scholarly journals Promising Multiple-Epitope Recombinant Vaccine against Foot-and-Mouth Disease Virus Type O in Swine

2010 ◽  
Vol 18 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Jun-Jun Shao ◽  
Chung Kai Wong ◽  
Tong Lin ◽  
Shuk Kwan Lee ◽  
Guo-Zheng Cong ◽  
...  
Keyword(s):  
Animal Health ◽  
Foot And Mouth Disease ◽  
Recombinant Vaccine ◽  
Mouth Disease ◽  
Inactivated Vaccine ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Heavy Chain Constant Region ◽  
World Organization ◽  
And Control

ABSTRACTIn order to develop a completely safe immunogen to replace the traditional inactivated vaccine, a tandem-repeat multiple-epitope recombinant vaccine against foot-and-mouth disease (FMD) virus (FMDV) type O was developed. It contained three copies each of residues 141 to 160 and 200 to 213 of VP1 of the O/China/99 strain of FMDV coupled with a swine immunoglobulin G heavy-chain constant region (scIgG). The data showed that the multiple-epitope recombinant vaccine elicited high titers of anti-FMDV specific antibodies in swine at 30 days postvaccination (dpv) and conferred complete protection against a challenge with 10350% swine infective doses of the O/China/99 strain. The anti-FMDV specific antibody titers were not significantly different between the multiple-epitope recombinant vaccine and the traditional vaccine (ttest,P> 0.05). The number of 50% pig protective doses was 6.47, which is higher than the number recommended by the World Organization for Animal Health. The multiple-epitope recombinant vaccine resulted in a duration of immunity of at least 6 months. We speculate that the multiple-epitope recombinant vaccine is a promising vaccine that may replace the traditional inactivated vaccine for the prevention and control of FMD in swine in the future.

scholarly journals Review on Outbreak Dynamics, the Endemic Serotypes, and Diversified Topotypic Profiles of Foot and Mouth Disease Virus Isolates in Ethiopia from 2008 to 2018

Viruses ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1076 ◽  
Author(s):  
Ashenafi Kiros Wubshet ◽  
Junfei Dai ◽  
Qian Li ◽  
Jie Zhang
Keyword(s):  
Animal Health ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Surveillance Systems ◽  
Spatial And Temporal Patterns ◽  
National Veterinary Institute ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Control And Prevention ◽  
And Control

Foot and mouth disease (FMD) endemicity in Ethiopia’s livestock remains an ongoing cause for economic concern, with new topotypes still arising even in previously unaffected areas. FMD outbreaks occur every year almost throughout the country. Understanding the outbreak dynamics, endemic serotypes, and lineage profiles of FMD in this country is very critical in designing control and prevention programs. For this, detailed information on outbreak dynamics in Ethiopia needs to be understood clearly. In this article, therefore, we review the spatial and temporal patterns and dynamics of FMD outbreaks from 2008 to 2018. The circulating serotypes and the topotypic profiles of the virus are also discussed. FMD outbreak data were obtained from; reports of MoARD (Ministry of Agriculture and Rural Development)/MoLF (Ministry of livestock and Fishery, NVI (National Veterinary Institute), and NAHDIC (National Animal Health Diagnostic and Investigation Center); published articles; MSc works; PhD theses; and documents from international organizations. To effectively control and prevent FMD outbreaks, animal health agencies should focus on building surveillance systems that can quickly identify and control ongoing outbreaks and implement efficient preventive measures.

scholarly journals Design and Construction of Multiple-Epitope Recombinant Vaccine Against Foot-and-Mouth Disease Virus Type O

2017 ◽  
Vol 8 (15) ◽  
pp. 115-123
Author(s):  
Mohammad Doosti ◽  
Mohammadreza Nassiri ◽  
Mojtaba Tahmoorespur ◽  
Alireza Haghparast ◽  
Saeed Zibaei
Keyword(s):  
Disease Virus ◽  
Virus Type ◽  
Foot And Mouth Disease ◽  
Recombinant Vaccine ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Disease Virus Type ◽  
Design And Construction

scholarly journals A meta-analysis and experiment assessing phage-based FMDV vaccine

2020 ◽  
Author(s):  
Peng Wu ◽  
Ningning Yang ◽  
Yueli Wang ◽  
Mingguo Xu ◽  
Yunfeng Zhang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Foot And Mouth Disease ◽  
Fixed Effect Model ◽  
Mouth Disease ◽  
Control Group ◽  
Phage Group ◽  
Mouth Disease Virus ◽  
Significant Difference ◽  
Foot And Mouth ◽  
And Control

AbstractFoot-and-mouth disease (FMD) is a pathological disease caused by the foot- and-mouth disease virus (FMDV), which mainly affects cloven-hoofed animals. This study was conducted to a meta-analysis and experiment on the effect of bacteriophages used in the development of FMDV vaccines. A systematic search was conducted for the collection of the protection effect for the phage-based FMDV vaccine using sensitive search strategies. The extracted data were analyzed using Rev-Man 5.4 software. This experiment used the T7 phage to express the capsid protein VP1 of the OHM-02 strain, and the recombinant VP1 phage was termed OHM-T7. Antibodies and cytokines levels were assessed after immunizing BALB/C mice with OHM-T7. The results showed that a total of 115 articles were retrieved, and 4 of them met the inclusion criteria. There was no heterogeneity with I2 = 0%, 20% or 43%. We used a fixed-effect model for meta-analysis, and the results showed a protective effect on FMDV between the phage group and control group (P<0.01) and between FMDV group and control group (P<0.01). Furthermore, when the phage group was compared to the FMDV group, there was also no significant difference (P>0.05). After successfully obtained the ohm-t7 strain and immunized the mice, it could induce high levels of IFN-γ levels in mice with little effect on IL-4 levels. OHM-T7 could be used to detect antibodies produced by mice immunized with different FMDV antigens and produce high levels of anti-FMD antibodies. In summary, these results showed the potential of phage-based FMDV vaccines in FMDV prevention.

scholarly journals The effect of repeated vaccination in an enzootic foot-and-mouth disease area on theincidence of virus carrier cattle

1974 ◽  
Vol 73 (2) ◽  
pp. 229-235 ◽  
Author(s):  
E. C. Anderson ◽  
W. J. Doughty ◽  
J. Anderson
Keyword(s):  
Disease Virus ◽  
Immune Status ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Inactivated Vaccine ◽  
Disease Area ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Virus Carrier ◽  
Enzootic Area

SUMMARYA comparison was made of the incidence of foot-and-mouth disease virus 'carrier' cattle in an unvaccinated enzootic area and an area where routine 6-monthly vaccination with an inactivated vaccine had been carried out for 3–4 years. The incidence of carriers in the vaccinated area was 0·49% as compared to 3·34% in the non-vaccinated area. The results indicate that, provided the immune status of the vaccinated herd is maintained at a level sufficient to prevent outbreaks of clinical disease and the re-introduction of virus is prevented through livestock movement controls, it should be possible to eradicate the disease from an enzootic area through vaccination.

Foot-and-mouth disease virus infection of sheep: implications for diagnosis and control

2002 ◽  
Vol 150 (23) ◽  
pp. 724-727 ◽  
Author(s):  
G. J. Hughes ◽  
V. Mioulet ◽  
R. P. Kitching ◽  
S. Alexandersen ◽  
A. I. Donaldson ◽  
...  
Keyword(s):  
Virus Infection ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
And Control

scholarly journals Vesicular stomatitis due to Indiana III (Alagoas/VSIV-3) is endemic in Brazilian state of Ceará

2020 ◽  
Vol 50 (6) ◽  
Author(s):  
Célio Souza da Rocha ◽  
Ilanna Vanessa Pristo de Medeiros Oliveira ◽  
Gabriela Hemylin Ferreira Moura ◽  
José Artur Brilhante Bezerra ◽  
Fernanda Cristina Macedo Rondon ◽  
...  
Keyword(s):  
Animal Health ◽  
Sandwich Elisa ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Diagnostic Challenge ◽  
Viral Neutralization ◽  
Probable Case ◽  
Foot And Mouth ◽  
Vesicular Stomatitis ◽  
World Organization

ABSTRACT: Although Northeast Brazil is considered free of foot and mouth disease (FMD) with vaccination, several economic and health damages are still recorded due to the occurrence of vesicular syndromes that can be evaluated, such as Vesicular Stomatitis (VS). Therefore, this study aimed to confirm the occurrence of this disease and to determine the predominant viral serotype in suspected cases notified to the Official Veterinary Service of Ceará in 2013 performing official diagnostic protocols recommended by the World Organization for Animal Health. After clinical and epidemiological investigation in 46 farms, 32 probable cases of VS were considered with 78 sampled animals, 65 bovines and 13 equines. Serum (54) and epithelium (24) samples were collected. Six (14.6%) of 41 bovines and 8 (61.5%) of 13 equines described seroconversion to Indiana Vesiculovirus (IVV) by viral neutralization. The IVV was detected in 15 (62.5%) of 24 bovines epithelia using the indirect sandwich ELISA. Finally, positive epithelium underwent complement fixation test viral subtyping that identified the occurrence of Indiana III serotype (Alagoas/IVV-3) in 11 (73.3%) of 15 previous positives cattle. These were the first confirmed cases of VS in Ceará with an official diagnosis of IVV-3, confirming the endemic character attributed to the state through previous unofficial serological surveys. The presence of VS is a continuing diagnostic challenge, given the risk of possible incursions of FMD. Vesicular stomatitis is recurrent and is a worrying in this area free of foot and mouth disease with vaccination that bring damage to producers and a maximum alert to the Sanitary Defense Organs in the face of a probable case of vesicular syndrome.

scholarly journals Foot and Mouth Disease: Exotic Animal Disease that must be Alert of Entry into Indonesia

2020 ◽  
Vol 30 (2) ◽  
pp. 61
Author(s):  
R.M. Abdul Adjid
Keyword(s):  
Animal Health ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Great Loss ◽  
Mouth Disease Virus ◽  
The World ◽  
Foot And Mouth ◽  
Exotic Animal ◽  
Health Organization ◽  
Disease Attack

<p>Foot and Mouth Disease (FMD) is a highly contagious disease attack cloven hoofed animals. Among the animals primarly livestock sensitive including cattles, bufalloes, pigs, sheed, and goats. The causative agent is the Foot and Mouth Disease Virus (FMDV). This disease is greatly feared by all countries as livestocks producer because it may raised great loss of economic impact. There are still many countries in the wolrd that are not yet free from FMD. The World Animal Health Organization (OIE/ Office des Internationale Epizootis) has included this disease in the list of disease taht must be reported “notifiable disease”. This FMD has become exotic for Indonesia since 1990, and currently included in the list of strategic infectious animal diseases in Indonesia. With current situation where the traffic of people and goods between countries in the world is very fast and frequent, it is possible for the disease to enter Indonesian territory. This paper discusses the FMD with aim of increasing alertness and readiness in preventing the entry and spread of the disease to Indonesia.</p>

scholarly journals Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 477
Author(s):  
Mar Forner ◽  
Rodrigo Cañas-Arranz ◽  
Sira Defaus ◽  
Patricia de León ◽  
Miguel Rodríguez-Pulido ◽  
...  
Keyword(s):  
T Cell ◽  
Animal Health ◽  
Foot And Mouth Disease ◽  
Infectious Agent ◽  
Mouth Disease ◽  
Cold Chain ◽  
Attractive Alternative ◽  
T Cell Epitopes ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.

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