Mice tuberculosis quantified by the lung density technique

1974 ◽  
Vol 20 (9) ◽  
pp. 1247-1255
Author(s):  
V. Portelance ◽  
R. P. Boulanger ◽  
P. Robillard

Groups of CF1 mice were respectively infected intravenously with four decreasing doses of the virulent H37Rv strain of Mycobacterium tuberculosis var. hominis and the progress of tuberculous disease was followed by three techniques yielding essentially objective results. Survival rates showed that 84% of the mice infected with the largest dose died within 30 days of infection but this technique was unable to differentiate among the other three groups of mice infected with smaller doses. Bacterial culture counts performed after increasing intervals of infection on spleen homogenates of similarly infected groups of mice showed that different degrees of tuberculous involvement had effectively been induced in the four groups. Lung density determinations performed on the same groups of animals gave results establishing that this technique was capable of distinguishing the four groups of mice one from another. The observation that the lung density technique reflects the degree of tuberculous disease accurately was further substantiated by experiments performed on groups of mice respectively injected intravenously with comparable numbers of viable cells of seven mycobacterial strains of different virulence, all harvested at the same "physiological age." Statistically significant differences existed between the experimental groups infected with the virulent strains on the one hand and those injected with the avirulent ones on the other; no differences existed among the groups infected with virulent strains or among those injected with avirulent ones. Of particular interest is the observation that the lung density technique can also differentiate groups of mice injected either with virulent or avirulent strains from those injected with the attenuated bovine BCG strain. The results of both the bacterial culture count and lung density techniques applied to the same groups of mice in the early and late phases of tuberculous disease are discussed.

1935 ◽  
Vol 62 (1) ◽  
pp. 11-21 ◽  
Author(s):  
L. A. Julianelle ◽  
C. W. Wieghard

1. Agglutination is not a precise method for the demonstration of serological types among staphylococci. 2. Precipitation of soluble specific substance derived from these organisms demonstrates the existence of at least two immunologically distinct types. 3. The one type, designated A, is composed of apparently virulent strains, while the other, Type B, contains the avirulent strains. 4. Precipitation tests performed with centrifugates of young broth cultures or with acid extracts of sedimented bacteria may also demonstrate type specificity. 5. Lysis by bacteriophage fails to detect the specific types of Staphylococcus. 6. Immunization by intravenous methods stimulates agglutinin formation in all rabbits and precipitin formation in only one of three or four animals. 7. Immunization by repeated intracutaneous injections of dead staphylococci or living organisms in an agar focus also stimulates agglutinin formation but fails to incite the formation of type specific precipitins.


2018 ◽  
Vol 40 ◽  
pp. 02011 ◽  
Author(s):  
M. Iakovleva ◽  
O. Shchelkova ◽  
E. Lubinskaya ◽  
O. Nikolaeva

The relevance of the problem is caused by the prevalence of cardiovascular diseases among the population, including coronary heart disease which requires surgical treatment, on the one hand, and low rates of treatment adherence among patients with chronic diseases, which reduce the effectiveness of the treatment and survival rates of patients, on the other hand. Patients after CABG were divided into groups according to the degree of their adherence to treatment and were examined by using the Big Five Questionnaire. Differences between the groups on the scales “conscientiousness” (p<0,001), “openness” (p<0,001), “agreeableness” (p<0,05), and “neuroticism” (p<0,05) were revealed. The study showed that the psychological factors are relevant in the definition of adherence to treatment and patients’ personality traits are potentially significant for the prediction of its degree among patients after CABG.


1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.


Author(s):  
Stefan Krause ◽  
Markus Appel

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.


2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.


2017 ◽  
Vol 47 (188) ◽  
pp. 487-494
Author(s):  
Daniel Mullis

In recent years, political and social conditions have changed dramatically. Many analyses help to capture these dynamics. However, they produce political pessimism: on the one hand there is the image of regression and on the other, a direct link is made between socio-economic decline and the rise of the far-right. To counter these aspects, this article argues that current political events are to be understood less as ‘regression’ but rather as a moment of movement and the return of deep political struggles. Referring to Jacques Ranciere’s political thought, the current conditions can be captured as the ‘end of post-democracy’. This approach changes the perspective on current social dynamics in a productive way. It allows for an emphasis on movement and the recognition of the windows of opportunity for emancipatory struggles.


1996 ◽  
pp. 13-23
Author(s):  
Mykhailo Babiy

Political ideological pluralism, religious diversity are characteristic features of modern Ukrainian society. On the one hand, multiculturalism, socio-political, religious differentiation of the latter appear as important characteristics of its democracy, as a practical expression of freedom, on the other - as a factor that led to the deconsocialization of society, gave rise to "nodal points" of tension, confrontational processes, in particular, in political and religious spheres.


2003 ◽  
pp. 15-26
Author(s):  
P. Wynarczyk
Keyword(s):  
The Core ◽  

Two aspects of Schumpeter' legacy are analyzed in the article. On the one hand, he can be viewed as the custodian of the neoclassical harvest supplementing to its stock of inherited knowledge. On the other hand, the innovative character of his works is emphasized that allows to consider him a proponent of hetherodoxy. It is stressed that Schumpeter's revolutionary challenge can lead to radical changes in modern economics.


2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.


2009 ◽  
pp. 18-31
Author(s):  
G. Rapoport ◽  
A. Guerts

In the article the global crisis of 2008-2009 is considered as superposition of a few regional crises that occurred simultaneously but for different reasons. However, they have something in common: developed countries tend to maintain a strong level of social security without increasing the real production output. On the one hand, this policy has resulted in trade deficit and partial destruction of market mechanisms. On the other hand, it has clashed with the desire of several oil and gas exporting countries to receive an exclusive price for their energy resources.


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