Repeatability of cell-mediated and innate immunity, and other fitness-related traits, in the Grey Partridge

2006 ◽  
Vol 84 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Marco Cucco ◽  
Giorgio Malacarne ◽  
Roberta Ottonelli ◽  
Mauro Patrone
Keyword(s):  
Innate Immunity ◽  
Egg Quality ◽  
Additive Genetic Variance ◽  
Theoretical Models ◽  
Egg Mass ◽  
Chick Survival ◽  
Grey Partridge ◽  
Mass Size ◽  
Host Parasite ◽  
First Time

Immunocompetence is considered a reliable indicator of general body condition and ultimately of fitness. It has been suggested that, as a parameter subjected to intense directional selection, the level of additive genetic variance expressed should be reduced; on the other hand, theoretical models of host–parasite coevolution assume that variation in parasite resistance has a genetic basis. Contradictory results have been reported in birds, since the heritability of immune responses varies from nil to high. In this study of Grey Partridge (Perdix perdix (L., 1758)), we examined the heritability of immune condition (PHA reaction, an index of T-cell-mediated immunocompetence) and of some parameters traditionally considered important for chick survival, such as egg mass and chick growth. Two statistical approaches were used: parent–offspring regression and full-sibling intra-clutch repeatability. The repeatability of other parameters that reflect egg quality (egg proteins, lipids, and carotenoids) and of substances that confer innate immunity (lysozyme and avidin) was also investigated. In agreement with previous studies, we found nonsignificant heritability for cell-mediated immunocompetence. In contrast, there were significant repeatabilities of chick mass and several egg characteristics (mass, size, total proteins), while lipid and carotenoid concentrations were not repeatable. For the first time in birds, we found significant repeatability of two molecules, lysozyme and avidin, that confer innate immunity to the developing embryo.

scholarly journals Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 725
Author(s):  
David Becerro-Recio ◽  
Javier González-Miguel ◽  
Alberto Ucero ◽  
Javier Sotillo ◽  
Álvaro Martínez-Moreno ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Fasciola Hepatica ◽  
Cathepsin L ◽  
Helminth Parasites ◽  
Glutathione S Transferase ◽  
Serum Samples ◽  
Secretory Products ◽  
Immunogenic Proteins ◽  
Host Parasite ◽  
First Time

Excretory/secretory products released by helminth parasites have been widely studied for their diagnostic utility, immunomodulatory properties, as well as for their use as vaccines. Due to their location at the host/parasite interface, the characterization of parasite secretions is important to unravel the molecular interactions governing the relationships between helminth parasites and their hosts. In this study, the excretory/secretory products from adult worms of the trematode Fasciola hepatica (FhES) were employed in a combination of two-dimensional electrophoresis, immunoblot and mass spectrometry, to analyze the immune response elicited in sheep during the course of an experimental infection. Ten different immunogenic proteins from FhES recognized by serum samples from infected sheep at 4, 8, and/or 12 weeks post-infection were identified. Among these, different isoforms of cathepsin L and B, peroxiredoxin, calmodulin, or glutathione S-transferase were recognized from the beginning to the end of the experimental infection, suggesting their potential role as immunomodulatory antigens. Furthermore, four FhES proteins (C2H2-type domain-containing protein, ferritin, superoxide dismutase, and globin-3) were identified for the first time as non-immunogenic proteins. These results may help to further understand host/parasite relationships in fasciolosis, and to identify potential diagnostic molecules and drug target candidates of F. hepatica.

scholarly journals The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Maher H. Gomaa ◽  
Emad Gamil Khidr ◽  
Ahmed Elshafei ◽  
Hala S. Hamza ◽  
Aya M. Fattouh ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Heart Disease ◽  
Gene Polymorphism ◽  
Rheumatic Heart Disease ◽  
Streptococcus Pyogenes ◽  
Gene Polymorphisms ◽  
Clinical Value ◽  
Homozygous Genotype ◽  
First Time ◽  
Rheumatic Heart

Abstract Objective Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD). We aimed to disclose if there is an association between ficolin-3 (FCN3) gene polymorphisms (rs4494157 and rs10794501) and RF with or without RHD for the first time in Egyptian adolescents. Results Serum ficolin-3 level was significantly elevated in patients suffering from RF with and without RHD in comparison with control. Regarding FCN3 gene (rs4494157) polymorphism, a significant correlation was found between the A allele and the susceptibility to RF with or without RHD (OR = 2.93, P = 0.0002 and OR = 2.23, P = 0.008 respectively). Besides, AA homozygous genotype showed a significant association with RHD risk (OR = 3.47, P = 0.026). Patients carrying the A allele (CA + AA) had significantly higher serum ficolin-3 than those carrying the CC genotype (P ˂ 0.0001). While the frequency of (rs10794501) polymorphism revealed no significant differences between the controls and RF patients with or without RHD (OR = 1.43, P = 0.261 and OR = 1.48, P = 0.208 respectively).

scholarly journals New terpenoid metabolites from the skin extracts, an egg mass, and dietary sponges of the Northeastern Pacific dorid nudibranch Cadlinaluteomarginata

1997 ◽  
Vol 75 (6) ◽  
pp. 773-789 ◽  
Author(s):  
Eric J. Dumdei ◽  
Julia Kubanek ◽  
John E. Coleman ◽  
Jana Pika ◽  
Raymond J. Andersen ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Egg Mass ◽  
The Novel ◽  
Egg Masses ◽  
Northeastern Pacific ◽  
First Time

Chemical investigations of Cadlinaluteomarginata skin extracts, egg masses, and dietary sponges have led to the identification of the novel terpenoids cadlinaldehyde (30), spongian 32, seco-spongian 35, 20-acetoxy-12-marginatone (38), and lutenolide (39) from the nudibranch skin extracts, the new drimane sesquiterpenoid 1α,2α-diacetoxyalbicanyl acetate (40) from the nudibranch's egg mass, and the new sesquiterpenoids O-methyl-9-oxofurodysininlactone (47), 2-oxomicro-cionin-2-lactone (48), and O-methyl-2-oxomicrocionin-2-lactone (49), from the dietary sponge Pleraplysilla sp. The known terpenoids furodysinin (1), furodysin (16), marginatafuran (21), and 9,11-dihydrogracillin A (37), which have been frequently isolated from C. luteomarginata skin extracts, were found for the first time in extracts of the dietary sponges Pleraplysilla sp. and Aplysilla sp. One of the new terpenoids, cadlinaldehyde (30), has an unprecedented degraded sesterterpenoid skeleton. Keywords: nudibranch, sponge, terpenoids, structure elucidation.

Indeterminate Chagas’ disease: Trypanosoma cruzi strain and re-infection are factors involved in the progression of cardiopathy

2003 ◽  
Vol 104 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Juan M. BUSTAMANTE ◽  
Héctor W. RIVAROLA ◽  
Alicia R. FERNÁNDEZ ◽  
Julio E. ENDERS ◽  
Ricardo FRETES ◽  
...  
Keyword(s):  
Survival Rate ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Infected Group ◽  
World Health ◽  
Cardiac Lesions ◽  
Health Organization ◽  
Host Parasite ◽  
Β Adrenergic Receptors ◽  
First Time

Chagas' disease is caused by Trypanosoma cruzi, which is transmitted by reduviid bugs. The World Health Organization has estimated that about 16–18 million people in the Americas are infected, and that more than 100 million are at risk. In the present study we have used a murine model to analyse if particular T. cruzi strains (Tulahuen strain and SGO-Z12 isolate from a chronic patient) and/or re-infection may determine, during the indeterminate phase of experimental Chagas' disease, changes that could explain the different evolution of cardiac lesions. Re-infected mice reached higher parasitaemias than those infected for the first time. The survival in the indeterminate phase of mice infected with Tulahuen strain was 50.0%, while the SGO-Z12-infected group presented a significantly higher survival rate (77.1%; P<0.01). The SGO-Z12-re-infected group showed a survival rate (70.9%) significantly higher than that of the Tulahuen-re-infected group (37.0%; P<0.01). Electrocardiographic abnormalities were found in 66% of Tulahuen-infected mice, while in SGO-Z12-infected group such abnormalities were found in only 36% of animals (P<0.01). The two groups exhibited similar percentages of electrocardiographic dysfunction on re-infection, although intraventricular blocks were more frequent in Tulahuen-re-infected mice (P<0.01). Hearts from infected or re-infected mice with either parasite showed mononuclear infiltrates. The SGO-Z12-re-infected and Tulahuen-re-infected groups exhibited a significantly diminished affinity (P<0.05) and a significantly increased density (P<0.05) of cardiac β-adrenergic receptors compared with the infected and non-infected groups. The indeterminate phase of Chagas' disease is defined as a prolonged period that is clinically silent, but the present findings show that different T. cruzi strains and re-infection are able to alter the host–parasite equilibrium, and these factors may be responsible for inducing progressive cardiopathy.

scholarly journals SAPU-SAPU FISH (Hyposarcus pardalis) AS A SINGLE PROTEIN SOURCE FOR LAYING MOJOSARI DUCKS

2016 ◽  
Vol 41 (3) ◽  
pp. 117-124 ◽  
Author(s):  
B. Indarsih ◽  
A. Asnawi ◽  
D. K. Purnamasari
Keyword(s):  
Body Weight ◽  
Feed Intake ◽  
Egg Production ◽  
Egg Quality ◽  
Production Performance ◽  
Protein Source ◽  
Egg Mass ◽  
Final Body Weight ◽  
Egg Number ◽  
Single Protein

The present study was conducted to evaluate the optimum level of dietary inclusion and the form of feeding sapu-sapu fish (SSF) as a single protein source for feed components of small holder Mojosari duck farming. A total of 180 twenty four wk-old laying ducks were fed with two forms (sun-dried and ground-fresh) and three levels of SSF (10, 20 and 30%) from 24 to 32 wk of age. Experimental diets were formulated containing 105.1; 141.5 and 177.9 g/kg crude protein and 3078; 3065 and 3052 kcal metabolizable energy (ME) /kg diet. Production performance and egg quality were measured. The form of SSF had a significant effect (P<0.0001) on feed intake, egg production, feed conversion, egg mass and egg number except final body weight. No significant effects (P>0.05) were found on all of the performance parameters measured due to feeding levels of SSF except feed intake and final body weight. The interaction of form and feeding level was significant (P<0.05) on egg and body weights. Low performance and egg quality were observed in the birds fed a diet containing the dried SSF. It can be suggested that local ducks required 20% SSF as a single protein source for maximum egg production (41.2%) and total egg number per wk (3.1 eggs/bird/wk) during 8 wk of rearing period. Egg quality can be improved by feeding the fresh SSF. However, due to be sufficiently better processing technique, the dried SSF would be potential to replace the common fish for laying ducks.

scholarly journals Does the vicinity of the Black-Headed Gull colony (Chroicocephalus ridibundus) increase the breeding success of the Common Tern (Sterna hirundo) on the islands of the middle Vistula?

2018 ◽  
Vol 16 (4) ◽  
pp. 43-50
Author(s):  
Dariusz Bukackiński ◽  
Monika Bukacińska ◽  
Milena Grabowska
Keyword(s):  
Hatching Success ◽  
Single Species ◽  
Common Tern ◽  
Egg Mass ◽  
Chick Survival ◽  
Effective Protection ◽  
Vistula River ◽  
Nesting Site ◽  
The Common ◽  
The City

We conducted our study in the Common Tern colony (STH) located on an island in the middle Vistula River course, at the height of the city of Dęblin (km 393–394 of the waterway), in 2017. Our goal was to investigate some aspects of the biology and reproductive ecology of this species. Due to the fact that STH breeds both in single-species as well as in two- or multi-species colonies, in associations with Little Terns (Sternula albifrons), Black-Headed Gulls (Chroicocephalus ridibundus) (LAR) and/or Mew Gulls (Larus canus), we wanted to investigate whether the neighborhood of other species (in this case LAR) affected hatching success and chick survival in STH. Our results clearly show that the presence of breeding terns in the neighborhood of the LAR colony was not accidental and/or caused by the lack of space on the island and/or the possibility of nesting elsewhere. The height of nesting site, type of nesting habitat, clutch size, mean egg volume and mean egg mass of these STH pairs did not differ significantly from those that formed a single species colony, on the same island but several hundred meters away. However, STH nests in the neighborhood of the LAR colony were established much earlier and both the hatching success and chick survival of STH during the early-chick stage were twice as high. Thus, we can conclude that the LAR colony could provide an effective protection against predation of crows, magpies and gulls, dangers which accounted for the vast majority of STH nest failures in the year of our study.

scholarly journals Pengaruh Pemberian Bungkil Kelapa Sawit Segar (BKS) dan Fermentasi (BKSF) Terhadap Kualitas Fisik Telur Itik

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Arif Pranata
Keyword(s):  
Shell Thickness ◽  
Mass Shell ◽  
Egg Quality ◽  
Palm Kernel ◽  
Egg Mass ◽  
Palm Kernel Cake ◽  
Dietary Treatments ◽  
Range Test ◽  
Haugh Unit

This research was conducted to utilize fresh and fermented palm kernel cake in the ducks diets on egg physical quality. One hundred and five laying ducks were randomly devided in to five diets treatments in three replications with seven laying ducks each the dietary treatments were K = control, was diet without palm kernel cake, BKS 10 and BKS 30 diets with addition 10 % and 30 % fresh palm kernel cake, BKSF 10 and BKSF 30 diets with addition 10 % and 30 % fermented palm kernel cake. The data collected were egg mass, shell thickness, Haugh Unit and yolk colour and will be analyzed by a one way classification of variance analysis (CRD), followed by testing the significant mean by Duncan’s New Multiple Range Test (DMRT). The results showed the egg mass, shell thickness, and HU had not significant different and egg mass were (64,74, 65,71, 67,22, 65,39, 63,52 g), shell thickness were (0,47, 0,49, 0,44, 0,48, 0,45 mm), Haught Unit were (86,81, 87,44, 90,94, 88,15, 88,08 %). Yolk colour had significant different between the treatment (9.31, 9,72, 9,81, 10,69, 10,74). It be concluded that the utilization 30% of fresh and fermented palm kernel cake in feed duck had not increase egg mass, shell tickness, and haugh unit, except on yolk colour. Key words :Fermentation, Egg Quality, Laying Duck, Palm kernel cake

scholarly journals Genetic variation in dispersal plasticity in an aquatic host-parasite model system

2020 ◽  
Author(s):  
Giacomo Zilio ◽  
Louise Solveig Noergaard ◽  
Giovanni Petrucci ◽  
Nathalie Zeballos ◽  
Claire Gougat-Barbera ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Internal State ◽  
Theoretical Models ◽  
Infection Prevalence ◽  
Main Role ◽  
Dependent Plasticity ◽  
Evolutionary Forces ◽  
State Dependent ◽  
Context Dependent ◽  
Host Parasite

Dispersal plays a main role in determining spatial dynamics, and both theory and empirical evidence indicate that evolutionary optima exist for constitutive or plastic dispersal behaviour. Plasticity in dispersal can be influenced by factors both internal (state-dependent) or external (context-dependent) to individuals. Parasitism is interesting in this context, as it can influence both types of host dispersal plasticity: individuals can disperse in response to internal infection status but might also respond to the presence of infected individuals around them. We still know little about the driving evolutionary forces of host dispersal plasticity, but a first requirement is the presence of a genetic basis on which natural selection can act. In this study, we used microcosm dispersal mazes to investigate plastic dispersal of 20 strains of the freshwater protist Paramecium caudatum in response to the bacterial parasite Holospora undulata. We additionally quantified the genetic component of the plastic responses, i.e. the heritability of state- and context-depended dispersal. We found that infection by the parasite can either increase or decrease dispersal of individual strains relative to the uninfected (state-dependent plasticity), and this to be heritable. We also found strain-specific change of dispersal of uninfected Paramecium when exposed to variable infection prevalence (context-dependent plasticity) with very low level of heritability. To our knowledge, this is the first explicit empirical demonstration and quantification of genetic variation of plastic dispersal in a host-parasite system, which could have important implications for meta-population and epidemiological dynamics. We discuss some of the underlying mechanisms of this variation and link our results to the existing theoretical models.

scholarly journals The effect of additional turmeric flour in rations on the performance and egg quality of laying chicken isa brown strain age 70th weeks

2021 ◽  
Vol 888 (1) ◽  
pp. 012054
Author(s):  
A Jaelani ◽  
N Abelina ◽  
R Samudera ◽  
T Rostini ◽  
Masganti ◽  
...  
Keyword(s):  
Research Method ◽  
Laying Hens ◽  
Egg Quality ◽  
Egg Mass ◽  
Feed Conversion ◽  
Unit Value ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Haugh Unit

Abstract This research aims to study and analyze the effect of adding turmeric flour (Curcuma domestica Val) in the rations on the performance of 70 weeks old Isa Brown strain of laying hens. The research method used in this study was an experimental method with a completely randomized design (CRD) step with five treatments and four replications. The number of chickens used was as many as 40 laying hens. The treatments given to the sample were P0 = feed without giving turmeric flour (control), P1 = feed with 0.3% turmeric flour, P2 = feed with 0.5% turmeric flour, P3 = feed with 0.7% turmeric flour and treatment P4 = feed by giving turmeric flour 0,9%. The results showed that giving turmeric flour in the rations of the Isa Brown strain of laying hens affected chicken performance and egg quality. This research concludes that giving turmeric flour a percentage of 0.7% in Isa Brown’s 70-week old laying hens is the best for ration consumption, Hen Day Production, egg weight, feed conversion, and egg quality: Haught Unit, yolk egg color, yolk egg index, grading egg and egg mass. Based on the haugh unit value, all eggs produced are still in the AA grade category

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