Hedgehog signaling and the axial patterning of Drosophila wings
Keyword(s):
Growth and cell fate in the anterior-posterior (A/P) axis of the developing wing of Drosophila melanogaster are controlled by a stripe of cells bisecting the axis called the A/P organizer. Hedgehog (Hh) signaling from posterior to anterior cells induces the organizer. Several Hh-responsive genes expressed by cells of the organizer mediate its patterning activity. The Hh-signaling pathway controls the post-translational modification of the transcription factor Cubitus-interruptus (Ci) and the resulting local activation of Ci is required for the correct location of the A/P organizer.Key words: Hedgehog, morphogen, Drosophila, limb development, signal transduction.
2002 ◽
Vol 116
(1-2)
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pp. 3-18
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2021 ◽
2016 ◽
Vol 113
(21)
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pp. 5982-5987
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2013 ◽
Vol 203
(4)
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pp. 575-583
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2005 ◽
Vol 25
(16)
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pp. 7042-7053
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