Republished: The relationship between serum TSH and free T4 in older people

2012 ◽  
Vol 88 (1045) ◽  
pp. 668-670 ◽  
Author(s):  
Penny M Clark ◽  
Roger L Holder ◽  
Sayeed M Haque ◽  
F D Richard Hobbs ◽  
Lesley M Roberts ◽  
...  
Keyword(s):  
Older People ◽  
Free T4 ◽  
The Relationship ◽  
Serum Tsh

The relationship between serum TSH and free T4 in older people: Figure 1

2012 ◽  
Vol 65 (5) ◽  
pp. 463-465 ◽  
Author(s):  
Penny M Clark ◽  
Roger L Holder ◽  
Sayeed M Haque ◽  
F D Richard Hobbs ◽  
Lesley M Roberts ◽  
...  
Keyword(s):  
Older People ◽  
Free T4 ◽  
The Relationship ◽  
Serum Tsh

Human cold air habituation is independent of thyroxine and thyrotropin

1992 ◽  
Vol 72 (6) ◽  
pp. 2134-2139 ◽  
Author(s):  
R. L. Hesslink ◽  
M. M. D'Alesandro ◽  
D. W. Armstrong ◽  
H. L. Reed
Keyword(s):  
Single Daily Dose ◽  
Plasma Norepinephrine ◽  
Free T4 ◽  
Cold Air ◽  
Brown Adipose ◽  
Daily Dose ◽  
Before And After ◽  
Serum T4 ◽  
The Relationship ◽  
Serum Tsh

Thyroxine (T4) is required in species possessing brown adipose tissue (BAT) for the maintenance of cold tolerance and adaptation. In humans, who possess negligible quantities of BAT, the importance of T4 has not been demonstrated. We studied the effects of decreased serum T4 and thyrotropin (TSH) on human cold habituation after repeated cold air exposures. Eight men (T3+) received a single daily dose of triiodothyronine (T3; 30 micrograms/day), and another eight men (T3-) received a placebo. All 16 normal thyroid men underwent a standardized cold air test (SCAT) under basal conditions in January and again in March after eighty 30-min 4.4 degrees C air exposures (10/wk). Measurements of basal metabolic rate (BMR), O2 consumption (VO2), mean arterial pressure (MAP), plasma norepinephrine (NE), serum TSH, free and total T4, and free and total T3 were repeated before and after 8 wk of exposure. TSH, free T4, and total T4 were 50% lower for T3+ than for T3- subjects. Total and free T3 were not different between groups. BMR was unchanged after habituation, whereas the cold-stimulated VO2, MAP, and NE were significantly reduced for all subjects in March. The relationship between VO2 and NE (r2 = 0.44, P less than 0.001) during the initial SCAT was unchanged with habituation. We suggest that human cold habituation is independent of major changes in circulating T4 and TSH.

scholarly journals Age and the Thyrotropin Response to Hypothyroxinemia

2010 ◽  
Vol 95 (8) ◽  
pp. 3675-3683 ◽  
Author(s):  
Rebecca Over ◽  
Sonia Mannan ◽  
Hala Nsouli-Maktabi ◽  
Kenneth D. Burman ◽  
Jacqueline Jonklaas
Keyword(s):  
Age Groups ◽  
Primary Hypothyroidism ◽  
Age Group ◽  
Older Individuals ◽  
Free T4 ◽  
Pathological Alteration ◽  
The Mean ◽  
The Relationship ◽  
Two Populations ◽  
Serum Tsh

Context: Some studies suggest altered pituitary functioning and TSH production with aging. Objective: Our objective was to test the hypothesis that less TSH production occurs despite comparable hypothyroxinemia with advancing age. Design: We retrospectively studied adult outpatients of all ages with confirmed hypothyroidism and documented their TSH and free T4 concentrations. Participants: Two populations of 112 patients were subdivided into four age groups: 1) patients newly diagnosed with primary hypothyroidism and 2) thyroid cancer patients undergoing l-T4 withdrawal in preparation for diagnostic or therapeutic radioiodine. Main Outcome Measure: The relationship between paired free T4 and TSH concentrations and patient age was studied. Results: With spontaneous hypothyroidism, the mean TSH concentration decreased nonsignificantly in each ascending age group with comparable free T4 (FT4) concentrations (<35 yr, 69 mIU/liter; 35–49 yr, 49 mIU/liter; 50–64 yr, 43 mIU/liter; >64 yr, 29 mIU/liter). With iatrogenic hypothyroidism, the mean TSH concentration decreased significantly in each ascending age group (<35 yr, 156 mIU/liter; 35–49 yr, 115 mIU/liter; 50–64 yr, 74 mIU/liter; >64 yr, 46 mIU/liter; P < 0.001) despite similar FT4 concentrations. The relationship between the log-transformed TSH and FT4 was significantly and inversely affected by age in multivariate analyses in both spontaneous hypothyroidism (P = 0.0005) and in iatrogenic hypothyroidism (P < 0.0001). Conclusions: Age modifies the pituitary set point or response to comparably reduced free T4 concentrations, resulting in lesser serum TSH elevation in older individuals. This phenomenon occurs with both spontaneous and iatrogenic hypothyroidism. This may be an adaptive response in normal aging or a pathological alteration of pituitary function with age.

The Relationship Between Antioxidant Nutrient Intake and Cataracts in Older People

2006 ◽  
Vol 76 (6) ◽  
pp. 359-366 ◽  
Author(s):  
Rodríguez-Rodríguez ◽  
Ortega ◽  
López-Sobaler ◽  
Aparicio ◽  
Bermejo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Older People ◽  
Dietary Intake ◽  
Protective Effect ◽  
Elderly People ◽  
Nutrient Intake ◽  
Institutionalized Elderly ◽  
Weighing Method ◽  
The Relationship

This study investigated the relationship between the intake of antioxidant nutrients and the suffering of cataracts in 177 institutionalized elderly people (61 men and 116 women) aged ≥ 65 years. Dietary intake was monitored for 7 consecutive days using a "precise individual weighing" method. Subjects, who during their earlier years were exposed by their work to sunlight, had a greater risk of suffering cataracts (OR = 3.2; Cl: 1.1–9.3, P < 0.05) than those who worked indoors. A relationship was found between increased vitamin C intake and a reduced prevalence of cataracts (i.e., when comparing those above P95 for vitamin C intake with those below P5; (OR = 0.08; Cl: 0.01–0.75, P 0.05). Among subjects with cataracts, 12.1% had vitamin C intakes of < 61 mg/day (P10) and only 2.2% had intakes of > 183 mg/day (P95) (p < 0.01). Subjects who consumed > 3290 μg/day (P95) of lutein were less likely to have cataracts (OR = 0.086; Cl: 0.007–1.084; p < 0.05) than those whose consumption was < 256 μg/day (P5). In men, high intakes of zeaxanthin seemed to provide a protective effect against the problem (OR = 0.96; Cl: 0.91–0.99; p < 0.05). The results suggest an association exists between exposure to sunlight and the development of cataracts, and that vitamin C, lutein, and zeaxanthin offer some protection against this disorder.

Oral health diseases among the older people: a general health perspective

2020 ◽  
Keyword(s):  
Public Health ◽  
Health Care ◽  
Oral Health ◽  
Older People ◽  
Health Professionals ◽  
General Health ◽  
Oral Health Care ◽  
Oral Diseases ◽  
Public Health Professionals ◽  
The Relationship

Background: The relationship between oral health and general health is gaining interest in geriatric research; however, a lack of studies dealing with this issue from a general perspective makes it somewhat inaccessible to non-clinical public health professionals. Purpose: The purpose of this review is to describe the relationship between oral health and general health of the elderly on the basis of literature review, and to give non-clinical medical professionals and public health professionals an overview of this discipline. Methods: This study was based on an in-depth review of the literature pertaining to the relationship between oral health and general health among the older people. The tools commonly used to evaluate dental health and the academic researches of male elderly people were also reviewed. And future research directions were summarized. Results: Dental caries, periodontal disease, edentulism, and xerostomia are common oral diseases among the older people. Dental caries and periodontal diseases are the leading causes of missing teeth and edentulism. Xerostomia, similar to dry mouth, is another common oral health disease in the older people. No clear correlation exists between the subjective feeling of dryness and an objective decrease of saliva. Rather, both conditions can be explained by changes in saliva. The General Oral Health Assessment Index (GOHAI) and the Oral Health Impact Profile (OHIP) are the main assessment tools used to examine oral health and quality of life in the older people. The GOHAI tends to be more sensitive to objective values pertaining to oral function. In addition, oral health studies in male elderly people are population-based cohort or cross-sectional studies, involving masticatory function, oral prevention, frailty problems, cardiovascular disease risk, and cognitive status. Conclusion: It is possible to reduce the incidence of certain oral diseases, even among individuals who take oral health care seriously. Oral health care should be based on the viewpoint of comprehensive treatment, including adequate nutrition, good life and psychology, and correct oral health care methods. In the future, researchers could combine the results of meta-analysis with the clinical experience of doctors to provide a more in-depth and broader discussion on oral health research topics concerning the older people.

HUBUNGAN KONDISI FISIK, PSIKOLOGIS, DAN SOSIAL LANJUT USIA DENGAN DISABILITAS FUNGSIONAL LANJUT USIA DI YOGYAKARTA

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Catur Hary Wibawa
Keyword(s):  
Older People ◽  
Physical Condition ◽  
Social Condition ◽  
Psychological Condition ◽  
High Category ◽  
Correlational Design ◽  
Functional Disabilities ◽  
Relationship Of ◽  
Spearman Test ◽  
The Relationship

Abstract This research aims to reveal 1. the condition of older people who lives in Plosokerep Shleter, 2. the psychological condition of older people in Plosokerep Shelter, 3. the social condition of older people in Plosokerep Shelter, 4. the relationship of physical condition experienced by older people with their functional disabilities in Plosokerep Shelter, 5. the relationship of psychological condition experienced by older people with their functional disabilities in Plosokerep Shleter, 6. to know the relatonship of social condition experienced by older people with their functional disabilities in Plosokerep Shelter. The research method used is explanatory-analytic correlational design, to examine the relationship of factors: Physical (X1 variable), Psychological (X2), and social (X3) with older people functional disabilities (Y variable) descriptive survey used explanatory-analytic correlational design. Data collection carried out through questionnaire. Research data analysis used descriptive statistic technique with Spearman test statistic. The result showed that: 1. some older people in Plosokerep shleter have high physical condition and the rest of them in the low physical condition category, 2. from the psychological condition some of older people are in high category, 3. Social condition experienced by older people who live in shelter are in high category, 4. The relationship of physical condition experienced by older people in the shelter with functional disabilities even though there is a correlation but not significant, 5. the relationship of psychological condition experienced by older people in shleter with functional disabilities even though there is a correlation but not significant, 6. the relationship of social condition experienced by older people in the shelter with functional disabilities even though there is a correlation but not significant, 7. the relationship of Physical, psychological and social condition together with functional disabilities even though there is a correlation but not significant.Keywords: physical, psychological, and social condition, functional disabilities, older people Abstrak Penelitian ini bertujuan untuk mengungkapkan: 1. Mengetahui kondisi fisik lanjut usia yang ada di shelter Plosokerep, 2. Mengetahui kondisi psikologis lanjut usia yang ada di shelter Plosokerep, 3. Mengetahui kondisi sosial lanjut usia yang ada di shelter Plosokerep, 4. Mengetahui hubungan kondisi fisik yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep, 5. Mengetahui hubungan kondisi psikologis yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep, 6. Mengetahui hubungan kondisi sosial yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep.Metode penelitian yang digunakan adalah disain korelasional eksplanatori-analitis, yaitu untuk menguji hubungan antara faktor-faktor: fisik (variabel X1), psikologis (X2), dan sosial (X3) dengan disabilitas fungsional lanjut usia (variabel Y)survey deskriptif dengan menggunakan disain penelitian korelasional eksplanatori-analitis. Teknik pengumpulan data dilakukan melalui kuesioner. Analisis data penelitian menggunakan teknik Statistik deskriptif, dengan statistik uji Spearman.Hasil penelitian menunjukkan bahwa: 1. Sebagian lanjut usia di shelter pengungsian Plosokerep memiliki kondisi fisik kategori tinggi, dan sebagian lagi berada dalam kondisi fisik kategori rendah, 2. Dilihat dari kondisi psikologis, sebagian besar lanjut usia berada dalam kategori tinggi, 3. Kondisi sosial yang dialami lanjut usia selama berada di shelter pengungsian, sebagian besar juga berada dalam kategori tinggi, 4. Hubungan kondisi fisik yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 5. Hubungan kondisi psikologis yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 6. Hubungan kondisi sosial yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 7. Hubungan kondisi fisik, psikologis, dan sosial secara bersama-sama dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan.Kata kunci:  disabilitas fungsional, kondisi fisik, psikologis, dan sosial, lanjut usia

scholarly journals Quality of Care Provided by Family Caregivers of Older People With Dementia: Measurement and Interpretations

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 152-152
Author(s):  
Afeez Hazzan
Keyword(s):  
Quality Of Care ◽  
Older People ◽  
Family Caregivers ◽  
Family Caregiver ◽  
Primary Reason ◽  
People With Dementia ◽  
High Level ◽  
The Impact ◽  
The Relationship

Abstract Family caregivers of older people living with dementia are relatives, friends, or neighbors who provide assistance related to this condition, but who are unpaid for the services they provide. Although caregiving could be personally rewarding, many caregivers report a high level of strain. Compared to caregivers of older adults who do not have dementia, family caregivers of older people living with dementia report lower quality-of-life (QoL). In a published systematic review examining the relationship between family caregiver QoL and the quality of care provided, only one study was found to be somewhat relevant. The study suggested that the primary reason for an absence of research into the link between family caregiver QoL and quality of care was the absence of a questionnaire for measuring quality of care in dementia. Therefore, any attempt to investigate the impact of caregiver QoL on the care provided to older people with dementia must first address the lack of an instrument to measure quality of care. To address this issue, we interviewed approximately 20 family caregivers in order to elicit feedback on measurements and interpretation of the quality of care provided by family caregivers of older people living with dementia. Content analysis of the interview transcripts revealed that the quality of relationships with family, caregiver availability to provide or supervise care, and availability of paid or volunteer help are important for the quality of care provided. These results have important implications, particularly for the development of an instrument to measure quality of care in dementia.

scholarly journals The Relationship Between TSH and Free T4 in a Large Population Is Complex and Nonlinear and Differs by Age and Sex

2013 ◽  
Vol 98 (7) ◽  
pp. 2936-2943 ◽  
Author(s):  
Narelle C. Hadlow ◽  
Karen M. Rothacker ◽  
Robert Wardrop ◽  
Suzanne J. Brown ◽  
Ee Mun Lim ◽  
...  
Keyword(s):  
Large Population ◽  
Free T4 ◽  
The Relationship ◽  
Age And Sex

scholarly journals Subclinical Hypothyroidism and Indices for Metabolic Syndrome in Japanese Women: One-Year Follow-Up Study

2013 ◽  
Vol 98 (8) ◽  
pp. 3280-3287 ◽  
Author(s):  
Yasuyo Nakajima ◽  
Masanobu Yamada ◽  
Masako Akuzawa ◽  
Sumiyasu Ishii ◽  
Yasuhiro Masamura ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Odds Ratio ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Free T4 ◽  
The Relationship

Context: Subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) increase with age; however, their relationship remains unclear. Objective: Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year. Design: Cross-sectional and longitudinal follow-up studies of cases were collected from Takasaki Hidaka Hospital between 2003 and 2007. Participants: Overall, 11 498 participants of health checkups were analyzed. The mean age was 48 ± 9 years. Main Outcome Measures: The relationship between SCH and indices of MetS were examined. Results: Serum free T4 levels were lower in women than men in most of the age groups, and the prevalence of SCH, 6.3% in women vs 3.4% in men, increased with age, reaching 14.6% in 70-year-old women. Multivariate logistic-regression analyses revealed that waist circumference and the serum triglyceride and low-density lipoprotein-cholesterol levels were significantly higher in subjects with SCH than without among women. Reflecting these findings, the adjusted odds ratio of MetS in patients with SCH was higher than in the euthyroid subjects in women with an odds ratio of 2.7 (95% confidence interval 1.1–5.6; P = .017) but not in men. Furthermore, progression from euthyroid into SCH resulted in a significant increase in the serum triglyceride levels but not low-density lipoprotein-cholesterol in women. Conclusion: Japanese women exhibited a high prevalence of SCH associated with low free T4 levels. There was a strong association between SCH and several indices of metabolic syndrome in women. SCH may affect serum triglyceride levels and be a risk factor for metabolic syndrome.

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