strategies progressively became more sophisticated, following the great development of epidemiology in Brazil in the recent decades. Thus, the journal has followed the success of public health interventions that permitted to control or eliminate numerous infectious diseases – which were responsible, in the past, for high rates of morbidity and mortality –, and also followed the reemergence of diseases already controlled and the emergence of until then unknown diseases, with a strong impact on the Brazilian population, establishing a little predictable and very challenging path.

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Polymeric antibacterial materials: design, platforms and applications

Journal of Materials Chemistry B ◽

10.1039/d1tb00109d ◽

2021 ◽

Vol 9 (12) ◽

pp. 2802-2815

Author(s):

Hao Luo ◽

Xue-Qian Yin ◽

Peng-Fei Tan ◽

Zhi-Peng Gu ◽

Zhen-Mi Liu ◽

...

Keyword(s):

Medical Care ◽

Materials Design ◽

Morbidity And Mortality ◽

Antibacterial Materials ◽

Pathogen Invasion ◽

The Past

Over the past decades, the morbidity and mortality caused by pathogen invasion remain stubbornly high even though medical care has increasingly improved worldwide.

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Changing SARS-CoV-2 variants in Karachi, Pakistan from alpha to delta through COVID-19 waves three and four

10.21203/rs.3.rs-828919/v1 ◽

2021 ◽

Author(s):

Zahra Hasan ◽

Uzma Bashir Aamir ◽

Asghar Nasir ◽

Akbar Kanji ◽

Azra Samreen ◽

...

Keyword(s):

Clinical Isolates ◽

Morbidity And Mortality ◽

Specific Mutation ◽

The Past ◽

Clinical Laboratories

Abstract We investigated the presence of SARS-CoV-2 variants of concern (VoC) in Karachi, Pakistan between April and July 2021 in specimens received at the Aga Khan University Clinical Laboratories. VoC were identified using a PCR based approach targeting lineage specific mutation. Of the 710 clinical isolates tested, 63% were VoC comprising; 36% alpha, 37% beta, 7% gamma and 21% delta variants. Alpha variants remained the majority whilst, delta strains increased to 43% of cases in July. Thirty-six per cent of all cases were admitted COVID-19 in-patient samples. Of the in-patient cases, 41% were alpha, 28% were beta, 8% were gamma and 24% were delta variants. Overall, we report an increase of delta variants in Karachi over the past two months which is concordant with the currently observed exacerbation in COVID-19 morbidity and mortality.

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