Quantification of clot spatial heterogeneity and its impact on thrombectomy

2021 ◽  
pp. neurintsurg-2021-018183
Author(s):  
Yang Liu ◽  
Waleed Brinjikji ◽  
Mehdi Abbasi ◽  
Daying Dai ◽  
Jorge L Arturo Larco ◽  
...  
Keyword(s):  
Spatial Heterogeneity ◽  
Structural Features ◽  
Qualitative Description ◽  
Ann Model ◽  
Cell Content ◽  
Intravenous Tissue Plasminogen Activator ◽  
Scanned Images ◽  
Artificial Neural Network Ann ◽  
Clot Structure ◽  
Iv Tpa

BackgroundCompositional and structural features of retrieved clots by thrombectomy can provide insight into improving the endovascular treatment of ischemic stroke. Currently, histological analysis is limited to quantification of compositions and qualitative description of the clot structure. We hypothesized that heterogeneous clots would be prone to poorer recanalization rates and performed a quantitative analysis to test this hypothesis.MethodsWe collected and did histology on clots retrieved by mechanical thrombectomy from 157 stroke cases (107 achieved first-pass effect (FPE) and 50 did not). Using an in-house algorithm, the scanned images were divided into grids (with sizes of 0.2, 0.3, 0.4, 0.5, and 0.6 mm) and the extent of non-uniformity of RBC distribution was computed using the proposed spatial heterogeneity index (SHI). Finally, we validated the clinical significance of clot heterogeneity using the Mann–Whitney test and an artificial neural network (ANN) model.ResultsFor cases with FPE, SHI values were smaller (0.033 vs 0.039 for grid size of 0.4 mm, P=0.028) compared with those without. In comparison, the clot composition was not statistically different between those two groups. From the ANN model, clot heterogeneity was the most important factor, followed by fibrin content, thrombectomy techniques, red blood cell content, clot area, platelet content, etiology, and admission of intravenous tissue plasminogen activator (IV-tPA). No statistical difference of clot heterogeneity was found for different etiologies, thrombectomy techniques, and IV-tPA administration.ConclusionsClot heterogeneity can affect the clot response to thrombectomy devices and is associated with lower FPE. SHI can be a useful metric to quantify clot heterogeneity.

scholarly journals Combining a QSAR Approach and Structural Analysis to Derive an SAR Map of Lyn Kinase Inhibition

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3271 ◽  
Author(s):  
Imane Naboulsi ◽  
Aziz Aboulmouhajir ◽  
Lamfeddal Kouisni ◽  
Faouzi Bekkaoui ◽  
Abdelaziz Yasri
Keyword(s):  
Tyrosine Kinases ◽  
Kinase Inhibitors ◽  
Structural Features ◽  
Ann Model ◽  
Training Set ◽  
Test Set ◽  
Lyn Kinase ◽  
Physico Chemical ◽  
The Mean ◽  
Artificial Neural Network Ann

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs. In the present study, using 176 molecules (123 training set molecules and 53 test set molecules) known by their inhibitory activities (IC50) against Lyn kinase, we constructed predictive models by linking their physico-chemical parameters (descriptors) to their biological activity. The models were derived using two different methods: the generalized linear model (GLM) and the artificial neural network (ANN). The ANN Model provided the best prediction precisions with a Square Correlation coefficient R2 = 0.92 and a Root of the Mean Square Error RMSE = 0.29. It was able to extrapolate to the test set successfully (R2 = 0.91 and RMSE = 0.33). In a second step, we have analyzed the used descriptors within the models as well as the structural features of the molecules in the training set. This analysis resulted in a transparent and informative SAR map that can be very useful for medicinal chemists to design new Lyn kinase inhibitors.

scholarly journals Prediction of mean wave overtopping at simple sloped breakwaters using kernel-based methods

2021 ◽  
Author(s):  
Shabnam Hosseinzadeh ◽  
Amir Etemad-Shahidi ◽  
Ali Koosheh
Keyword(s):  
Neural Network ◽  
Sensitivity Analysis ◽  
Gaussian Process Regression ◽  
Structural Features ◽  
Support Vector ◽  
Ann Model ◽  
Wave Overtopping ◽  
Taylor Diagram ◽  
The Mean ◽  
Artificial Neural Network Ann

Abstract The accurate prediction of the mean wave overtopping rate at breakwaters is vital to have a safe design. Hence, providing a robust tool as a preliminary estimator can be useful for practitioners. Recently, soft computing tools such as artificial neural network (ANN) have been developed as alternatives to traditional overtopping formulae. The goal of this paper is to assess the capabilities of two kernel-based methods namely Gaussian process regression (GPR) and support vector regression for the prediction of mean wave overtopping rate at sloped breakwaters. An extensive dataset taken from EurOtop (2018) database, including rubble mound structures with permeable core, straight slopes, without berm, and crown wall, was employed to develop the models. Different combinations of the important dimensionless parameters representing structural features and wave conditions were tested based on the sensitivity analysis for developing the models. The obtained results were compared with those of the ANN model and the existing empirical formulae. The modified Taylor diagram was used to compare the models graphically. The results showed the superiority of kernel-based models, especially the GPR model over the ANN model and empirical formulae. In addition, the optimal input combination was introduced based on accuracy and the number of input parameters criteria. Finally, the physical consistencies of developed models were investigated the results, of which demonstrated the reliability of kernel-based models in terms of delivering physics of overtopping phenomenon.

Questions to the Article: An Artificial Intelligence Model to Predict the Mortality of COVID-19 Patients at Hospital Admission Time Using Routine Blood Samples (Preprint)

2020 ◽  
Author(s):  
Shu-Chun Kuo ◽  
CHIEN WEI ◽  
Willy Chou
Keyword(s):  
Data Entry ◽  
Ann Model ◽  
Model Accuracy ◽  
Data Format ◽  
Raw Data ◽  
Probability Of Survival ◽  
Testing Data ◽  
Laboratory Results ◽  
Data Yield ◽  
Artificial Neural Network Ann

UNSTRUCTURED The recent article published on December 23 27 in 2020 is well-written and of interest, but remains several questions that are required for clarifications, including (1) 30 feature variables with normalized format(mean=0 and SD=1) required to compare model accuracy with those with the raw-data format; (2)inconsistency in variable numbers between entry and preview panels in Figure 4 and reference typos; and (3) data-entry format with raw blood laboratory results in Figure 4 inconsistent with the model designed using normalized data to estimate parameters. We conducted a study using the training and testing data provided by the previous study. An artificial neural network(ANN) model was performed to estimate parameters and compare the model accuracy with those eight models provided by the previous study. We found that (1) normalized data yield higher accuracy than that with the raw data; (2) typos definitely exist at the bottom review (=32>30 variables in the entry) panels in Figure 4 and typos in Table 6; and (3)the ANN earns a probability of survival(=0.91) higher than that(=0.71) in the previous study using the similar entry data when the raw data are assumed in the app. We also demonstrated an author-made app using the visualization to display the prediction result, which is novel and innovative to make the result improved with a dashboard in comparison with the previous study.

scholarly journals Predicting the 14-Day Hospital Readmission of Patients with Pneumonia Using Artificial Neural Networks (ANN)

2021 ◽  
Vol 18 (10) ◽  
pp. 5110
Author(s):  
Shu-Farn Tey ◽  
Chung-Feng Liu ◽  
Tsair-Wei Chien ◽  
Chin-Wei Hsu ◽  
Kun-Chen Chan ◽  
...  
Keyword(s):  
Neural Network ◽  
Early Stage ◽  
Characteristic Curve ◽  
Patient Discharge ◽  
Ann Model ◽  
Healthcare Settings ◽  
High Area ◽  
Icd 10 ◽  
Artificial Neural ◽  
Artificial Neural Network Ann

Unplanned patient readmission (UPRA) is frequent and costly in healthcare settings. No indicators during hospitalization have been suggested to clinicians as useful for identifying patients at high risk of UPRA. This study aimed to create a prediction model for the early detection of 14-day UPRA of patients with pneumonia. We downloaded the data of patients with pneumonia as the primary disease (e.g., ICD-10:J12*-J18*) at three hospitals in Taiwan from 2016 to 2018. A total of 21,892 cases (1208 (6%) for UPRA) were collected. Two models, namely, artificial neural network (ANN) and convolutional neural network (CNN), were compared using the training (n = 15,324; ≅70%) and test (n = 6568; ≅30%) sets to verify the model accuracy. An app was developed for the prediction and classification of UPRA. We observed that (i) the 17 feature variables extracted in this study yielded a high area under the receiver operating characteristic curve of 0.75 using the ANN model and that (ii) the ANN exhibited better AUC (0.73) than the CNN (0.50), and (iii) a ready and available app for predicting UHA was developed. The app could help clinicians predict UPRA of patients with pneumonia at an early stage and enable them to formulate preparedness plans near or after patient discharge from hospitalization.

scholarly journals Modeling Fused Filament Fabrication using Artificial Neural Networks

2021 ◽  
Author(s):  
Paul Oehlmann ◽  
Paul Osswald ◽  
Juan Camilo Blanco ◽  
Martin Friedrich ◽  
Dominik Rietzel ◽  
...  
Keyword(s):  
Real Time ◽  
Large Scale ◽  
Cost Effective ◽  
Print Quality ◽  
Ann Model ◽  
Production Environment ◽  
Fused Filament Fabrication ◽  
Artificial Neural ◽  
Using Data ◽  
Artificial Neural Network Ann

AbstractWith industries pushing towards digitalized production, adaption to expectations and increasing requirements for modern applications, has brought additive manufacturing (AM) to the forefront of Industry 4.0. In fact, AM is a main accelerator for digital production with its possibilities in structural design, such as topology optimization, production flexibility, customization, product development, to name a few. Fused Filament Fabrication (FFF) is a widespread and practical tool for rapid prototyping that also demonstrates the importance of AM technologies through its accessibility to the general public by creating cost effective desktop solutions. An increasing integration of systems in an intelligent production environment also enables the generation of large-scale data to be used for process monitoring and process control. Deep learning as a form of artificial intelligence (AI) and more specifically, a method of machine learning (ML) is ideal for handling big data. This study uses a trained artificial neural network (ANN) model as a digital shadow to predict the force within the nozzle of an FFF printer using filament speed and nozzle temperatures as input data. After the ANN model was tested using data from a theoretical model it was implemented to predict the behavior using real-time printer data. For this purpose, an FFF printer was equipped with sensors that collect real time printer data during the printing process. The ANN model reflected the kinematics of melting and flow predicted by models currently available for various speeds of printing. The model allows for a deeper understanding of the influencing process parameters which ultimately results in the determination of the optimum combination of process speed and print quality.

A comparative study and combined application of RSM and ANN in adsorptive removal of diuron using biomass ashes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sunil K. Deokar ◽  
Nachiket A. Gokhale ◽  
Sachin A. Mandavgane
Keyword(s):  
Three Dimensional ◽  
Current Approach ◽  
Coefficient Of Determination ◽  
Ann Model ◽  
Operational Parameters ◽  
Initial Concentration ◽  
Combined Application ◽  
Artificial Neural Network Ann ◽  
Relationship Of ◽  
Biomass Ashes

Abstract Biomass ashes like rice husk ash (RHA), bagasse fly ash (BFA), were used for aqueous phase removal of a pesticide, diuron. Response surface methodology (RSM) and artificial neural network (ANN) were successfully applied to estimate and optimize the conditions for the maximum diuron adsorption using biomass ashes. The effect of operational parameters such as initial concentration (10–30 mg/L); contact time (0.93–16.07 h) and adsorbent dosage (20–308 mg) on adsorption were studied using central composite design (CCD) matrix. Same design was also employed to gain a training set for ANN. The maximum diuron removal of 88.95 and 99.78% was obtained at initial concentration of 15 mg/L, time of 12 h, RHA dosage of 250 mg and at initial concentration of 14 mg/L, time of 13 h, BFA dosage of 60 mg respectively. Estimation of coefficient of determination (R 2) and mean errors obtained for ANN and RSM (R 2 RHA = 0.976, R 2 BFA = 0.943) proved ANN (R 2 RHA = 0.997, R 2 BFA = 0.982) fits better. By employing RSM coupled with ANN model, the qualitative and quantitative activity relationship of experimental data was visualized in three dimensional spaces. The current approach will be instrumental in providing quick preliminary estimations in process and product development.

scholarly journals User Automotive Powertrain-Type Choice Model and Analysis Using Neural Networks

2021 ◽  
Vol 13 (2) ◽  
pp. 585
Author(s):  
Fabio Luis Marques dos Santos ◽  
Paolo Tecchio ◽  
Fulvio Ardente ◽  
Ferenc Pekár
Keyword(s):  
Internal Combustion Engine ◽  
User Behavior ◽  
Choice Model ◽  
Combustion Engine ◽  
Stated Preference ◽  
Operating Cost ◽  
Internal Combustion ◽  
Ann Model ◽  
Purchase Cost ◽  
Artificial Neural Network Ann

This paper presents an artificial neural network (ANN) model that simulates user’s choice of electric or internal combustion engine automotive vehicles based on basic vehicle attributes (purchase price, range, operating cost, taxes due to emissions, time to refuel/recharge and vehicle price depreciation), with the objective of analyzing user behavior and creating a model that can be used to support policymaking. The ANN was trained using stated preference data from a survey carried out in six European countries, taking into account petrol, diesel and battery electric automotive vehicle attributes. Model results show that the electric vehicle parameters (especially purchase cost, range and recharge times), as well as the purchase cost of internal combustion engine vehicles, have the most influence on consumers’ vehicle choices. A graphical interface was created for the model, to make it easier to understand the interactions between different attributes and their impacts on consumer choices and thus help policy decisions.

Modeling of lime production process using artificial neural network

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Abolghasem Daeichian ◽  
Rana Shahramfar ◽  
Elham Heidari
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Production Process ◽  
High Energy ◽  
Ann Model ◽  
Artificial Neural ◽  
Rotary Kilns ◽  
Input Variables ◽  
Artificial Neural Network Ann ◽  
Lime Production

Abstract Lime is a significant material in many industrial processes, including steelmaking by blast furnace. Lime production through rotary kilns is a standard method in industries, yet it has depreciation, high energy consumption, and environmental pollution. A model of the lime production process can help to not only increase our knowledge and awareness but also can help reduce its disadvantages. This paper presents a black-box model by Artificial Neural Network (ANN) for the lime production process considering pre-heater, rotary kiln, and cooler parameters. To this end, actual data are collected from Zobahan Isfahan Steel Company, Iran, which consists of 746 data obtained in a duration of one year. The proposed model considers 23 input variables, predicting the amount of produced lime as an output variable. The ANN parameters such as number of hidden layers, number of neurons in each layer, activation functions, and training algorithm are optimized. Then, the sensitivity of the optimum model to the input variables is investigated. Top-three input variables are selected on the basis of one-group sensitivity analysis and their interactions are studied. Finally, an ANN model is developed considering the top-three most effective input variables. The mean square error of the proposed models with 23 and 3 inputs are equal to 0.000693 and 0.004061, respectively, which shows a high prediction capability of the two proposed models.

scholarly journals Neural Components of Reading Revealed by Distributed and Symbolic Computational Models

2020 ◽  
Vol 1 (4) ◽  
pp. 381-401
Author(s):  
Ryan Staples ◽  
William W. Graves
Keyword(s):  
Neural Activity ◽  
Neural Coding ◽  
Computational Models ◽  
Ann Model ◽  
Distributed Representations ◽  
Neural Data ◽  
Cognitive Components ◽  
Components Of Reading ◽  
Artificial Neural Network Ann ◽  
Models Of Reading

Determining how the cognitive components of reading—orthographic, phonological, and semantic representations—are instantiated in the brain has been a long-standing goal of psychology and human cognitive neuroscience. The two most prominent computational models of reading instantiate different cognitive processes, implying different neural processes. Artificial neural network (ANN) models of reading posit nonsymbolic, distributed representations. The dual-route cascaded (DRC) model instead suggests two routes of processing, one representing symbolic rules of spelling–to–sound correspondence, the other representing orthographic and phonological lexicons. These models are not adjudicated by behavioral data and have never before been directly compared in terms of neural plausibility. We used representational similarity analysis to compare the predictions of these models to neural data from participants reading aloud. Both the ANN and DRC model representations corresponded to neural activity. However, the ANN model representations correlated to more reading-relevant areas of cortex. When contributions from the DRC model were statistically controlled, partial correlations revealed that the ANN model accounted for significant variance in the neural data. The opposite analysis, examining the variance explained by the DRC model with contributions from the ANN model factored out, revealed no correspondence to neural activity. Our results suggest that ANNs trained using distributed representations provide a better correspondence between cognitive and neural coding. Additionally, this framework provides a principled approach for comparing computational models of cognitive function to gain insight into neural representations.

Sign in / Sign up

Export Citation Format

Share Document