scholarly journals Age and the Thyrotropin Response to Hypothyroxinemia

2010 ◽  
Vol 95 (8) ◽  
pp. 3675-3683 ◽  
Author(s):  
Rebecca Over ◽  
Sonia Mannan ◽  
Hala Nsouli-Maktabi ◽  
Kenneth D. Burman ◽  
Jacqueline Jonklaas
Keyword(s):  
Age Groups ◽  
Primary Hypothyroidism ◽  
Age Group ◽  
Older Individuals ◽  
Free T4 ◽  
Pathological Alteration ◽  
The Mean ◽  
The Relationship ◽  
Two Populations ◽  
Serum Tsh

Context: Some studies suggest altered pituitary functioning and TSH production with aging. Objective: Our objective was to test the hypothesis that less TSH production occurs despite comparable hypothyroxinemia with advancing age. Design: We retrospectively studied adult outpatients of all ages with confirmed hypothyroidism and documented their TSH and free T4 concentrations. Participants: Two populations of 112 patients were subdivided into four age groups: 1) patients newly diagnosed with primary hypothyroidism and 2) thyroid cancer patients undergoing l-T4 withdrawal in preparation for diagnostic or therapeutic radioiodine. Main Outcome Measure: The relationship between paired free T4 and TSH concentrations and patient age was studied. Results: With spontaneous hypothyroidism, the mean TSH concentration decreased nonsignificantly in each ascending age group with comparable free T4 (FT4) concentrations (<35 yr, 69 mIU/liter; 35–49 yr, 49 mIU/liter; 50–64 yr, 43 mIU/liter; >64 yr, 29 mIU/liter). With iatrogenic hypothyroidism, the mean TSH concentration decreased significantly in each ascending age group (<35 yr, 156 mIU/liter; 35–49 yr, 115 mIU/liter; 50–64 yr, 74 mIU/liter; >64 yr, 46 mIU/liter; P < 0.001) despite similar FT4 concentrations. The relationship between the log-transformed TSH and FT4 was significantly and inversely affected by age in multivariate analyses in both spontaneous hypothyroidism (P = 0.0005) and in iatrogenic hypothyroidism (P < 0.0001). Conclusions: Age modifies the pituitary set point or response to comparably reduced free T4 concentrations, resulting in lesser serum TSH elevation in older individuals. This phenomenon occurs with both spontaneous and iatrogenic hypothyroidism. This may be an adaptive response in normal aging or a pathological alteration of pituitary function with age.

scholarly journals Relationship between Histopathological Subtypes of Intracranial Astrocytoma Patients

2014 ◽  
Vol 27 (2) ◽  
pp. 87-93
Author(s):  
Fazle Mahmud ◽  
Haradhan Deb Nath ◽  
Kanak Kanti Barua ◽  
Afzal Hossain
Keyword(s):  
Age Groups ◽  
Low Grade ◽  
Age Group ◽  
Who Grade ◽  
Grade Ii ◽  
The Mean ◽  
The Relationship

Background : The study was carried out in the department of neurosurgery, BSMMU, Dhaka during the period of July 2003 to June 2005. Objective: This study was done to elucidate the relationship between age groups and histopathologicas subtypes in case of intracranial astrocytoma patients. For this purpose, a total number of 44 cases were studied. Results: The mean age of all the patients was 33.1 years (range:1-65 years). The highest incidence was found in the age group of 20 years or below group. Male were more commonly effected than female. WHO grade I astrocytoma was the commonest type. Mean age of low grade astrocytoma (WHO grade II) and glioblastoma were nearly similar to other studies, but the mean age of presentation of grade I astrocytomas patients was little late and for anaplastic actrocytoma a little early in comparison to other study. Conclusion: This showed subtype of astrocytoma has definitive relation to age. Bangladesh Journal of Neuroscience 2011; Vol. 27 (2) : 87-93 DOI: http://dx.doi.org/10.3329/bjn.v27i2.17575

scholarly journals Measles and Mumps Outbreaks in Lebanon : Trends and Links

2019 ◽  
Author(s):  
Talal El Zarif ◽  
Mohamed Faisal Kassir ◽  
Nazih Bizri ◽  
Ghida Kassir ◽  
Umayya Musharrafieh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Vaccination Status ◽  
Epidemiological Surveillance ◽  
Age Group ◽  
Public Database ◽  
The Past ◽  
The Mean ◽  
Measles Outbreaks ◽  
The Relationship

Abstract Abstract: Background: Lebanon has experienced several measles and mumps outbreaks in the past twenty years . In this article, the trend of measles outbreaks in Lebanon was studied in an attempt to outline factors contributing to the failure of elimination plans, and to provide potential solutions. The relationship between measles and mumps outbreaks in Lebanon was described and explored. Methods: A retrospective descriptive study of confirmed cases of measles and mumps in Lebanon between 2003 and 2018 collected from the Lebanese Ministry of Public Health Epidemiological Surveillance Unit public database was carried out. The information collected was graphically represented taking into consideration dates of cases, age groups affected, and vaccination status. Results: The mean number of measles cases was 150.25 cases/year in the 1-4 years age group, 87 cases/year in individuals aging between 5 and 14, and 63.68 cases/year in those > 14 years old. In the latter group, only 18.05% were unvaccinated. The mean number of mumps cases was 30.4 cases/year in the <4 year age group and 53.8 cases/year in the 10-19 years age group. During the study period, every spike in measles cases was followed by a similar spike in mumps. 9.66% of measles cases occurred in individuals who received at least 2 doses of the vaccine, 52.26% in the unvaccinated, and 38% in those whose vaccination status was undetermined. Conclusions: Measles in Lebanon is a disease of the pediatric population, but adults remain at risk. Outbreaks of mumps followed those of measles and were mainly among adolescents. Presence of a large number of Syrian refugees in the country may further complicate the situation. Vaccination activities need to be intensified. Keywords: Measles, mumps, elimination, vaccine, Lebanon.

scholarly journals Measles and Mumps Outbreaks in Lebanon : Trends and Links

2020 ◽  
Author(s):  
Talal El Zarif ◽  
Mohamed Faisal Kassir ◽  
Nazih Bizri ◽  
Ghida Kassir ◽  
Umayya Musharrafieh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Vaccination Status ◽  
Epidemiological Surveillance ◽  
Age Group ◽  
Syrian Refugees ◽  
Public Database ◽  
The Past ◽  
The Mean ◽  
The Relationship

Abstract Background: Lebanon has experienced several measles and mumps outbreaks in the past twenty years. In this article, a case-based surveillance of both measles and mumps outbreaks in Lebanon was carried out in an attempt to outline factors contributing to the failure of elimination plans and to provide potential solutions. The relationship between the outbreaks of both diseases was described and explored. Methods: A retrospective descriptive study of confirmed cases of measles and mumps in Lebanon between 2003 and 2018 collected from the Lebanese Ministry of Public Health Epidemiological Surveillance Unit public database was carried out. The information collected was graphically represented taking into consideration dates of reported cases, age groups affected, and vaccination status. Results: The mean number of measles cases was 150.25 cases/year in the 1-4 years age group, 87 cases/year in individuals aging between 5 and 14, and 63.68 cases/year in those > 14 years old. In the latter group, only 18.05% were unvaccinated. The mean number of mumps cases was 30.4 cases/year in the <4 year age group and 53.8 cases/year in the 10-19 years age group. During the study period, every spike in measles cases was followed by a similar spike in mumps. 9.66% of measles cases occurred in individuals who received at least 2 doses of the vaccine, 52.26% in the unvaccinated, and 38% in those whose vaccination status was undetermined. Conclusions: Measles in Lebanon is a disease of the pediatric population, but adults remain at risk. Outbreaks of mumps followed those of measles and were mainly among adolescents. Presence of a large number of Syrian refugees in the country may further complicate the situation. Vaccination activities need to be intensified.

scholarly journals Measles and Mumps Outbreaks in Lebanon : Trends and Links

2020 ◽  
Author(s):  
Talal El Zarif ◽  
Mohamed Faisal Kassir ◽  
Nazih Bizri ◽  
Ghida Kassir ◽  
Umayya Musharrafieh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Vaccination Status ◽  
Epidemiological Surveillance ◽  
Age Group ◽  
Public Database ◽  
The Past ◽  
The Mean ◽  
Measles Outbreaks ◽  
The Relationship

Abstract Background: Lebanon has experienced several measles and mumps outbreaks in the past twenty years . In this article, the trend of measles outbreaks in Lebanon was studied in an attempt to outline factors contributing to the failure of elimination plans, and to provide potential solutions. The relationship between measles and mumps outbreaks in Lebanon was described and explored. Methods: A retrospective descriptive study of confirmed cases of measles and mumps in Lebanon between 2003 and 2018 collected from the Lebanese Ministry of Public Health Epidemiological Surveillance Unit public database was carried out. The information collected was graphically represented taking into consideration dates of cases, age groups affected, and vaccination status. Results: The mean number of measles cases was 150.25 cases/year in the 1-4 years age group, 87 cases/year in individuals aging between 5 and 14, and 63.68 cases/year in those > 14 years old. In the latter group, only 18.05% were unvaccinated. The mean number of mumps cases was 30.4 cases/year in the <4 year age group and 53.8 cases/year in the 10-19 years age group. During the study period, every spike in measles cases was followed by a similar spike in mumps. 9.66% of measles cases occurred in individuals who received at least 2 doses of the vaccine, 52.26% in the unvaccinated, and 38% in those whose vaccination status was undetermined. Conclusions: Measles in Lebanon is a disease of the pediatric population, but adults remain at risk. Outbreaks of mumps followed those of measles and were mainly among adolescents. Presence of a large number of Syrian refugees in the country may further complicate the situation. Vaccination activities need to be intensified. Keywords: Measles, mumps, elimination, vaccine, Lebanon.

ENDOCRINE CHANGES BEFORE AND AFTER THE MENARCHE

1973 ◽  
Vol 74 (4) ◽  
pp. 695-702 ◽  
Author(s):  
B.-A. Lamberg ◽  
R.-L. Kantero ◽  
P. Saarinen ◽  
O. Widholm
Keyword(s):  
Age Groups ◽  
Age Group ◽  
Significant Elevation ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
The Individual ◽  
Almost All ◽  
Normal Adults ◽  
Serum Tsh

ABSTRACT In an endocrine survey of healthy girls aged 8 to 20 years before and after the menarche the serum TSH was measured by radioimmunoassay along with some parameters of thyroid function which are described separately. The subjects were grouped according to the skeletal age (SA) until the menarche and after this in the post-menarcheal age (PMA) expressed in years. The TSH value was highest in the youngest age group and from then on decreased. However, within 0.5 years after the menarche another significantly elevated TSH peak occurred. There was no significant difference between the means for TSH before (5.4 μU/ml) and after the menarche (5.7 μU/ml). Both values, however, as well as the means for almost all the individual age groups, were significantly higher than the mean for 13 boys aged 12 to 16 years (3.9 μU/ml) and that for normal adults (3.6 μU/ml). When the girls were grouped according to the stage of puberty, the TSH peak at the time of menarche disappeared. When they were grouped according to SA, a gradual declining trend was seen from age 8 to 16 years. It is concluded that the maturation process in girls in some way involves a significant elevation of serum TSH and an increase in the total and free T4 level which is not dependent on binding proteins.

scholarly journals Measles and Mumps Outbreaks in Lebanon : Trends and Links

2020 ◽  
Author(s):  
Talal El Zarif ◽  
Mohamed Faisal Kassir ◽  
Nazih Bizri ◽  
Ghida Kassir ◽  
Umayya Musharrafieh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Vaccination Status ◽  
Epidemiological Surveillance ◽  
Age Group ◽  
Syrian Refugees ◽  
Public Database ◽  
The Past ◽  
The Mean ◽  
The Relationship

Abstract Background: Lebanon has experienced several measles and mumps outbreaks in the past twenty years. In this article, a case-based surveillance of both measles and mumps outbreaks in Lebanon was carried out in an attempt to outline factors contributing to the failure of elimination plans and to provide potential solutions. The relationship between the outbreaks of both diseases was described and explored. Methods: A retrospective descriptive study of confirmed cases of measles and mumps in Lebanon between 2003 and 2018 collected from the Lebanese Ministry of Public Health Epidemiological Surveillance Unit public database was carried out. The information collected was graphically represented taking into consideration dates of reported cases, age groups affected, and vaccination status. Results: The mean number of measles cases was 150.25 cases/year in the 1-4 years age group, 87 cases/year in individuals aging between 5 and 14, and 63.68 cases/year in those > 14 years old. In the latter group, only 18.05% were unvaccinated. The mean number of mumps cases was 30.4 cases/year in the <4 year age group and 53.8 cases/year in the 10-19 years age group. During the study period, every spike in measles cases was followed by a similar spike in mumps. 9.66% of measles cases occurred in individuals who received at least 2 doses of the vaccine, 52.26% in the unvaccinated, and 38% in those whose vaccination status was undetermined. Conclusions: Measles in Lebanon is a disease of the pediatric population, but adults remain at risk. Outbreaks of mumps followed those of measles and were mainly among adolescents. Presence of a large number of Syrian refugees in the country may further complicate the situation. Vaccination activities need to be intensified. Keywords: Measles, mumps, elimination, vaccine, Lebanon.

SERUM THYROTROPHIN AND THE RESPONSE TO THYROTROPHIN RELEASING HORMONE IN SYMPTOMLESS AUTOIMMUNE THYROIDITIS AND IN BORDERLINE AND OVERT HYPOTHYROIDISM

1974 ◽  
Vol 75 (2) ◽  
pp. 274-285 ◽  
Author(s):  
A. Gordin ◽  
P. Saarinen ◽  
R. Pelkonen ◽  
B.-A. Lamberg
Keyword(s):  
Autoimmune Thyroiditis ◽  
Elevated Serum ◽  
Mean Value ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
The Individual ◽  
Serum Tsh

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

scholarly journals Acute coronary syndrome: which age group tends to delay call for help?

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Ahmed Ayuna ◽  
Ayyaz Sultan
Keyword(s):  
Acute Coronary Syndrome ◽  
Time Delay ◽  
Local Population ◽  
Age Groups ◽  
Age Group ◽  
Teaching Programme ◽  
The Road ◽  
Coronary Syndrome ◽  
The Mean ◽  
Mean Time

Abstract Background Early diagnosis and treatment of ACS can reduce the risk of complications and death. Delay calling for help can increase morbidity and mortality. It is unclear which age group among patients with acute coronary syndrome tend to delay their call for help. Results Our observational retrospective study showed that men and women in their 50s and 40s respectively tend to delay their call for help from symptoms onset. For the former, the mean time delays (590 ± 71.1 min), whereas for the latter it was (1084 ± 120.1 min). Moreover, these groups tend to have a longer time delay between symptoms onset and arrival at the hospital. Among deaths, we observed that the death rate was proportional to the time delay, which is not unexpected. Next step, we plan to perform a qualitative study in the form of questionnaires to target the individuals with a high risk of CVD within these age groups. Conclusion Middle age group of both genders tend to delay their call for help when they experience symptoms of ACS; moreover, regardless of the age, the longer the delay, the higher the mortality rate. The results of this study gave us a better understanding of our local population and will pave the road for a well-structured teaching programme for them to minimise the time delay for calling for help.

scholarly journals Assessment of intraocular pressure in chinchillas of different age groups using rebound tonometry

2016 ◽  
Vol 46 (8) ◽  
pp. 1466-1471 ◽  
Author(s):  
Flor Diana Yokoay Claros Chacaltana ◽  
João Antonio Tadeu Pigatto ◽  
Ione Terezinha Denardin
Keyword(s):  
Intraocular Pressure ◽  
Age Groups ◽  
Time Of Day ◽  
Age Group ◽  
Group Iii ◽  
Rebound Tonometer ◽  
Indirect Ophthalmoscopy ◽  
Group I ◽  
Schirmer Tear Test ◽  
The Mean

ABSTRACT: The aim of this research was to measure the intraocular pressure (IOP) of normal chinchilla eyes using the rebound tonometer. A further aim was to assess whether there were differences in the values of intraocular pressure in relation to animals age, gender and time of day. Thirty-six chinchillas were divided into three groups of 12 chinchillas each, by age: Group I (2-6-month-old), Group II (20 and 34 months) and Group III (37 and 135 months). Ophthalmic examination was performed previously by Schirmer tear test, slit lamp biomicroscopy, indirect ophthalmoscopy and fluorescein test in all chinchillas. Three measurements of intraocular pressure were assessed on the same day (7, 12 and 19h). Tonometry was performed on both eyes using the rebound tonometer after calibration in "p" mode. Statistical analysis was performed with SigmaPlot for Windows. The mean IOP for groups I, II and III were 2.47±0.581mmHg, 2.47±0.581mmHg and 2.51±0.531mmHg, respectively. No significant differences were reported between age and IOP and no significant differences were reported between the time of day and IOP. The IOP in chinchillas did not differ significantly between genders or ages of the animals, and did not change with time of day.

Human cold air habituation is independent of thyroxine and thyrotropin

1992 ◽  
Vol 72 (6) ◽  
pp. 2134-2139 ◽  
Author(s):  
R. L. Hesslink ◽  
M. M. D'Alesandro ◽  
D. W. Armstrong ◽  
H. L. Reed
Keyword(s):  
Single Daily Dose ◽  
Plasma Norepinephrine ◽  
Free T4 ◽  
Cold Air ◽  
Brown Adipose ◽  
Daily Dose ◽  
Before And After ◽  
Serum T4 ◽  
The Relationship ◽  
Serum Tsh

Thyroxine (T4) is required in species possessing brown adipose tissue (BAT) for the maintenance of cold tolerance and adaptation. In humans, who possess negligible quantities of BAT, the importance of T4 has not been demonstrated. We studied the effects of decreased serum T4 and thyrotropin (TSH) on human cold habituation after repeated cold air exposures. Eight men (T3+) received a single daily dose of triiodothyronine (T3; 30 micrograms/day), and another eight men (T3-) received a placebo. All 16 normal thyroid men underwent a standardized cold air test (SCAT) under basal conditions in January and again in March after eighty 30-min 4.4 degrees C air exposures (10/wk). Measurements of basal metabolic rate (BMR), O2 consumption (VO2), mean arterial pressure (MAP), plasma norepinephrine (NE), serum TSH, free and total T4, and free and total T3 were repeated before and after 8 wk of exposure. TSH, free T4, and total T4 were 50% lower for T3+ than for T3- subjects. Total and free T3 were not different between groups. BMR was unchanged after habituation, whereas the cold-stimulated VO2, MAP, and NE were significantly reduced for all subjects in March. The relationship between VO2 and NE (r2 = 0.44, P less than 0.001) during the initial SCAT was unchanged with habituation. We suggest that human cold habituation is independent of major changes in circulating T4 and TSH.

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