Welding fumes and lung cancer: a meta-analysis of case-control and cohort studies

BackgroundAn estimated 110 million workers are exposed to welding fumes worldwide. Welding fumes are classified by the International Agency for Research on Cancer as carcinogenic to humans (group 1), based on sufficient evidence of lung cancer from epidemiological studies.ObjectiveTo conduct a meta-analysis of case-control and cohort studies on welding or exposure to welding fumes and risk of lung cancer, accounting for confounding by exposure to asbestos and tobacco smoking.MethodsThe literature was searched comprehensively in PubMed, reference lists of relevant publications and additional databases. Overlapping populations were removed. Meta-relative risks (mRRs) were calculated using random effects models. Publication bias was assessed using funnel plot, Eggers’s test and Begg’s test.ResultsForty-five studies met the inclusion criteria (20 case-control, 25 cohort/nested case-control), which reduced to 37 when overlapping study populations were removed. For ‘ever’ compared with ‘never’ being a welder or exposed to welding fumes, mRRs and 95% CIs were 1.29 (1.20 to 1.39; I2=26.4%; 22 studies) for cohort studies, 1.87 (1.53 to 2.29; I2=44.1%; 15 studies) for case-control studies and 1.17 (1.04 to 1.38; I2=41.2%) for 8 case-control studies that adjusted for smoking and asbestos exposure. The mRRs were 1.32 (95% CI 1.20 to 1.45; I2=6.3%; 15 studies) among ‘shipyard welders’, 1.44 (95% CI 1.07 to 1.95; I2=35.8%; 3 studies) for ‘mild steel welders’ and 1.38 (95% CI 0.89 to 2.13; I2=68.1%; 5 studies) among ‘stainless steel welders’. Increased risks persisted regardless of time period, geographic location, study design, occupational setting, exposure assessment method and histological subtype.ConclusionsThese results support the conclusion that exposure to welding fumes increases the risk of lung cancer, regardless of the type of steel welded, the welding method (arc vs gas welding) and independent of exposure to asbestos or tobacco smoking.

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Faculty Opinions recommendation of Welding fumes and lung cancer: a meta-analysis of case-control and cohort studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735470097.793560427 ◽

2019 ◽

Author(s):

Sherwood Burge

Keyword(s):

Lung Cancer ◽

Cohort Studies ◽

Meta Analysis ◽

Case Control ◽

Welding Fumes

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Association of Lung Cancer and Tea-Drinking Habits of Different Subgroup Populations: Meta-Analysis of Case-Control Studies and Cohort Studies

Iranian Journal of Public Health ◽

10.18502/ijph.v48i9.3013 ◽

2020 ◽

Author(s):

Zijun GUO ◽

Mei JIANG ◽

Wenting LUO ◽

Huimin HUANG ◽

Baoqing SUN

Keyword(s):

Lung Cancer ◽

Cohort Studies ◽

Protective Effect ◽

Protective Factor ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Drinking Habits ◽

Tea Drinking

Background: We aimed to investigate the association between lung cancer and tea-drinking habits of different subgroup populations. Methods: Systematic search of the PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Sinomed databases from database construction until January 2017 for English and Chinese language articles on association of lung cancer and tea drinking. Meta-analysis was used to calculate the combined odds ratio (OR) value and its 95% confidence interval (95% CI). The Newcastle-Ottawa scale was used to evaluate the quality of the studies and Q-test and I2 was used for heterogeneity testing. Results: Forty two papers were included, 30 case-control studies included 14578 lung cancer patients and 180574 controls, 12 cohort studies included 543825 subjects, of which the outcome was 5085 with lung cancer. Tea drinkers were found to have a decreased OR of lung cancer compared with non-tea drinkers (OR 0. 80, 95% CI: 0. 73, 0. 87). Consumption of green, black or unspecified tea has a protective effect compared with not drinking tea at all. Increased intake of green tea to 7. 5 g per day can further reduce the OR of lung cancer (OR 0. 69, 95% CI: 0. 48-0. 98). Tea consumption had a protective effect against lung cancer in non-smokers, Further analysis found that drinking of one or more cups of tea a day has a protective effect on smokers (OR 0. 79, 95%CI: 0. 64–0. 96). Conclusion: Tea drinking could be a protective factor in lung cancer.

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Soy Consumption with Risk of Coronary Heart Disease and Stroke: A Meta-Analysis of Observational Studies

Neuroepidemiology ◽

10.1159/000444324 ◽

2016 ◽

Vol 46 (4) ◽

pp. 242-252 ◽

Cited By ~ 11

Author(s):

Danfei Lou ◽

Yuehua Li ◽

Guoliang Yan ◽

Jianhong Bu ◽

Haihui Wang

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Cohort Studies ◽

Observational Studies ◽

Meta Analysis ◽

Case Control ◽

Inverse Association ◽

Case Control Studies ◽

Relative Risks ◽

Product Consumption

Background: The association of soy product consumption with the relative risk of cardiovascular disease remains controversial. This meta-analysis aimed at investigating whether an association exists between soy consumption and the risk of stroke and coronary heart disease (CHD) in observational studies. Methods: A systematic search of the PubMed and EMBASE databases was performed for case-control and cohort studies that assessed soy consumption and the risk of stroke and CHD. Summary relative risks (SRRs) and 95% CIs were combined by using a random-effects model. Results: Of a total of 1,266 abstracts, 5 prospective cohort and 6 case-control studies met our inclusion criteria, and comprised 4,954 stroke and 7,616 CHD events. Based on the high vs. low analyses, combining cohort studies showed no association between soy intake and risk of stroke (SRR 0.92; 95% CI 0.70-1.10; Pheterogeneity = 0.236; I2 = 29.4%) or CHD (SRR 0.97; 95% CI 0.74-1.27; Pheterogeneity = 0.020; I2 = 62.7%), although a significantly inverse association between soy intake and the risk of stroke (SRR 0.54; 95% CI 0.34-0.87; Pheterogeneity = 0.001; I2 = 79.3%) and CHD (SRR 0.66; 95% CI 0.56-0.77; Pheterogeneity = 0.421; I2 = 0) was observed in case-control studies. No association between soy isoflavone intake and the risk of stroke and CHD was identified. Conclusion: There was limited evidence to indicate that soy consumption was inversely associated with the risk of stroke and CHD, although further studies, with prospective designs that use validated questionnaires and control for important confounders, are warranted.

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Meta-analysis of case–control studies on the relationship between lung cancer and indoor radon exposure

Radiation and Environmental Biophysics ◽

10.1007/s00411-018-0770-5 ◽

2018 ◽

Vol 58 (1) ◽

pp. 39-47 ◽

Cited By ~ 2

Author(s):

Georgy Malinovsky ◽

Ilia Yarmoshenko ◽

Aleksey Vasilyev

Keyword(s):

Lung Cancer ◽

Indoor Radon ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Radon Exposure ◽

The Relationship

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Dietary patterns and CVD: a systematic review and meta-analysis of observational studies

British Journal Of Nutrition ◽

10.1017/s0007114515003177 ◽

2015 ◽

Vol 114 (9) ◽

pp. 1341-1359 ◽

Cited By ~ 75

Author(s):

Míriam Rodríguez-Monforte ◽

Gemma Flores-Mateo ◽

Emília Sánchez

Keyword(s):

Cohort Studies ◽

Dietary Patterns ◽

Observational Studies ◽

Protective Factor ◽

Meta Analysis ◽

Epidemiological Studies ◽

Case Control ◽

Case Control Studies ◽

Chd Risk ◽

Control Comparison

AbstractEpidemiological studies show that diet is linked to the risk of developing CVD. The objective of this meta-analysis was to estimate the association between empirically derived dietary patterns and CVD. PubMed was searched for observational studies of data-driven dietary patterns that reported outcomes of cardiovascular events. The association between dietary patterns and CVD was estimated using a random-effects meta-analysis with 95 % CI. Totally, twenty-two observational studies met the inclusion criteria. The pooled relative risk (RR) for CVD, CHD and stroke in a comparison of the highest to the lowest category of prudent/healthy dietary patterns in cohort studies was 0·69 (95 % CI 0·60, 0·78; I2=0 %), 0·83 (95 % CI 0·75, 0·92; I2=44·6 %) and 0·86 (95 % CI 0·74, 1·01; I2=59·5 %), respectively. The pooled RR of CHD in a case–control comparison of the highest to the lowest category of prudent/healthy dietary patterns was 0·71 (95 % CI 0·63, 0·80; I2=0 %). The pooled RR for CVD, CHD and stroke in a comparison of the highest to the lowest category of western dietary patterns in cohort studies was 1·14 (95 % CI 0·92, 1·42; I2=56·9 %), 1·03 (95 % CI 0·90, 1·17; I2=59·4 %) and 1·05 (95 % CI 0·91, 1·22; I2=27·6 %), respectively; in case–control studies, there was evidence of increased CHD risk. Our results support the evidence of the prudent/healthy pattern as a protective factor for CVD.

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Meta-analysis of twenty radon and lung cancer case–control studies

Radioactivity in the Environment - The Natural Radiation Environment VII: VIIth Int. Symp. On the NRE ◽

10.1016/s1569-4860(04)07095-0 ◽

2005 ◽

pp. 762-771 ◽

Cited By ~ 4

Author(s):

I.V. Yarmoshenko ◽

I.A. Kirdin ◽

M.V. Zhukovsky ◽

S.Y. Astrakhantseva

Keyword(s):

Lung Cancer ◽

Meta Analysis ◽

Case Control ◽

Cancer Case ◽

Lung Cancer Case ◽

Case Control Studies

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Association of Helicobacter pylori Infection with the Risk of Metabolic Syndrome and Insulin Resistance: An Updated Systematic Review and Meta-Analysis

10.21203/rs.3.rs-789572/v1 ◽

2021 ◽

Author(s):

Mobin Azami ◽

Hamid Reza Baradaran ◽

Parisa Kohnepoushi ◽

Lotfolah Saed ◽

Asra Moradkhani ◽

...

Keyword(s):

Systematic Review ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Helicobacter Pylori ◽

Cohort Studies ◽

Odds Ratio ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

H Pylori

Abstract Background Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome. Methods To identify case-control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval (95%CI) to quantify the effect of case-control studies and risk ratio with its 95%CI for the effect of cohort studies. Results 22 studies with 206911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case-control studies was 1.19 (95%CI: 1.05, 1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95%CI: 1.13, 1.51; I2 = 0%). Besides, case-control studies showed the pooled odds ratio of 1.54 (95%CI: 1.19, 1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance. Conclusion A positive association was found between H. pylori infection and insulin resistance as well as metabolic syndrome, so planning to eliminate or eradicate H. pylori infection could be an effective solution to improve metabolic syndrome or insulin resistance, and vice versa.

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Abstract 12672: Post-Implantation Hematoma Increases Risk of Cardiac Implantable Electronic Device Infection: A Systematic Review and Meta-analysis

Circulation ◽

10.1161/circ.142.suppl_3.12672 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Jakrin Kewcharoen ◽

Chanavuth Kanitsoraphan ◽

Sittinun Thangjui ◽

Thiratest Leesutipornchai ◽

Leenhapong Navaravong

Keyword(s):

Systematic Review ◽

Cohort Studies ◽

Electronic Device ◽

Meta Analysis ◽

Case Control ◽

Cardiac Implantable Electronic Device ◽

Case Control Studies ◽

Randomized Controlled ◽

Device Infection ◽

Post Implantation

Introduction: Several studies have shown inconsistent relationship between post-implantation hematoma (PH) and cardiac implantable electronic device (CIED) infection. In this study, we performed a systematic review and meta-analysis to explore the effect of PH and the risk of CIED infection. Hypothesis: PH increases the risk of CIED infection. Methods: We searched the databases of MEDLINE and EMBASE from inception to March 2020. Included studies were cohort studies, case-control studies, cross-sectional studies and randomized controlled trials that reported incidence of PH and CIED infection during the follow-up period. CIED infection was defined as either a device-related local or systemic infection. Data from each study were combined using the random-effects, generic inverse variance method of Der Simonian and Laird to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: Fourteen studies from 2006 to 2018 were included, involving a total of 28,319 participants. There were 6 cohort studies, 7 case-control studies and 1 randomized controlled trial. In random-effect model, we found that PH significantly increases the risk of overall CIED infection (OR = 6.30, 95%CI: 3.87-10.24, I2=49.3%) (Figure 1). There was no publication bias observed in the funnel plot as well as no small-study effect observed in Egger’s test. Conclusions: Our meta-analysis demonstrated that PH significantly increases the risk of CIED infection. Precaution should be taken to during device implantation to reduce PH and subsequent CIED infection.

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Effect of Exposure to Cats and Dogs on the Risk of Asthma and Allergic Rhinitis: A Systematic Review and Meta-analysis

American Journal of Rhinology and Allergy ◽

10.1177/1945892420932487 ◽

2020 ◽

Vol 34 (5) ◽

pp. 703-714

Author(s):

Xiaoping Gao ◽

Mei Yin ◽

Pei Yang ◽

Xia Li ◽

Lingling Di ◽

...

Keyword(s):

Systematic Review ◽

Allergic Rhinitis ◽

Cohort Studies ◽

Meta Analysis ◽

Pooled Analysis ◽

Protective Role ◽

Case Control ◽

Favorable Effect ◽

Case Control Studies

Background Controversies persist regarding whether exposure to cat or dog increases the risk of asthma and allergic rhinitis. Objective This meta-analysis aimed to assess the associations between exposure to cats or dogs and the development of asthma and allergic rhinitis. Methods A systematic review was performed to identify case-control and cohort studies before May 2019, evaluating the association between exposure to cats and dogs and the risk of asthma and rhinitis. The risk of bias was assessed using the Newcastle–Ottawa Scale. The odds ratios (ORs) and risk ratios (RRs) were pooled for case-control and cohort studies, respectively. Subgroup analyses were performed on prespecified study-level characteristics. Results The meta-analysis of 34 cohort studies showed a protective role of exposure to cats [RR: 0.88, 95% confidence interval (CI): 0.77–0.99] or dogs (RR: 0.85, 95% CI: 0.73–0.97) in the development of asthma. The subgroup analysis of birth cohort (RR: 0.74, 95% CI: 0.56–0.93) and children population (RR: 0.83, 95% CI: 0.70–0.96) also suggested a favorable role of exposure to dogs in the development of asthma. Pooled evidence from 13 case-control studies indicated no significant impact of cats (OR: 1.66, 95% CI: 0.39–2.94) and dogs (OR: 1.22, 95% CI: 0.92–1.52) on the development of asthma. A pooled analysis of five cohort studies showed a favorable effect of exposure to cats (RR: 0.60, 95% CI: 0.33–0.86) or dogs (RR: 0.68, 95% CI 0.44–0.90) on the development of allergic rhinitis. Conclusion The findings indicated a protective effect of exposure to cats and dogs, especially ownership, on the development of asthma and allergic rhinitis.

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