scholarly journals Natural history and associated early life factors of childhood asthma: a population registry-based cohort study in Denmark

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e045728
Author(s):  
Qian Chen ◽  
Ji Chen ◽  
Yingchun Zhou ◽  
Lisu Huang ◽  
Yincai Tang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Natural History ◽  
Childhood Asthma ◽  
Early Life ◽  
Lower Risk ◽  
Remission Rate ◽  
Large Population ◽  
Natural Course ◽  
Occurrence Rate ◽  
Early Life Factors

ObjectiveAsthma is a common chronic disease that imposes a substantial burden on individuals and society. However, the natural history of childhood asthma in a large population remained to be studied. This study aimed to describe the natural course of childhood asthma and examine the association between early life factors and childhood asthma.DesignA population-based cohort study.SettingThis study was based on the national registry data in Denmark.ParticipantsAll liveborn singletons in Denmark during 1995–1997 were identified and followed them till the end of 2009. Finally, 193 673 children were eligible for our study.ExposuresThe following characteristics were examined as potential early life factors associated with childhood asthma, including parity, maternal asthma history, maternal smoking during pregnancy, maternal social status, delivery method and gender.Main outcomes and measuresAsthma cases were identified on the basis of hospitalisation for asthma and prescriptions for antiasthmatic medications. Asthma remission was defined as no hospitalisation or prescription recorded for 2 years. Cox proportional hazards’ regression and logistic regression were used to evaluate the association between early life factors and the occurrence and remission of childhood asthma.ResultsThe cumulative occurrence rate of asthma in children aged 3–14 years was 13.3% and the remission rate was 44.1%. The occurrence rate decreased with age. Being female had a lower risk of asthma (HR: 0.72, 95% CI 0.70 to 0.74) and higher remission rate of asthma (HR: 1.18, 1.13 to 1.22), while maternal asthma was associated with a higher risk of asthma (HR: 2.15, 2.04 to 2.26) and decreased remission rate of asthma (HR: 0.79, 0.73 to 0.85). These patterns remained the same for early onset asthma.ConclusionsFemale gender had a lower risk of asthma and a better chance of remission, while maternal asthma history had an opposite effect. The early life factors may influence the natural course of childhood asthma.

Association between early-life factors and risk of child-onset Crohnʼs disease among victorian children born 1983–1998: A birth cohort study

2009 ◽  
Vol 15 (6) ◽  
pp. 858-866 ◽  
Author(s):  
Anne-Louise Ponsonby ◽  
Anthony G. Catto-Smith ◽  
Angela Pezic ◽  
Sandy Dupuis ◽  
Jane Halliday ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Early Life ◽  
Birth Cohort Study ◽  
Early Life Factors

scholarly journals Early-Life Factors and Risk of Parkinson’s Disease: A Register-Based Cohort Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0152841 ◽  
Author(s):  
Bojing Liu ◽  
Honglei Chen ◽  
Fang Fang ◽  
Annika Tillander ◽  
Karin Wirdefeldt
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Early Life ◽  
Early Life Factors

scholarly journals Prevalence and early-life determinants of mid-life multimorbidity: evidence from the 1970 British birth cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dawid Gondek ◽  
David Bann ◽  
Matt Brown ◽  
Mark Hamer ◽  
Alice Sullivan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Birth Cohort ◽  
Risk Ratio ◽  
Early Life ◽  
Lower Risk ◽  
Alcohol Problems ◽  
Occupational Class ◽  
British Cohort Study ◽  
Prospective Longitudinal

Abstract Background We sought to: [1] estimate the prevalence of multimorbidity at age 46–48 in the 1970 British Cohort Study—a nationally representative sample in mid-life; and [2] examine the association between early-life characteristics and mid-life multimorbidity. Method A prospective longitudinal birth cohort of a community-based sample from the 1970 British Cohort Study (BCS70). Participants included all surviving children born in mainland Britain in a single week in April 1970; the analytical sample included those with valid data at age 46–48 (n = 7951; 2016–2018). The main outcome was multimorbidity, which was operationalised as a binary indicator of two or more long-term health conditions where at least one of these conditions was of physical health. It also included symptom complexes (e.g., chronic pain), sensory impairments, and alcohol problems. Results Prevalence of mid-life multimorbidity was 33.8% at age 46–48. Those with fathers from unskilled social occupational class (vs professional) at birth had 43% higher risk of mid-life multimorbidity (risk ratio = 1.43, 95% confidence interval 1.15 to 1.77). After accounting for potential child and family confounding, an additional kilogram of birthweight was associated with 10% reduced risk of multimorbidity (risk ratio = 0.90, 95% confidence interval 0.84 to 0.96); a decrease of one body mass index point at age 10 was associated with 3% lower risk (risk ratio = 1.03, 95% confidence interval 1.01 to 1.05); one standard deviation higher cognitive ability score at age 10 corresponded to 4% lower risk (risk ratio = 0.96, 95% confidence interval 0.91 to 1.00); an increase of one internalising problem at age 16 was equated with 4% higher risk (risk ratio = 1.04, 95% confidence interval 1.00 to 1.08) and of one externalising problem at age 16 with 6% higher risk (risk ratio = 1.06, 1.03 to 1.09). Conclusion Prevalence of multimorbidity was high in mid-life (33.8% at age 46–48) in Britain. Potentially modifiable early-life exposures, including early-life social circumstances, cognitive, physical and emotional development, were associated with elevated risk of mid-life multimorbidity.

scholarly journals Prevalence and early-life determinants of mid-life multimorbidity: evidence from the 1970 British birth cohort

2020 ◽  
Author(s):  
Dawid Gondek ◽  
David Bann ◽  
Matt Brown ◽  
Mark Hamer ◽  
Alice Sullivan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Birth Cohort ◽  
Risk Ratio ◽  
Early Life ◽  
Lower Risk ◽  
Health Conditions ◽  
List Type ◽  
British Cohort Study ◽  
Nationally Representative

AbstractObjectivesWe sought to: (1) estimate the prevalence of multimorbidity at age 46-48 in the 1970 British Cohort Study—a nationally representative sample in mid-life; and (2) examine the association between early-life characteristics and mid-life multimorbidity in the 1970 British Cohort Study.DesignProspective longitudinal birth cohort.SettingA community based sample from the 1970 British Cohort Study (BCS70).ParticipantsAll surviving children born in mainland Britain in a single week in April 1970; the analytical sample was those with valid data at age 46-48 (n=7,951; 2016-2018).Main outcome measureMultimorbidity was operationalised as a binary indicator of two or more long-term health conditions where at least one of these conditions was of physical health. It also included symptom complexes (e.g. chronic pain), sensory impairments, and alcohol problems.ResultsPrevalence of mid-life multimorbidity was 33.8% at age 46-48. Those with fathers from unskilled social occupational class (vs. professional) at birth had 43% higher risk of mid-life multimorbidity (risk ratio=1.43, 95% confidence interval 1.15 to 1.70). After accounting for a range of potential child and family confounders, an additional kilogram of birthweight was associated with 10% reduced risk of multimorbidity (risk ratio=0.90, 95% confidence interval 0.84 to 0.96); a decrease of one body mass index point at age 10 was associated with 3% lower risk (risk ratio=1.03, 95% confidence interval 1.01 to 1.05); one standard deviation higher cognitive ability score at age 10 corresponded to 4% lower risk (risk ratio=0.96, 95% confidence interval 0.91 to 1.00); an increase of one internalising problem at age 16 was equated with 4% higher risk (risk ratio=1.04, 95% confidence interval 1.00 to 1.08) and of one externalising problem at age 16 with 6% higher risk (risk ratio=1.06, 1.03 to 1.09).ConclusionPrevalence of multimorbidity was high in mid-life (33.8% at age 46-48) in Britain, with those in a more disadvantaged social class a birth being disproportionally affected. Potentially modifiable early-life exposures including early-life social circumstances, cognitive, physical and emotional development were associated with mid-life multimorbidity.What is already known on this topic?Due to differences in outcome definition, estimates of multimorbidity prevalence in mid-life (age 40-60) have varied extensively in high-income countries—from 15 to 80% between 1961 and 2013.There is a lack of contemporary national data in Great Britain describing the burden and nature of multimorbidity according to an agreed definition.The association between early-life risk factors and individual health conditions have been widely studied, however it is unknown if they are associated with multimorbidity.What this study addsPrevalence of multimorbidity in mid-life (age 46-48) was 33.8% in a nationally representative birth cohort in 2016-2018.Disadvantaged early-life parental social class, lower birthweight, lower cognitive ability, higher childhood body-mass index, and a higher number of internalising and externalising problems were found to be associated with a higher mid-life multimorbidity.

scholarly journals Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study

2014 ◽  
Vol 5 (6) ◽  
pp. 453-458 ◽  
Author(s):  
M. A. Clynes ◽  
C. Parsons ◽  
M. H. Edwards ◽  
K. A. Jameson ◽  
N. C. Harvey ◽  
...  
Keyword(s):  
Cohort Study ◽  
Early Life ◽  
Lateral Compartment ◽  
Study Data ◽  
American College Of Rheumatology ◽  
Low Weight ◽  
Kellgren And Lawrence ◽  
Early Life Factors ◽  
Hertfordshire Cohort Study ◽  
One Year

Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, P=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, P=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, P=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.

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