scholarly journals IDDF2020-ABS-0203 Investigating the evidence of prebiotic supplementation in the attenuation of age-related neurodegeneration in in vivo studies: a systematic review and meta-analysis with bayesian inference

2020 ◽  
Author(s):  
Christopher Chi Hang Mak ◽  
Henry Yue Hong Meng ◽  
Joyce Wing Yan Mak ◽  
Owen Ho Ko ◽  
Zuo Tao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bayesian Inference ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Age Related

scholarly journals Does systemic oral administration of curcumin effectively reduce alveolar bone loss associated with periodontal disease? A systematic review and meta-analysis of preclinical in vivo studies

2020 ◽  
Vol 75 ◽  
pp. 104226
Author(s):  
Juliana Simeão Borges ◽  
Luiz Renato Paranhos ◽  
Gabriela Leite de Souza ◽  
Felipe de Souza Matos ◽  
Ítalo de Macedo Bernardino ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Oral Administration ◽  
Alveolar Bone ◽  
Meta Analysis ◽  
Alveolar Bone Loss ◽  
In Vivo Studies

scholarly journals Microleakage of Direct Restorations. Comparisonbetween Bulk-Fill and Traditional Composite Resins:Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Francesca Zotti ◽  
Edoardo Falavigna ◽  
Giorgia Capocasale ◽  
Daniele De Santis ◽  
Massimo Albanese
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Adhesive System ◽  
Risk Of Bias ◽  
Composite Resins ◽  
In Vivo Studies ◽  
Marginal Adaptation ◽  
Posterior Teeth

AbstractSince the bulk-fill composites were produced, there was a progressive diffusion of their use for direct conservative treatment in posterior teeth. Their chemical structure increases the depth of cure and decreases the polymerization contraction; in this manner, bulk-fill composites can be placed in 4 mm single layers and the treatment times are considerably reduced. However, aesthetic and mechanical properties and impact on microleakage of bulk-fill resins are still unclear.This systematic review and meta-analysis aimed to assess the risk of microleakage of direct posterior restorations made of bulk-fill versus conventional composite resins.Researches were performed on PubMed and Scopus databases. Eligible in vivo studies, published since 2006, were reviewed. Outcomes of marginal discoloration, marginal adaptation, and recurrent caries were considered to conduct the systematic review and meta-analysis. Secondary data were examined to implement additional analysis and assess the risk of bias.Eight randomized clinical trials were analyzed, involving 778 direct restorations. The summary of RCTs led to significant but inconsistent results; the marginal discoloration and recurrent caries were found to be improved respectively by 5.1 and 1.4%, whereas the marginal adaptation was reduced of 6.5%. Secondary analyses revealed that follow-up periods, the adhesive system used and the class of carious lesions evaluated are confounding factors, and they result in a risk of bias across studies.Bulk-fill composites are innovative materials for conservative dentistry and they can be used to reduce treatment steps and duration of operative times. There are insufficient data to explore the relationship between bulk-fill composites and microleakage and further investigations are needed.

scholarly journals Effect of Computer-Aided Navigation Techniques on the Accuracy of Endodontic Access Cavities: A Systematic Review and Meta-Analysis

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 212
Author(s):  
Álvaro Zubizarreta-Macho ◽  
Sara Valle Castaño ◽  
José María Montiel-Company ◽  
Jesús Mena-Álvarez
Keyword(s):  
Systematic Review ◽  
Success Rate ◽  
Root Canal ◽  
Prediction Interval ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
P Value ◽  
Computer Aided

The present systematic review and meta-analysis aims to determine the effect of computer-aided navigation techniques on the accuracy of endodontic access cavities. Materials and methods: A systematic literature review and meta-analysis of clinical studies, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, was performed that evaluated the root canal location rate of computer-aided navigation techniques applied to endodontic access cavities. Four different databases were used to consult the literature: PubMed-Medline, Scopus, Cochrane, and Web of Science. After discarding duplicate articles and applying inclusion criteria, 14 articles were selected for qualitative analysis and 13 for quantitative analysis. Results: the root canal location success rate started at 98.1% (CI: 95.7–100%) of the cases performed through a computer-aided navigation technique. The prediction interval ranged from 93.3% to 100%. The meta-analysis did not detect heterogeneity between the combined studies (Q-test = 17.3; p = 0.185; I2 = 25%). No statistically significant differences were found between computer-aided static navigation techniques (success rate: 98.5%) and computer-aided dynamic navigation techniques (success rate: 94.5%) (Q test = 0.57; p = 0.451), nor between in vitro studies (success rate: 96.2%) and in vivo studies (success rate: 100%) (Q test = 2.53; p-value = 0.112). An odds success ratio of 13.1 (CI: 95%; 3.48, 49.1) encourages the use of computer-aided navigation techniques over conventional endodontic access cavity procedures. Conclusions: the endodontic access cavities created using static and dynamic computer-aided navigation techniques are highly accurate in locating the root canal system.

scholarly journals Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-34
Author(s):  
Carla P. Vieira ◽  
Anisio Iuri L. S. Rosario ◽  
Carini A. Lelis ◽  
Bruna Samara S. Rekowsky ◽  
Anna Paula A. Carvalho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bioactive Compounds ◽  
Meta Analysis ◽  
Health Effect ◽  
In Vivo Studies ◽  
Therapeutic Effects ◽  
Microbial Composition ◽  
Functional Potential

Despite evidence of health benefits from kefir administration, a systematic review with meta-analysis on bioactive compounds associated with these benefits is still absent in the literature. Kefir is fermented milk resulting from the metabolism of a complex microbiota in symbiosis. Recent researches have investigated the bioactive compounds responsible for the preventive and therapeutic effects attributed to kefir. However, differences in functional potential between industrial and artisanal kefir are still controversial. Firstly, we identified differences in the microbial composition among both types of kefir. Available evidence concerning the action of different bioactive compounds from kefir on health, both from in vitro and in vivo studies, was subsequently summarized to draw a primary conclusion of the dose and the intervention time for effect, the producer microorganisms, the precursor in the milk, and the action mechanism. Meta-analysis was performed to investigate the statistically significant differences ( P < 0.05 ) between intervention and control and between both types of kefir for each health effect studied. In summary, the bioactive compounds more commonly reported were exopolysaccharides, including kefiran, bioactive peptides, and organic acids, especially lactic acid. Kefir bioactive compounds presented antimicrobial, anticancer, and immune-modulatory activities corroborated by the meta-analysis. However, clinical evidence is urgently needed to strengthen the practical applicability of these bioactive compounds. The mechanisms of their action were diverse, indicating that they can act by different signaling pathways. Still, industrial and artisanal kefir may differ regarding functional potential—OR of 8.56 (95% CI: 2.27–32.21, P ≤ .001 )—according to the observed health effect, which can be associated with differences in the microbial composition between both types of kefir.

scholarly journals Automation of citation screening in pre-clinical systematic reviews

2018 ◽  
Author(s):  
J. Liao ◽  
S. Ananiadou ◽  
L. G. Currie ◽  
B. E. Howard ◽  
A. Rice ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
Systematic Review ◽  
Vitamin D ◽  
Neuropathic Pain ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Citation Screening ◽  
Field Systematic

AbstractBackgroundThe amount of published in vivo studies and the speed researchers are publishing them make it virtually impossible to follow the recent development in the field. Systematic review emerged as a method to summarise and analyse the studies quantitatively and critically but it is often out-of-date due to its lengthy process.MethodWe invited five machine learning and text-mining groups to build classifiers for identifying publications relevant to neuropathic pain (33814 training publications). We kept 1188 publications for the assessment of the performance of different classifiers. Two groups participated in the next stage: testing their algorithm on datasets labeled for psychosis (11777/2944) and datasets labeled for Vitamin D in multiple sclerosis (train/text: 2038/510).ResultThe performances (sensitive/specificity) of the most promising classifier built for neuropathic pain are: 95%/84%. The performance for psychosis and Vitamin D in multiple sclerosis datasets are 95%/73% and 100%/45%.ConclusionsMachine learning can significantly reduce the irrelevant publications in a systematic review, and save the scientists’ time and money. Classifier algorithms built for one dataset can be reapplied on another dataset in different field. We are building a machine learning service at the back of Systematic Review & Meta-analysis Facility (SyRF).

scholarly journals Wollastonite/TCP composites for bone regeneration: systematic review and meta-analysis

Cerâmica ◽  
2020 ◽  
Vol 66 (379) ◽  
pp. 277-283
Author(s):  
G. G. dos Santos ◽  
E. C. A. Meireles ◽  
F. B. Miguel
Keyword(s):  
Systematic Review ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Porous Scaffold ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Clinical Use ◽  
Electronic Library ◽  
Data Comparison

Abstract Composite biomaterials have gained notoriety in recent decades due to the ability to combine desirable properties of each material. Thus, associating bioactivity of wollastonite (W) with biodegradability of tricalcium phosphate (TCP) becomes promising for bone repair. Therefore, this study investigated, through systematic review and meta-analysis, in vivo studies that evaluated histomorphometrically the bone repair after implantation of W/TCP composites. The searches were performed in the PubMed/MEDLINE, LILACS/BIREME/Virtual Health Library (VHL), and Scientific Electronic Library Online (SciELO) databases. A total of 312 studies were identified in the databases, of which 6 were included. In data comparison, it was considered the percentage of neoformed bone (NB). Composites with a higher percentage of W and/or in the scaffold format presented higher NB. These results suggested that the association of these two materials, as well as the porous scaffold format, was determinant on NB, which makes these new composites potential for clinical use.

scholarly journals Synthetic Blocks for Bone Regeneration: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 20 (17) ◽  
pp. 4221 ◽  
Author(s):  
Tumedei ◽  
Savadori ◽  
Del Fabbro
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Formation ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Control Group ◽  
Bone Augmentation ◽  
New Bone Formation ◽  
Bias Assessment

This systematic review is aimed at evaluating the effectiveness of synthetic block materials for bone augmentation in preclinical in vivo studies. An electronic search was performed on Pubmed, Scopus, EMBASE. Articles selected underwent risk-of-bias assessment. The outcomes were: new bone formation and residual graft with histomorphometry, radiographic bone density, soft tissue parameters, complications. Meta-analysis was performed to compare new bone formation in test (synthetic blocks) vs. control group (autogenous blocks or spontaneous healing). The search yielded 214 articles. After screening, 39 studies were included, all performed on animal models: rabbits (n = 18 studies), dogs (n = 4), rats (n = 7), minipigs (n = 4), goats (n = 4), and sheep (n = 2). The meta-analysis on rabbit studies showed significantly higher new bone formation for synthetic blocks with respect to autogenous blocks both at four-week (mean difference (MD): 5.91%, 95% confidence intervals (CI): 1.04, 10.79%, p = 0.02) and at eight-week healing (MD: 4.44%, 95% CI: 0.71, 8.17%, p = 0.02). Other animal models evidenced a trend for better outcomes with synthetic blocks, though only based on qualitative analysis. Synthetic blocks may represent a viable resource in bone regenerative surgery for achieving new bone formation. Differences in the animal models, the design of included studies, and the bone defects treated should be considered when generalizing the results. Clinical studies are needed to confirm the effectiveness of synthetic blocks in bone augmentation procedures.

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