Brain benzodiazepine levels following intravenous administration of [3H]diazepam: Relationship to the potentiation of purinergic depression of central nervous system neurons
1979 ◽
Vol 57
(9)
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pp. 1040-1042
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Keyword(s):
Levels of [3H] benzodiazepine were measured in rat cerebral cortex following intravenous injection of [3H]diazepam using a dose and time schedule reported to elicit a marked potentiation of the depressant effects of iontophoretically applied 5′-AMP to rat cerebral cortical neurons. The levels of [3H]benzodiazepine obtained strongly suggest (i) that blockade of adenosine uptake as a mechanism for this potentiation is not consistent with the potency of diazepam as an inhibitor of adenosine uptake in vitro, and (ii) that a potentiative interaction of adenosine and diazepam may reflect the binding of these compounds to benzodiazepine receptors.
2004 ◽
Vol 78
(10)
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pp. 5466-5475
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1998 ◽
Vol 31
(4)
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pp. 563-567
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Keyword(s):
1986 ◽
Vol 102
(3)
◽
pp. 803-811
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Keyword(s):
2020 ◽
1995 ◽
Vol 53
◽
pp. 958-959