REPAIR EFFICIENCY ESTIMATION IN THE ARI1 IMPERFECT REPAIR MODEL

Author(s):  
LAURENT DOYEN
2020 ◽  
Vol 21 (1) ◽  
pp. 81-90
Author(s):  
Marthen Robinson Pellokila

ABTRACT Efficiency is one of the important indicators to assess the performance of a company or farm. Efficiency guarantees the use of certain inputs to achieve maximum output levels (technical efficiency) and also efficiency ensures the use of certain inputs that maximize profits (price efficiency or allocative efficiency). This article discusses the application of the estimation of price efficiency / allocative efficiency of the use of production inputs in bean farming using the linearized Cobb-Douglas Production function. The results of the analysis shows that the application of price efficiency estimation for production inputs using the Cobb-Douglas production function is satisfactory as long as the classical assumptions required by the multiple regression are fulfilled. Of the five production inputs included in the model, only one production input provides a significant value to production, namely the production input for the land area use. Thus, only the production input for land area use is estimated at the value of its price efficiency. Based on the results of the analysis, it is found that the use of production inputs for land area use has not yet reached its price efficiency.


Author(s):  
L.A. Pashkevich

The research the purpose of which was in estimation of quality and competitiveness of dishwashing liquids was carried out. The research was carried out with expert-graphic method. In the article the results of efficiency estimation of dishwashing liquids by means of carrying out “plate’ test, and the results of expert estimation of marking informativeness, design and package convenience and price are presented. On the basis of score estimation of quality indicators and competitiveness of dishwashing means the competitiveness radar was constructed.


2021 ◽  
Vol 1 (2) ◽  
pp. 225-238
Author(s):  
Mohsen Hooshyar ◽  
Daniel Burnside ◽  
Maryam Hajikarimlou ◽  
Katayoun Omidi ◽  
Alexander Jesso ◽  
...  

DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage and are repaired through non-homologous end-joining (NHEJ) or homologous recombination (HR). Repair initiation, regulation and communication with signaling pathways require several histone-modifying and chromatin-remodeling complexes. In budding yeast, this involves three primary complexes: INO80-C, which is primarily associated with HR, SWR1-C, which promotes NHEJ, and RSC-C, which is involved in both pathways as well as the general DNA damage response. Here we identify ARP6 as a factor involved in DSB repair through an RSC-C-related pathway. The loss of ARP6 significantly reduces the NHEJ repair efficiency of linearized plasmids with cohesive ends, impairs the repair of chromosomal breaks, and sensitizes cells to DNA-damaging agents. Genetic interaction analysis indicates that ARP6, MRE11 and RSC-C function within the same pathway, and the overexpression of ARP6 rescues rsc2∆ and mre11∆ sensitivity to DNA-damaging agents. Double mutants of ARP6, and members of the INO80 and SWR1 complexes, cause a significant reduction in repair efficiency, suggesting that ARP6 functions independently of SWR1-C and INO80-C. These findings support a novel role for ARP6 in DSB repair that is independent of the SWR1 chromatin remodeling complex, through an apparent RSC-C and MRE11-associated DNA repair pathway.


Author(s):  
Qixiang Zhang ◽  
Qiyan Feng ◽  
Xueqiang Zhu ◽  
Mei Zhang ◽  
Yanjun Wang ◽  
...  

In order to describe the changes of soil temperature field, air flow field and remediation situation with time during the process of thermally enhanced SVE (soil vapor extraction), a remediation experiment of benzene contaminated soil with single extraction pipe was carried out in a box device. The results showed that the whole temperature of the system was raised to 80 °C in 4 h. 43% of benzene were removed in the first 2% of the extraction time. After 24 h, the repair efficiency was close to 100%. The device can efficiently remove benzene from soil. By continuously monitoring the parameters in the operation process of the system, the spatial distribution of temperature and soil gas pollutant concentration with time was plotted. It showed the benzene concentration distribution in the soil gas was more consistent with the temperature distribution before the start of ventilation, and the concentration of benzene in the soil gas dropped rapidly after ventilation, while the temperature distribution was almost unaffected. In the treatment of soil with a benzene content of 17.8 mg∙kg−1, when the soil gas benzene concentration is the highest at 180 min, the peak value is 11,200 mg∙m−3, and the average concentration is 7629.4 mg∙m−3.


BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Umit Akkose ◽  
Veysel Ogulcan Kaya ◽  
Laura Lindsey-Boltz ◽  
Zeynep Karagoz ◽  
Adam D. Brown ◽  
...  

Abstract Background Nucleotide excision repair is the primary DNA repair mechanism that removes bulky DNA adducts such as UV-induced pyrimidine dimers. Correspondingly, genome-wide mapping of nucleotide excision repair with eXcision Repair sequencing (XR-seq), provides comprehensive profiling of DNA damage repair. A number of XR-seq experiments at a variety of conditions for different damage types revealed heterogenous repair in the human genome. Although human repair profiles were extensively studied, how repair maps vary between primates is yet to be investigated. Here, we characterized the genome-wide UV-induced damage repair in gray mouse lemur, Microcebus murinus, in comparison to human. Results We derived fibroblast cell lines from mouse lemur, exposed them to UV irradiation, and analyzed the repair events genome-wide using the XR-seq protocol. Mouse lemur repair profiles were analyzed in comparison to the equivalent human fibroblast datasets. We found that overall UV sensitivity, repair efficiency, and transcription-coupled repair levels differ between the two primates. Despite this, comparative analysis of human and mouse lemur fibroblasts revealed that genome-wide repair profiles of the homologous regions are highly correlated, and this correlation is stronger for highly expressed genes. With the inclusion of an additional XR-seq sample derived from another human cell line in the analysis, we found that fibroblasts of the two primates repair UV-induced DNA lesions in a more similar pattern than two distinct human cell lines do. Conclusion Our results suggest that mouse lemurs and humans, and possibly primates in general, share a homologous repair mechanism as well as genomic variance distribution, albeit with their variable repair efficiency. This result also emphasizes the deep homologies of individual tissue types across the eukaryotic phylogeny.


2016 ◽  
Vol 685 ◽  
pp. 487-491 ◽  
Author(s):  
Mikhail Chukin ◽  
Marina Polyakova ◽  
Alexandr Gulin ◽  
Olga Nikitenko

It is shown that combination of strain effects leads to possessing the ultra-fine grain structure in carbon wire. The continuous method of wire deformation nanostructuring was developed on the basis of simultaneous applying of tension deformation by drawing, bending deformation when going through the system of rolls and torsional deformation on a continuously moving wire. One of the main advantages of the developed method is that various hardware devices and tools already applied for steel wire production can be used to implement this method thus simplifying its introduction to the current industrial equipment. The efficiency estimation of the developed continuous method of deformation nanostructuring was carried out using carbon wire with different carbon content. It is shown that the mechanical properties of the wire after combination of different kinds of strain can vary over a wide range. This method makes it possible to choose such modes of strain effect, which can provide the necessary combination of strength and ductile properties of carbon wire depending on its further processing modes and application.


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