Population-based cohort of 500 patients with Gaucher disease in Israel

ObjectiveTo characterise a population-based cohort of patients with Gaucher disease (GD) in Israel relative to the general population and describe sociodemographic and clinical differences by disease severity (ie, enzyme replacement therapy [ERT] use).DesignA cross-sectional study was conducted.SettingData from the Clalit Health Services electronic health record (EHR) database were used.ParticipantsThe study population included all patients in the Clalit EHR database identified as having GD as of 30 June 2014.ResultsA total of 500 patients with GD were identified and assessed. The majority were ≥18 years of age (90.6%), female (54.0%), Jewish (93.6%) and 34.8% had high socioeconomic status, compared with 19.0% in the general Clalit population. Over half of patients with GD with available data (51.0%) were overweight/obese and 63.5% had a Charlson Comorbidity Index ≥1, compared with 46.6% and 30.4%, respectively, in the general Clalit population. The majority of patients with GD had a history of anaemia (69.6%) or thrombocytopaenia (62.0%), 40.4% had a history of bone events and 22.2% had a history of cancer. Overall, 41.2% had received ERT.ConclusionsEstablishing a population-based cohort of patients with GD is essential to understanding disease progression and management. In this study, we highlight the need for physicians to monitor patients with GD regardless of their ERT status.

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PREVALENCE OF HYPERTENSION IN ADULT POPULATION OF HAYATABAD PESHAWAR

Journal of Saidu Medical College, Swat ◽

10.52206/jsmc.2015.5.1.644-647 ◽

1969 ◽

Vol 5 (1) ◽

pp. 644-647

Author(s):

SARA GUL ◽

ATIF HUSSAIN ◽

KASHIF UR REHMAN KHALIL ◽

IMRANULLAH ◽

MUHAMMAD ISHTIAQ ◽

...

Keyword(s):

Communicable Disease ◽

Adult Population ◽

Positive Association ◽

Developed Countries ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Study Results ◽

History Of ◽

Study Population

BACKGROUND: Hypertension is one of the common non communicable disease and is reported to beprevalent in 20% to 50% of the adult population, hypertension is one of the major contributor ofmortality and morbidity in developing and developed countries. The cross-sectional descriptive studywas formulated to find the prevalence and to assess different etiological factors of hypertension.MATERIAL & METHODS: This cross-sectional study among 400 adults of age 25-75 years wasconducted in months of June to December 2014 in Phase 5, Hayatabad Peshawar. A detailed structuredproforma having important questions was used to collect important data regarding various variables.RESULTS: Our study results showed that 22.75% of the study people were hypertensive i.e. 10.25% ofmales and 12.5% of females; and the prevalence of hypertension showed positive association withadvancing age. Out of all respondents; 60.25% were males while 39.75% were females; 28.5% weresmokers; 5.25% consume predominantly meat; 32.5% were obese & overweight; 36.75% checked theirB.P regularly; and 19.75% had positive history of hypertension in family.CONCLUSION: We conclude that hypertension prevalence was high among our study population andwas associated with various modifiable and non modifiable risk factors thus population based preventivestrategies are needed to control and prevent hypertension.KEY WORDS: Hypertension, Age, Diet, Smokers, Hayatabad, Peshawar.

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PREVALENCE OF TYPE 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH SOCIOECONOMIC STATUS IN KANDAHAR CITY: A CROSS-SECTIONAL STUDY

Malaysian Journal of Public Health Medicine ◽

10.37268/mjphm/vol.21/no.3/art.1101 ◽

2021 ◽

Vol 21 (3) ◽

pp. 26-35

Author(s):

Abdul Wahed Wasiq ◽

Najibullah Fazli ◽

Abdul Nasir Ahadi ◽

Mohammad Zakariya Amirzada ◽

Mohammad Sami Hayat ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Socioeconomic Status ◽

Type 2 Diabetes Mellitus ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Study Population

Diabetes mellitus is a chronic disease with a life long duration and generally of gradual progression. Beside the upward trend in the prevalence rate, diabetes and its complications also have a significant economic impact on countries and their health systems. This study was aimed to assess the prevalence of type 2 diabetes mellitus (T2DM) and its association with socioeconomic status (SES) in the urban population of Kandahar city. A population-based cross-sectional study was conducted from January 2019 to May 2019 in the urban area of Kandahar province. A total of 1308 subjects, 837 (64%) women and 471 (36%) men, were included in the study. Data on sociodemographic characteristics, medical history, dietary intake and physical activity were collected in a standardized questionnaire. Diagnosis of diabetes was established according to the WHO criteria. Mean age (SD) was significantly higher in men than in women (50.3 (14.4) vs. 44.9 (11.4) years). The difference in BMI was not significant between men and women (28.1 vs. 28.7 kg/m2). Majority of the study population was aged 40-54 years (46.3%), married (86.7%), illiterate (87.4%), and obese (39%). 6.6% were tobacco smokers, higher in men (13.6%) than in women (2.6%). The prevalence of diabetes mellitus, hypertension, obesity and central obesity was 15.2%, 25.5%, 39%, and 67.1%, respectively. In this study population, it could be suggested that socioeconomic factors are associated with T2DM and socioeconomic status is worth further investigation nationwide to properly understand the role of SES.

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Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study

10.21203/rs.2.19240/v1 ◽

2019 ◽

Author(s):

Sarah Cuschieri ◽

Julian Mamo

Keyword(s):

Communicable Disease ◽

Population Level ◽

Female Gender ◽

Educational Status ◽

Population Based ◽

Cross Sectional Study ◽

Health Concern ◽

Sectional Study ◽

Cross Sectional ◽

History Of

Abstract Background Depression is an ever more common chronic non communicable disease and its control constitutes a growing public health concern given its links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level across groups of different glycaemic status, whilst establishing its socioeconomic phenotypic characteristics.Methods A nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and socio-economic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression.Results Depression was prevalent in 17.15% (CI 95%: 16.01 – 18.36) with a female predominance. The normoglycaemic sub-population had the highest depression rates. However, persons with known diabetes had a higher probability of having a history of depression (OR:2.36 CI 95%:1.12 – 4.96), as well as with being of the female gender, having lower educational status, having a history of smoking tobacco and having established cardiovascular disease.Conclusions Depression was highly prevalent among the normoglycaemic population especially as age progress. Physicians in primary care should implement a depression screening tool as part of their routine health check-ups, with special attention to those with cardiovascular co-morbidities and any signs of psycho-socio-economic burden.

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A Cross-Sectional Study of Risk Factors for Irritable Bowel Syndrome in Children 8–13 Years of Age in Suzhou, China

Gastroenterology Research and Practice ◽

10.1155/2014/198461 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Xueping Zhu ◽

Weichang Chen ◽

Xiaoli Zhu ◽

Yueping Shen

Keyword(s):

Risk Factors ◽

Significant Risk ◽

Cross Sectional Study ◽

Trend Test ◽

Sectional Study ◽

Cross Sectional ◽

Parental History ◽

History Of ◽

Study Population ◽

Irritable Bowel

To determine the prevalence and risk factors of IBS in children 8–13 years of age in Suzhou city, a cross-sectional study was conducted on children in grades 1 through 6 in public elementary schools in three districts of Suzhou. A multistage stratified random-sampling survey was conducted in a primary investigation using standardized questionnaires. Rome II criteria were used to confirm IBS and their risk factors were analyzed. Of 8,000 questionnaires 7,472 responded satisfactorily for a response rate of 93.4%. IBS was diagnosed in 10.81%. A decrease in the prevalence of IBS was significantly associated with advancing age and grade in school (trend test,P<0.05). The prevalence of IBS in females was higher but not significantly different than males. The significant risk factors for IBS included young age (OR = 0.94), food allergy (OR = 1.53), gastroenteritis during childhood (OR = 1.29), eating fried food (OR = 1.62), anxiety (OR = 1.49), psychological insults in early childhood (OR = 1.47), and parental history of constipation (OR = 1.81; allP<0.05). IBS prevalence of 10.81% in study population warrants preventive measures such as encouraging dietary changes, preventing gastroenteritis and childhood psychological insults.

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The association of acne and menstrual symptoms among young women (18–25 years) in Egypt: a population-based cross-sectional study

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2019-0220 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Ahmed Arafa ◽

Alshimaa Mostafa ◽

Yasser Khamis

Keyword(s):

Young Women ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Multi Stage ◽

Menstrual Symptoms ◽

History Of ◽

The Relationship ◽

Age Of Menarche

AbstractBackgroundAcne and menstrual symptoms are highly prevalent among young women. Since both acne and menstrual symptoms have similar hormonal pathogenesis, it is highly suggested that the two conditions are associated. Herein, we conducted this study to assess the relationship between acne and menstrual symptoms among young women.Subjects and methodsIn this population-based cross-sectional study, a multi-stage random sampling approach was used to include 3065 young women (18–25 years) from Egypt. Women were interviewed for their socio-demographic characteristics, gynecological history, premenstrual and menstrual symptoms, and history of acne and perimenstrual acne flare during the past 6 months.ResultsThe mean age of women was 21.5 ± 2.2 and their age of menarche was 13.1 ± 1.5 years. During the previous 6 months, 44.8% of participants had acne. After adjusting for socio-demographic and gynecological characteristics, acne was associated with most menstrual symptoms with odds ratios (ORs) and 95% confidence intervals (CIs) as follows: [premenstrual symptoms: 1.23 (1.05–1.44) for irritation or nervousness, 1.45 (1.24–1.68) for fatigue, 1.37 (1.15–1.62) for breast tenderness, 1.48 (1.21–1.80) for abdominal bloating, and 1.36 (1.11–1.66) for nausea or vomiting], [menstrual symptoms: 1.63 (1.19–2.23) for dysmenorrhea and 1.24 (1.06–1.45) for dysmenorrhea requiring drugs], and [symptoms severity: 1.44 (1.24–1.68) for missing events and 1.38 (1.16–1.64) for medical consultation]. Of acne patients, 56.7% reported perimenstrual acne flare: 58.5% before menses, 35% during menses, and 6.5% after menses.ConclusionThis study supports the concept that acne is associated with menstrual symptoms. Physicians should consider screening for menstrual symptoms among young women with acne.

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Prevalence and risk factors of hypertension among the bank employees of Western Maharashtra – a cross sectional study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20171361 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1267 ◽

Cited By ~ 2

Author(s):

Tanuja R. Brahmankar ◽

Priya M. Prabhu

Keyword(s):

Risk Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Study Population ◽

Bank Employees ◽

Sedentary Life Style ◽

Socio Demographic Factors ◽

Multistage Sampling

Background: Hypertension, the “silent killer” - is a modern day’s epidemic and is becoming a public health emergency worldwide, especially in the developing countries. Sedentary life-style and stress are important risk factors for hypertension. The job of bank employees is both sedentary in nature and accompanies high levels of mental stress, thereby at a higher risk of developing hypertension. Hence the present study was conducted to study the prevalence and risk factors of hypertension among the bank employees in Western Maharashtra.Methods: A cross-sectional study was conducted during January 2014 to December 2015 to assess the prevalence and risk factors of hypertension among the bank employees in Western Maharashtra. By using multistage sampling method, total 340 bank employees from 40 branches were included in the study after fulfilling the inclusion and exclusion criteria. After all ethical considerations, the data were collected by using pre-designed, pre-tested and semi-structured questionnaire and then analysed using MS Excel, SPSS-22 and Primer of Biostatistics.Results: Overall prevalence of hypertension was 39.7% and that of pre-hypertension was 41.8% among the study population. Socio-demographic factors like age, male gender, family history of hypertension, mode of travel, physical activity, overweight, years of service, intake of coffee and smoking had shown significant association with hypertension.Conclusions: Prevalence of hypertension was found as significantly higher in bank employees than the general population of India. Among the non-hypertensives large part was pre-hypertensives which are also at high risk of developing hypertension in the future.

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A CROSS-SECTIONAL STUDY ON THANDAGAVATHAM (LUMBAR SPONDYLOSIS) TO ASSESS THE LIFESTYLE FACTORS IN PATIENTS

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.1205139 ◽

2021 ◽

Vol 12 (5) ◽

pp. 38-41

Author(s):

K Mahalakshmi ◽

H Vetha Merlin Kumari ◽

H Nalini Sofia ◽

T Lakshmi Kantham ◽

R Meena Kumari

Keyword(s):

Socioeconomic Status ◽

Informed Consent ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

Sectional Study ◽

Cross Sectional ◽

Lumbar Spondylosis ◽

History Of ◽

Study Population

Lumbar Spondylosis in earlier days used to be an ailment of people in their 60s and above. In recent years this trend is changing. Many lifestyle factors are blamed for this transition. Yet the factors are different for each population. In National Institute of Siddha Hospital, Lumbar spondylosis is one of the most common ailments for which patient visits OPD. Hence, A cross-sectional study was carried out to get an idea about which of those factors were common in the Thandagavatham patients visiting this hospital. Aim: To establish the most common lifestyle factors in Thandagavatham patients reporting at Ayothidoss Pandithar hospital OPD, National Institute of Siddha. Materials and methods: All the patients with a known history of Thandagavatham (Lumbar Spondylosis) were screened for this study. After obtaining informed consent, about 200 people were questioned to know about their lifestyle. Data was collected using the pre-designed questionnaire. The frequency for each factor was obtained after feeding the data in MS excel software. Result: Out of 14 factors considered in the study, age, menopause, BMI, socioeconomic status, exercise, history of falls were common among the study population.

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Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study

10.21203/rs.3.rs-33911/v2 ◽

2020 ◽

Author(s):

Beatriz León-Salas ◽

Edurne Zabaleta-del-Olmo ◽

Joan LLobera ◽

Bonaventura Bolíbar-Ribas ◽

Tomas López-Jiménez ◽

...

Keyword(s):

Social Support ◽

Cancer Survivors ◽

Perceived Health ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Multiple Risk Behavior ◽

History Of Cancer

Abstract Objective: To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention.Results: Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8±7 years vs. 58.7±8 years (P<0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9% vs. 3.5%, P<0.001). No differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or social support. Cancer survivors were more likely to have worse self-perceived health (OR 1.82; 95% CI 1.02–2.75), more comorbidities (OR 1.68; 95% CI 1.18–2.39), COPD (OR 2.17; 95% CI 1.25–3.78), and depression (OR 1.65; 95% CI 1.06–2.57). Older age and worse self-perceived health were independent predictors of survivorship in the adjusted analysis.

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Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

10.53350/pjmhs211561299 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1299-1301

Author(s):

A. Malik ◽

S. A H. Kazmi

Keyword(s):

Teaching Hospital ◽

Polycystic Ovarian Syndrome ◽

Acne Vulgaris ◽

Cross Sectional Study ◽

Normal Weight ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Study Population ◽

Ovarian Syndrome

Background: Polycystic syndrome (PCOS) is the most common endocrine disorder in the world affecting 8% of women. The main characters of PCOS are enlarged ovaries, chronic ovulation, menstrual cycles disturbance, androgen overdose, and insulin resistance leading to acne, hirsutism, and reproductive problems. Acne is a quite common dermatological condition in daily practice. Aim: To determine the association of acne vulgaris with polycystic ovarian syndrome in patients visiting the University of Lahore Teaching Hospital. Study design: Descriptive cross-sectional study. Place and duration of study: Dermatology Outpatient Department, University of Lahore Teaching Hospital Lahore from March 2019 to March 2020. Methodology: It was a descriptive cross-sectional study from March 2019 to March 2020 conducted at the Dermatology Out-patient Department, University of Lahore Teaching Hospital. All patients between the ages of 18 and 40, with acne vulgaris were included in the study. After obtaining informed consent, 101 women with acne vulgaris in I-IV (Indian stages), between the ages of 18-40 years, presented in the Department of Dermatology, University of Lahore Teaching Hospital, from March 2019 to March 2020, were selected for the study. Pregnant females, lactating mothers, and women on hormonal treatment (oral contraceptives or injections) were excluded from the study. A history of acne, oligomenorrhea, hirsutism, seborrhea, alopecia, acanthosis nigricans infertility, obesity and amenorrhea were taken. Weight and height were measured to calculate BMI. Data were collected in a special statistically tool and analyzed using SPSS-25. Results: A total of 101 women were examined having acne vulgaris issue. A total of 101 female were assessed and having history of acne vulgaris. Out of this, 33 were 18–23 years old, while 24 (23.4%) have ages 24–28 years. There were 18 (17.8%) patients who have 29–33 years old. while 38–40 years were 10 (9.9%) years old. Irregular menstrualcycle was reported 34.6% of the study population. As Perth WHO criteria, only 17% of the participants had BMI in normal weight range. The proportion of women, who were overweight and obese were 50.4% and 32.6% in the study population. Conclusion: Acne vulgaris has been identified as a serious skin disease found in all age groups. PCOS is more common among women with acne and obesity is a major risk factor for PCOS.

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Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension: A Preliminary Population-Based Cross-Sectional Study

Cardiology Research and Practice ◽

10.1155/2014/879037 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Geórgia das Graças Pena ◽

Andre L. S. Guimarães ◽

Rosângela R. Veloso ◽

Tatiana C. Reis ◽

Crizian S. Gomes ◽

...

Keyword(s):

Leptin Receptor ◽

Receptor Gene ◽

Rflp Analysis ◽

Population Based ◽

Cross Sectional Study ◽

High Morbidity ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Gln223arg Polymorphism

Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive. Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hypertension prevalence by genotypes. The study includes 470 participants. The frequency of GG polymorphism variant was 10.43%, 46.81% AG, and 42.77% AA. The distribution of hypertension frequency by LEPR genotypes was the following: AA 43.8%, AG 40.4%, and GG 40.8%; there were no significant differences between groups. Comparative analysis which used multivariate Poisson regression adjusted by many potential confounders (age, sex, schooling, smoking, alcohol intake, obesity, and family history of parental obesity) did not modify this result. In this large sample of population-based study, the association of the LEPR Gln223Arg gene polymorphism with hypertension was not observed.

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