Magnesium intake is associated with the metabolically healthy obese phenotype

Although magnesium intake is inversely associated with the risk of metabolic abnormalities, whether magnesium intake plays a role on metabolically healthy obese (MHO) phenotype has not been explored. Therefore, the purpose of this study was to determine whether the magnesium intake is associated with the MHO phenotype. Apparently, healthy women and men aged 20–65 years with obesity were enrolled in a cross-sectional study. Subjects were allocated into MHO (n=124) and metabolically unhealthy obese (MUO) (n=123) groups. MHO phenotype was defined by abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm in women) and none, or not more than one of the following risk factors: triglyceride levels ≥150 mg/dL; high-density lipoprotein cholesterol (HDL-C) levels <40 mg/dL in men and <50 mg/dL in women; fasting glucose ≥100 mg/dL; and systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg. The MUO individuals were characterized by abdominal obesity and the presence of two or more of the aforementioned criteria. The proportion of individuals with high blood pressure (40.7% vs 5.6%, p<0.001), hyperglycemia (69.1% vs 16.9%, p<0.001), hypertriglyceridemia (84.6% vs 36.3%, p<0.001), and low HDL-C (51.2% vs 12.9%, p<0.001) was significantly higher in the MUO individuals as compared with individuals in the MHO group. The logistic regression analysis adjusted by sex and age showed that dietary magnesium intake is significantly associated with the MHO phenotype (OR=1.17; 95% CI 1.07 to 1.25, p=0.005). Our results show that magnesium intake is significantly associated with the MHO phenotype.

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Characterisation of body size phenotypes in a middle-aged Maltese population

Journal of Nutritional Science ◽

10.1017/jns.2021.74 ◽

2021 ◽

Vol 10 ◽

Author(s):

Rachel Agius ◽

Nikolai Paul Pace ◽

Stephen Fava

Keyword(s):

Normal Weight ◽

Cross Sectional ◽

Metabolically Healthy Obese ◽

High Prevalence ◽

Low Hdl ◽

Healthy Obese ◽

Metabolically Healthy ◽

High Fasting Plasma Glucose ◽

Sectional Analysis ◽

Metabolic Syndrome Components

Abstract Obesity is increasingly recognised as being a heterogeneous disease. Some obese individuals may present a metabolically healthy profile (metabolically healthy obese (MHO)), while some normal weight individuals exhibit an adverse cardiometabolic phenotype (metabolically unhealthy normal weight individuals (MUHNW)). The objectives of the present study were to examine the prevalence and associated characteristics of the different body composition phenotypes within a Maltese cohort. This was a cross-sectional analysis involving 521 individuals aged 41 ± 5 years. The metabolically unhealthy state was defined as the presence of ≥2 metabolic syndrome components (NCEP-ATPIII parameters), while individuals with ≤1 cardiometabolic abnormalities were classified as metabolically healthy. Overall, 70 % of the studied population was overweight or obese and 30⋅7 % had ≥2 cardiometabolic abnormalities. The prevalence of MHO and MUHNW was 10⋅7 and 2⋅1 %, respectively. Individuals with the healthy phenotype were more likely to consume alcohol, participate in regular physical activity and less likely to be smokers. While the MHO phenotype had similar values for waist, hip and neck circumferences, waist–hip ratio and insulin resistance when compared with MUHNW individuals, there was a lower proportion of MHO subjects having a high fasting plasma glucose, hypertriglyceridaemia or low HDL-C when compared with the unhealthy lean individuals. A high prevalence of the metabolically unhealthy phenotype was observed in this relatively young population which may result in significant future cardiovascular disease burden if timely assessment and management of modifiable risk factors are not implemented. Furthermore, the present study suggests that the MHO phenotype is not totally benign as previously thought.

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Can Gamma Glutamyle Transferase Predict Unhealthy Metabolic Phenotype in Healthcare Workers in Azar Cohort Study?

10.21203/rs.3.rs-114625/v1 ◽

2020 ◽

Author(s):

Mohammadhossein Somi ◽

Sina Zakavi ◽

Alireza Ostadrahimi ◽

Negin Frounchi ◽

Neda Gilani ◽

...

Keyword(s):

Healthcare Workers ◽

Cross Sectional Study ◽

Metabolic Phenotype ◽

P Value ◽

Cross Sectional ◽

Metabolically Healthy Obese ◽

The Metabolic Syndrome ◽

Healthy Obese ◽

Metabolically Healthy ◽

The Relationship

Abstract Background: There is a close connection between serum gamma-glutamyltransferase (GGT), insulin resistance, and the increased number of the components of the metabolic syndrome (MetS). However, there are no studies evaluating the correlation between GGT and cardiometabolic phenotype. Thus, the main objective of the current study is to evaluate the relationship between GGT and cardiometabolic phenotypes among healthcare workers in Azar Cohort Study.Method: In this cross-sectional study, anthropometric measurements, fasting blood sugar (FBS), triglyceride (TG), cholesterol, high lipoprotein density (HDL), GGT, and blood pressure of 1458 healthcare workers were evaluated. MetS was determined according to the report by the National Cholesterol Education Program Adult Treatment Panel III (ATP III). We classified participants into four cardiometabolic phenotypes. These phenotypes consist of metabolically-healthy lean (MHL) (no MetS and BMI < 25 kg/m2), metabolically-unhealthy lean (MUHL) (MetS present and BMI < 25 kg/m2), metabolically-healthy obese (MHO) (no MetS and BMI ≥25 kg/m2), and metabolically-unhealthy obese (MUHO) (MetS present and BMI ≥ 25 kg/m2).Results: The first and third GGT tertiles have the highest prevalence of MHL (31%) and MHO (65.1%), respectively, which is statistically significant (P-value ≤ 0.001). In comparison with the lowest GGT tertile, the odds of MHO and MUHO increased by 2.84 (95% CI 2.01-4.01) and 9.12 (95%CI 5.54-15), respectively. However, the correlation between MUHL and GGT tertile does not show a similar trend. According to the ROC curve, the cutoff value of 18.5 U/l for GGT allowed us to distinguish between MHO and MUHO.Conclusions: Based on the findings of the study, the GGT can be used as a biomarker to reveal the risk of MetS, and we believe that the GGT level can be used for the early detection of MHO at risk of MetS and for administering proper interventions.

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Prevalence of metabolically healthy obese phenotype and associated factors in South American overweight adolescents: A cross-sectional study

Nutrition ◽

10.1016/j.nut.2018.08.017 ◽

2019 ◽

Vol 60 ◽

pp. 19-24 ◽

Cited By ~ 1

Author(s):

Jane Maria Remor ◽

Wendell Arthur Lopes ◽

João Carlos Locateli ◽

Ronano Pereira Oliveira ◽

Caroline Ferraz Simões ◽

...

Keyword(s):

Associated Factors ◽

Cross Sectional Study ◽

South American ◽

Sectional Study ◽

Cross Sectional ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy ◽

Overweight Adolescents ◽

Obese Phenotype

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Hospital-level Variation in the Management of Blood Pressure and Low-density Lipoprotein in the Outpatient Hypertensives in China-a Cross Sectional Study

Case Medical Research ◽

10.31525/ct1-nct03862183 ◽

2019 ◽

Author(s):

Keyword(s):

Blood Pressure ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Low Density ◽

Sectional Study ◽

Level Variation ◽

Hospital Level ◽

Cross Sectional

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Characterization of Differentially Expressed Circulating miRNAs in Metabolically Healthy versus Unhealthy Obesity

Biomedicines ◽

10.3390/biomedicines9030321 ◽

2021 ◽

Vol 9 (3) ◽

pp. 321

Author(s):

Susana Rovira-Llopis ◽

Rubén Díaz-Rúa ◽

Carmen Grau-del Valle ◽

Francesca Iannantuoni ◽

Zaida Abad-Jimenez ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Metabolism ◽

Insulin Signalling ◽

Cross Sectional Study ◽

Differentially Expressed ◽

Circulating Mirnas ◽

Oxidative Stress Biomarkers ◽

Cross Sectional ◽

Metabolically Healthy Obese ◽

Metabolically Healthy

Obese individuals without metabolic comorbidities are categorized as metabolically healthy obese (MHO). MicroRNAs (miRNAs) may be implicated in MHO. This cross-sectional study explores the link between circulating miRNAs and the main components of metabolic syndrome (MetS) in the context of obesity. We also examine oxidative stress biomarkers in MHO vs. metabolically unhealthy obesity (MUO). We analysed 3536 serum miRNAs in 20 middle-aged obese individuals: 10 MHO and 10 MUO. A total of 159 miRNAs were differentially expressed, of which, 72 miRNAs (45.2%) were higher and 87 miRNAs (54.7%) were lower in the MUO group. In addition, miRNAs related to insulin signalling and lipid metabolism pathways were upregulated in the MUO group. Among these miRNAs, hsa-miR-6796-5p and hsa-miR-4697-3p, which regulate oxidative stress, showed significant correlations with glucose, triglycerides, HbA1c and HDLc. Our results provide evidence of a pattern of differentially expressed miRNAs in obesity according to MetS, and identify those related to insulin resistance and lipid metabolism pathways.

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Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽

10.3390/metabo11110771 ◽

2021 ◽

Vol 11 (11) ◽

pp. 771

Author(s):

Lourdes Balcázar-Hernandez ◽

Lourdes Basurto ◽

Leticia Manuel-Apolinar ◽

Sara Vega-García ◽

Norma Basurto-Acevedo ◽

...

Keyword(s):

Body Size ◽

Cross Sectional Study ◽

Normal Weight ◽

The Body ◽

Metabolic Phenotype ◽

Obese Women ◽

Middle Aged ◽

Cross Sectional ◽

Metabolically Healthy Obese ◽

Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

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The prevalence of metabolically healthy obesity according to the sample of the Moscow region

Obesity and metabolism ◽

10.14341/omet2017451-56 ◽

2017 ◽

Vol 14 (4) ◽

pp. 51-56 ◽

Cited By ~ 2

Author(s):

Elena V. Ostrovskaya ◽

Tatiana I. Romantsova ◽

Andrei N. Gerasimov ◽

Tamara E. Novoselova

Keyword(s):

Metabolic Syndrome ◽

Carbohydrate Metabolism ◽

Medical Records ◽

Density Lipoprotein ◽

Homa Index ◽

Obese Patients ◽

Hip Circumference ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

Introduction. Obesity is a major factor for cardiometabolic risk. However, there is a category of obese patients without disorders of lipid, carbohydrate metabolism and cardiovascular disease metabolically healthy obese (MHO). Aim. Our goal was to investigate the prevalence and characteristics of this phenotype compared to patients with metabolic syndrome (MS). Materials and methods. To evaluate the prevalence of the MHO phenotype we analyzed 389 medical records of females aged 1860 years with obesity. Three types of MHO criteria were used: 1) HOMA index (2.7); 2) IDF-criteria of metabolic syndrome, 2005; 3) the BioSHaRE-EU 2013 criteria (obese patients without any symptoms of MS). We conducted a comparative analysis of anthropometry, status of lipid and carbohydrate metabolism, the functional state of the liver. Results. The MHO prevalence was: 34.5% according to HOMA index, according to the definitions of MS 2005 38.6%, in BioSHaRE-EU 9.6%. In groups of MHO and MS dyslipidemia was observed in 27.3 and 49.5% (p0.05), hypertension in 25% and 71.6% (p0.05), steatogepatosis in 47.7% vs 51.3% (p0.05) of observations, respectively. Among comorbidities the gynecological pathology was most prevalent - 50.8 and 61.4% (p0.05), disorders of carbohydrate metabolism differed significantly in frequency- 6.82 and 39.1% of patients (p0.05). Patients with MHO had a shorter duration of the existence of obesity than MS (18.7 vs. 24 years) (p=0.0004) and less likely to have attempted to reduce weight 85.8% and 91.6%. Average BMI, waist circumference, hip circumference, fasting glucose, total cholesterol, insulin basal, basal C-peptide, HOMA index in groups of MHO and MS differed significantly (p0.05). Median ALT was 20 and 23.2 U/l, AST 20 and 23 U/l, triglycerides 1.1 and 1.8 mmol/l, high-density lipoprotein 1.4 and 1.1 mmol/l, respectively. Conclusions. The MHO prevalence was maximal according to the MS definitions from 2005, and minimal with BioSHaRE-EU criteria. The main analyzed indicators differed significantly in groups MHO and MS. Longer obesity existence in the MS group may suggest an instability of MHO phenotype over time.

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Hypertriglyceridemic Waist and Associated Factors: A Cross-Sectional Study of Bank Employees

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_026 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1398-1398

Author(s):

Júlia Ferreira ◽

Rebeca Oliveira ◽

Monica Cattafesta ◽

Luciane Salaroli

Keyword(s):

Elevated Serum ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Health Condition ◽

Sectional Study ◽

Serum Triglycerides ◽

Cross Sectional ◽

Hypertriglyceridemic Waist ◽

Low Hdl ◽

Men Elderly

Abstract Objectives This paper investigates the prevalence of hypertriglyceridemic waist in bank workers and its association with socioeconomic, labor, behavioral, anthropometric and health condition factors. Methods This is a cross-sectional study based on information from 525 bank workers. Hypertriglyceridemic waist was defined by the simultaneous presence of abdominal obesity, verified by the waist circumference, and elevated serum triglycerides. Associations were verified with sociodemographic, labor, behavioral, anthropometric and health condition variables. Results The investigation resulted in a phenotype prevalence of 19.4%, being higher in men, elderly, married and working in the bank for more than 5 years. The phenotype was also associated with overweight, low HDL-c (high-density lipoprotein), mixed hyperlipidemia, high triglyceride/HDL-c ratio and arterial hypertension. Being over 50 years of age and being overweight increased the chances of the bankers presenting the phenotype. Being female and having adequate levels of HDL-c were shown to be protective factors against the phenotype. Conclusions It was concluded that the prevalence of hypertriglyceridemic waist is high and is associated mainly with the excess weight and unfavorable lipid profile of this population. Funding Sources This research received no external funding.

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Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0077 ◽

2020 ◽

Vol 33 (2) ◽

pp. 215-222 ◽

Cited By ~ 2

Author(s):

María Lola Evia-Viscarra ◽

Rodolfo Guardado-Mendoza

Keyword(s):

Blood Pressure ◽

Family Background ◽

Density Lipoprotein ◽

Model Assessment ◽

Metabolically Healthy Obesity ◽

Cvd Risk ◽

Cross Sectional ◽

Mexican Children ◽

Metabolically Healthy ◽

Metabolically Unhealthy Obesity

AbstractBackgroundThere is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children.ObjectivesTo estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and metabolically unhealthy obesity (MUO), and to evaluate the association between MUO and cardiovascular disease (CVD) risk, anthropometrics and family background using different definitions in children.MethodsThis was a cross-sectional study. Participants included 224 obese children between the years 2007 and 2017. MHO was defined by three different criteria: (i) absence of metabolic syndrome (MHO-MS), (ii) no insulin resistance (IR) by homeostatic model assessment (HOMA) <3.16 cut-off (MHO-IR3.16) and (iii) absence of IR at <95th percentile for Mexican children (MHO-95th).ResultsThe prevalence of MHO-MS, MHO-IR3.16 and MHO-IR95th was 12.9%, 56.3% and 41.5%, respectively. The prevalence of simultaneous MHO-MS plus MHO-IR95th was 5.36%. Children with MHO-MS vs. MUO-MS showed lower height, weight and body mass index (BMI) percentiles; MHO-IR3.16 vs. MUO-IR3.16 showed lower age, acanthosis, Tanner, waist circumference (WC), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glucose; and MHO-IR95th vs. MUO-IR95th showed lower acanthosis, WC, DBP, glucose and high high-density lipoprotein cholesterol (HDL-C). MUO-MS was associated with WC > 90th, type 2 diabetes mellitus (T2DM) in first-degree relatives and obesity in siblings. MUO-IR3.16 was associated with pubertal stages, WC > 90th, WHtR > 0.55 and fasting hyperglycemia. MUO-IR95th was associated with WHtR > 0.55 and HDL < 10th. MHO-MS and MHO-IR3.16 or MHO-IR95th did not have agreement.ConclusionsThe prevalence of MHO varied depending on the definition, although the real MHO with no MS or IR is very low. Low DBP and high HDL-C in MHO were present in any definition. Association of MUO with anthropometric, biochemical and family background differs across definitions.

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Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-119877 ◽

2017 ◽

Vol 126 (05) ◽

pp. 309-315

Author(s):

Katarína Šebeková ◽

Melinda Csongová ◽

Radana Gurecká ◽

Zora Krivošíková ◽

Jozef Šebek

Keyword(s):

Blood Pressure ◽

Waist Circumference ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Central Obesity ◽

Cross Sectional Study ◽

Normal Weight ◽

Cross Sectional ◽

Fasting Plasma ◽

Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

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