scholarly journals Acute adrenal failure: a potentially fatal consequence of an adulterated herbal remedy

2019 ◽  
Vol 12 (2) ◽  
pp. bcr-2018-228443 ◽  
Author(s):  
Harminder Sensi ◽  
Harit Buch ◽  
Loretta Ford ◽  
Rousseau Gama
Keyword(s):  
Herbal Remedy ◽  
Acute Illness ◽  
Herbal Remedies ◽  
Adrenal Crisis ◽  
Adrenal Failure ◽  
Tablet Analysis ◽  
Potential Risks ◽  
Acute Adrenal Failure ◽  
Fatal Consequence

Herbal remedies adulterated with glucocorticoids can cause Cushing’s syndrome. We report a severe presentation of a ‘herbal remedy’ adulterated with glucocorticoids; causing a potentially fatal adrenal crisis precipitated by acute illness. Investigations were consistent with adrenal suppression and confirmed, after tablet analysis, to be due to a ‘herbal remedy’ containing synthetic betamethasone/dexamethasone. This case highlights the need for clinical vigilance and patient education about the potential risks associated with the use of unlicensed treatments and the role of tablet analysis in routine biochemistry.

scholarly journals Problem-based review: The Patient with Acute Adrenal Failure

2013 ◽  
Vol 12 (1) ◽  
pp. 38-43
Author(s):  
Angela Rogers ◽  
◽  
Toby Pillinger ◽  
John A H Wass ◽  
◽  
...  
Keyword(s):  
Steroid Treatment ◽  
Adrenal Crisis ◽  
Adrenal Failure ◽  
Important Condition ◽  
Initial Management ◽  
Medical Unit ◽  
Acute Medical Unit ◽  
Acute Adrenal Failure ◽  
Key Aspects

Acute adrenal crisis is an important condition to consider in any shocked patient presenting to the acute medical unit. This article aims to highlight the key aspects of initial management, focussing on the importance of rapid recognition and prompt initiation of steroid treatment.

The Role of Shared Decision-Making in Audiologic Rehabilitation

2014 ◽  
Vol 21 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Helen Pryce ◽  
Amanda Hall
Keyword(s):  
Decision Making ◽  
Shared Decision Making ◽  
Behavior Changes ◽  
Shared Decision ◽  
Patient Centered ◽  
Treatment Information ◽  
Centered Care ◽  
Potential Risks ◽  
Audiologic Rehabilitation

Shared decision-making (SDM), a component of patient-centered care, is the process in which the clinician and patient both participate in decision-making about treatment; information is shared between the parties and both agree with the decision. Shared decision-making is appropriate for health care conditions in which there is more than one evidence-based treatment or management option that have different benefits and risks. The patient's involvement ensures that the decisions regarding treatment are sensitive to the patient's values and preferences. Audiologic rehabilitation requires substantial behavior changes on the part of patients and includes benefits to their communication as well as compromises and potential risks. This article identifies the importance of shared decision-making in audiologic rehabilitation and the changes required to implement it effectively.

The potential role of tea in periodontal therapy: An updated review

2020 ◽  
Vol 17 ◽  
Author(s):  
Ali Forouzanfar ◽  
Hamideh Sadat Mohammadipour ◽  
Fatemeh Forouzanfar
Keyword(s):  
Green Tea ◽  
Potential Role ◽  
Wide Spectrum ◽  
Periodontal Diseases ◽  
Herbal Remedies ◽  
World Population ◽  
Tea Leaves ◽  
The World ◽  
Green Tea Leaves

: Periodontal diseases are highly prevalent and can affect high percentage of the world population. Oxidative stress and inflammation plays an important role in the pathogenesis of periodontal diseases. Nowadays, more attention has been focused on the herbal remedies in the field of drug discovery. Green tea is an important source of polyphenol antioxidants, it has long been used as a beverage worldwide. The most interesting polyphenol components of green tea leaves that are related with health benefits are the catechins. Taken together this review suggested that green tea with its wide spectrum of activities could be a healthy alternative for controlling the damaging reactions seen in periodontal diseases.

Cholesterol and its Ayurvedic Complement – Depicting its role in Pathogenesis as well as Management of Diabetes

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Divya Kajaria
Keyword(s):  
Treatment Modality ◽  
Review Article ◽  
Therapeutic Interventions ◽  
Herbal Remedies ◽  
Natural Properties ◽  
Lipid Balance ◽  
Vast Area

Role of cholesterol in the pathogenesis of diabetes is the emergent are of research with full of potential; it not only open a vast area of therapeutic interventions but also can change the prevailing treatment modality. Ayurveda, the Indian system of medicine materialize the concept of lipocenteric approach for the management of diabetes even thousands of years back. According to Ayurveda, the natural properties of lipid are deranged that causes diabetes. It may prove beneficial to quest the search of herbal remedies that can harmonize the lipid balance and uproot the pathogenesis. In the presenting review article, role of cholesterol in the pathogenesis of diabetes is discussed along with detailed description of Ayurvedic concepts regarding pathogenesis and a brief description of herbal management.

scholarly journals Shedding light on autistic traits in struggling learners: A blind spot in medical education

2021 ◽  
Author(s):  
Marie Giroux ◽  
Luce Pélissier-Simard
Keyword(s):  
Medical Education ◽  
Autistic Traits ◽  
Blind Spot ◽  
Autism Spectrum ◽  
Struggling Learners ◽  
Accountability Standards ◽  
Broader Phenotype ◽  
Potential Risks ◽  
Medical Competence

AbstractSome highly challenging, seemingly “unsolvable” situations that arise in medical education could be the result of autistic traits (AT) in learners. AT exist in physicians and learners, ranging from profiles compatible with DSM-5’s criteria for autism spectrum disorder (ASD) to more subtle manifestations of ASD’s “broader phenotype.” Often associated with strengths and talents, AT may nonetheless pose significant challenges for learning, teaching, and practising medicine. Since AT remain widely under-recognized and misunderstood by educators, clinicians, and affected individuals alike, they represent a blind spot in medical education. The use of a “neurodiversity lens” to examine challenging situations may help educators consider different pedagogical approaches to address those potentially stemming from AT.This paper aims to raise awareness and understanding of AT-related difficulties in struggling medical learners. To overcome the blind spot challenge and help develop this “neurodiversity lens,” we explore different angles. Beyond any diagnostic consideration, we offer a series of contextual examples, paralleled with explanatory concepts from the field of ASD. We also underline the role of context on functional impact and describe the often ill-defined pattern of challenges encountered, as well as the fertile grounds for interpersonal misunderstandings and disrespect. We propose historical, cultural, and clinical reasons likely contributing to the blind spot. Mindful of the potential risks of prejudice associated with identifying AT-related difficulties, we underline the necessity and feasibility of conciliating diversity and dignity with accountability standards for medical competence.

scholarly journals Primary Adrenal Failure due to Antiphospholipid Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Murat Sahin ◽  
Ayten Oguz ◽  
Dilek Tuzun ◽  
Serife Nur Boysan ◽  
Bülent Mese ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Antiphospholipid Syndrome ◽  
Anticardiolipin Antibody ◽  
Adrenal Crisis ◽  
Adrenal Failure ◽  
Primary Adrenal Insufficiency ◽  
Warfarin Sodium ◽  
Laboratory Examinations ◽  
Case Presentations ◽  
Antibody Levels

Background. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure.Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness. In laboratory examinations, hyponatremia (135 mmol/L), hyperpotassemia (6 mmol/L), and thrombocytopenia (83 K/µL) were determined. Cortisol (1.91 µg/dL) and adrenocorticotropic (550 pg/mL) hormone levels were also evaluated. The patient was hospitalized with a diagnosis of acute adrenal crisis due to primary adrenal insufficiency. A Doppler ultrasound revealed venous thrombosis. The patient was diagnosed with antiphospholipid syndrome after the detection of venous thrombosis, thrombocytopenia, elevated aPTT, and anticardiolipin antibody levels. Anticoagulation treatment was started for antiphospholipid syndrome. The patient is now following up with hydrocortisone, fludrocortisone, and warfarin sodium.Conclusion. Antiphospholipid syndrome is a rare reason for adrenal failure. Antiphospholipid syndrome should be suspected if patients have morbidity secondary to venous-arterial thrombosis.

scholarly journals The impact of COVID-19 “infodemic” on drug-utilization behaviors: implication for Pharmacovigilance

2020 ◽  
Author(s):  
Marco Tuccori ◽  
Irma Convertino ◽  
Sara Ferraro ◽  
Emiliano Cappello ◽  
Giulia Valdiserra ◽  
...  
Keyword(s):  
Social Media ◽  
Emergency Management ◽  
Opinion Leaders ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonists ◽  
The World ◽  
Potential Risks ◽  
The Impact ◽  
Hazardous Use

The COVID-19 pandemic that hit the world in 2020 triggered a massive dissemination of information (“infodemic”) about the disease channeled through the web and social media. This “infodemic” included also sensational and distorted information about drugs, which likely affected primarily opinion leaders and people particularly active on social media, and subsequently other peoples leading to inadequate choices by individual patients everywhere. In particular, for some drugs approved with other indications, namely chloroquine, hydroxychloroquine, NSAIDs, ACE inhibitors, angiotensin II receptor antagonists, favipiravir and umifenovir, information has spread that has led to a hazardous use. In this article, we analyzed the rationale behind the claim for use of these drugs in COVID-19, the communication about their effect on the disease, the consequences of this communication on people's behavior and the response of some influential regulatory authorities in an attempt to minimize the actual or potential risks arising from this behavior. Finally, we discussed the role of pharmacovigilance stakeholders in emergency management and possible strategies to be put in place to deal with other similar situations in the future.

scholarly journals Specification and DNA Barcoding of Thai Traditional Remedy for Chronic Kidney Disease: Pikad Tri-phol-sa-mut-than

Plants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2023
Author(s):  
Suwimol Thariwong ◽  
Aekkhaluck Intharuksa ◽  
Panee Sirisa-ard ◽  
Wannaree Charoensup ◽  
Sunee Chansakaow
Keyword(s):  
Dna Barcoding ◽  
Herbal Remedy ◽  
Raw Materials ◽  
Dna Barcode ◽  
Raw Material ◽  
Morinda Citrifolia ◽  
Herbal Remedies ◽  
Scientific Database ◽  
Kidney Deficiency ◽  
Fruit Species

The Pikad Tri-phol-sa-mut-than (TS) remedy, a Thai traditional medicine, is officially recorded in Tamra Paetsart Sonkrau Chabub Anurak for its capabilities in treating kidney deficiency. TS remedy is composed of three fruit species—Aegle marmelos (L.) Corrêa., Coriandrum sativum L., and Morinda citrifolia L.—in an equal part by weight. The quality of the raw material is one of the essential factors that can affect the effectiveness and safety of treatment by herbal remedy. The pharmacognostic evaluation and DNA barcode of the three fruit species and TS remedy were performed in this study to authenticate them from contamination, and to provide the scientific database for further uses. Macroscopic and microscopic examination, chemical profile by TLC, and DNA barcoding were employed to positively identify the raw materials bought from the herbal market, especially the powder form. Consequently, the outcomes of this investigation can be used to develop an essential and effective tool for the authentication of crude drugs and herbal remedies.

scholarly journals Surgery and Medicinal Plants: A review of important indigenous medicinal plants of Iran for burn wound healing

2019 ◽  
Vol 6 (2) ◽  
pp. 264-269
Author(s):  
Masoud Sharifian ◽  
Afshin Hasanvand ◽  
Gholam Basati ◽  
Saber Abbaszadeh
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Herbal Remedy ◽  
Medical Science ◽  
Aloe Vera ◽  
Centella Asiatica ◽  
Recovery Process ◽  
Herbal Remedies ◽  
Burn Wound ◽  
Burn Wounds

Surgical Science is one of the branches of medical science that deals with surgical and medicinal interventions, which can cure surgical wounds, cuts, burns and so on. The accelerated recovery process has always been a concern for surgeons and physicians. Standard local antibiotic drugs such as silver nitrate, mafenide acetate, sulfadiazine silver and AgNO3 are also used to treat wounds which are associated with some complications. Considering the fact that no effective herbal remedy has been introduced for wound healing, the purpose of this review is to investigate and identify indigenous Iranian herbs used for wound healing after surgery, especially burn wounds. In this systematic review paper, published articles in the period 1952 to 2017 with keywords of surgery, wound healing, burns, herbs, etc. from databases such as SID, MEDLIB, ProQuest, Magiran, Europe PubMed Central and Google Scholar. Abstract and title of all articles were studied and non-relevant articles were deleted and remaining articles were used for review. Based on the results of the study, Malva sylvestris, Camellia sinensis, Aloe vera, Cydonia oblonga, Scrophularia striata, Centella asiatica, Arnebia euchroma, Calendula officinalis and Hypericum perforatum are the most important herbal remedies for burn restoration. The following is an explanation of the most important herbal remedies for native burn wounds in Iran.

Recommendations for Developmental Monitoring: The Role of Surveillance

PEDIATRICS ◽  
1990 ◽  
Vol 85 (6) ◽  
pp. 1127-1128
Author(s):  
ROBERT D. CUNNINGHAM
Keyword(s):  
Mental Retardation ◽  
Acute Illness ◽  
Overwhelming Majority ◽  
Mild Mental Retardation ◽  
Cognitive Demands ◽  
The Past ◽  
Well Child Visit ◽  
Child Visit

To the Editor.— Dr Dworkin raises many good points in his review, "British and American Recommendations for Developmental Monitoring: The Role of Surveillance." However, I am skeptical that the concept of "surveillance" is actually different from what physicians have practiced in the past. Dr Dworkin acknowledges "that mild mental retardation is not typically identified until the child is confronted with the cognitive demands of school...," especially when physicians rely on subjective impressions. With the concept of "surveillance," "eyeball" estimates will continue to be made of a child's development; and with each well-child visit and frequently each acute illness visit being of relatively brief duration, I strongly suspect that the overwhelming majority of mildly retarded children will continue to elude detection.

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