scholarly journals AB0181 EXPLORING THE ROLE OF IL-6 BLOCKADE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHTITIS AND CHRONIC PERIODONTITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1116.1-1116
Author(s):  
C. Ancuta ◽  
E. Ancuta ◽  
R. Chirieac ◽  
O. Tanculescu ◽  
C. Iordache
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Inflammatory Mediators ◽  
Chronic Periodontitis ◽  
Current Evidence ◽  
Clinical Activity ◽  
Dramatic Decrease ◽  
Periodontal Status ◽  
Periodontal Inflammation ◽  
Prospective Longitudinal

Background:Recent data have renewed the interest in common pathobiologic pathways in autoimmune rheumatic conditions and periodontal disease, especially on dual impact of innovative anti-rheumatic drugs in modulating both inflammatory and immune articular as well as periodontal damage. Although consistent data about TNF inhibitors and chronic periodontitis are already published, the influence of IL-6 blockade.Objectives:We aimed to explore the influence of weekly subcutaneously IL-6 receptor inhibitor tocilizumab on periodontal health in a local cohort of patients with rheumatoid arthritis (RA) and chronic periodontitis (PD).Methods:We performed a prospective longitudinal 6 months study in 68 patients with moderate-to-severe RA starting tocilizumab (TCZ) in accordance to local recommendations. Extensive rheumatologic (clinical activity, inflammatory, serological biomarkers) and dental (plaque index PI, gingival index GI, bleeding on probing BOP, pocket probing depth PPD, clinical attachment level CAL) assessments were done. Changes in RA activity and periodontal status were reassessed after 3 and 6 months.Results:51 RA and concomitant t of 68 patients in our initial cohort were finally analyzed. Aggressive periodontal disease was reported particularly in disease subsets with excessive inflammatory (serum C reactive protein level) and serologic biomarkers (anti-citrullinated peptide antibodies ACPA). Furthermore, significant correlations between periodontal status, clinical disease activity and ACPA levels were also demonstrated (p<0.05). We also noticed consistent improvement was noticed in both RA-related parameters sand periodontal inflammation (GI and sites with bleeding of probing) after only 3 months (p < 0.05), while PPD improved after 6 months; overall, CAL presented only slight changes without statistical any significance as well as teeth count and plaque levels (p > 0.05).Conclusion:IL-6 inhibition is able to improve periodontal outcomes in patients with RA and concomitant PD, essentially related to dramatic decrease in serum inflammatory mediators.References:[1]de Molon Scaf, R., Rossa, C.; Thurlings, R.M.; Cirelli, J.A.; Koenders, M.I. Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions, Int. J. Mol. Sci. 2019, 20, 4541.[2]Genco, R.J.; Sanz, M. Clinical and public health implications of periodontal and systemic diseases: An overview. Periodont. 20002020, 83 (1), 08 May.[3]Rinaudo-Gaujous, M.; Blasco-Baque, V.; Miossec, P. et al. Infliximab induced a dissociated response of severe periodontal biomarkers in rheumatoid arthritis patients. J Clin Med2019. 8, 751.[4]Eezammuddeen, N.N.; Vaithilingam, R.D.; Mohamad Hassan, N.H.; Bartold, IL-6 inhibition is able to improve periodontal outcomes in patients with RA and concomitant PD, essentially related to dramatic decrease in serum inflammatory mediators.Disclosure of Interests:CODRINA ANCUTA Speakers bureau: ABBVIE, PFIZER, UCB, NOVARTIS, LILLY, SANDOZ, Consultant of: ABBVIE, PFIZER, UCB, NOVARTIS, LILLY, SANDOZ, EUGEN ANCUTA: None declared, Rodica Chirieac Speakers bureau: ABBVIE, PFIZER, UCB, NOVARTIS, LILLY, SANDOZ, OANA TANCULESCU: None declared, CRISTINA IORDACHE: None declared

Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach

2017 ◽  
Vol 68 (2) ◽  
pp. 369-372 ◽  
Author(s):  
Codrina Ancuta ◽  
Eugen Ancuta ◽  
Rodica Chirieac ◽  
Magda Antohe ◽  
Cristina Iordache
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Periodontal Disease ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Periodontal Status ◽  
Factor Alpha ◽  
Prospective Longitudinal ◽  
Necrosis Factor

Although the relationship between periodontal disease and rheumatoid arthritis (RA) is widely documented, centered by common pathobiologic pathways, the effect of various tumor necrosis factor alpha (TNF) antagonists in modulating not only inflammatory and immune articular damage, but also periodontal microenvironment remain debatable. We aimed to evaluate the periodontal status with and without TNF inhibitors in RA patients and to identify potential relation among these entities. We performed a prospective longitudinal 6-months analysis on 96 RA initiating their first biological therapy. Standard assessments included a dual rheumatologic (RA activity, disability, serological, inflammatory prolife) and dental evaluation such as plaque index (PI), gingival index (GI), bleeding on probing (BOP), pocket depth (PD), clinical attachment level (CAL). More than half of RA presented at baseline with chronic periodontitis, as suggested by high prevalence of sites with dental plaque, abnormal BOP, PD and CAL. Advanced inflammatory (CRP, ESR) and immune (anti-cyclic citrullinated peptide antibodies, ACPA) markers were described in RA subsets presenting with aggressive periodontal diseases, while significant correlations between dental pathology, RA activity and ACPA levels were also reported (p[0.05). Furthermore, we revealed significant improvement in both RA-related characteristics and periodontal status after 6 months of anti-TNF therapy (p[0.05). RA, particularly active severe, ACPA positive disease, is essentially accompanied by comorbid periodontal disease. TNF blockade is efficient in patients with active RA and potentially able to modulate the inflammatory process in the periodontal tissue.

scholarly journals Should We Be Screening for and Treating Periodontal Disease in Individuals Who Are at Risk of Rheumatoid Arthritis?

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1326
Author(s):  
Zhain Mustufvi ◽  
Stefan Serban ◽  
James Chesterman ◽  
Kulveer Mankia
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Joint Inflammation ◽  
Disease Association ◽  
Musculoskeletal Symptoms ◽  
Future Research ◽  
Periodontal Inflammation ◽  
Citrullinated Protein

There is increasing evidence supporting an association between periodontal disease (PD) and rheumatoid arthritis (RA), both mechanistically and clinically. Trials have shown that treating PD in people with RA may improve RA disease activity. Patients with musculoskeletal symptoms without arthritis, who test positive for cyclic-citrullinated protein antibodies, are at risk of RA (CCP+ at-risk), with seropositivity preceding arthritis onset by months or years. Importantly, there is evidence to suggest that periodontal inflammation may precede joint inflammation in CCP+ at-risk and, therefore, this could be a trigger for RA. There has been increased research interest in RA prevention and the phenotyping of the pre-RA disease phase. This review will examine the merits of identifying individuals who are CCP+ at-risk and performing screening for PD. In addition, we discuss how PD should be treated once identified. Finally, the review will consider future research needed to advance our understanding of this disease association.

scholarly journals Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

2018 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Gabriel R. Fernandes ◽  
Débora Cerqueira Calderaro ◽  
Santuza Maria Souza Mendonça ◽  
Janine Mayra Silva ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Bacterial Load ◽  
Oral Bacteria ◽  
The Body ◽  
Rrna Gene ◽  
Oral Microbiota ◽  
Periodontal Inflammation ◽  
The Impact ◽  
Subgingival Microbiota

AbstractRheumatoid arthritis (RA) is an autoimmune disorder associated with increased periodontal destruction. It is thought that RA increases the risk of periodontal disease; it is not known how it influences the oral microbiota. Our aim was to analyze the impact of RA on subgingival microbiota and its association with periodontal inflammation and RA activity. Forty-two patients with RA were compared to 47 control subjects without RA. Patients were screened for probing depth, clinical attachment level, bleeding on probing and classified as with or without periodontitis. Subgingival plaque was examined by Illumina MiSeq Sequencing of 16S rRNA gene V4 region and inflammatory cytokines were measured in saliva. RA was associated to severe periodontal disease. In addition, the severity of RA, reflected by the number of tender and swollen joints, was significantly correlated with the presence of pathogenic oral bacteria (i.e. Fusobacterium nucleatum and Treponema socransky). Non-periodontitis RA patients compared to healthy controls had increased microbial diversity and bacterial load, higher levels of pathogenic species (Prevotella, Selenomonas, Anaeroglobus geminatus, Parvimonas micra, Aggregatibacter actinomycetemcomitans) and reduction of health-related species (Streptococcus, Rothia aeria, Kingela oralis). Genes involved with bacterial virulence (i.e. lipopolysaccharide biosynthesis, peptidases) were more prevalent in the subgingival metagenome of subjects with RA. In addition, the degree of oral inflammation reflected by IL-2, IL-6, TNF-α, IFN-γ salivary levels was increased in non-periodontitis RA patients in comparison with controls. Our findings support the hypothesis that RA triggers dysbiosis of subgingival microbiota, which may contribute to worsening periodontal status.Author SummaryRheumatoid arthritis (RA) is an autoimmune disease characterized by joints inflammation, swelling, pain and stiffness. Exactly what starts this disease is still unclear. Some recent studies have suggested mucosal surfaces in the body, like those in the gums, could affect the disease process. It has been observed that people with RA have higher risk of periodontitis (a bacterial inflammatory disease of the gums), compared with the general population, and this may be the start of the autoimmune process. Also, periodontitis increases the severity of RA while interventions by treating periodontitis can improve the symptoms of RA. One of the possible mechanisms that link the higher prevalence of periodontitis in RA patients is the dysbiosis of the oral microbiota triggered by the chronic inflammation in RA. Increased levels of molecules of inflammation may affect the oral environment and change the type of bacteria that live there. Here, we examined RA patients and healthy subjects, screening their oral health and inflammatory markers. We collected their saliva and the dental plaque from the space between the teeth and the gum. We found that RA patients exhibited severe periodontitis, increased levels of inflammatory mediators on their saliva and distinct bacterial communities, with higher proportions of bacteria species linked to periodontal disease, even in patients without periodontitis. We also found that the presence of these bacteria species was linked to worse RA conditions. Our study provides new insights to understand the bi-directional mechanisms linking periodontal disease to the development of RA, showing that we need to pay attention to the oral cavity in patients with RA and refer people for dental evaluation. This practice might have a positive impact in the course of RA.

scholarly journals Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ildikó Tar ◽  
Éva Csősz ◽  
Edit Végh ◽  
Karin Lundberg ◽  
Nastya Kharlamova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Control Group ◽  
Healthy Controls ◽  
Periodontal Status ◽  
Protein Levels ◽  
Reduced Height ◽  
Significant Difference ◽  
Citrullinated Proteins ◽  
Citrullinated Protein

AbstractPeriodontal disease (PD) can be an important precipitating factor in the production of citrullinated proteins. Its importance is emphasized, but it is not the only way to produce citrullinated proteins. The aim of the current study was to determine the periodontal conditions and the salivary citrullinated protein content in patients with rheumatoid arthritis (RA) compared to healthy controls. We also wished to correlate citrullinated protein levels in the saliva and serum biomarkers with the periodontal status and temporomandibular joint (TMJ) involvement of patients with RA. Twenty-three patients with RA and 17 healthy controls participated the study. Saliva samples were taken: citrulline content of saliva was measured. Blood test results for patients with RA were collected. TMJ disorders were described. Cariological and periodontal indices were registered. Periodontal conditions and periodontal staging were also registered. Comparison of measured values between groups was performed. Intragroup correlation of patients’ values was counted. The prevalence of TMJ complaints was significantly higher in the RA group (8/23) versus controls (1/17). The patients with RA had worse periodontal condition because more patients with RA had gingivitis with a significantly higher bleeding on probing (BOP) (RA: 22.4 ± 25.0%; controls: 6.36 ± 11.6%; p = 0.018). Gingival index (GI) was also significantly higher in the patients than in controls (RA: 0.68 ± 0.58; controls: 0.19 ± 0.38; p = 0.010). The citrullinated protein (relative) content of saliva did not differ significantly (p = 0.147) between patients with RA (1102.2 ± 530.8) and healthy controls (1873.1 ± 1594.9). In RA, the salivary anti-CCP levels positively correlated with PD staging (R = 0.464, p = 0.039) . Control subjects more commonly had healthy gingiva than RA patients. Moreover, in the control group more individuals had intact and reduced height periodontium than periodontitis compared to the RA group. There was no significant difference in the levels of salivary citrulline between patients with RA and controls, despite the significant differences in their periodontal status. Thus, salivary citrulline levels are not associated with RA disease severity.

scholarly journals Periodontal Treatment Downregulates Protease-Activated Receptor 2 in Human Gingival Crevicular Fluid Cells

2013 ◽  
Vol 81 (12) ◽  
pp. 4399-4407 ◽  
Author(s):  
Vanessa Tubero Euzebio Alves ◽  
Henrique Aparecido Bueno da Silva ◽  
Bruno Nunes de França ◽  
Rosangela Santos Eichler ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Growth Factor ◽  
Inflammatory Mediators ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Treatment ◽  
Positive Staining ◽  
Proinflammatory Mediators ◽  
Periodontal Inflammation ◽  
Crevicular Fluid ◽  
Protease Activated Receptor 2

ABSTRACTProtease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced byPorphyromonas gingivalisand by neutrophil protease 3 (P3). PAR2 activation plays a relevant role in inflammatory processes by inducing the release of important inflammatory mediators associated with periodontal breakdown. The effects of periodontal treatment on PAR2 expression and its association with levels of proinflammatory mediators and activating proteases were investigated in chronic periodontitis patients. Positive staining for PAR2 was observed in gingival crevicular fluid cells and was reflective of tissue destruction. Overexpression of PAR2 was positively associated with inflammatory clinical parameters and with the levels of interleukin-6 (IL-6), IL-8, tumor necrosis factor alpha, matrix metalloprotease 2 (MMP-2), MMP-8, hepatocyte growth factor, and vascular endothelial growth factor. Elevated levels of gingipain and P3 and decreased levels of dentilisin and the protease inhibitors secretory leukocyte protease inhibitor and elafin were also associated with PAR2 overexpression. Healthy periodontal sites from individuals with chronic periodontitis showed diminished expression of PAR2 mRNA and the PAR2 protein (P< 0.05). Furthermore, periodontal treatment resulted in decreased PAR2 expression and correlated with decreased expression of inflammatory mediators and activating proteases. We concluded that periodontal treatment resulted in decreased levels of proteases and that proinflammatory mediators are associated with decreased PAR2 expression, suggesting that PAR2 expression is influenced by the presence of periodontal infection and is not a constitutive characteristic favoring periodontal inflammation.

scholarly journals Correlation between chronic periodontitis and rheumatoid arthritis: A periodontist perspective

2021 ◽  
Vol 9 (2) ◽  
pp. 67-71
Author(s):  
Shilpi Gangwar ◽  
Patel Umesh Bhai Becharbhai ◽  
Vaibhav Sheel ◽  
Umesh Chandra Chaudhary
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Inflammatory Diseases ◽  
Pcr Amplification ◽  
Current Evidence ◽  
Oligonucleotide Primer ◽  
Serum Samples ◽  
Tannerella Forsythia ◽  
Bacterial Dna ◽  
The Relationship

In this study, we evaluate the relationship between rheumatoid arthritis (RA) and chronic periodontitis on the basis of clinical attachment present and severity of attachment loss in both the cases. First of all Diagnosis of rheumatoid arthritis and chronic periodontitis was performed, thereafter bacterial DNA extraction from blood serum sample and subgingival dental plaque of each group through PCR and later DNA purification through Spin protocol was performed, oligonucleotide primer was used to detect t.forcythia and PCR amplification was done to detect T. Denticola for both the groups .PBDNA was detected in both SGP and serum samples of both the groups. In SGP samples, Tannerella forsythia was more frequently detected as compared to serum samples of both the groups. In result theclinical attachment Level (CAL) was observed to be higher in RA group as compared to CP group. Comparison of CAL according to severity was also observed in both the groups which suggested that RA group has mild periodontitis as compared to CP group in which moderate to severe periodontitis was seen, Detection of periodontal bacterial DNA by PCR assay PBDNA was detected in both SGP and serum samples. In SGP samples, Tannerella forsythia was more frequently detected as compared to serum samples of both the groups. So these are two common chronic inflammatory diseases with a similar host-mediated pathogenesis. Current evidence suggests that an association exists between periodontitis and RA. Well-designed multicenter longitudinal clinical trials and studies with sufficient sample sizes are needed to ascertain the relationship between these two diseases and whether periodontal treatment can reduce the severity of RA or prevent its onset.

scholarly journals ALKALINE PHOSPHATASE – A DIAGNOSTIC MARKER OF PERIODONTITIS IN POSTMENOPAUSAL WOMEN – A. B. OCHEMICAL STUDY

2013 ◽  
Vol 03 (04) ◽  
pp. 071-073
Author(s):  
Amitha Ramesh ◽  
Rahul Bhandary ◽  
Biju Thomas ◽  
Sheehan R. D'Souza ◽  
Suchetha Kumari
Keyword(s):  
Alkaline Phosphatase ◽  
Periodontal Disease ◽  
Postmenopausal Women ◽  
Chronic Periodontitis ◽  
Diagnostic Marker ◽  
Saliva Sample ◽  
P Value ◽  
Bone Homeostasis ◽  
Periodontal Inflammation ◽  
Group 2

Abstract Background and objective: Periodontal disease is one of the common inflammatory diseases with complex etiology and is multifactorial in origin.Several enzymes are evaluated for the early diagnosis of periodontal disease. The enzyme ALP plays a role in bone metabolism. In the periodontium, ALP is very important enzyme as it is part of normal turnover of periodontal ligament, root cementum, and bone homeostasis. The deficiency of estrogen in women at menopause is contributing factor to osteoporosis and considered one of the risk factors for periodontal disease. It has been hypothesized that osteoporosis decreases alveolar bone density and in turn increases its susceptibility to resorption due to periodontal inflammation. Accelerated bone loss in menopause is related to increased bone turnover. This is accompanied by increased levels of biochemical markers such as Alkaline Phosphatase. Alteration in salivary Alkaline Phosphatase levels might be expected as an indication of periodontal disease activity. Methods: The study included 40 subjects, 20 in each group in the age group of 50-60 years. Group 1 comprised of 20 Postmenopausal women without chronic periodontitis. Group 2 comprised of 20 Postmenopausal women with chronic periodontitis. Each saliva sample was estimated for ALP levels. Results: The present study showed significant increase in Alkaline Phosphatase in postmenopausal women with periodontitis (Group 2) with p value <0.0001. Interpretation and conclusion: Alkaline phosphatase can be used as a diagnostic marker of Periodontitis in postmenopausal women. However ALP cannot be solely responsible for Periodontitis but it can be used as a additional aid in diagnosing Periodontitis.

scholarly journals Clinical and Biological Study of Rheumatoid Arthritis Influence on Salivary Biomarkers in Patients with Periodontal Disease

2015 ◽  
Vol 19 (3) ◽  
pp. 150-152
Author(s):  
Madalin Boatca ◽  
Loredana Hurjui ◽  
Ioana Rudnic ◽  
Ovidiu Nicolaiciuc ◽  
Silvia Martu
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Antibody Therapy ◽  
Oral Disease ◽  
Biological Study ◽  
Control Group ◽  
Salivary Biomarkers ◽  
Periodontal Inflammation ◽  
Tnf Α ◽  
Factor Α

SummaryAim: The purpose was to identify if rheumatoid arthritis (RA) influenced levels of salivary biomarkers of periodontal disease.Methods: Biological assessments and periodontal examinations were performed in 15 patients with RA, 10 patients with chronic periodontitis and 11 healthy patients as controls. Unstimulated whole salivasamples were analysed for interleukin-1b (IL-1b) and tumour necrosis factor-α (TNF-α) concentrations.Results: The arthritis and healthy patients had significantly less oral disease than the periodontitis group but the arthritis group had significantly moresites bleeding on probing (BOP) than the control group. Salivary levels ofIL-1b were significantly elevated in the periodontal disease group, and IL-1b was the only biomarker with significantly higher levels in the arthritis group compared with control group. Arthritis patients receiving anti-TNF-α antibody therapy had significantly lower IL-1b and TNF-α levels compared with arthritis patients not on the anti-TNF-α therapy and healthy controls, respectively.Conclusion: RA patients have higher levels of periodontal inflammation than healthy control group and also an increased BOP. Systemic inflammation appears to influence levels of selected salivary biomarkers of periodontal disease, and anti-TNF-α therapy significantly modified lowered salivary levels IL-1b and TNF-α levels in RA.

TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis

2017 ◽  
Vol 68 (8) ◽  
pp. 1914-1918
Author(s):  
Codrina Ancuta ◽  
Eugen Ancuta ◽  
Rodica Chirieac ◽  
Carmen Anton ◽  
Zenaida Surlari ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Tnf Inhibitors ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Inflammatory Parameters ◽  
Periodontal Inflammation

The link between immune mediated rheumatic disorders and oral health, particularly periodontal disease, is widely accepted, based on shared immune and inflammatory processes as well as local (articular, gingival) damage mediated by similar pro-inflammatory cytokine and destructive mediators. We aimed to evaluate periodontal status in psoriatic arthritis (PsA) before and after 24-weeks treatment with TNF inhibitors and to identify potential relation between disease activity, inflammatory parameters, therapeutic response and chronic periodontitis. Patients were prospectively assessed according to a standard protocol comprising a complex rheumatologic (PsA activity, inflammatory prolife) and dental evaluation (plaque and gingival index, bleeding on probing, periodontal pocket depth, clinical attachment level). Up to one third PsA presented with moderate to severe periodontitis at baseline, with high prevalence of sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Higher levels of inflammatory parameters were described in the subset of PsA presenting with aggressive periodontal diseases, while significant correlation between dental pathology and CRP (p[0.05). A significant improvement in both PsA-related parameters and periodontal status was demonstrated after 24 weeks of anti-TNF therapy (p[0.05). Periodontal disease may develop in PsA and should be commonly evaluated, particularly patients with active disease. Benefits of TNF inhibitors, with significant response in articular and periodontal parameters, suggest common inflammatory pathways in both entities.

scholarly journals The correlation between immunoexpression of estrogen receptor and the severity of periodontal disease

2010 ◽  
Vol 43 (3) ◽  
pp. 117
Author(s):  
Yuliana Mahdiyah Da’at Arina ◽  
S. Sunardhi Widyaputra ◽  
Koeswadji Koeswadji
Keyword(s):  
Risk Factors ◽  
Estrogen Receptor ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Estrogen Receptor Α ◽  
Periodontal Pocket ◽  
Periodontal Tissue ◽  
Pocket Depth ◽  
Periodontal Status ◽  
Menopausal Women

Background: The decreased level of estrogen during menopause may be one of the risk factors of periodontal disease. The influence of estrogen to periodontal tissue disturbance is mediated by the presence of estrogen receptor on tissue. The precise mechanism how the estrogens mediate this effect is still unclear. Purpose: The aim of this study was to determine the correlation between estrogen receptor α and ß on the periodontal pocket of women who had severe chronic periodontitis measured based on the periodontal pocket depth. Methods: Twenty four periodontitis patients from menopausal and productive women according to the criteria were examined upon her periodontal status and immunoexpression of estrogen receptor α and ß on their periodontal pocket wall. Results: The result showed that in the menopausal and productive women, immunoexpression of estrogen receptor α and ß was not correlated with the periodontal pocket depth (p>0.05). However, the pocket depth seemed to show higher correlation with immunoexpression of estrogen receptor α than that with estrogen receptor ß, r=0.37 vs. r=0.12 for menopausal women, and r=41 vs. r=0.11 for productive women. Conclusion: It was concluded that no significant correlation was found between the estrogen receptor and periodontal pocket depth both on menopausal and productive women, presumed that estrogen has little role in the severity of periodontitis based on periodontal pocket depth. However, the estrogen receptor α has valuable effect on the severity of periodontal disease more than the estrogen receptor ß.Latar belakang: Berkurangnya kadar estrogen pada masa menopause merupakan salah satu faktor resiko penyakit periodontal. Peran estrogen dalam kerusakan jaringan periodontal dimediatori oleh reseptor estrogen α dan ß yang terdapat dalam jaringan. Akan tetapi, mekanisme estrogen mempengaruhi efek ini sampai saat ini masih belum jelas. Tujuan: Penelitian ini bertujuan untuk menentukan korelasi antara reseptor estrogen pada poket periodontal wanita menopause penderita periodontitis kronis dengan keparahan periodontitis yang ditentukan berdasarkan kedalaman poket. Metode: Dilakukan pemeriksaan status periodontal dan immunoekspresi reseptor estrogen α dan ß pada dinding poket periodontal dari 24 wanita menopause dan belum menopause penderita periodontitis yang sesuai dengan kriteria yang telah ditetapkan. Hasil: Hasil mendapatkan bahwa immunoekspresi reseptor estrogen α dan ß tidak berkorelasi dengan kedalaman poket periodontal wanita menopause dan belum menopause (p>0,05). Meskipun demikian, kedalaman poket periodontal tampak lebih berkorelasi dengan reseptor estrogen α daripada dengan reseptor estrogen ß, dengan nilai r=0,37 vs r=0,12 pada wanita menopause, dan r=0,41 vs r=0,11 pada wanita belum menopause. Kesimpulan: Dapat disimpulkan bahwa tidak terdapat korelasi yang signifikan antara reseptor estrogen dan kedalaman poket periodontal wanita menopause dan belum menopause sehingga diduga bahwa estrogen mempunyai sedikit pengaruh pada keparahan periodontitis. Meskipun demikian, reseptor estrogen α tampak lebih berperan terhadap keparahan penyakit periodontal dibandingkan reseptor estrogen ß.

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