Hypercalcaemic encephalopathy as a presenting manifestation of sarcoidosis

2021 ◽  
Vol 14 (9) ◽  
pp. e241246
Author(s):  
Adrija Ray ◽  
Animesh Kar ◽  
Biman Kanti Ray ◽  
Souvik Dubey
Keyword(s):  
Renal Function ◽  
Biochemical Parameters ◽  
Maculopapular Rash ◽  
Pharmacological Therapy ◽  
Granulomatous Disease ◽  
Stepwise Approach ◽  
Hypercalcaemic Crisis

A 66-year-old woman presented to us with features of encephalopathy with asterixis, preceded by unsteadiness of gait and behavioural abnormalities. On subsequent investigations, hypercalcaemic crisis and compromised renal function were noted. Stepwise approach to determine the cause behind hypercalcaemia with compromised renal function revealed underlying granulomatous disease (sarcoidosis). Later, development of maculopapular rash and subsequent biopsy from the lesion confirmed the diagnosis of sarcoidosis. Her clinical and biochemical parameters improved considerably on initiation of conservative pharmacological therapy.

Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in STZ-induced diabetic rats

2016 ◽  
Vol 27 (1) ◽  
Author(s):  
Alok Shiomurti Tripathi ◽  
Papiya Mitra Mazumder ◽  
Anil Vilasrao Chandewar
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Triglyceride Level ◽  
Biochemical Parameters ◽  
Treated Group ◽  
Diabetic Rats ◽  
Treatment Results ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Phosphodiesterase Type

AbstractThe present study evaluates the possible mechanism of sildenafil citrate (SIL) for the attenuation of renal failure in diabetic nephropathic (DN) animals.Diabetic nephropathy was induced by a single dose of streptozotocin (STZ) (60 mg/kg, i.p.) and confirmed by assessing the blood and urine biochemical parameters on the 28th day of its induction. The selected DN animals were treated with glimepiride (0.5 mg/kg, p.o.) and SIL (2.5 mg/kg, p.o.) for a period of 6 weeks. Biochemical parameters in blood and urine were estimated after the 29th and 70th day of the protocol for the estimation of the effect of SIL.There were significant alterations in the blood and urine biochemical parameters in STZ-treated groups which confirmed DN. There was a significant decrease in the triglyceride level in the SIL-only-treated group on the 70th day of the protocol. The histopathology study also suggested that SIL treatment results in the improvement in the podocyte count in DN animals.The present study concludes that SIL improves the renal function by decreasing the triglyceride level and improving the podocyte count in DN animals.

scholarly journals Comparative efficacy of protein creatinine ratio and calcium creatinine ratio in determining organ dysfunction in ante-natal patients with pre-eclampsia

2021 ◽  
Vol 7 (3) ◽  
pp. 28-34
Author(s):  
Dr. Shanti Sah ◽  
◽  
Dr. Shipra Gupta ◽  
Dr. Ruchica Goel ◽  
◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Function ◽  
Liver Function Test ◽  
Biochemical Parameters ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Creatinine Ratio ◽  
Renal Function Test ◽  
Induced Hypertension ◽  
Function Test

Aim: To evaluate the biochemical parameters in determining the severity of pre-eclampsia andcompare the efficacy between protein creatinine ratio and calcium creatinine ratio in determiningorgan dysfunction in ante-natal women with pregnancy-induced hypertension. Material andMethods: 150 cases of pregnancy-induced hypertension admitted in the labour room were studiedin the Department of Obstetrics and Gynaecology, SRMSIMS and were divided into two groups mildand severe pre-eclampsia depending on blood pressure, clinical and biochemical parameters. Variousparameters for renal function and liver function were evaluated along with fundoscopy. Results: Onthe evaluation of various parameters of renal function test and liver function test, a statisticallysignificant p-value was observed with increase in grade of pre-eclampsia. When abnormal organfunctions were compared, it was observed that PCR ≥ 0.3 is associated with 85%, 75.6% and81.25% cases of abnormal fundoscopy, deranged renal function test and deranged liver function testcompared to CCR ≤ 0.04 which was associated with 77%, 78.6% and 65% cases of abnormalfundoscopy, deranged renal function test and deranged liver function test respectively. Conclusion:The degree of derangement among biochemical parameters increases as the disease progresses.Early determination by a single test helps to predict organ involvement and correlates with diseaseseverity.

scholarly journals Biochemical Parameters of Diabetes Ketoacidosis in patients with End-Stage Kidney Disease and Preserved Renal Function

2021 ◽  
Author(s):  
Rodolfo J Galindo ◽  
Francisco J Pasquel ◽  
Priyathama Vellanki ◽  
Cesar Zambrano ◽  
Bonnie Albury ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
University Hospitals ◽  
End Stage Kidney Disease ◽  
Emory University ◽  
End Stage ◽  
The Relationship ◽  
Moderate Renal Failure

Abstract Introduction Differences in biochemical parameters of diabetic ketoacidosis in patients with end-stage kidney disease (ESKD) has not been established. Accordingly, we assessed the relationship between degree of metabolic acidosis and ß -hydroxybutyrate in patients ESKD (eGFR <15 mL/min/1.73 m 2), moderate renal failure (eGFR 15-60) or preserved renal function (eGFR >60). Methods This observational study included adults (18-80 years) with DKA, admitted to Emory University Hospitals between 01/01/2006 to 12/31/2016. DKA and renal stages were confirmed on admission laboratory values. Results Admission bicarbonate levels (13.9±5 vs 13.4±5.3 vs 13.8±4.2 mmol/L, p=0.7), and pH levels (7.2±0.3 vs 7.2±0.2 vs 7.2±0.2, p=0.8) were similar among groups. Patients with ESKD had lower mean ß -hydroxybutyrate (4.3±3.3 vs 5.6±2.9 vs 5.9±2.5 mmol/L, p=0.01), but higher admission glucose (852±340.4 vs 714.6±253.3 mg/dL vs 518±185.7 mg/dL, p <0.01), anion gap (23.4±7.6 vs 23±6.9 vs 19.5±4.7 mmol/L, p <0.01), and osmolality (306±20.6 vs 303.5± vs 293.1±3.1mOsm/kg, p<0.01), compared to patients with moderate renal failure and preserved renal function. The sensitivity of ß-hydroxybutyrate >3 mmol/L for diagnosing DKA by bicarbonate level <15 and <18 mmol/L was 86.9% and 72% in ESKD, 89.3% and 83.7% in moderate renal failure and 96.2% and 88.3% in preserved renal function. In patients with ESKD, the corresponding ß-hydroxybutyrate with bicarbonate levels <10, 10-15, <18 mmol/L were 5.5, 3.9, 3.0 mmol/L, respectively. Conclusions Significant metabolic differences were found among DKA patients with different levels of renal function. In patients with ESKD, a ß-hydroxybutyrate level > 3 mmol/L may assist with confirmation of DKA diagnosis.

Biochemical Parameters, Renal Function, and Outcome of Pregnancy in Kidney Transplant Recipient

2011 ◽  
Vol 43 (7) ◽  
pp. 2579-2583 ◽  
Author(s):  
G. Çelik ◽  
H. Töz ◽  
M. Ertilav ◽  
N. Aşgar ◽  
M. Özkahya ◽  
...  
Keyword(s):  
Renal Function ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Biochemical Parameters ◽  
Kidney Transplant Recipient

scholarly journals Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)—A Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2654
Author(s):  
Gracjan Różański ◽  
Sławomir Kujawski ◽  
Julia L. Newton ◽  
Paweł Zalewski ◽  
Joanna Słomko
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Biochemical Parameters ◽  
Public Health Problem ◽  
Pharmacological Therapy ◽  
Alcoholic Fatty Liver ◽  
Significant Public Health ◽  
Health Promoting ◽  
The Individual

Metabolic-associated fatty liver disease (MAFLD), formerly non-alcoholic fatty liver disease (NAFLD), is characterized by excessive fat accumulation in hepatocytes. It is the most common chronic liver disease worldwide and is a significant public health problem. In the absence of pharmacological therapy, other treatments such as diet, physical activity, or supplementation are sought. Non-pharmacological therapies may include curcumin supplementation, which has been shown to have many health-promoting properties, including antioxidant, anti-inflammatory, and anti-cancer effects. For this reason, we reviewed available databases to analyze publications describing the effect of curcumin supplementation on biochemical parameters in MAFLD. Nine studies (eight RCTs and one CT) based solely on supplementation of patients with curcumin were included in this review. The results from the individual trials were varied and did not allow clear conclusions. Although they suggest that curcumin shows some potential in the treatment of MAFLD, further research is needed.

scholarly journals Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock

2016 ◽  
Vol 62 (3) ◽  
pp. 295-301
Author(s):  
A.V. Maksimenko ◽  
A.V. Vavaeva ◽  
M.A. Zvyagintseva ◽  
A.A. Abramov ◽  
A.A. Timoshin ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Renal Function ◽  
Survival Rate ◽  
Protective Effect ◽  
Chondroitin Sulfate ◽  
Biochemical Parameters ◽  
Protective Action ◽  
Endotoxic Shock ◽  
Endotoxin Shock ◽  
The State

Previously it found that the bienzymatic conjugate superoxide dismutase-chondroitin sulfate, catalase (SOD-CHS-CAT) increased the survival rate of rats with endotoxic shock caused by the administration of lipopolysaccharide (LPS). This effect was observed both in preventive (before LPS) and therapeutic conjugate administration (after the administration of LPS). This study shows that the development of endotoxic shock is accompanied by increased levels of NO in the liver, lungs, kidneys, heart; administration of the SOD-CHS-CAT conjugate insignificantly influenced this parameter. At the same time, the changes in blood urea and creatinine suggest the protective effect of the conjugate on renal function, while diverse changes in biochemical parameters studied complicate the formation of the agreed conclusions on the state of other organs.

scholarly journals A Descriptive Study of Colorectal Cancer in Hiwa Cancer Hospital, Sulaymaniyah, Iraq

2017 ◽  
Vol 5 (3) ◽  
pp. 244
Author(s):  
Kochar I Mahmood ◽  
Kadhim F. Namiq ◽  
Chovin A. Muhamad ◽  
Begard O. Muhamad ◽  
Kurdistan M. Majed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Renal Function ◽  
Liver Function ◽  
Blood Cells ◽  
Biochemical Parameters ◽  
Impaired Renal Function ◽  
White Blood Cells ◽  
P Value ◽  
Demographic Parameters ◽  
Cancer Hospital

Colorectal cancer is the third most common cancer and the fourth leading cause of death from cancer worldwide. This study provides an overview of changes in sociod-demographic parameters in patients with colorectal cancer (henceforth CRC) disease in a local cancer hospital in Sulaymaniyah province of Kurdistan region of Iraq. The study included 113 patients admitted to Hiwa Cancer Hospital, Sulaymaniyah from January 2014 to December 2015. The data collection lasted for 3 weeks (from 19/12/2015 to 11/01/2016) and was obtained from the management department of Hiwa Cancer Hospital. Several socio-demographic parameters including age, gender, and smoking, as well as biochemical parameters such as liver function, renal function and blood glucose level were studied and statistically analyzed. Results have shown that the majority of CRC patients were neither current smoker nor x-smoker (P-value < 0.05). Males suffered from CRC at an earlier age compared to females (P-value < 0.05). Regarding the biochemical tests, there was no significant correlation between CRC and impaired liver function during the diagnosis process and most of the study patients had a normal liver function test on presentation. In contrast, the correlation between CRC and impaired renal function on presentation was statistically siginificant (P-value < 0.05). No significant difference was noted in the means of hematological and biochemical parameters between males and females, except for white blood cells and serum Aspartate Aminotransferase. White blood cells and total serum bilirubin showed significant differences (P-value < 0.05) between smoker and nonsmoker sub-populations. It was concluded that CRC is one of the common cancers in Sulaymaniyah province. Males develop it at an earlier age compared to females, and the impaired renal function is a significant finding on presentation.

scholarly journals Ozone Therapy on Rats Submitted to Subtotal Nephrectomy: Role of Antioxidant System

2005 ◽  
Vol 2005 (4) ◽  
pp. 221-227 ◽  
Author(s):  
José Luis Calunga ◽  
Zullyt B. Zamora ◽  
Aluet Borrego ◽  
Sarahí del Río ◽  
Ernesto Barber ◽  
...  
Keyword(s):  
Renal Function ◽  
Biochemical Parameters ◽  
Sham Group ◽  
Positive Control ◽  
Positive Control Group ◽  
Oxygen Mixture ◽  
Control Group ◽  
Urine Excretion ◽  
Ozone Therapy ◽  
Subtotal Nephrectomy

Chronic renal failure (CRF) represents a world health problem. Ozone increases the endogenous antioxidant defense system, preserving the cell redox state. The aim of this study is to evaluate the effect of ozone/oxygen mixture in the renal function, morphology, and biochemical parameters, in an experimental model of CRF (subtotal nephrectomy). Ozone/oxygen mixture was applied daily, by rectal insufflation (0.5mg/kg) for 15 sessions after the nephrectomy. Renal function was evaluated, as well as different biochemical parameters, at the beginning and at the end of the study (10 weeks). Renal plasmatic flow (RPF), glomerular filtration rate (GFR), the urine excretion index, and the sodium and potassium excretions (as a measurement of tubular function) in the ozone group were similar to those in Sham group. Nevertheless, nephrectomized rats without ozone (positive control group) showed the lowest RPF, GFR, and urine excretion figures, as well as tubular function. Animals treated with ozone showed systolic arterial pressure (SAP) figures lower than those in the positive control group, but higher values compared to Sham group. Serum creatinine values and protein excretion in 24 hours in the ozone group were decreased compared with nephrectomized rats, but were still higher than normal values. Histological study demonstrated that animals treated with ozone showed less number of lesions in comparison with nephrectomized rats. Thiobarbituric acid reactive substances were significantly increased in nephrectomized and ozone-treated nephrectomized rats in comparison with Sham group. In the positive control group, superoxide dismutase (SOD) and catalase (CAT) showed the lowest figures in comparison with the other groups. However, ozone/oxygen mixture induced a significant stimulation in the enzymatic activity of CAT, SOD, and glutathione peroxidase, as well as reduced glutathione in relation with Sham and positive control groups. In this animal model of CRF, ozone rectal administrations produced a delay in the advance of the disease, protecting the kidneys against vascular, hemorheological, and oxidative mechanisms. This behavior suggests ozone therapy has a protective effect on renal tissue by downregulation of the oxidative stress shown in CRF.

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