Control of Plasma Potential with an Electron Emissive Grid in a Q-Machine

Background: Application of cold atmospheric plasma to medium generates “plasma-activated medium” that induces apoptosis selectively in tumor cells and that has an antitumor effect in vivo. The underlying mechanisms are not well understood. Objective: Elucidation of potential chemical interactions within plasma-activated medium and of reactions of medium components with specific target structures of tumor cells should allow to define the active principle in plasma activated medium. Methods: Established knowledge of intercellular apoptosis-inducing reactive oxygen/nitrogen species-dependent signaling and its control by membrane-associated catalase and SOD was reviewed. Model experiments using extracellular singlet oxygen were analyzed with respect to catalase inactivation and their relevance for the antitumor action of cold atmospheric plasma. Potential interactions of this tumor cell-specific control system with components of plasma-activated medium or its reaction products were discussed within the scope of the reviewed signaling principles. Results: None of the long-lived species found in plasma-activated medium, such as nitrite and H2O2, nor OCl- or .NO seemed to have the potential to interfere with catalase-dependent control of apoptosis-inducing signaling of tumor cells when acting alone. However, the combination of H2O2 and nitrite might generate peroxynitrite. The protonation of peroxnitrite to peroxynitrous acid allows for the generation of hydroxyl radicals that react with H2O2, leading to the formation of hydroperoxide radicals. These allow for singlet oxygen generation and inactivation of membrane-associated catalase through an autoamplificatory mechanism, followed by intercellular apoptosis-inducing signaling. Conclusion: Nitrite and H2O2 in plasma-activated medium establish singlet oxygen-dependent interference selectively with the control system of tumor cells.

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Across-Polarity Quantification Method for Broad Metabolome Coverage Based on Consecutive Nanoconfined Liquid Phase Nanoextraction Technology: Application in Discovering the Plasma Potential Biomarkers of Different Types of Cancer

Analytica Chimica Acta ◽

10.1016/j.aca.2021.338577 ◽

2021 ◽

pp. 338577

Author(s):

Chunyu Yu ◽

Qian Zhang ◽

Yilin Zou ◽

Ran Liu ◽

Jinhua Zhao ◽

...

Keyword(s):

Liquid Phase ◽

Plasma Potential ◽

Technology Application ◽

Quantification Method ◽

Different Types ◽

Potential Biomarkers

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Temporal evolution of plasma potential in a large-area pulsed dual-frequency inductively coupled discharge

Journal of Physics D Applied Physics ◽

10.1088/0022-3727/46/23/235203 ◽

2013 ◽

Vol 46 (23) ◽

pp. 235203 ◽

Cited By ~ 11

Author(s):

Anurag Mishra ◽

Jin Seok Seo ◽

Kyong Nam Kim ◽

Geun Young Yeom

Keyword(s):

Temporal Evolution ◽

Plasma Potential ◽

Dual Frequency ◽

Large Area ◽

Inductively Coupled

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Investigation of plasma potential and pulsed discharge characteristics in enhanced glow discharge plasma immersion ion implantation and deposition

Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms ◽

10.1016/j.nimb.2009.01.109 ◽

2009 ◽

Vol 267 (8-9) ◽

pp. 1696-1700 ◽

Cited By ~ 3

Author(s):

Liuhe Li ◽

Qiuyuan Lu ◽

Ricky K.Y. Fu ◽

Paul K. Chu

Keyword(s):

Glow Discharge ◽

Ion Implantation ◽

Discharge Plasma ◽

Plasma Potential ◽

Glow Discharge Plasma ◽

Pulsed Discharge ◽

Discharge Characteristics ◽

Plasma Immersion Ion Implantation

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Control system for maintaining a Langmuir probe at plasma potential

Review of Scientific Instruments ◽

10.1063/1.1135217 ◽

1977 ◽

Vol 48 (9) ◽

pp. 1174-1178 ◽

Cited By ~ 1

Author(s):

J. L. Michau

Keyword(s):

Control System ◽

Langmuir Probe ◽

Plasma Potential

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Synthesis of Crystallized TiNi Films by Ion Irradiation

Advances in Science and Technology ◽

10.4028/www.scientific.net/ast.78.87 ◽

2012 ◽

Vol 78 ◽

pp. 87-91

Author(s):

Noriaki Ikenaga ◽

Yoichi Kishi ◽

Zenjiro Yajima ◽

Noriyuki Sakudo

Keyword(s):

Shape Memory ◽

Crystallization Temperature ◽

Ion Irradiation ◽

Deposition Process ◽

Plasma Potential ◽

Micro Electro Mechanical Systems ◽

Ion Energy ◽

Crystal Film ◽

Irradiation Energy ◽

New Apparatus

TiNi is well known as a typical shape-memory alloy, and is expected to be a promising material for micro actuators. In order to realize micro electro mechanical systems (MEMS) with this material, we have to get thin crystal film of the material, since the shape-memory property appears only when the structure is crystalline. In our previous studies we developed a new apparatus as well as a new deposition process for lowering the crystallization temperature by using ion irradiation. In addition, we have found that the deposited film by the process can be crystallized at very low temperature (below 473 K) without annealing but with simultaneous irradiation of Ar ions during sputter-deposition. In this study, we aim for the realization of crystallized TiNi film, which is deposited on Si substrate below 373 K substrate temperature. In order to realization the purpose, we have revealed the effect of Ar ion energy on lowering the crystallization temperature. The ion energy is measured with a quadrupole mass spectrometer (QMS) having an ion energy analyzer. The deposited TiNi films are examined with an X-ray diffraction (XRD). We found the plasma potential against the reactor chamber is important to be considered in the ion irradiation energy. The effects of ion energy for the crystallization of TiNi film are discussed.

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