scholarly journals Specification and DNA Barcoding of Thai Traditional Remedy for Chronic Kidney Disease: Pikad Tri-phol-sa-mut-than

Plants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2023
Author(s):  
Suwimol Thariwong ◽  
Aekkhaluck Intharuksa ◽  
Panee Sirisa-ard ◽  
Wannaree Charoensup ◽  
Sunee Chansakaow
Keyword(s):  
Dna Barcoding ◽  
Herbal Remedy ◽  
Raw Materials ◽  
Dna Barcode ◽  
Raw Material ◽  
Morinda Citrifolia ◽  
Herbal Remedies ◽  
Scientific Database ◽  
Kidney Deficiency ◽  
Fruit Species

The Pikad Tri-phol-sa-mut-than (TS) remedy, a Thai traditional medicine, is officially recorded in Tamra Paetsart Sonkrau Chabub Anurak for its capabilities in treating kidney deficiency. TS remedy is composed of three fruit species—Aegle marmelos (L.) Corrêa., Coriandrum sativum L., and Morinda citrifolia L.—in an equal part by weight. The quality of the raw material is one of the essential factors that can affect the effectiveness and safety of treatment by herbal remedy. The pharmacognostic evaluation and DNA barcode of the three fruit species and TS remedy were performed in this study to authenticate them from contamination, and to provide the scientific database for further uses. Macroscopic and microscopic examination, chemical profile by TLC, and DNA barcoding were employed to positively identify the raw materials bought from the herbal market, especially the powder form. Consequently, the outcomes of this investigation can be used to develop an essential and effective tool for the authentication of crude drugs and herbal remedies.

scholarly journals Single-Laboratory Validation of a Two-Tiered DNA Barcoding Method for Raw Botanical Identification

2019 ◽  
Vol 102 (5) ◽  
pp. 1435-1447 ◽  
Author(s):  
Zhengfei Lu ◽  
Christopher M Thompson ◽  
Tiffany Chua ◽  
Silva Babajanian ◽  
Yanjun Zhang ◽  
...  
Keyword(s):  
Dna Barcoding ◽  
Raw Materials ◽  
Dna Barcode ◽  
Sampling Technique ◽  
Regulatory Compliance ◽  
Raw Material ◽  
Animal Products ◽  
Policy Makers ◽  
Plant Parts ◽  
Wide Range

Abstract Background: The applications of deoxyribonucleic acid (DNA) barcoding methods have been extended from authenticating taxonomic provenance of animal products to identifying botanicals used as herbal medicine and in botanical dietary supplements. DNA barcoding methods for botanical identification must be adequately validated to meet regulatory compliance. Objective: The goal of this study is to provide a validation protocol for a two-tiered DNA barcoding method that aims to identify raw botanicals. Methods: A barcode database was computationally validated to define the barcode combinations that can unambiguously identify botanicals in the database. A maximum variation sampling technique was used to capture a wide range of perspectives relating to DNA barcode-based botanical identification, including plant parts and species distance, for the experimental validation. Twenty-two authenticated botanicals were purposively sampled from different plant parts—covering both closely related and distantly related species—to validate the two-tiered DNA barcoding method. The performance of the method was assessed on accuracy, precision, ruggedness, and uncertainty. Results: High accuracy (100%) and precision (1.0) were obtained from the validation samples. The method was also found to be rugged and have acceptable uncertainty. Conclusions: The method was validated and suitable for DNA-based identification of botanical raw materials listed in the current database. Highlights: This work will provide support guidance for manufacturers and regulatory policy makers to implement equivalent validated and compliant DNA-based testing in quality control processes to improve botanical raw material identification and authentication.

scholarly journals Manufacturing process of high quality phytopreparation on example of herbal sedative

2013 ◽  
Vol 66 (3-4) ◽  
pp. 170-176
Author(s):  
Sofija Djordjevic ◽  
Aleksandra Dickov ◽  
Sava Pavkov ◽  
Vanja Tadic ◽  
Ivana Arsic ◽  
...  
Keyword(s):  
Quality Control ◽  
Production Process ◽  
Manufacturing Process ◽  
Herbal Remedy ◽  
Raw Materials ◽  
Good Manufacturing Practice ◽  
Valeric Acid ◽  
Herbal Remedies ◽  
Modern Concept ◽  
High Quality

Introduction. Rational phytotherapy is a modern concept of using plant-originated drugs which has emerged from the need to improve phytotherapy in order to make the use of herbal remedies more efficient and safer. The aim of this study was to give the health-care workers more information on the manufacturing process of high quality phytopreparation following principles of Good Manufacturing Practice and Good Laboratory Practice on the example of herbal sedative, Odoval S? capsules. Material and Methods. This study was designed to reflect the production process of a high-quality and safe herbal remedy, starting from defining the formulation and the production procedure to the quality control of raw materials, characterization of the final product, and testing stability of active ingredients in the capsules. Results. Formulation of the phytopreparation, validation of the production process, quality control and stability testing, all together have resulted in the production of capsules with defined valeric acid content (1 mg valeric acid per capsule). Discussion. The preparation is recommended to relieve the symptoms caused by chronic stress (anxiety, irritability, fatigue, lack of concentration, heart palpitations) and for mild insomnia. Conclusion. This paper presents the complete cycle of the production of a phytopreparation on the example of a new herbal sedative - Odoval S? capsules.

scholarly journals PROSPECTS OF STUDYING OF VOLATILE OILS OF TANACETUM PARTHENIUM (L.) SCHULTZ BIP. FOR ISSUES IN CHEMOSYSTEMATICS OF TANACETUM GENUS

2020 ◽  
pp. 102-107
Author(s):  
Karyna Hordiei ◽  
Tetiana Gontova ◽  
Valentina Gaponenko
Keyword(s):  
Herbal Remedy ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Volatile Oil ◽  
Component Composition ◽  
Biologically Active ◽  
Raw Material ◽  
Gas Chromatography Mass Spectrometry ◽  
Comparative Characteristic ◽  
Anti Inflammatory

The search for new sources of biologically active substances is an actual issue of pharmaceutical science. Feverfew is a prospective member of the Tanacetum genus. Recently an interest to this plant has grown. Sesquiterpene lactones and phenolic compounds are known to be cause its anti-inflammatory and antimigraine activity. The study of volatile compounds and chemosystematics of the feverfew in this group of BAS has not been conducted before. The aim of the research was to obtain the volatile oil from the feverfew herb, studying of the component composition, an identification of compounds, that can be used for chemosystematics of the genus and establishing of the pharmacological activity according to the chemical content of volatile oil. Materials and methods. The object of research was the samples of the feverfew herb grown and collected in the period of its mass flowering. The volatile oil obtained by steam distillation from the feverfew herb was studied using gas chromatography–mass spectrometry. Results. The comparative characteristic of the representatives of the genus Tanacetum according to chemosystematic features was carried out. As a result of the research of the volatile oil 44 compounds were found, from which 40 were identified. According to the research, the raw material contained 34.71 % of camphor, this is a typical feature of all species of the genus Tanacetum. Fenchyl acetate was identified in a high enough content – 7,44 % in the domestic raw material, but this compound was not identified in the foreign samples. Chrysanthenyl acetate is accumulated in representatives of the genus Tanacetum in the form of a cis or trans isomer. In our study, the content of trans-chrysanthene acetate was 23.30 %. In the domestic raw materials, monoterpenes – α- and β- thujone – were not identified, which are associated with the toxicity of the raw material. Conclusions. In the volatile oil 44 compounds were found, from which 40 were identified. Monoterpenes prevailed among terpenes, namely camphor, trans-chrysanthenyl acetate and fenchyl acetate, which are typical and can be used for chemosystematic issues of the genus Tanacetum. The identified compounds require anti-inflammatory, antiseptic, antispasmodic, analgesic activities of the volatile oil, therefore creation of the medicinal herbal remedy based on the volatile oil of the feverfew herb is prospective.

scholarly journals DNA Barcoding for Industrial Quality Assurance

Planta Medica ◽  
2017 ◽  
Vol 83 (14/15) ◽  
pp. 1117-1129 ◽  
Author(s):  
Tiziana Sgamma ◽  
Claire Lockie-Williams ◽  
Marco Kreuzer ◽  
Sarah Williams ◽  
Ulrike Scheyhing ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Dna Barcoding ◽  
High Throughput Screening ◽  
Raw Materials ◽  
Dna Barcode ◽  
Positive Control ◽  
Herbal Drug ◽  
High Resolution Melt ◽  
Plant Materials

AbstractDNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these methods by industry will be accelerated by the introduction of DNA-based identification techniques into regulatory standards and monographs. The introduction of DNA methods into the British Pharmacopoeia is described, along with a reference standard for use as a positive control for DNA extraction and polymerase chain reaction (PCR). A general troubleshooting chart is provided to guide the user through the problems that may be encountered during this process. Nevertheless, the nature of the plant materials and the demands of industrial quality control procedures mean that conventional DNA barcoding is not the method of choice for industrial quality control. The design of DNA barcode-targeted quantitative PCR and high resolution melt curve tests is one strategy for developing rapid, robust, and reliable protocols for high-throughput screening of raw materials. The development of authentication tests for wild-harvested Rhodiola rosea L. is used as a case study to exemplify these relatively simple tests. By way of contrast, the application of next-generation sequencing to create a complete profile of all the biological entities in a mixed herbal drug is described and its potential for industrial quality assurance discussed.

scholarly journals DETERMINATION OF OPTIMAL EXTRACTION CONDITIONS OF PHENOLIC COMPOUNDS FROM ACORUS CALAMUS LEAVES

2020 ◽  
Vol 3 ◽  
pp. 63-70
Author(s):  
Maksym Yaremenko ◽  
Tetiana Gontova ◽  
Liudmyla Boryak ◽  
Olga Mala ◽  
Oleksiy Andryushayev
Keyword(s):  
Phenolic Compounds ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Extraction Time ◽  
Herbal Remedies ◽  
Acorus Calamus ◽  
Technological Parameters ◽  
Active Substances

From the beginning of its existence and until now, interest in herbal remedies has only grown. Not surprisingly, medicinal herbs are a source of unique combinations of biologically active components that are capable of exhibiting significant pharmacological effects. One of these medicinal plants is Acorus calamus (sweet flag), whose rhizomes have long been used in official and folk medicine, cooking and cosmetology. However, recent studies point to the considerable potential of the aerial part of Acorus calamus as a novel herbal remedy, which is associated with the presence in the leaf of the plant, in addition to essential oil, a considerable amount of substances of phenolic nature. The aim of the research was to determine the optimal conditions for the removal of phenolic compounds from the leaves of Acorus calamus and to determine the technological parameters of raw materials. Materials and methods. During the research, samples of raw materials collected on the territory of Kharkiv region were used, as well as methods that are given in the State Pharmacopoeia of Ukraine. Result. As a result of the research, the extraction conditions at which there was highest content of the extraction of biologically active substances were determined. The extractant, the degree of grinding of the raw material and the optimum extraction time were selected, which allowed to extract almost 80 % of the quantitative content of flavonoids from the raw material. The main technological parameters of Acorus calamus leaves were also determined. The obtained results will be the basis for the development of the technology of obtaining phyto-substance from the leaves of Acorus calamus. Conclusions. The selection of optimal extraction conditions of biologically active compounds from Acorus calamus leaves was carried out. The obtained results show that in order to obtain extracts with the maximum content of biologically active substances (flavonoids), it is advisable to use raw materials with a particle size of 0.5 to 1.0 mm, as an extractant 70 % alcohol and an extraction time of 4 hours.

RHEOLOGICAL PROPERTIES OF CERAMIC MASSES: IMPROVEMENT BY COMPLEX MATERIAL ACTIVATION

2019 ◽  
Vol 16 (3) ◽  
pp. 334-351
Author(s):  
A. S. Mavlyanov ◽  
E. K. Sardarbekova
Keyword(s):  
Rheological Properties ◽  
Raw Materials ◽  
Sensitivity Coefficient ◽  
Raw Material ◽  
Clay Material ◽  
Fibrous Materials ◽  
Chemical Production ◽  
Production Wastes ◽  
Pass Through ◽  
The Masses

Introduction. The objective of the research is to study the effect of the complex activation of the alumina raw material on the rheological properties of the ceramic mass. In addition, the authors investigate solutions for the application of optimal coagulation structures based on loams and ash together with plastic certificates.Materials and methods. The authors used the local forest like reserves of clay loams at the BashKarasu, ash fields of the Bishkek Central Heating Centre (BTEC) and plasticizer (sodium naphthenate obtained from alkaline chemical production wastes) as fibrous materials. Moreover, the authors defined technological properties of raw materials within standard laboratory methodology in accordance with current GOSTs.Results. The researchers tested plastic durability on variously prepared masses for the choice of optimal structures. The paper demonstrated the plastic durability of complexly activated compounds comparing with non-activated and mechanically activated compounds. The sensitivity coefficient increased the amount of clay loams by mechanically and complexly activated, which predetermined the possibility of intensifying the process of drying samples based on complexly activated masses.Discussion and conclusions. However, mechanical activation of clay material reduces the period of relaxation and increases the elasticity coefficient of ceramic masses by 1.8–3.4 times, meanwhile decreases elasticity, viscosity and the conventional power during molding, which generally worsens the molding properties of the masses. Сomplex activation of ash-clay material decreases the period of relaxation and provides an increase in elasticity, plasticity of ceramic masses by 46–47%, reduction in viscosity by 1.5–2 times, conventional power on molding by 37–122% in comparison with MA clay loams. Ceramic masses based on spacecraft alumina raw materials belong to the SMT with improved rheological properties; products based on them pass through the mouthpiece for 5–7 seconds.

ANALYSIS FOR POTENCY AND PRODUCTION OF GRANULE ORGANIC FERTILIZER BASED ON MANURE

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Firman L. Sahwan
Keyword(s):  
Organic Material ◽  
Organic Materials ◽  
Raw Materials ◽  
Organic Fertilizer ◽  
Raw Material ◽  
Cow Manure ◽  
Production Potential ◽  
Natural Organic Material ◽  
Very High

Organic materials that are generally used as raw material for organic fertilizer granules (POG) is a natural organic material that has been degrade, smooth and dry. One of the main raw materials are always used with a very high percentage of usage, is manure. Manure potential in Indonesia is very high, amounting to 113.6 million tons per year, or 64.7 million tons per year to the island of Java. From this amount, it will be generated numbers POG production potential of 17.5 million tons per year (total Indonesia) or 9.9 million tons per year for the island of Java. While the realistic POG production predictions figures made from raw manure is 2.5 million tons annually, a figure that has been unable to meet the number requirement of POG greater than 4 million tons per year. Therefore, in producing POG, it should be to maximize the using of the potential of other organic materials so that the use of manure can be saved. With the use of a small amount of manure (maximum 30% for cow manure), it would be useful also to avoid the production of POG with high Fe content.keywods: organic material, manure, granule organic fertilizer

Nutritional Value Research of Spelt Pasta with Vegetable Additives

Food Industry ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 61-70
Author(s):  
Oliya Fazullina ◽  
Stanislav Smirnov
Keyword(s):  
Dietary Fiber ◽  
Nutritional Value ◽  
Raw Materials ◽  
Health Indicators ◽  
Dietary Treatment ◽  
Raw Material ◽  
Whole Wheat ◽  
Healthy Nutrition ◽  
Physiologically Active Substances ◽  
Simple Carbohydrates

Health indicators of the population depend significantly on the food quality and nutritional value. Simple carbohydrates excess of and lack of protein, dietary fiber, vitamins, minerals, antioxidants and other physiologically active substances increase the risk of socially significant disease progress. The development and production of mass-consumed products with high nutritional and biological value, including affordable non-traditional raw materials use, are promising areas of the food industry development aimed at improving the nutritional status of the population. The article presents the research results on the developed Noodle products recipes from non-traditional raw materials that meet modern healthy nutrition requirements, intended for dietary treatment and dietary prevention of people with overweight / obesity. The research aimed at expanding the range of macaroni products with these characteristics. As the main raw material, a man selected whole-wheat flour – new spelt flour, and as additional raw materials – buckwheat flour, broccoli and celery powders. The researchers found that the introduction of macaroni products from buckwheat spelt, broccoli and celery powders into the recipe had a multidirectional effect, reducing or increasing various indicators of its nutritional value. The changes range did not affect the overall characteristics. The satisfaction degree of the average daily need for food substances and energy when consuming a portion of 100 g for each sample of developed Noodle products allows them to be classified as functional products that are protein and dietary fiber sources, according to the requirements of the TR CU 022/2011.

UNIDO, Industrial Processing of Natural Resources. New York: United Nations. 1981. viii + 78pp.US $ 5.00. [United Nations Publication Sales No. E. 81. 11 . B.1]

1982 ◽  
Vol 21 (4) ◽  
pp. 329-333
Author(s):  
Rashid Aziz
Keyword(s):  
New York ◽  
United Nations ◽  
Industrial Development ◽  
Raw Materials ◽  
Developed Countries ◽  
Raw Material ◽  
Industrial Processing ◽  
Depth Study ◽  
Manufactured Exports ◽  
Year 2000

The book under review is a concise but fairly in-depth study of the prospects for export diversification from the Less Developed Countries (henceforth labeled as LDCs) particularly to Developed Countries (henceforth labeled as OCs). Given the multiple problems faced by the LOCs in exporting to the OCs - protectionist policies with regards to manufactured exports, volatility of prices obtained for raw material exports, etc. - the study analyses the potential for following an intermediate route. The important issues in the export of semi -processed and wholly processed raw materials are discussed. 111ese issues range from the problems and potentials for the location of processing facilities in the LOCs to the formulation of appropriate policies to encourage an export of processed goods rather than raw materials. Such policies will be useful both in solving the balance of-payments problems of the LDCs and in attaining the goal of the Lima Declaration and Plan of Action on Industrial Development and Co-operation, that called for 2S percent of world industrial production to be located in the LOCs by the year 2000.

PENGARUH HARGA DAN PEMAKAIAN PERSEDIAAN BAHAN BAKU TERHADAP VOLUME PRODUKSI PADA PT. KELOLA MINA LAUT DI GRESIK

MANAJERIAL ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 66
Author(s):  
BAYU YRI WIDHARTO
Keyword(s):  
Linear Regression ◽  
Hypothesis Testing ◽  
Multiple Linear Regression ◽  
Raw Materials ◽  
T Test ◽  
Raw Material ◽  
Analysis Tool ◽  
Production Volume ◽  
F Test ◽  
Material Price

The purpose of the research was to know the affect of many factors which affected to the production volume in PT. Kelola Mina Laut Gresik. What the price of raw materials was and the used of raw materials partially and simultan eously affected on the production volume. The analysis tool which used was a model of multiple linear regression. Hypothesis testing used t test and F test, both at the significant level 5%. Based of the analysis of research on PT Kelola Mina Laut Gresik. Partially, inventory raw material price had not significant effect on the production volume, consumption of raw material inventory affected significantly of the production volume. Inventory of raw material price and the use of raw material simultan eously affect significantly to the production volume.

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