EFFECTS OF DIABETES MELLITUS ON VISCOELASTICITY OF ULTRASTRUCTURES OF PERIPHERAL NERVES: THREE-DIMENSIONAL FINITE ELEMENT ANALYSES

2019 ◽  
Vol 19 (04) ◽  
pp. 1950022
Author(s):  
GUAN-HAO TSENG ◽  
CHENG-TAO CHANG ◽  
CHOU-CHING K. LIN ◽  
TERRY YUAN-FANG CHEN ◽  
MING-SHAUNG JU

Diabetes mellitus induces a variety of neuropathies and causes various symptoms. Understanding how diabetes affects mechanical properties of nerves is useful for preventing complications of diabetes mellitus such as the carpal tunnel syndrome. In a previous study, a two-dimensional hyper-viscoelastic finite element model (FEM) of the ultra-structures of normal rat sciatic nerves was developed using an optical coherence tomography (OCT) microscope and in vitro parallel compression tests. The main goal of this study was to extend the FEM from two to three dimensions and use it to explore hyper-viscoelasticity of ultra-structures of sciatic nerves of diabetic rats. A modification of the compression testing system to enhance OCT cross-sectional images of the nerve samples was also conducted. The results showed that the instantaneous shear moduli of the perineurium, epineurium, and endoneurium of the diabetic rat were all greater than those of the normal rats. Due to high instantaneous shear moduli and low percentage of relaxation, the diabetic nerve is prone to damage when subjected to prolonged mechanical loads.

2002 ◽  
Vol 124 (6) ◽  
pp. 734-741 ◽  
Author(s):  
Alexander I. Veress ◽  
Jeffrey A. Weiss ◽  
Grant T. Gullberg ◽  
D. Geoffrey Vince ◽  
Richard D. Rabbitt

Atherosclerotic plaque rupture is responsible for the majority of myocardial infarctions and acute coronary syndromes. Rupture is initiated by mechanical failure of the plaque cap, and thus study of the deformation of the plaque in the artery can elucidate the events that lead to myocardial infarction. Intravascular ultrasound (IVUS) provides high resolution in vitro and in vivo cross-sectional images of blood vessels. To extract the deformation field from sequences of IVUS images, a registration process must be performed to correlate material points between image pairs. The objective of this study was to determine the efficacy of an image registration technique termed Warping to determine strains in plaques and coronary arteries from paired IVUS images representing two different states of deformation. The Warping technique uses pointwise differences in pixel intensities between image pairs to generate a distributed body force that acts to deform a finite element model. The strain distribution estimated by image-based Warping showed excellent agreement with a known forward finite element solution, representing the gold standard, from which the displaced image was created. The Warping technique had a low sensitivity to changes in material parameters or material model and had a low dependency on the noise present in the images. The Warping analysis was also able to produce accurate strain distributions when the constitutive model used for the Warping analysis and the forward analysis was different. The results of this study demonstrate that Warping in conjunction with in vivo IVUS imaging will determine the change in the strain distribution resulting from physiological loading and may be useful as a diagnostic tool for predicting the likelihood of plaque rupture through the determination of the relative stiffness of the plaque constituents.


1982 ◽  
Vol 104 (2) ◽  
pp. 119-124 ◽  
Author(s):  
E. Rooz ◽  
D. F. Young ◽  
T. R. Rogge

A finite-element model for pulsatile flow in a straight flexible partially obstructed tube is developed. In the unobstructed sections of the tube the model considers the continuity equation, the one-dimensional momentum equation, and an equation of state relating tube cross-sectional area to pressure. For the obstructed region, a nonlinear relationship between the flow and the pressure drop across the stenosis is considered. The applicability of a model is checked by comparing predicted flow and pressure waveforms with corresponding in-vitro experimental measurements obtained on a mechanical system. These comparisons indicate that the model satisfactorily predicts pressures and flows under variety of frequencies of oscillation and stenosis severities.


Author(s):  
Z Abbasi ◽  
F Honarvar

In recent years, Higher Order Modes Cluster (HOMC) guided waves have been considered for ultrasonic testing of plates and pipes. HOMC guided waves consist of higher order Lamb wave modes that travel together as a single nondispersive wave packet. The objective of this paper is to investigate the effect of frequency-thickness value on the contribution of Lamb wave modes in an HOMC guided wave. This is an important issue that has not been thoroughly investigated before. The contribution of each Lamb wave mode in an HOMC guided wave is studied by using a two-dimensional finite element model. The level of contribution of various Lamb wave modes to the wave cluster is verified by using a 2D FFT analysis. The results show that by increasing the frequency-thickness value, the order of contributing modes in the HOMC wave packet increases. The number of modes that comprise a cluster also increases up to a specific frequency-thickness value and then it starts to decrease. Plotting of the cross-sectional displacement patterns along the HOMC guided wave paths confirms the shifting of dominant modes from lower to higher order modes with increase of frequency-thickness value. Experimental measurements conducted on a mild steel plate are used to verify the finite element simulations. The experimental results are found to be in good agreement with simulations and confirm the changes observed in the level of contribution of Lamb wave modes in a wave cluster by changing the frequency-thickness value.


2018 ◽  
Vol 4 (2) ◽  
pp. 1 ◽  
Author(s):  
Angelica Campigotto ◽  
Stephane Leahy ◽  
Ayan Choudhury ◽  
Guowei Zhao ◽  
Yongjun Lai

A novel, inexpensive, and easy-to-use strain sensor using polydimethylsiloxane (PDMS)  was developed. The sensor consists of a microchannel that is partially filled with a coloured liquid and embedded in a piece of PDMS. A finite element model was developed to optimize the geometry of the microchannel to achieve higher sensitivity. The highest gauge factor that was measured experimentally was 41. The gauge factor was affected by the microchannel’s square cross-sectional area, the number of basic units in the microchannel, and the inlet and outlet configuration. As a case study, the developed strain sensors were used to measure the rotation angle of the wrist and finger joints.


2018 ◽  
Vol 22 (3) ◽  
pp. 613-625 ◽  
Author(s):  
M Anbarasu ◽  
M Venkatesan

This work reports numerical results concerning the cold-formed steel built-up I-section columns composed of four U-profiles under axial compression. A finite element model is developed by using the software program ABAQUS. The developed model includes geometric, material nonlinearities and geometric imperfections. The finite element model was verified against the experimental results reported in the cold-formed steel built-up open section columns. In the parametric study, the sections are analysed with several cross-sectional dimension ratios and lengths, in order to assess their influence on the buckling behaviour and ultimate strength of cold-formed steel built-up I-section columns. After presenting and discussing the numerical parametric results, the article shows that the current direct strength method in the North American Specification for cold-formed steel compression members design curve fails to predict adequately the ultimate strength of some of the columns analysed and addresses the modification proposed on current direct strength method curves, providing improved predictions of all the numerical ultimate strength available. The proposed method is also assessed by reliability analysis.


Author(s):  
Mohammad S. Davoud ◽  
Xiaomin Deng

Predictions of transient temperature distributions in welding can help the selection of welding process parameters that minimize residual stresses. A three-dimensional (3D) thermal finite element model of bead-on-plate gas metal are welding (GMAW) is presented and is used to evaluate a cross-sectional, two-dimensional (2D) counterpart model. While the thermomechanical problem of welding is 3D in nature, it is shown that the 2D model can provide temperature field predictions comparable to those of the 3D model, even though the 2D model tends to predict peak temperatures higher than those of the 3D model. Both types of model predictions are compared to welding test measurements.


2015 ◽  
Vol 76 (10) ◽  
Author(s):  
Nor Fazli Adull Manan ◽  
Jamaluddin Mahmud ◽  
Aidah Jumahat

This paper for the first time attempts to establish the biomechanical characteristics of bovine skin via experiment-theory integration and finite element simulation. 30 specimens prepared from fresh slaughtered bovine were uniaxially stretched in-vitro using tensile tests machine. The experimental raw data are then input into a Matlab programme, which quantified the hyperelastic parameters based on Ogden constitutive equation. It is found that the Ogden coefficient and exponent for bovine skin are μ = 0.017 MPa and α = 11.049 respectively. For comparison of results, the quantified Ogden parameters are then input into a simple but robust finite element model, which is developed to replicate the experimental setup and simulate the deformation of the bovine skin. Results from experiment-theory integration and finite element simulation are compared. It is found that the stress-stretch curves are close to one another. The results and finding prove that the current study is significant and has contributed to knowledge enhancement about the deformation behaviour of bovine skin.


2019 ◽  
Vol 11 (1) ◽  
pp. 109-130 ◽  
Author(s):  
Hosein Andami ◽  
Hamid Toopchi-Nezhad

The performance of rigid polyurethane foams, as an energy absorbent core of sandwich panels covered with two exterior steel sheets, was investigated numerically through finite element methods. After verifying the finite element model, numerical studies were conducted to investigate the role of thickness and density of the foam layer in the response behavior of sandwich panels under blast loads. A set of cylindrical polyurethane foam specimens were manufactured at five different nominal densities, 90, 140, 175, 220, and 250 kg/m3, and their stress–strain curves were evaluated using uniaxial compression tests. The test data were then employed to define characteristics of the polyurethane foams in the finite element model. Based on the results of finite element analysis runs, the optimum density of the foam layer was determined by assessing two response parameters including the peak pressure transmitted to the back face of the foam layer and the maximum deflection of sandwich panel. These response parameters were found to be affected differently by variations in the density of the foam layer within the panel. An increase in the thickness of the foam layer, to a certain extent, was found to be beneficial to the mitigation capability of sandwich panel.


2007 ◽  
Vol 344 ◽  
pp. 637-644 ◽  
Author(s):  
Gerd Sebastiani ◽  
Alexander Brosius ◽  
Werner Homberg ◽  
Matthias Kleiner

Sheet Metal Spinning is a flexible manufacturing process for axially-symmetric hollow components. While the process itself is already known for centuries, process planning is still based on undocumented expertise, thus requiring specialized craftsmen for new process layouts. Current process descriptions indicate a vast scope of different dynamic influences while the underlying mechanical model uses a simple static approach. Thus, a 3D Finite Element Model of the process has been set up at IUL in order to analyze the process in detail, providing online as well as cross sectional data of the specimen formed. Within the scope of this article, the results of the above mentioned Finite Element Analysis (FEA) are presented and discussed with respect to the qualitative stress distributions introduced in the existing theoretical models. Main emphasis of this paper is set on a discussion of the qualitative stress distribution, which is, to the current state, only known in theory.


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