scholarly journals SAT0481 RELATIONSHIP BETWEEN SARCOPENIA AND BONE MINERAL DENSITY IN MEN WITH CORONARY HEART DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1197.2-1197
Author(s):  
I. Grigoreva ◽  
T. Raskina ◽  
J. Averkieva ◽  
M. Letaeva ◽  
O. Malyshenko ◽  
...  

Objectives:To study the relationship of indicators of muscle mass, muscle strength and muscle function with bone mineral density (BMD) in men with coronary heart disease (CHD).Methods:79 men aged over 50 years with verified CHD were examined (mean age 63 (57; 66) years).The BMD (g/cm2) and T-criterion (standard deviation) of the femoral neck and lumbar spine (L1-L4) were evaluated using dual-energy x-ray absorptiometry (DXA) on the lunar Prodigy Primo bone densitometer (USA).To assess muscle mass, the total area (cm2) of the lumbar muscles of the axial section at the level of the 3rd lumbar vertebra (L3) was determined using multispiral computed tomography on a 64-slice computer tomograph “Somatom Sensation 64” (Siemens AG Medical Solution, Germany). The ratio of the obtained index of the area of skeletal muscle to the square of the patient’s growth index determined the “musculoskeletal index L3” (SMI). The media considered the threshold value to be 52.4 cm2/m2. Evaluation of muscle strength was performed using a mechanical wrist dynamometer DC-25. Muscle function was examined using a short physical performance battery (SPPB).Results:The data obtained from the results of correlation analysis show that there is a reliable direct correlation between BMD and hand dynamometry indicators (r=0.250; p=0.026 for the right hand and r=0.247; p=0.028 for the left hand), the T-criterion of the femoral neck and hand dynamometry indicators (r=0.245; p=0.030 for the right hand and r=0.242; p=0.032 for the left hand). A similar relationship was established between the BMD of the lumbar vertebra and the parameters of dynamometry (r=0.237; p=0.036 for the right hand and r=0.228; p=0.043 for the left hand) and T-criterion for the lumbar region and dynamometry parameters (r=0.232; p=0.039 for the right hand and r=0.220; p=0.051 for the left hand). There is no significant relationship between densitometry scores and the result of SPPB tests.There was a significant direct relationship between the total SPPB score and the area of skeletal muscle at the L3 level (r=0.249, p=0.026), the total SPPB score and the musculoskeletal index (r=0.233, p=0.039). A similar relationship was established between the result of the chair lift test and the total area of skeletal muscle at the L3 level (r=0.262, p=0.019) and the musculoskeletal index (r=0.220, p=0.050).A significant negative relationship between walking speed and the musculoskeletal index was found (r= -0.260, p=0.021). The relationship between muscle mass and strength could not be traced.Conclusion:A decrease in muscle strength correlates with the severity of bone loss, while a decrease in muscle function correlates with a decrease in muscle mass. The results obtained confirm the probability of common mechanisms in the development of sarcopenia and osteoporosis in patients with CHD.Disclosure of Interests:None declared

2000 ◽  
Vol 99 (4) ◽  
pp. 309 ◽  
Author(s):  
Sarah L. ELKIN ◽  
Lauren WILLIAMS ◽  
Margaret MOORE ◽  
Margaret E. HODSON ◽  
Olga M. RUTHERFORD

2019 ◽  
Vol 4 (2) ◽  
pp. 112
Author(s):  
Susanti Susanti ◽  
Susanti Susanti ◽  
Difran Nobel BIstara

Background: The weakness muscle is the biggest impact on patients with stroke, to the practice Range Of Motion with the aim is to maintain or preserve muscle strength, to maintain mobility joints and simulate circulation. With an increase in the incidence of stroke and disability, if the practice Range Of Motion is not implemented it will be a significant decrease in muscle strength, cause muscle kontraktur and a decubitus. Objective: The study aims to find his Range of Motion of muscle strength in patients with stroke in the Puskesmas Bulak Banteng Surabaya. Methods: This study uses Pra-eksperimental One Grup Pra-Post Test Design. Population in this study is a stroke patient who live in the Puskesmas Bulak Banteng Surabaya and sampels 32 of responden. The sample by using techniques simple random sampling. Variables independent in this study is Range Of Motion and the variables dependent is muscle strength. The instrument used in the collection of data is an observation to the strength of muscle and Range of Motion. Result: Wilcoxon test results show the significance level p value = 0.00 with α = 0.05 (p <α) on the right hand while in the left hand shows a significant level p value = 0.00 with α = 0.02 (p<α ).Conclusion:  H0 is rejected that there is influence between ROM exercises gripping the ball against the muscle tone in the right hand and left hand that suffered a stroke.Keywords: Range Of Motion, muscle strength.


2009 ◽  
Vol 161 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Oliver Klefter ◽  
Ulla Feldt-Rasmussen

ObjectiveAdult patients with GH deficiency (GHD) are characterized by a reduced muscle mass, but also reduced bone mineral density (BMD) and content (BMC), which have been ascribed to GHD per se.The aim of this study was to investigate if changes in BMD/BMC in adult GHD patients could be due to a muscle modulating effect, and if treatment with GH would primarily increase muscle mass and strength with a secondary increase in BMD/BMC, thus supporting the present physiological concept that mass and strength of bones are mainly determined by dynamic loads from the skeletal muscles.MethodWe performed a systematic literature analysis, including 51 clinical trials published between 1996 and 2008, which had studied the development in muscle mass, muscle strength, BMD, and/or BMC in GH-treated adult GHD patients.ResultsGH therapy had an anabolic effect on skeletal muscle. The largest increase in muscle mass occurred during the first 12 months of therapy. Most trials measuring BMD/BMC reported significant increases from baseline values. The significant increases in BMD/BMC occurred after 12–18 months of treatment, i.e. usually later than the increases in muscle parameters. Only seven trials studied both muscle and bone variables concomitantly. No trials studied the relationship between the changes in muscle and bone measurements.ConclusionAlthough in vitro studies have shown that GH has a direct effect on bone remodeling, present physiological concepts and the results of clinical trials from 1996 to 2008 suggest that the anabolic changes in muscle mass and strength may also contribute to changes in BMD/BMC in GH-treated adult GHD patients.


2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Young Hye Cho ◽  
Sang Yeoup Lee ◽  
Cheol Min Kim ◽  
Nam Deuk Kim ◽  
Sangmin Choe ◽  
...  

Ursolic acid (UA) is the major active component of the loquat leaf extract (LLE) and several previous studies have indicated that UA may have the ability to prevent skeletal muscle atrophy. Therefore, we conducted a randomized, double-blind, and placebo-controlled study to investigate the effects of the LLE on muscle strength, muscle mass, muscle function, and metabolic markers in healthy adults; the safety of the compound was also evaluated. We examined the peak torque/body weight at 60°/s knee extension, handgrip strength, skeletal muscle mass, physical performance, and metabolic parameters at baseline, as well as after 4 and 12 weeks of intervention. Either 500 mg of LLE (50.94 mg of UA) or a placebo was administered to fifty-four healthy adults each day for 12 weeks; no differences in muscle strength, muscle mass, and physical performance were observed between the two groups. However, the right-handgrip strength of female subjects in the LLE group was found to be significantly better than that of subjects in the control group (P=0.047). Further studies are required to determine the optimal dose and duration of LLE supplementation to confirm the first-stage study results for clinical application. ClinicalTrials.gov Identifier isNCT02401113.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
P Argüello ◽  
A Gálvez ◽  
L Castro ◽  
I Sánchez ◽  
P Melo

Abstract Background Body composition is a parameter that is evaluated to predict the nutritional status of the population. This is assessed by bioelectric impedance analysis, which reports BMI, fat percentage, skeletal muscle mass, phase angle (AP), among others. The latter, in recent years has become important because it is a direct electrical measurement in the body, used for the clinical prognosis of diseases such as cancer, anorexy nervous, sarcopenia and chronic liver disease. AP is an index of vitality and integrality of the cell membrane and an indicator of muscle strength and endurance; likewise, it is inversely related to BMI, age and gender, normal values in healthy populations range between 5.5° to 9°, it is believed that physical activity and sport can also modify AP values. Therefore, the purpose of the study was to determine the relationship between body composition and AP in soccer players in Bogotá, Colombia. Methods Quantitative, cross-sectional, correlational approach. The sample was 84 soccer players (age: 18.67 + 2.9 years; height: 1.73 + 0.07 m; weight: 66.58 + 9.94 Kg), who were assessed using the Bioimpedance method through InBody 770®. Results The averages obtained were: AP 6.46°+0.58; muscle mass 32.25 + 5.06 Kg, percentage of fat mass 15.90 + 3.97. There was a direct relationship between AP, skeletal muscle mass and lean mass in the right, left arm, trunk and right leg (p &lt; 0.01), while with the percentage of body fat mass of the right and left arm the relationship was inverse. Conclusions Body composition with high values of musculoskeletal mass and AP favor the functionality and development of strength, which in turn are protective factors for the presence of diseases such as sarcopenia. Key messages The Phase Angle is constituted as an easily accessible marker of nutritional health and morphofunctional profile in athletes. The Phase Angle and body composition as determinants of the profile in athletes.


Author(s):  
Abeline Kapuczinski ◽  
Muhammad S. Soyfoo ◽  
Sandra De Breucker ◽  
Joëlle Margaux

AbstractFibromyalgia is a chronic disorder characterized by persistent widespread musculoskeletal pain. Patients with fibromyalgia have reduced physical activity and increased sedentary rate. The age-associated reduction of skeletal muscle mass and function is called sarcopenia. The European Working Group on Sarcopenia in Older People developed a practical clinical definition and consensus diagnostic criteria for sarcopenia. Loss of muscle function is common in fibromyalgia and in the elderly. The goal of this study is to determine whether the reduction of muscle function in fibromyalgia is related to sarcopenia according to the European Working Group on Sarcopenia in Older People criteria. Forty-five patients with fibromyalgia and thirty-nine healthy control female subjects were included. All the participants were assessed by Fibromyalgia Impact Questionnaire and SARC-F questionnaire. Muscle mass was evaluated by bioimpedance analysis, muscle strength by handgrip strength test and physical performance with the Short Physical Performance Battery. Fibromyalgia Impact Questionnaire and SARC-F scores were statistically significantly higher in the fibromyalgia group than in the control group, showing severe disease and a higher risk of sarcopenia in the fibromyalgia group (p < 0.001). Muscle strength and physical performance were statistically significantly lower in the group with fibromyalgia than in the control group (p < 0.001). There was no statistical difference between fibromyalgia and control groups regarding skeletal muscle mass (p = 0.263). Our study demonstrated a significant reduction in muscle function in fibromyalgia patients without any loss of muscle mass. Loss of muscle function without decrease in muscle mass is called dynapenia.


2019 ◽  
Vol 100 (5) ◽  
pp. 785-790
Author(s):  
A A Efremushkina ◽  
Ya A Kozhedub ◽  
V A Elykomov

Aim. To estimate in dynamics the changes in muscle strength of hand flexors, muscle mass and gait rate in men with ischemic heart disease and myocardial infarction during cardiac rehabilitation at the outpatient polyclinic stage where daily dosed walking with individually selected frequency steps under self-control was used as a physical component. Methods. The study included 66 men. Patients were divided into two groups comparable by age: 41 men with myocardial infarction (mean age 56.497.33 years) and 25 men with exertional angina without myocardial infarction (mean age 61.094.67 years). In all patients before and after 3 months of cardiac rehabilitation, where the physical component was represented by dosed walking, clinical and anamnestic characteristics were determined, muscle mass using bioimpedancemetry, muscle strength by wrist dynamometry, and walking speed using 6-minute walk test were measured. Statistical processing of the obtained materials was carried out by generally accepted methods. Results. In patients with coronary heart disease and myocardial infarction, the muscle strength of the hand flexor on the right hand increased from 45.2611 daN to 46.37 daN (p=0.05) and on the left hand from 43.7811 to 43.7811 (p=0.05), absence of changes in muscle-to-fat tissue ratio 48.5 (47.7; 49.7) to 48.9 (48.5; 49.9) (p=0.08), increase in gait speed from 450 m (420; 500) to 480 m (440; 500) (p=0.05). In patients with coronary heart disease without myocardial infarction, muscle-to-fat tissue ratio decreased from 48.6 (47.7; 49.2) to 47.7 (46.5; 48.3) (p=0.04); gait speed decreased from 400 m (380; 431) to 390 m (350; 400) (p=0.05), the muscle strength of the hand flexors did not change (from 45.728.03 to 44.88 for the right hand (p=0.54) and from 42.1810 to 42.610 for the left hand (p=0.6). Conclusion. After 3 months of cardiac rehabilitation at the outpatient polyclinic stage, patients with myocardial infarction had a positive effect reflected by muscle strength of flexors on both hands, insignificant increase of muscle mass relative to fat tissue and increase of gait speed as opposed to patients with coronary heart disease without myocardial infarction, who had a decrease in muscle strength of hand flexors, muscle-to-fat tissue ratio and gait speed during this period of time.


2021 ◽  
Vol 9 (11) ◽  
pp. 907-911
Author(s):  
Gwunireama I.U. ◽  
◽  
Ogoun T.R. ◽  
Adheke O.M. ◽  
Wariboko L.I. ◽  
...  

Vitiligo is a skin pigmentation disorder that is caused by a loss of melanocytes, characterized by white spots around certain parts of the body. The aim of this study was to investigate the relationship between digit length, digit (2D:4D) ratio and vitiligo among vitiligo patients within a south-southern Nigeria. Informed consents were obtained from 98 vitiligo adult subjects (69 females and 29 males) in the age range of 18 – 50 years. The measurements that were obtained were the digit lengths of second and fourth fingers for both hands using the digital vernier caliper. The mean and standard deviation values were calculated for all measurements. A Pearson correlation was used to analyse the relationship between the various measurements for both hands in the study. Results showed that the mean ± standard deviation of the various parameters for the female category. Right 2D length was 6.67± 7.53cm, left 2D length was 6.68 ± 7.32cm, right 4D length and left 4D length were 6.86 ± 8.57cm and 6.89 ± 8.50cm respectively. While, the mean and standard deviation values for right and left 2D:4D ratios for the female category were 0.98 ± 0.15 and 0.98 ± 0.12 respectively. In the males, right 2D length was 6.66 ± 9.66cm, left 2D length was 6.64 ± 9.86cm, right 4D length and left 4D length were 6.99 ± 10.09cm and 7.03± 10.40cm respectively. While, the mean and standard deviation values for right and left 2D:4D ratios for the male category were 0.95 ± 0.03 and 0.95 ± 0.03 respectively. In the females for the right hand, there was a significant positive correlation between 2D length and 4D length (r = 0.761, p = 0.000) while there was a significant negative correlation between 4D length and digit ratio (r = -0.473, p = 0.000) at p < 0.01. For the left hand, there was a significant positive correlation between 2D length and 4D length (r = 0.783, p = 0.000). In the males for the right hand, there was a significant positive correlation between 2D length and 4D length (r = 0.976, p = 0.000). For the left hand, there was a significant positive correlation between 2D length and 4D length (r = 0.981, p = 0.000).It can be concluded that the knowledge of 2D:4D ratio among vitiligosubjects could be helpful in clinical anthropometry however, more research has to be done considering that the sample size of this study is relatively small.


2012 ◽  
Vol 3 (3) ◽  
pp. 192-192
Author(s):  
G. Christoffersen ◽  
L. Petrini ◽  
L. Arendt-Nielsen

Abstract Background/aims Being able to modulate pain through visual input raises the possibility that visually distorting body size also will reduce pain. The aim of the present study was to investigate whether experimental cold/heat pain could be modulated through a visual illusion of an increased/decreased hand size and whether pain perception correlated with the perceived sense of control of movement. Methods 20 healthy right-handed volunteers were recruited. Hand sizes were modulated through an AR setting designed to act as a mirror. Four conditions were included: (1) No AR setting; (2) left/right hands were the same size; (3) left hand enlarged; (4) left hand decreased. Pain thresholds (PT) for both hands were alternately assessed using two thermodes, placed on each palmar side of the hands. After each condition subjects rated the following statement: “I could control the movements of my left/right hand”. Results Heat pain: no main effect for conditions or hands (left/right). Cold pain: Significant main effects for conditions, but not for hands – condition (2) is significantly more painful than all conditions. Control of movements when the left hand is stimulated: the more control subjects have of right hand in condition (4), the higher the cold PT for the left hand in conditions (1) and (2). Control of movements when the right hand is stimulated: the more control subjects have of the right hand in condition (4), the higher the heat PT in the right hand for condition (2). Conclusions Visual illusions can modulate pain, however the modulating factors do not only depend on the size of the limbs that are been viewed but also on how much control subjects feel they have of the movements in their hands-specifically the relationship to the right hand condition (4) seems to have an analgesic effect for cold pain and heat pain.


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