The entropy of formation of the mercury/methanol interface

1982 ◽  
Vol 60 (14) ◽  
pp. 1787-1792 ◽  
Author(s):  
Z. Borkowska ◽  
W. R. Fawcett
Keyword(s):  
Negative Charge ◽  
Positive Charge ◽  
Charge Densities ◽  
Mercury Surface ◽  
Carbonate Solutions ◽  
Excess Surface ◽  
Double Layer Capacity ◽  
Charge Dependence ◽  
Entropy Of Formation ◽  
Three State Model

The entropy of formation of the mercury/methanol interface has been calculated from double layer capacity and interfacial tension measurements. In contrast to results for aqueous and propylene carbonate solutions, the plot of entropy against electrode charge density passes through a minimum at negative charge densities and a maximum at positive charge densities in the same regions where a minimum and maximum are found on the capacity curve. The excess surface entropy of methanol is negative for all charge densities, indicating that the solvent is more structured at the mercury surface than in the bulk. The results have been discussed in terms of the three state model in which the charge dependence of the entropy is attributed to reorientation of solvent dipoles at the interface.

scholarly journals Zerumbone Inhibits Helicobacter pylori Urease Activity

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2663
Author(s):  
Hyun Jun Woo ◽  
Ji Yeong Yang ◽  
Pyeongjae Lee ◽  
Jong-Bae Kim ◽  
Sa-Hyun Kim
Keyword(s):  
Helicobacter Pylori ◽  
Carbon Atom ◽  
Natural Compound ◽  
Urease Activity ◽  
Negative Charge ◽  
Positive Charge ◽  
Gastric Epithelium ◽  
Functional Inhibition ◽  
Electrical Gradient ◽  
H Pylori

Helicobacter pylori (H. pylori) produces urease in order to improve its settlement and growth in the human gastric epithelium. Urease inhibitors likely represent potentially powerful therapeutics for treating H. pylori; however, their instability and toxicity have proven problematic in human clinical trials. In this study, we investigate the ability of a natural compound extracted from Zingiber zerumbet Smith, zerumbone, to inhibit the urease activity of H. pylori by formation of urease dimers, trimers, or tetramers. As an oxygen atom possesses stronger electronegativity than the first carbon atom bonded to it, in the zerumbone structure, the neighboring second carbon atom shows a relatively negative charge (δ−) and the next carbon atom shows a positive charge (δ+), sequentially. Due to this electrical gradient, it is possible that H. pylori urease with its negative charges (such as thiol radicals) might bind to the β-position carbon of zerumbone. Our results show that zerumbone dimerized, trimerized, or tetramerized with both H. pylori urease A and urease B molecules, and that this formation of complex inhibited H. pylori urease activity. Although zerumbone did not affect either gene transcription or the protein expression of urease A and urease B, our study demonstrated that zerumbone could effectively dimerize with both urease molecules and caused significant functional inhibition of urease activity. In short, our findings suggest that zerumbone may be an effective H. pylori urease inhibitor that may be suitable for therapeutic use in humans.

scholarly journals Indication of the Coronavirus Model Using a Nanowire Biosensor

Proceedings ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 50
Author(s):  
Vladimir Generalov ◽  
Olga Naumova ◽  
Dmitry Shcherbakov ◽  
Alexander Safatov ◽  
Boris Zaitsev ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Negative Charge ◽  
Positive Charge ◽  
Silicon On Insulator ◽  
Nanowire Surface ◽  
Before And After ◽  
Effect Transistor ◽  
Current Value ◽  
Silicon On Insulator Technology

The presented results indicate virus-like particles of the coronavirus (CVP) using a nanowire (NW) biosensor based on silicon-on-insulator technology. In the experiment, we used suspensions of CVP and of specific antibodies to the virus. Measurements of the current value of the field-effect transistor before and after the introduction of the CVP on the surface of the nanowire were performed. Results showed antibody + CVP complexes on the phase section with the surface of the nanowire modulate the current of the field-effect transistor; CVP has an electrically positive charge on the phase section “nanowire surface-viral suspension»; antibody + CVP complexes have an electrically negative charge on the phase section “nanowire surface-viral suspension”; the sensitivity of the biosensor is made up of 10−18 M; the time display was 200–300 s.

scholarly journals The mechanism of spray electrification: the waterfall effect

2016 ◽  
Author(s):  
James K. Beattie
Keyword(s):  
Negative Charge ◽  
Positive Charge ◽  
Hydrophobic Hydration ◽  
General Phenomenon ◽  
Aqueous Interfaces ◽  
Preferential Adsorption ◽  
Negative Surface ◽  
Negative Surface Charge ◽  
Low Permittivity ◽  
Net Positive Charge

Abstract. The waterfall effect describes the separation of charge by splashing at the base of a waterfall. Smaller drops that have a net negative charge are created, while larger drops and/or the bulk maintain overall charge neutrality with a net positive charge. Since it was first described by Lenard (1892) the effect has been confirmed many times, but a molecular explanation has not been available. Application of our fluctuation-correlation model of hydrophobic hydration accounts for the negative charge observed at aqueous interfaces with low permittivity materials. The negative surface charge observed in the waterfall effect is created by the preferential adsorption of hydroxide ions generated from the autolysis of water. On splashing, shear forces generate small negative drops from the surface, leaving a positive charge on the remaining large fragment. The waterfall effect is a manifestation of the general phenomenon of the negative charge at the interface between water and hydrophobic surfaces that is created by the preferential adsorption of hydroxide ions.

Charge density studies on methylene blue – a potential anti-Alzheimer agent

2018 ◽  
Vol 73 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Peter Luger ◽  
Birger Dittrich ◽  
Leonard Benecke ◽  
Hannes Sterzel
Keyword(s):  
Methylene Blue ◽  
Charge Density ◽  
Molecular Electrostatic Potential ◽  
Positive Charge ◽  
Atomic Charges ◽  
Charge Densities ◽  
Density Distributions ◽  
Atomic Properties ◽  
Counter Ions ◽  
Medical Interest

AbstractMotivated by the medical interest in methylene blue as potential anti-Alzheimer agent, the charge densities of three salt structures containing the methylene blue cation with nitrate (as dihydrate), chloride (as pentahydrate) and thiocyanate counter-ions were generated by application of the invariom formalism and examined. The so-obtained charge density distributions were analyzed using the QTAIM formalism to yield bond topological and atomic properties. The atomic charges on the methylene blue cation indicate a delocalized charge distribution; only a small positive charge on the sulfur atom was found. Electrostatic potentials mapped onto iso-surfaces of electron density for the cations, and for the methylene blue cations with anions, were compared. The effect of hydrogen disorder on the molecular electrostatic potential was investigated for the thiocyanate structure.

Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities

2018 ◽  
Vol 6 (11) ◽  
pp. 1633-1639 ◽  
Author(s):  
Hainan Sun ◽  
Yin Liu ◽  
Xue Bai ◽  
Xiaofei Zhou ◽  
Hongyu Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Positive Charge ◽  
Charge Densities

Gold nanoparticles with various positive charge densities and hydrophobicities induce cellular oxidative stress differently and sensitize cancer cells to paclitaxel.

Do primary carriers of both positive charge and unpaired electron spin exist in irradiated propylene carbonate?

2017 ◽  
Vol 19 (1) ◽  
pp. 49-53 ◽  
Author(s):  
V. I. Borovkov
Keyword(s):  
Magnetic Field ◽  
Propylene Carbonate ◽  
Electron Spin ◽  
Unpaired Electron ◽  
Positive Charge ◽  
Radical Cations ◽  
Carbonate Solutions ◽  
Solvent Molecules

Magnetic field sensitive fluorescence from irradiated propylene carbonate solutions indicates the existence of previously unobserved radical cations formed from the solvent molecules.

THE EFFECT OF PROCOAGULANT PHOSPHOLIPID VESICLES WITH NET POSITIVE CHARGE ON THE ACTIVITY OF PROTHROMBINASE

1987 ◽  
Author(s):  
J Rosing ◽  
H Speijer ◽  
J W P Govers-Riemslag ◽  
R F A Zwaal
Keyword(s):  
Vitamin K ◽  
Negative Charge ◽  
Positive Charge ◽  
Coagulation Factor ◽  
Phospholipid Vesicles ◽  
Electrostatic Model ◽  
Acidic Phospholipid ◽  
Positively Charged ◽  
Net Positive Charge ◽  
Prothrombin Activation

It is generally thought that procoagulant phospholipid surfaces that promote the activation of vitamin K-dependent coagulation factors should have a net negative charge in order to promote calcium-dependent binding of the enzymes (FVIIa, FIXa and FXa) and substrates (prothrombin and FX) of the coagulation factor-activating complexes. Two models have been proposed to explain calcium-mediated association of vitamin K-dependent proteins with phospholipid: a) an electrostatic model, in which a positively-charged protein-calcium complex is attracted by a negatively-charged phospholipid surface and b) a chelation model in which a coordination complex is formed between calcium ions, γ-carboxyglutamic acids of the proteins and negatively-charged membrane phospholipids. To study the effect of the electrostatic potential of phospholipid vesicles on their activity in the pro-thrombinase complex the net charge of vesicles was varied by introduction of varying amounts of positively-charged stearylamine in the membrane surface. Introduction of 0-15 mole% stearylamine in phospholipid vesicles that contained 5 mole% phosphatidylseri-ne (PS) hardly affected their activity in prothrombin activation. Electrophoretic analysis showed that vesicles with > 5 mole% stearylamine had a net positive charge. The procoagulant activity of vesicles that contained phosphatidic acid, phosphatidylglyce-rol, phosphatidylinositol or phosphatidyl-glactate (PLac) as acidic phospholipid was much more effected by incorporation of stearylamine. Amounts of stearylamine that compensated the negative charge of acidic phospholipid caused considerable inhibition of the activity of the latter vesicles in prothrombin activation. The comparison of vesicles containing PS and PLac as acidic phospholipid is of special interest. PS and PLac only differ by the presence of NH+ 3-group in the serine moiety of PS. Thus, in spite of the fact that vesicles with PLac are more negatively charged than vesicles with PS, they are less procoagulant. Our results show that a) although procoagulant membranes have to contain acidic phospholipids there is no requirement for a net negative charge, b) the amino group of phosphatidylserine has an important function in the interaction of procoagulant membranes with vitamin K-dependent proteins and c) the chelation model can satisfactorily explain calcium-mediated lipid-protein association.

Electrokinetic properties of Cassiterite

1953 ◽  
Vol 6 (3) ◽  
pp. 278 ◽  
Author(s):  
DJ O'Connor ◽  
AS Buchanan
Keyword(s):  
Negative Charge ◽  
Positive Charge ◽  
Weak Acid ◽  
Surface Conductivity ◽  
Surface Ionization ◽  
Conductivity Measurements ◽  
The Third ◽  
Three Samples ◽  
Negative Surface ◽  
Flotation Collector

Simultaneous ζ-potential and surface conductivity measurements have been made on three samples of cassiterite (SnO2) in water, in solutions of HCl, alkalis, inorganic salts, and the flotation collector reagent sodium cetyl sulphate. It is probable that the intrinsic surface charge of cassiterite in water is negative and that it is due to surface ionization as a very weak acid. Two of the solids possessed a negative surface whilst the positive charge of the third seemed to be due to ionization of a strongly basic impurity. Those samples having a negative charge showed little reaction with sodium cetyl sulphate alone, but appreciable adsorption of cetyl sulphate ion took place in acid solution. On the other hand, the sample with the positive surface reacted with cetyl sulphate ion even in the absence of acid. In all cases adsorption of cetyl sulphate was completely reversible.

scholarly journals Electrical and Polarimetric Radar Observations of a Multicell Storm in TELEX

2007 ◽  
Vol 135 (7) ◽  
pp. 2525-2544 ◽  
Author(s):  
Eric C. Bruning ◽  
W. David Rust ◽  
Terry J. Schuur ◽  
Donald R. MacGorman ◽  
Paul R. Krehbiel ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Negative Charge ◽  
Positive Charge ◽  
Three Dimensional ◽  
Phase Region ◽  
Polarimetric Radar ◽  
Radar Observations ◽  
Mapping Array ◽  
Lightning Initiation

Abstract On 28–29 June 2004 a multicellular thunderstorm west of Oklahoma City, Oklahoma, was probed as part of the Thunderstorm Electrification and Lightning Experiment field program. This study makes use of radar observations from the Norman, Oklahoma, polarimetric Weather Surveillance Radar-1988 Doppler, three-dimensional lightning mapping data from the Oklahoma Lightning Mapping Array (LMA), and balloon-borne vector electric field meter (EFM) measurements. The storm had a low flash rate (30 flashes in 40 min). Four charge regions were inferred from a combination of LMA and EFM data. Lower positive charge near 4 km and midlevel negative charge from 4.5 to 6 km MSL (from 0° to −6.5°C) were generated in and adjacent to a vigorous updraft pulse. Further midlevel negative charge from 4.5 to 6 km MSL and upper positive charge from 6 to 8 km (from −6.5° to −19°C) were generated later in quantity sufficient to initiate lightning as the updraft decayed. A negative screening layer was present near the storm top (8.5 km MSL, −25°C). Initial lightning flashes were between lower positive and midlevel negative charge and started occurring shortly after a cell began lofting hydrometeors into the mixed phase region, where graupel was formed. A leader from the storm’s first flash avoided a region where polarimetric radar suggested wet growth and the resultant absence of noninductive charging of those hydrometeors. Initiation locations of later flashes that propagated into the upper positive charge tracked the descending location of a polarimetric signature of graupel. As the storm decayed, electric fields greater than 160 kV m−1 exceeded the minimum threshold for lightning initiation suggested by the hypothesized runaway breakdown process at 5.5 km MSL, but lightning did not occur. The small spatial extent (≈100 m) of the large electric field may not have been sufficient to allow runaway breakdown to fully develop and initiate lightning.

The influence of organic matter extracted from humified clover on the properties of amorphous aluminosilicates. I. Surface charge

Soil Research ◽  
1978 ◽  
Vol 16 (3) ◽  
pp. 327 ◽  
Author(s):  
KW Perrott
Keyword(s):  
Surface Charge ◽  
Negative Charge ◽  
Positive Charge ◽  
Degree Of Polymerization ◽  
Aqueous Extracts ◽  
Hydrous Oxides ◽  
Soil Clays ◽  
Charge Balancing ◽  
Inorganic Components ◽  
Allophanic Soil

A series of synthetic amorphous aluminosilicates, hydrous oxides and allophanic soil clays were treated with aqueous extracts of humified clover. The resulting changes in surface charge due to organic treatment were determined by comparing the charge characteristics of these organic treated samples and samples treated with a synthetic mixture of the inorganic components of the humified clover extract. Organic treatment caused a change of net surface charge to more negative values. The change in surface charge varied with the mole ratio Al/(Al+Si) of the aluminosilicate, being largest at low values of Al/(Al+Si). Where the aluminosilicates contain positive charges these are reduced by the organic treatment. This is a major contributor to the alteration of net surface charge in the more aluminous samples. The effect of organic treatment on the charge characteristics of allophanic soil clays was similar to that for the synthetic aluminosilicates of intermediate composition. The inorganic treatments also caused an increase in negative charge, and this is attributed to the neutralization of positive charge by the adsorption of phosphate and the removal of charge-balancing aluminium-hydroxy material. The effect of the organic and inorganic treatments on the positive and negative charge components of amorphous aluminosilicates is discussed in terms of the degree of polymerization of chargebalancing hydroxy-aluminium as envisaged in current models of the structure of amorphous aluminosilicates.

Sign in / Sign up

Export Citation Format

Share Document