scholarly journals AB0168 BODY MASS INDEX IS ASSOCIATED WITH SIGNIFICANT ECHOCARDIOGRAPHIC ABNORMALITIES IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1110.2-1111
Author(s):  
S. Hannawi ◽  
K. Naeem ◽  
H. Hannawi
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Right Ventricular ◽  
Body Mass ◽  
Explanatory Variable ◽  
Left Ventricular ◽  
The Body ◽  
The Mean ◽  
And Function

Background:Overweight/obesity is associated with a high incidence of chronic autoimmune diseases such as rheumatoid arthritis (RA). In RA, obesity represents an increasingly prevalent comorbidity even at its first presentation, with more than 60% of patients with RA classified as overweight or obese by the body mass index (BMI ≥25 kg/m2). On the other hand, RA is related with excess cardiovascular disease (CVD) mortality, which accounts for over 50% of premature deaths in RA. Obesity contributes to the development of inflammation via changes in metabolism and function of adipose tissue and it appears to coexist with other CVD risk factors such as hypertension, insulin resistance and dyslipidemia.Objectives:For the first time, this study looks at the effect of the BMI on echocardiography parameters in established RA cases.Methods:A cross section study was carried out to recruit patients meeting the 2010 ACR/EULAR criteria during 2019. Standard trans-thoracic echocardiography examination was performed by a specialist cardio-sonographer who was blinded to the status of the participants. The echocardiography parameters studied included left ventricular dimensions, wall geometry, systolic and diastolic parameters, ejection fraction, right ventricular size and function, valve structure and function, aortic root dimensions, pulmonary pressures and pericardium. Anthropometric measurements of BMI were carried out as weight in kilograms divided by the square of height in meters (kg/m2). Data was analysed using the BMI as the explanatory variable and repeating the simple linear regression analysis using the echocardiography parameters as outcome variables. P value of <0.05 was considered significant.Results:During the one-year period, 44 RA patients were recruited, of which 91% (40) were female and 4 (9 %) male. The mean (SD) of age was 50±13 years (Min 28, Max 72). The mean (SD) of BMI was 30.887 ± 6.348 Kg/m2 (Min 21, Max 44.38). As per BMI classification of obesity, only 11% patients were found to have normal BMI. Echocardiography revealed that 14% patients had aortic regurgitation, 2% had aortic stenosis, 2% had mitral stenosis, and 7% had tricuspid regurgitation.Using BMI as an explanatory variable, with echocardiography parameters as outcome variables, it was found that BMI contributed positively in a linear manner to the Interventricular Septal thickness in diastole (mm) (p=0.004, CI: 0.048-0.227), LV End Diastolic Diameter (mm) (p=0.033, CI: 0.033-0.722), LV mass (g) (0.04, CI: 0.022-6.339), Early Diastolic Velocity, E, by PW mitral inflow measurement (cm/s) (p=0.02, CI: 0.150-1.933), E/E’ ratio by Tissue Doppler study (p=0.01, CI: 0.025-0.225), and to Right Ventricle function measured by Tricuspid Annular Plane Systolic Excursion (TAPSE) (mm) (p=0.02, CI: 0.035-0.346).Conclusion:Obesity and Inflammation overlap syndrome may interplay to produce various cardiovascular abnormalities. Body Mass Index is shown to be associated with significant echocardiographic abnormalities including left ventricular dimension, diastolic parameters and right ventricular function. In view of the complex interrelation between obesity, rheumatoid arthritis and cardiovascular disease, measuring Body Mass Index might help predict adverse cardiovascular events in rheumatoid arthritis patients.References:[1]Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis. Qin B, Yang M, Fu H, Ma N, Wei T, Tang Q, Hu Z, Liang Y, Yang Z, Zhong R. Arthritis Res Ther. 2015; 17(1): 86. doi: 10.1186/s13075-015-0601-x.[2]Cardiac eccentric remodeling in patients with rheumatoid arthritis. Pascale V, Finelli R, Giannotti R, Coscioni E, Izzo R, Rozza F, Caputo D, Moscato P, Iaccarino G, Ciccarelli M. Sci Rep. 2018; 8: 5867. doi: 10.1038/s41598-018-24323-0.Disclosure of Interests:None declared

scholarly journals AB0244 BODY MASS INDEX AND BODY COMPOSITIONS CORRELATES WITH CAROTID INTIMA MEDIA THICKNESS IN RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1422.1-1422
Author(s):  
S. Hannawi ◽  
H. Hannawi ◽  
M. Alamadi ◽  
R. Sultan ◽  
I. Al Salmi
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Composition ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
The Body ◽  
Composition Analysis ◽  
Cvd Risk ◽  
The Mean

Background:Risk of rheumatoid arthritis (RA) had been reported in overweight obese compared with normal weight people. More, obesity is associated with high prevalence of cardiovascular disease (CVD) risk factors in RA. No previous publications have examined the detailed body composition parameters among RA, or its relation to CVD in RA.Objectives:This study looked at the body composition and the body mass index and correlated it with the subclinical cardiovascular disease as manifested by carotid intima media thickness (cIMT).Methods:During 2019, a cross-sectional study was carried out to recruit cases that met the 2010 American College of Rheumatology/EULAR criteria for diagnosis of RA. All the patients were free of cardiovascular and or cerebrovascular disease. Patients with clinical diagnosis of hypertension, diabetes, renal disease, dyslipidemia, thyroid disorder and pregnant female were excluded. None of the participants is smoker or had history of smoking.cMIT ultrasound (US) measures were obtained using a real-time US scanner equipped with a 7.5 MHz linear probe by a single sonographer. Patients underwent a detailed body composition analysis within the same week of the cIMT measurement. The body composition analysis involved assessing the level of total body water, protein, minerals, body fat mass, intra- and extracellular water, basal metabolic rate, waist hip ratio, visceral fat level, obesity degree, bone mineral content, body cell mass, arm and arm muscle circumference, detailed muscle fat analysis, obesity analysis, segmental lean analysis, weight control parameters, and segmental fat analysis.Results:During 2019, 35 female RA patients were recruited that met the inclusion criteria. The mean (SD) of the age was 52 (10) with a minimum of 20 and maximum of 72 years old. The mean (SD) of cIMT was 0.59 (0.098) mm with a minimum of 0 .38 and maximum of 0.87. The mean (SD) of the BMI was 30.7 (7.0) with a minimum of 20 and maximum of 56.9 Kg/m2. Mean systolic blood pressure was 126 (19) with a minimum of 91 and maximum of 140 mmHg. Also, the mean diastolic blood pressure was mmHg 74 (11) with a minimum of 49 and maximum of 96.The correlation of cIMT with the parameters of the body composition in a linear regression analysis showed a positive linear relationship between cIMT and each of the Body fat mass (kg): P=0.045, CI 0.000-0.004), BMI (p=0.029, CI: 0.001, 0 .009), the target weight (p=0.040, CI: 0.000- 0.001), extracellular water (P=0.033, CI: 0.002, 0.034) and bone mineral content (p=0.031, CI: 0.009, 0.192).The Multiple linear regression analysis showed persistence of the relationship between the cIMT and the age of the participants (p=0.049, CI:0.001-0.007) and the BMI (p=0.031, CI: 0.002- 0.032), with R2of the model was 0.38.Conclusion:To the best of our knowledge, this is the first paper to examine the detailed body composition parameters among RA and found a good correlation with subclinical cardiovascular disease as manifested by cIMT. More research with larger study population is needed to look at the association between body mass index and CVD risk factor in RA.References:[1]Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis. Qin B, Yang M, Fu H, Ma N, Wei T, Tang Q, Hu Z, Liang Y, Yang Z, Zhong R. Arthritis Res Ther. 2015; 17(1): 86. doi: 10.1186/s13075-015-0601-x[2]Body Mass Index and the Risk of Rheumatoid Arthritis: An Updated Dose-Response Meta-Analysis. Feng X, Xu X, Shi Y, Liu X, Liu H, Hou H, Ji L, Li Y, Wang W, Wang Y, Li D. Biomed Res Int. 2019; 2019: 3579081. doi: 10.1155/2019/3579081Disclosure of Interests:None declared

scholarly journals Features of structural and functional remodeling of the left ventricle in patients suffering from arterial hypertension with concomitant hypothyroidism

2019 ◽  
Vol 26 (5) ◽  
pp. 43-52
Author(s):  
V. I. Tseluyko ◽  
L. M. Yakovleva ◽  
D. A. Korchagina
Keyword(s):  
Body Mass Index ◽  
Left Ventricle ◽  
Arterial Hypertension ◽  
Diastolic Dysfunction ◽  
Body Mass ◽  
Mean Value ◽  
Left Ventricular ◽  
Control Group ◽  
Functional Remodeling ◽  
The Mean

The aim – to study the features of structural and functional remodeling of the left ventricle in patients suffering from arterial hypertension with concomitant hypothyroidism and to determine clinical and past medical history and laboratory factors associated with their development. Materials and methods. 50 patients suffering from hypertension with concomitant hypothyroidism were enrolled into the study. Depending on the level of thyroid stimulating hormone in the serum the examined patients were distributed into two groups of 25 patients with the compensated and 25 with decompensated course of hypothyroidism. The control group consisted of 30 patients with hypertension in which the pathology of the thyroid gland was excluded. The comparison of the main parameters of the echocardiography study of the myocardium has been performed depending on hypothyroidism compensation. Assessment of parameters of transmitral diastolic blood flow has been performed. A regression analysis has been conducted to detect the relation of clinical and past medical history factors and echocardiographic parameters with the development of diastolic dysfunction by E/A ratio. The values of central hemodynamics have been studied for evaluation of the contractile function of the myocardium. Results and discussion. According to the results of the echocardiography of both examined groups it has been found that the final systolic and stroke volume exceeded the parameters of the control group. The mean value of the left ventricle ejection fraction was statistically significantly lower than in the control group (p=0.004). The left ventricle myocardial mass in patients with hypothyroidism was statistically significantly greater than in the control group. It was proved that in patients, who were diagnosed with decompensated hypothyroidism, the mean value of the left atrium size to growth by the degree of 2.7 was statistically significantly higher than in the control group (p=0.01), whereas the average value of the ratio of the size of the left atrium to the surface area of the body had no statistically significant differences between the groups. It has been found that in both groups the proportion of patients with diastolic dysfunction in which the E/A ratio was less than 1.0 was higher than in the control group (р=0.01 and p=0.03, respectively). The independent factors of diastolic dysfunction of the left ventricle in patients with hypertension in the presence of hypothyroidism have been found. Conclusions. In the presence of decompensated hypothyroidism in patients with arterial hypertension, both with obesity and with normal body mass index, left ventricular mass indexes were significantly higher in comparison with a control group. Regardless of the compensation of the thyroid state in patients with arterial hypertension, the ejection fraction was significantly lower. According to regression analysis, independent factors for the development of diastolic dysfunction in patients with arterial hypertension and hypothyroidism with a body mass index ≥ 30 kg/m2 is the index of mass of the left ventricular myocardium, determined by the degree of 2.7, the level of total cholesterol to statistical significance – the level of office systolic blood pressure and the duration of hormone replacement therapy for hypothyroidism; with body mass index < 30 kg/m2 – age and left atrial index, determined by body surface area. For patients with arterial hypertension and reduced thyroid gland function, violation of the left ventricular myocardial relaxation is typical as evidenced by a higher proportion of patients with a decrease in E/A to less than 0.8 in these patients.

scholarly journals Effect of Body Mass Index on Auricular Morphology and Auditory Functions

2019 ◽  
Vol 98 (7) ◽  
pp. E81-E86 ◽  
Author(s):  
Mehmet Surmeli ◽  
Ildem Deveci ◽  
Hasan Canakci ◽  
Mustafa Salih Canpolat ◽  
Burak Karabulut ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Soft Tissue ◽  
Body Mass ◽  
Significant Negative Correlation ◽  
The Body ◽  
Sulcus Angle ◽  
Soft Tissue Thickness ◽  
Negative Effect ◽  
The Mean ◽  
Auditory Functions

In this study, we aimed to investigate the relationship between the body mass index (BMI) and the morphometric properties of auricula and its acoustic gain characteristics. A total of 45 participants between 18 and 45 years of age were enrolled into the study. Participants’ height and weight measurements were recorded for the BMI calculation. On both sides, the morphometric properties of the auricula were measured and recorded. Additionally, the participants were subjected to multidirectional dynamic real ear measurements (REMs) to specify the intensity and frequency values of the maximum hearing gain. Participants consisted of 24 women and 21 men. The mean BMI was 23.42. The mean auricular area was 22.70 cm2. Statistically significant positive correlation was found between the auricular area and BMI ( r = 0.427, P = .03). The mean postauricular sulcus angle was 20.99°. The mastoid-helix distance was 16.07 mm. There was no statistically significant correlation between BMI level and postauricular sulcus angle and mastoid-helix distance ( P > .05). The mean dynamic REM measurement was evaluated. The maximum acoustic gain at anterior, lateral, and posterior vectorial stimulation was calculated as 20.9, 24.2, and 20.7 dB Sound Presure Level (SPL), respectively. Statistically significant negative correlation was found between the three directions acoustic gain level and BMI in the statistical examination ( r = −0.365, r = −0.386, r = −0.453, respectively, and P < .05 for all). The results of acoustic gain frequency were 2967.4, 2963, and 2934 Hz, respectively. There was no statistically significant correlation between acoustic gain frequency and BMI ( P > .05). When participants were grouped according to their BMI, participants with a BMI >25 had a statistically significantly bigger auricular area and lower maximum acoustic gain when compared with those with BMI <25 ( P < .05). We found that the auricular area increased with BMI. We think that this is related to soft tissue thickening of the auricula related to high BMI. In addition, we found that the acoustic gain level decreased inversely with BMI. We believe that the decrease in acoustic gain is due to the increase of acoustic resistance after the increase of soft tissue thickness. In conclusion, we think that BMI has a negative effect on auditory function according to findings in our study.

AB0453 Response to TOCILIZUMAB in Rheumatoid Arthritis is not Influenced by the Body Mass Index of the Patient

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 958.1-958 ◽  
Author(s):  
Y.-M. Pers ◽  
M. Godfrin-Valnet ◽  
J. Lambert ◽  
C. Fortunet ◽  
E. Constant ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Body Mass ◽  
The Body

SAT0054 The Body Mass Index and Its Influence on the Activity of Rheumatoid Arthritis: Results from the QUEST-RA Study Morocco.

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A598.1-A598
Author(s):  
M. Ezzahri ◽  
B. Amine ◽  
N. Hajjaj-Hassouni ◽  
B. Benchakroun ◽  
L. Benbrahim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Body Mass ◽  
The Body

scholarly journals How Relevant Is the Place Where First-Year College Students Live in Relation to the Increase in Body Mass Index?

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1638
Author(s):  
Antonio Viñuela ◽  
Juan José Criado-Álvarez ◽  
Javier Aceituno-Gómez ◽  
Carlos Durantez-Fernández ◽  
José Luis Martín-Conty ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Nursing Students ◽  
Body Mass ◽  
Repeated Measures ◽  
Eating Habits ◽  
The Body ◽  
P Value ◽  
First Year ◽  
Significant Difference ◽  
The Mean

(1) Objective: This study analyzes the evolution of the body mass index (BMI) throughout the academic year associated with changes in the lifestyle associated with the place where students live during the course, lifestyle design, and health strategies for the university community. (2) Methods: A total of 93 first-year nursing students participated in this study. Data were collected throughout the course by administering self-reported questionnaires about eating habits and lifestyles, weight, and height to calculate their BMI and place of residence throughout the course. Data were analyzed using statistical analysis (Mann–Whitney, chi-square, Student’s t-test, repeated-measures analysis of variance, and least significant difference tests). (3) Results: We found that the mean BMI increases significantly throughout the course among all students regardless of sex, age, eating habits, or where they live during the course. At the beginning of the course, the mean BMI was 22.10 ± 3.64. The mean difference between the beginning of the course and the middle has a value of p-value < 0.015 and between the middle of the course and the end a p-value < 0.009. The group that increased the most is found among students who continue to live in the family nucleus rather than those who live alone or in residence. Students significantly changed their eating and health habits, especially those who live alone or in residence. (4) Conclusions: There is an increase in BMI among students. It is necessary to carry out seminars or talks that can help students understand the importance of good eating practices and healthy habits to maintain their weight and, therefore, their health, in the short, medium, and long term and acquire a good quality of life.

scholarly journals Age relative height, weight and body mass index percentiles of children in Jos, North-Central Nigeria

2021 ◽  
Vol 12 (8) ◽  
pp. 149-154
Author(s):  
Ovayoza O. Mosugu ◽  
Francis Shinku ◽  
Jacob C. Nyam ◽  
Emmanuel S. Mador
Keyword(s):  
Body Mass Index ◽  
Childhood Obesity ◽  
Body Mass ◽  
Weight Status ◽  
Body Height ◽  
Mean Value ◽  
The Body ◽  
Healthy Weight ◽  
North Central ◽  
The Mean

Background: Interpretation of body mass index in children is quite different from that in adults which use standard weight status categories that are the same for all ages and for both men and women. Aims and Objective: The study was aimed at determining the prevalence of childhood obesity in Jos. Materials and Methods: A total of 371 children were enrolled in the study. Weight was taken with only light clothing and without foot wears. Height obtained without head-gears or shoes and the measuring flat tops pressed down to avoid errors due to tall hair. Body mass index were calculated for each subject as ratio of body weight to body height. All data were analyzed statistically and separately for different ages and the mean values for height against age, weight against age, height against weight and BMI for age was obtained with centiles of absolute deviations from the mean. Results: The age of the studied population ranged from 3 – 14 years with mean of 8.4 ± 2.8. Height of the children on the other hand ranged from 0.9 – 1.64 meters with mean value of 1.26 ± 0.15 and their weight ranged from 10 – 76 kg with mean value of 25.6 ± 9.2. Out of the 371 children studied, 14 (3.8%) were found to be underweight, 302 (81.4%) had healthy weight while 41 (11%) were at risk of overweight and 14 (3.8%) were overweight. In addition, the body mass index of girls was found to be significantly higher than those of boys at 12 and 13 years only. Conclusion: It is concluded that the prevalence of childhood obesity is high in Jos, North-central Nigeria.

scholarly journals Changes in Cardiac Morphology and Function in Individuals With Diabetes Mellitus

2019 ◽  
Vol 12 (9) ◽  
Author(s):  
Magnus T. Jensen ◽  
Kenneth Fung ◽  
Nay Aung ◽  
Mihir M. Sanghvi ◽  
Sucharitha Chadalavada ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Left Ventricular ◽  
Right Atrial ◽  
Ventricular Ejection Fraction ◽  
End Diastolic Volume ◽  
Lv Mass ◽  
Lv Ejection Fraction ◽  
And Function

Background: Diabetes mellitus (DM) is associated with increased risk of cardiovascular disease. Detection of early cardiac changes before manifest disease develops is important. We investigated early alterations in cardiac structure and function associated with DM using cardiovascular magnetic resonance imaging. Methods: Participants from the UK Biobank Cardiovascular Magnetic Resonance Substudy, a community cohort study, without known cardiovascular disease and left ventricular ejection fraction ≥50% were included. Multivariable linear regression models were performed. The investigators were blinded to DM status. Results: A total of 3984 individuals, 45% men, (mean [SD]) age 61.3 (7.5) years, hereof 143 individuals (3.6%) with DM. There was no difference in left ventricular (LV) ejection fraction (DM versus no DM; coefficient [95% CI]: −0.86% [−1.8 to 0.5]; P =0.065), LV mass (−0.13 g/m 2 [−1.6 to 1.3], P =0.86), or right ventricular ejection fraction (−0.23% [−1.2 to 0.8], P =0.65). However, both LV and right ventricular volumes were significantly smaller in DM, (LV end-diastolic volume/m 2 : −3.46 mL/m 2 [−5.8 to −1.2], P =0.003, right ventricular end-diastolic volume/m 2 : −4.2 mL/m 2 [−6.8 to −1.7], P =0.001, LV stroke volume/m 2 : −3.0 mL/m 2 [−4.5 to −1.5], P <0.001; right ventricular stroke volume/m 2 : −3.8 mL/m 2 [−6.5 to −1.1], P =0.005), LV mass/volume: 0.026 (0.01 to 0.04) g/mL, P =0.006. Both left atrial and right atrial emptying fraction were lower in DM (right atrial emptying fraction: −6.2% [−10.2 to −2.1], P =0.003; left atrial emptying fraction:−3.5% [−6.9 to −0.1], P =0.043). LV global circumferential strain was impaired in DM (coefficient [95% CI]: 0.38% [0.01 to 0.7], P =0.045). Conclusions: In a low-risk general population without known cardiovascular disease and with preserved LV ejection fraction, DM is associated with early changes in all 4 cardiac chambers. These findings suggest that diabetic cardiomyopathy is not a regional condition of the LV but affects the heart globally.

Abstract 5714: Influence of Body Mass Index on Early Diastolic Untwisting Velocity in Healthy Children

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Christine O’Reilly ◽  
Katrina Abhayaratna ◽  
Satoru Sakuragi ◽  
Richard Telford ◽  
Walter P Abhayaratna
Keyword(s):  
Body Mass Index ◽  
Heart Rate ◽  
Body Mass ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Left Ventricular ◽  
Lv Function ◽  
Healthy Children ◽  
Diastolic Relaxation ◽  
And Function

Background: Childhood obesity is increasingly prevalent in the community and is predictive of adverse cardiovascular outcomes in adulthood. We hypothesised that increased body mass index (BMI) in children has an adverse influence on left ventricular (LV) untwisting, a sensitive marker of LV function that reflects a key process in the transition between LV relaxation and suction. Methods: Cardiac structure and function were assessed by transthoracic echocardiography. LV twist mechanics were quantitated using 2-dimensional speckle tracking imaging of the LV base and apex in short axis. Univariate associations of LV untwisting velocity (Er) were evaluated using Spearman’s correlation analysis. Significant univariate predictors (p≤0.10) were included into multivariable regression analysis to determine the independent relationship between body mass and Er (rad/s). Results: Of the first 150 children assessed (age 10.2 ± 0.3 years; 83 boys), the mean BMI was 18.2 ± 2.8 kg/m 2 . In univariate analysis, Er was inversely related to BMI (ρ= −0.13, p=0.10), LV end-diastolic diameter (ρ= −0.13, p=0.10) and LV end-systolic diameter (ρ= −0.28, p<0.001); and positively correlated with LV torsion (ρ=0.55, p<0.001), LV twisting velocity (ρ=0.29, p<0.001), early diastolic annular velocity (e′) (ρ=0.13, p=0.10), LV ejection fraction (EF) (ρ=0.14, p=0.09) and heart rate (ρ=0.18, p=0.03). There was no correlation between Er and LV relative wall thickness or mass index (p>0.25). In multivariable analysis, body mass index was independently associated with Er, independent of LV torsion, heart rate, EF, LV chamber size and e′ (Table ). Conclusion: Increased body mass is independently related to lower LV untwisting velocity during early diastole in healthy children. Additional studies are required to evaluate whether lifestyle measures to reduce body mass will attenuate further deterioration in LV diastolic relaxation and suction. Table: Independent Predictors of Left Ventricular Untwisting Velocity in Children

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