scholarly journals Loneliness and its predictors among older adults prior to and during the COVID-19 pandemic: cross-sectional and longitudinal survey findings from participants of the Atherosclerosis Risk in Communities (ARIC) Study cohort in the USA

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e053542
Author(s):  
Anna Kucharska-Newton ◽  
Kunihiro Matsushita ◽  
Yejin Mok ◽  
Melissa Minotti ◽  
Elizabeth C Oelsner ◽  
...  
Keyword(s):  
High School ◽  
Older Adults ◽  
Los Angeles ◽  
Study Cohort ◽  
Cross Sectional ◽  
Emotional Resilience ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
The Usa ◽  
Aric Study

ObjectivesWe aimed to ascertain the prevalence of perceived loneliness among older adults following the onset of the COVID-19 pandemic and to examine factors contributing to the perception of loneliness.DesignCross-sectional and longitudinal data from the Atherosclerosis Risk in Communities (ARIC) Study cohort.SettingThe ARIC Study cohort, a prospective cohort that recruited (1987–1989) participants from four distinct communities in the USA.Participants2984 ARIC cohort members.Primary and secondary outcomesPerceived loneliness assessed using the University of California at Los Angeles (UCLA) UCLA three-item Loneliness Scale telephone interviews conducted May–October 2020 and prior to March 2020.ResultsOf the total 5037 participants alive in 2020, 2984 (56.2%) responded to the UCLA three-item questionnaire (mean age 82.6 (SD 4.6) years, 586 (19.6%) black participants, 1081 (36.2%) men), of which 66 (2.2%) reported having had a COVID-19 infection during the observation period. The proportion of participants reporting feeling lonely was 56.3% (n=1680). Among participants with repeat measures of loneliness (n=516), 35.2% (n=182) reported feeling more lonely following pandemic onset. Self-rated health and emotional resilience were strongly associated with self-perceived loneliness. The burden of COVID-19 infections, concern about the pandemic and decreased self-reported physical activity were greater among black as compared with white participants and among those with an educational attainment of less than high school as compared with high school or more.ConclusionFindings from this study document the increase in perceived loneliness among older adults during the COVID-19 pandemic in the USA.

1398-P: Mortality Implications of Comorbid Health Status in Older Adults with Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1398-P
Author(s):  
MARY R. ROONEY ◽  
OLIVE TANG ◽  
B. GWEN WINDHAM ◽  
JUSTIN B. ECHOUFFO TCHEUGUI ◽  
PAMELA LUTSEY ◽  
...  
Keyword(s):  
Older Adults ◽  
Health Status ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

2016 ◽  
Vol 18 (12) ◽  
pp. 1222-1227 ◽  
Author(s):  
Hirofumi Tanaka ◽  
Gerardo Heiss ◽  
Elizabeth L. McCabe ◽  
Michelle L. Meyer ◽  
Amil M. Shah ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Associations of Cardiac, Kidney, and Diabetes Biomarkers With Peripheral Neuropathy among Older Adults in the Atherosclerosis Risk in Communities (ARIC) Study

2020 ◽  
Vol 66 (5) ◽  
pp. 686-696 ◽  
Author(s):  
Caitlin W Hicks ◽  
Dan Wang ◽  
Natalie R Daya ◽  
B Gwen Windham ◽  
Christie M Ballantyne ◽  
...  
Keyword(s):  
Older Adults ◽  
Peripheral Neuropathy ◽  
Glycated Albumin ◽  
Creatinine Ratio ◽  
Atherosclerosis Risk In Communities ◽  
Hb A1c ◽  
Urine Albumin ◽  
Diabetes Status ◽  
Atherosclerosis Risk ◽  
Aric Study

Abstract Background The aim of this study was to assess the association of high-sensitivity cardiac troponin (hs-cTnT) and other cardiac, kidney, hyperglycemia, and inflammatory biomarkers with peripheral neuropathy (PN) in a community-based population. Methods We conducted a cross-sectional analysis of 3056 black and white participants in the Atherosclerosis Risk in Communities (ARIC) study who underwent standardized monofilament PN testing and had measures of cardiac function (hs-cTnT, N-terminal pro–B-type natriuretic peptide [NT-proBNP], and growth differentiation factor 15 [GDF15]), kidney function (serum creatinine, cystatin C, β-2 microglobulin, urine albumin-to-creatinine ratio), hyperglycemia (fasting glucose, hemoglobin A1c [Hb A1c], fructosamine, glycated albumin, 1,5-anhydroglucitol), and inflammation (C-reactive protein) assessed at visit 6 (2016–2017; age 71–94 years). We used logistic regression to assess the associations of these biomarkers (modeled in diabetes-specific tertiles) with PN in older adults with and without diabetes after adjusting for traditional risk factors. Results In total, 33.5% of participants had PN (37.3% with diabetes and 31.9% without diabetes). There was an independent association of hs-cTnT with PN regardless of diabetes status (diabetes T3 vs. T1: odds ratio [OR], 2.15 [95% CI, 1.44–3.22]; no diabetes: OR, 2.31 [95%CI, 1.76–3.03]; P = 0.72 for interaction). Among participants without diabetes, there were also significant associations of NT-proBNP (OR, 1.40 [95% CI, 1.08–1.81]) and urine albumin-to-creatinine ratio (OR, 1.55 [95% CI, 1.22–1.97]) with PN. Associations of hyperglycemia biomarkers including Hb A1c (OR, 1.76 [95% CI, 1.22–2.54]), fructosamine (OR, 1.71 [95% CI, 1.19–2.46]), and glycated albumin (OR, 1.45 [95% CI, 1.03–2.03]) with PN were significant only among participants with diabetes. Conclusions Overall, hs-cTnT appears to be a global marker of end organ damage, including PN. Laboratory biomarkers may be able to help us identify those individuals with PN.

Abstract P024: Associations Between Carotid-femoral And Estimated Pulse Wave Velocity In Older Adults: The Atherosclerosis Risk In Communities (ARIC) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Patricia Pagan Lassalle ◽  
Michelle L Meyer ◽  
Kevin S Heffernan ◽  
Adam W Kiefer ◽  
Lauren C Bates ◽  
...  
Keyword(s):  
Older Adults ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Atherosclerosis Risk In Communities ◽  
Black And White ◽  
Simple Alternative ◽  
Atherosclerosis Risk ◽  
Screening Device ◽  
Aric Study

Background: Carotid to femoral pulse wave velocity (cfPWV), the gold-standard measure of aortic stiffness, is associated with the incidence of cardiovascular disease (CVD) events. Most cfPWV measurements depend on technical proficiency, which limit broader implementation in clinical settings. Recently, an estimated pulse wave velocity (ePWV) measure derived from age and mean arterial pressure (MAP) has been shown to be associated with the risk of CVD events and all-cause mortality and may be a simple alternative to cfPWV. However, ePWV is poorly predictive in non-White individuals, possibly because it was originally developed from European Cohorts. Consequently, our purpose was to: estimate the strength of association between cfPWV and ePWV, and determine whether agreement is consistent across race. Hypothesis: cfPWV and ePWV are in good agreement and association would be consistent across race. Methods: We included Black and White older adults (n= 4,478; 75.2 [5.0] years) from visit 5 (2011-13) of the community-based Atherosclerosis Risk in Communities Study (ARIC). cfPWV was measured using an automated cardiovascular screening device. ePWV was calculated as presented in Fig 1. Association between cfPWV and ePWV was determined using Pearson’s correlation coefficient (r) and Bland-Altman plots. Results: As reported in Fig 1, there was a weak (r=0.35) correlation between cfPWV and ePWV for the total population, with similar correlations when stratified by Blacks (r=0.31) and Whites (r=0.36). Bland-Altman plots indicated significant systematic differences between cfPWV and ePWV (-0.17 m/s, 95% confidence interval: -0.25 to -0.09 m/s, P <.001), which was consistent by race. Conclusion: In older adults, there was weak correlation between cfPWV and ePWV and systematic differences in agreement. Our results do not support ePWV as a surrogate measure of cfPWV in a sample of older White and Black adults.

Abstract P275: Growth Differentiation Factor (gdf)-15 and Metabolic Outcomes: The ARIC Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Justin B Echouffo Tcheugui ◽  
Natalie R Daya ◽  
Kunihiro Matsushita ◽  
Chiadi E Ndumele ◽  
Ron C Hoogeveen ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Differentiation Factor ◽  
Metabolic States ◽  
Unit Increase ◽  
Sectional Analysis ◽  
Roche Diagnostics ◽  
Aric Study

Introduction: Mechanistic studies suggest an involvement of growth differentiation factor 15 (GDF-15) in metabolic dysregulation. However, the potential utility of GDF-15 as a marker of diabetes or metabolic syndrome (MetS) risk remains unclear, especially in older adults. Hypothesis: GDF-15 is positively associated with biomarkers of hyperglycemia, diabetes, and MetS. Methods: We conducted a cross-sectional analysis of older adults who attended visit 6 (2016-2017) of the Atherosclerosis Risk in Communities (ARIC) Study. GDF-15 was measured using electrochemiluminescence immunoassay (Elecsys, Roche Diagnostics). Linear regression was used to assess continuous outcomes after appropriate transformations, and multivariable-adjusted odds of diabetes or MetS by quartiles of GDF-15 were derived using logistic regression. Results: Among 3,792 participants (mean age 80 years, 59% women, 23% blacks and 77% whites), higher GDF-15 concentrations (per 1-unit increase in ln[GDF-15]) were associated with higher levels of fasting plasma glucose (mg/dL) (adjusted β coefficient : 10.98, 95% CI:8.86 - 13.09) and HbA 1C (%)(0.41, 95% CI: 0.35 - 0.48). Higher GDF-15 was associated with greater odds of diabetes (adjusted odds ratio [OR]: 5.81 for highest vs. lowest GDF-15 quartile, 95% CI 4.43-7.61) and of MetS syndrome (adjusted OR: 2.57, 95% CI 2.01-3.20) among individuals without diabetes (Figure). Conclusions: In this sample of older adults, elevated GDF-15 was strongly associated with diabetes and metabolic syndrome. These data strongly suggest that GDF-15 could be a robust biomarker of adverse metabolic states.

scholarly journals Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Danni Li ◽  
Aniqa B. Alam ◽  
Fang Yu ◽  
Anna Kucharska-Newton ◽  
B. Gwen Windham ◽  
...  
Keyword(s):  
Physical Function ◽  
Walking Speed ◽  
Plasma Concentrations ◽  
P Value ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
The Stability ◽  
Aric Study ◽  
Long Chain

AbstractLong-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective of this study was to examine the cross-sectional and longitudinal associations of long-chain SMs [SM (41:1), SM (41:2), SM (43:1)] and ceramides [Cer (41:1) and Cer (43:1)] with physical function in the Atherosclerosis Risk in Communities (ARIC) study. Plasma concentrations of SM (41:1), SM (41:2), SM (43:1), Cer (41:1) and Cer (43:1) were measured in 389 ARIC participants in 2011–13. Physical function was assessed by grip strength, Short Physical Performance Battery (SPPB), 4-m walking speed at both 2011–13 and 2016–17, and the modified Rosow-Breslau questionnaire in 2016–2017. Multivariable linear and logistic regression analyses were performed, controlling for demographic and clinical confounders. In cross-sectional analyses, plasma concentrations of SM 41:1 were positively associated with SPPB score (β-coefficients [95% confidence internal]: 0.33 [0.02, 0.63] per 1 standard deviation [SD] increase in log-transformed concentration, p value 0.04), 4-m walking speed (0.042 m/s [0.01, 0.07], p value 0.003), and negatively with self-reported disability (odds ratio = 0.73 [0.65, 0.82], p value < 0.0001). Plasma concentrations of the five metabolites examined were not significantly associated with longitudinal changes in physical function or incidence of poor mobility. In older adults, plasma concentrations of long-chain SM 41:1 were cross-sectionally positively associated with physical function.

scholarly journals Role of BMI in the Association of theTCF7L2rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Anna M. Kucharska-Newton ◽  
Keri L. Monda ◽  
Suzette J. Bielinski ◽  
Eric Boerwinkle ◽  
Thomas D. Rea ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Hazard Ratio ◽  
Study Cohort ◽  
Atherosclerosis Risk In Communities ◽  
Cox Proportional Hazard ◽  
Chd Risk ◽  
Atherosclerosis Risk ◽  
Cox Proportional Hazard Regression ◽  
Aric Study

We examined the association of variation in the type 2 diabetes risk-conferringTCF7L2gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category. For 9,865 whites, a significant increase in the risk of CHD was seen only among lean (BMI<25 kg/m2) individuals homozygous for theTallele of theTCF7L2rs7903146 gene risk variant (hazard ratio 1.42; 95% CI 1.03,1.97;P=.01). No association was found among 3,631 blacks, regardless of BMI status. An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members. This study suggests that body mass modifies the association of theTCF7L2rs7903146 T allele with CHD risk.

scholarly journals Endogenous Testosterone and its Relationship to Preclinical and Clinical Measures of Cardiovascular Disease in the Atherosclerosis Risk in Communities Study

2015 ◽  
Vol 100 (4) ◽  
pp. 1602-1608 ◽  
Author(s):  
Reshmi Srinath ◽  
Sherita Hill Golden ◽  
Kathryn A. Carson ◽  
Adrian Dobs
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiac Mortality ◽  
Cardiac Events ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
All Cause Mortality ◽  
Aric Study

Context: Epidemiologic studies suggest that endogenous testosterone (T) levels in males may be implicated in cardiovascular disease (CVD), however further clarification is needed. Objective: We assessed the cross-sectional relationship between endogenous plasma T and mean carotid intima media thickness (cIMT), and the longitudinal relationship with incident clinical CVD events, cardiac mortality, and all-cause mortality using male participants in the Atherosclerosis Risk in Communities (ARIC) study. Design: This study involved a subset of men from visit 4 of the ARIC study. Setting: The study was conducted in a community based cohort. Participants: Males who provided a morning blood sample excluding those taking androgen therapy, with prevalent coronary heart disease (CHD), stroke, or heart failure (HF) (n = 1558). Intervention: None. Main Outcome Measures: Plasma T by liquid chromatography mass spectrometry and carotid IMT using high resolution B-mode ultrasound were obtained at visit 4. Incident CHD, HF, cardiac mortality, and all-cause mortality were identified by surveillance through 2010 (median 12.8 years). Results: Lower T was significantly associated with higher body mass index, greater waist circumference, diabetes, hypertension, lower HDL, and never smoking (P = 0.01). T was not associated with mean cIMT in unadjusted or adjusted analyses. Following multivariable adjustment, there was no association of quartile (Q) of T with incident CHD [hazard ratio (HR) = 0.87 (95% CI = 0.60–1.26) for Q1; 0.97 (95% CI = 0.69–1.38) for Q2; 0.97 (95% CI = 0.69–1.36) for Q3 compared to reference of Q4] or for incident HF [HR = 0.77 (95% CI = 0.46–1.29) for Q1; 0.72 (95% CI = 0.43–1.21) for Q2; 0.87 (95% CI = 0.53–1.42) for Q3 compared to reference of Q4]. Similarly there was no association of Q of T with mortality or cardiac-associated mortality. Conclusions: Low male plasma T is cross-sectionally associated with key CVD risk factors, but after adjustment there was no association with mean cIMT, incident cardiac events, or mortality. Our results are reassuring that neither high nor low T levels directly predict atherosclerosis, but are a marker for other cardiovascular risk factors.

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