Comparison of 2 vitamin D supplementation modalities in newborns: adherence and preference

2011 ◽  
Vol 36 (3) ◽  
pp. 414-418 ◽  
Author(s):  
Celia Rodd ◽  
Sonia Jean-Philippe ◽  
Catherine Vanstone ◽  
Hope Weiler
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Confidence Interval ◽  
Vitamin D Supplementation ◽  
Healthy Infants ◽  
Parent Preference

Lack of adherence with vitamin D supplementation is still a risk factor for rickets. In a randomized cross-over design, infants received 400 IU cholecalciferol by dropper (1 mL syrup) or filmstrip. Infant and parent preference scores and adherence were then compared. Forty-three parents of healthy infants preferred the filmstrip (85.4% of parents; 95% confidence interval of 70.1%–93.9%; p < 0.001), a result that was corroborated by higher infant and parental scores and compliance. Ease of administration of supplements with improved acceptance may improve adherence.

Association Between cardiometabolic risk factor and responsiveness to vitamin D supplementation: A New Approach using Artificial Neural Network analysis

2020 ◽  
Author(s):  
Elahe Allahyari ◽  
Parichehr Hanachi ◽  
Seyed Jamal Mirmoosavi ◽  
Gordon A. Ferns ◽  
Afsane Bahrami ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Cardiometabolic Risk ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Cardiometabolic Risk Factor ◽  
Baseline Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Artificial Neural

Abstract BackgroundAccumulating data have highlighted the prominence of supplementation as an effective approach for vitamin D deficiency. But individuals vary in their response to vitamin D supplementation. In this study, the effect of cardiometabolic risk factors were evaluate on magnitude of response to vitamin D supplementation by using novel statistical analysis, artificial neural networks(ANNs).Methods608 participants aged between 12 to 19 years old were assed in this prospective interventional study. Nine vitamin D capsules containing 50000IU vitamin D/weekly were given to all participants over the 9 week period. The change in serum 25(OH)D level was calculated as the difference between post-supplementation and basal levels. Suitable ANNs model were selected between different algorithms in the hidden and output layers and different numbers of neurons in the hidden layer. Then, the major determinants in predicting response to vitamin D supplementations were identified (Trial registration: IRCT201509047117N7; 2015-11-25; Retrospectively registered)ResultsSigmoid in both hidden and output layers with 4 hidden neurons had acceptable sensitivity, specificity and accuracy area under the ROC curve in our study. Baseline serum vitamin D (30.4%), waist to hip ratio (10.5%), BMI (10.5%), systolic blood pressure (8%), heart rate (6.4%), and waist circumference (6.1%) were the greatest importance in predicting the response in serum vitamin D levels. ConclusionWe provide the first attempt to relate anthropometric specific recommendations to attain serum vitamin D targets. With the exception of cardiometabolic risk factor, the relative importance of other factors and the mechanisms by which these factors may affect the response requires further analysis in future studies.

scholarly journals 2332. Low Serum Vitamin D Levels Are Related to Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S801-S801
Author(s):  
Fausto Martin Ferolla ◽  
Eduardo Walter Yfran ◽  
Maria Gabriela Ballerini ◽  
Analia Toledano ◽  
Ana Caratozzolo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Respiratory Syncytial Virus ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Healthy Infants ◽  
Vitamin D Levels ◽  
Life Threatening ◽  
Rsv Infection ◽  
Syncytial Virus

Abstract Background Serum 25-hydroxy-vitamin D (VD) effects on lung growth and immune system modulation might affect respiratory infections outcomes. Data are controversial regarding the role of VD status in the severity of Respiratory Syncytial Virus (RSV) infection. The aim of this study was to assess serum VD levels and its association with life-threatening disease (LTD) in previously healthy infants infected with RSV. Methods Prospective cohort study including previously healthy infants <12 months, hospitalized with a first RSV infection in 2017–2018. Viral load (VL) was assessed by qRT–PCR in nasopharyngeal aspirates and serum VD levels measured by ECLIA, in samples obtained on admission. VD deficiency was defined as levels <20 ng/mL, VD insufficiency 20–29 ng/mL, and LTD as need of intensive care and mechanical or noninvasive ventilation Results 98 patients, mean age 4.5 months (±3.1), 55 (56.1%) male. VD status: 18 (18.4%) with deficiency, 32 (32.6%) with insufficiency; 14 (77.8%) patients with deficiency had not received VD supplementation. There was no relationship between VD deficiency and anemia (P = 0.28) or age (P = 0.27). LTD was observed in 17 infants, with no significant differences in socioeconomic, pregnancy and infant variables compared with other RSV cases. Patients with LTD had significantly lower levels of VD (17.5 ng/mL [IQR 15.2–26.3] vs. 31.8 ng/mL [IQR 23.5–52.1, P < 0.001)], Figure 1. 15 patients, 88.2% of all infants with VD levels ≤29 ng/mL developed LTD compared with a study population frequency of LTD of 17.3%. Multivariable regression analysis including breastfeeding confirmed VD deficiency as a risk factor for LTD (aOR 14.3, 95% CI 3.9–51.5, P < 0.001). Normal VD values conferred protection (aOR 0.1, 95% CI 0.02–0.49, P = 0.004). VD levels inversely correlated with days of hypoxemia (P = 0.007); VD deficiency increased the risk of requiring O2 supplementation >7 days (aOR 8.5, P < 0.001). VL did not correlate with VD levels (P = 0.696), length of stay (P = 0.378), days of hypoxemia (P = 0.681). VL was not associated with LTD (P = 0.42). Conclusion Vitamin D deficiency was a risk factor for LTD in previously healthy infants with RSV infection. Viral titers did not correlate with VD levels. These findings provide additional evidence for the development of low-cost preventive and therapeutic strategies. Disclosures All authors: No reported disclosures.

D-vitamin és kalciumpótlás az időskori csípőtáji törések megelőzésében

2017 ◽  
Vol 158 (43) ◽  
pp. 1699-1707
Author(s):  
Antal Salamon ◽  
Erzsébet Toldy ◽  
Csaba Biró ◽  
Ákos Mátrai ◽  
Tibor Balassa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Eating Habits ◽  
Bone Matrix ◽  
Age Groups ◽  
Vitamin D Supplementation ◽  
Significant Loss ◽  
The Other ◽  
Final Decision ◽  
Different Doses

Abstract: Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution. On the other hand, some metaanalyses give contradictory results and propose further investigations. It is important to consider the patients’ eating habits and lifestyle as well as the risk of cardiovascular and other chronic diseases. Further trials should be done in different age groups in order to examine the effects of different doses of vitamin D without and with calcium to make a final decision. Orv Hetil. 2017; 158(43): 1699–1707.

scholarly journals Effect of Vitamin D Supplementation on Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 8 ◽  
Author(s):  
Ziyi Li ◽  
Liangzhi Wu ◽  
Junguo Zhang ◽  
Xin Huang ◽  
Lehana Thabane ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Vitamin D ◽  
Confidence Interval ◽  
Protective Effect ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Randomized Controlled

Objective: Laboratory findings indicated that vitamin D might have a potent protective effect on breast cancer, but epidemiology studies reported conflicting results. The aim of the study was to conduct a systematic review and meta-analysis to clarify the efficacy of vitamin D supplementation on risk of breast cancer.Methods: MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and abstracts of three major conferences were searched (up to December 8, 2020). Parallel randomized controlled trials (RCTs) examining the efficacy of vitamin D supplementation on risk of breast cancer or change of mammography compared with placebo in females were included. Data were meta-analyzed using a random-effects model. Bayesian meta-analysis was conducted to synthesize the results using data from observational studies as priors.Results: Seven RCTs were identified for effect of vitamin D on risk of breast cancer, with 19,137 females included for meta-analysis. No statistically significant effect of vitamin D on risk of breast cancer was found in classical random-effects meta-analysis (risk ratio = 1.04, 95% confidence interval: 0.84–1.28, p = 0.71). When Bayesian meta-analyses were conducted, results remained non-significant. There was no statistically significant effect of vitamin D on mammography density observed: mean difference = 0.46, 95% confidence interval: −2.06 to 2.98, p = 0.72.Conclusion: There is insufficient evidence to support the efficacy of vitamin D supplementation in breast cancer risk and change of mammography density. The protective effect of vitamin D on risk of breast cancer from previous observational studies may be overestimated.Systematic Review Registration: PROSPERO, identifier CRD42019138718.

scholarly journals Phosphate concentrations and modifying factors in healthy children from 12 to 24 months of age

2021 ◽  
Author(s):  
Laura Koljonen ◽  
Maria Enlund-Cerullo ◽  
Helena Hauta-alus ◽  
Elisa Holmlund-Suila ◽  
Saara Valkama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Repeated Measurements ◽  
Phosphate Concentration ◽  
Healthy Children ◽  
Plasma Phosphate ◽  
Time Points ◽  
Modifying Factors ◽  
Healthy Infants ◽  
Vitamin D3 Supplementation

Abstract Context Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. Objective To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. Design This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention (VIDI) trial and received daily vitamin D3 supplementation of either 10 or 30 μg from age two weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. Main Outcome Measures Plasma phosphate concentrations at 12 and 24 months of age. Results Mean (SD) phosphate concentration decreased from 12 months (1.9±0.15 mmol/L) to 24 months (1.6±0.17 mmol/L) of age (p&lt;0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, 25OHD, intact and C-terminal FGF23, mean plasma phosphate was higher in boys than girls during follow-up (p=0.019). Phosphate concentrations were similar in the vitamin D intervention groups (p&gt;0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005, 95% CI 0.004 to 0.009 and 0.002 to 0.008, p&lt;0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007, 95% CI 0.003 to 0.011, p&lt;0.001). Conclusion Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations.

scholarly journals Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics

2020 ◽  
Author(s):  
D. De Smet ◽  
K. De Smet ◽  
P. Herroelen ◽  
S. Gryspeerdt ◽  
G.A. Martens
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Observational Study ◽  
Lung Disease ◽  
Vitamin D Deficiency ◽  
Reference Population ◽  
Vitamin D Supplementation ◽  
Disease Stage ◽  
List Type ◽  
Stage 1

Structured abstractImportanceVitamin D deficiency increases the incidence of respiratory virus infections. More than 1 billion people worldwide are vitamin D deficient. If vitamin D deficiency is associated to incidence or severity of SARS-CoV-2 infection, a global call could be made for vitamin D supplementation to mitigate the pandemic.Objectiveto determine if lower serum 25-hydroxyvitamin D (25(OH)D) levels are correlated to the risk for COVID-19 and its severity as measured by CTDesignsingle-center observational studySettingAZ Delta general hospitalParticipants186 consecutive patients with PCR-confirmed SARS-CoV-2 infection hospitalized for COVID-19 from March 1, 2020 to April 7, 2020Main outcome and measurescomparative analysis of 25(OH)D levels in patients hospitalized for COVID-19 at various radiological stages and a season/age/sex-matched diseased control populationResultswe report on 186 SARS-CoV-2 infected patients requiring hospitalization for severe COVID-19: 109 males (median age 68 years, IQR 53–79 years) and 77 females (median age 71 years, IQR 65–74 years). At admission patients were screened by CT to determine temporal changes of COVID-19 lung disease and classified as stage 1 (ground glass opacities), 2 (crazy paving pattern) and 3 (consolidation). At intake, 25(OH)D levels were measured and compared to a season-matched population of 2717 diseased controls, consisting of 999 males (median age 69 years, IQR 53–81 years) and 1718 females (median age 68 years, IQR 43–83 years). Male and female COVID-19 patients combined showed lower median 25(OH)D than controls (18.6 ng/mL, IQR 12.6–25.3, versus 21.5 ng/mL, IQR 13.9–30.8; P=0.0016) and a higher fraction of vitamin D deficiency (58.6% versus 45.2%, P=0.0005). A strong sexual dimorphism was found: female patients had comparable vitamin D status as control females. Male COVID-19 patients, however, showed markedly higher percentage of vitamin D deficiency than controls (67.0% versus 49.2%, P=0.0006) and this effect was more pronounced with advanced radiological stage ranging from 55.2% in stage 1 to 74% in stage 3.Conclusions and relevancevitamin D deficiency is a possible risk factor for severe SARS-CoV-2 infection in males. Vitamin D supplementation might be an inexpensive, accessible and safe mitigation for the SARS-CoV-2 pandemic.Key pointsQuestion: does vitamin D deficiency predispose to severity of SARS-CoV-2 infection?Findings: in this observational study on 186 consecutive patients hospitalized with PCR-confirmed SARS-CoV-2 infection, we find that patients with severe COVID-19 show lower median serum 25(OH)D and a higher percentage of vitamin D deficiency at intake than a season/age-matched reference population. The correlation between vitamin D deficiency and the need for hospitalization due to COVID-19 was only seen in male patients. In males but not females, the percentage of vitamin D deficient patients also increased with more advanced COVID-19 disease stage as measured by CT.Meaning: our data indicate a strong statistical correlation between the degree of vitamin D deficiency and severity of COVID-19 lung disease. With more than 1 billion people worldwide affected by vitamin D deficiency, vitamin D supplementation might be a lifesaving, inexpensive, accessible and safe component of primary prevention during the SARS-CoV-2 pandemic and beyond

scholarly journals The Analysis of Clinical Features of Systemic Lupus Erythematosus (SLE) in Children

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Ying Liang ◽  
Pingping Zhang ◽  
Huiqin Chen ◽  
Xiangqin Luo ◽  
Yesheng Ling ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Blood Lipid ◽  
Vitamin D Supplementation ◽  
Dsdna Antibody ◽  
Female Children ◽  
The Difference

Objective: Observe the clinical characteristics of children with SLE, namely, to observe the symptoms and laboratory examinations, such as blood routine, blood lipid, immunoglobulin, complement, autoantibodies, serum 25 (OH) D and other indicators, and to explore the clinical characteristics, the difference and the significance of vitamin D supplements between male and female SLE patients in children respectively. Methods: We enrolled 64 cases of SLE patients in children who were admitted into the department of pediatrics and rheumatology of the third affiliated hospital of sun yat-sen university in guangzhou from May 1, 2011 to February 1, 2019, They were analyzed retrospectively, adopting ?² test for statistical analysis. Results: 64 cases of SLE in children, which included 10 cases of male and 54 cases of female. Clinical manifestations: facial skin rash in 48 patients (75%), fever in 38 cases (59.4%), arthritis in 28 cases (43.8%), oral ulcer in 18 cases (28.1%), serositis in13 cases (20.3%), and the sun allergy in 9 cases (14.1%), the damage of central nervous system in 7 cases (10.9%) . Laboratory examination: 30 cases of leukopenia (46.9%), anemia in 30 cases (46.9%), thrombocytopenia in 12 cases (18.8%), hematuria in 18 cases (28.1%), proteinuria in 33 cases (51.2%), 6 patients with renal impairment (9.4%), antinuclear antibody positive in 63 cases (98.4%), anti-double-stranded DNA (dsDNA) antibody positive in 48 cases (75%), anti SSA antibody positive in 44 cases (68.7%), SSB antibody positive in 33 cases (51.6%), Sm antibody positive in 40 cases (62.5%), nucleosome antibody positive in 28 cases (43.8%) .Among these children, male SLE patients were higher than female children with SLE in the damage of kidney, Sm antibodies and resisting nucleosome antibody positive rates (?²= 4.451, 8.336, 6.803, P<0.05), the female children with SLE was higher than male SLE Children in the anti-SSB antibody positive rate (?²=4.945, P < 0.05). In 64 cases of SLE children, which included 52 cases were lower than the normal level of serum 25 (OH) D measurements, 12 cases were in the normal lower limit of serum 25 (OH) D measurements, at the same time, the female SLE. Patients was higher than male children with SLE in the reduce rate of serum 25 (OH) D (?²= 8.351, P < 0.05). Conclusion: Male SLE patients which appeared damage of kidney easier than female patients , the proteinuria was the most common in the damage of kidney. Resistance to Sm antibodies which was the risk factor of renal injury with higher incidence in male children with SLE; Anti nucleosome antibody which was the risk factor for the disease activity in male children with SLE were higher than female children with SLE. It was estimated that the risk of Sjogren's syndrome appeared in female with SLE were higher than that in male SLE children. In this retrospective study, the serum 25 (OH) D levels were significantly lower in children with SLE, and vitamin D supplementation was required.

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