Report on Session 2a

Author(s):  
K. D. Privett

IntroductionThe papers in this session of the conference concentrate on some of the processes described by the Theme Lecturer, Professor Hutchinson, and the engineering properties of the materials. Engineering implications are referred to in the papers but are included in this session because the process/properties element is stressed. This report is intended to provide a brief introduction to the session papers and all references are to papers in this conference.The term “periglacial” is sometimes restricted to geomorphological processes where freeze-thaw is the dominant action but the definition generally is widened to include all those processes, and their landforms, taking place in cold climated outside the margins of an ice sheet and so encompasses everything that is not directly glacial. This conference has used this wider definition and thus deposits such as laminated glacial lake sediments (Bell and Coultard) are included in this session. Table 1 illustrated the range of features that could be considered, many of which are discussed to varying degress in the papers.TABLE 1: List of periglacial features/processes.LARGE-SCALE LANDSLIPSSOLIFLUCTION, MUDFLOWS, SHEARSASYMMETRIC VALLEYSFROST CREEPCAMBERS, VALLEY BULGESICE WEDGESPOLYGONSFROST HEAVE, INVOLUTIONSFROST MOUNDS, PINGOSFROST SHATTERINGLOESS DEPOSITIONLAMINATED LAKE DEPOSITSCHEMICAL OF CaCO3SLOPE PROCESSESThe various processes involved in the formation and modification of slopes, either in their natural condition, or if modified by some engineering works. Is is not surprising then, that the majority of papers submitted to this session concern periglacial slope processes.

Author(s):  
А. Sarsembayeva ◽  
◽  
A. Zhusshupbekov ◽  
Ph.E.F. Collins ◽  
◽  
...  

Frost heaving in clayey soils with a low coefficient of permeability raises a lot of questions regarding the cryosuction, surface tension forces, and accompanying phase transfer of water. The freeze-thaw laboratory test results were considered in this work in terms of temperature and volumetric parameters change, dry density, and water mass transfer. The article presents a model for calculating the mass transfer of water (vapour) in the gas state under the influence of cryogenic forces. Findings include the improved understanding of the heat and mass transfer phenomenon during the unidirectional freezing of soils in an open system. Most of the tests for engineering properties registered a slight reduction in relation to strength, cohesion, and angle of internal friction. However, there was a significant increase in the coefficient of permeability after the freeze-thaw cycles with initially dense compacted soil samples, which was due to loosening and moistening of the soil samples during the heave at sub-zero temperatures. The conceptual model for frost heave in soils was developed based on the vapour mass transfer. There was presented algorithm of vapour flow calculation in unsaturated soils using fundamental thermodynamic equations.


Geosciences ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 174
Author(s):  
Marco Emanuele Discenza ◽  
Carlo Esposito ◽  
Goro Komatsu ◽  
Enrico Miccadei

The availability of high-quality surface data acquired by recent Mars missions and the development of increasingly accurate methods for analysis have made it possible to identify, describe, and analyze many geological and geomorphological processes previously unknown or unstudied on Mars. Among these, the slow and large-scale slope deformational phenomena, generally known as Deep-Seated Gravitational Slope Deformations (DSGSDs), are of particular interest. Since the early 2000s, several studies were conducted in order to identify and analyze Martian large-scale gravitational processes. Similar to what happens on Earth, these phenomena apparently occur in diverse morpho-structural conditions on Mars. Nevertheless, the difficulty of directly studying geological, structural, and geomorphological characteristics of the planet makes the analysis of these phenomena particularly complex, leaving numerous questions to be answered. This paper reports a synthesis of all the known studies conducted on large-scale deformational processes on Mars to date, in order to provide a complete and exhaustive picture of the phenomena. After the synthesis of the literature studies, the specific characteristics of the phenomena are analyzed, and the remaining main open issued are described.


2021 ◽  
Vol 22 (4) ◽  
Author(s):  
Bruna Minatovicz ◽  
Robin Bogner ◽  
Bodhisattwa Chaudhuri

2016 ◽  
Vol 43 (10) ◽  
pp. 865-874 ◽  
Author(s):  
Sheng-lin Wang ◽  
Qing-feng Lv ◽  
Hassan Baaj ◽  
Xiao-yuan Li ◽  
Yan-xu Zhao

Freeze–thaw action is considered to be one of the most destructive actions that can induce significant damage in stabilized subgrades in seasonally frozen loess areas. Laboratory tests including frost heave – thaw shrinkage and microstructure change during freeze–thaw cycles were conducted to evaluate the volume change rate of loess stabilized with cement, lime, and fly ash under the impact of cyclic freeze–thaw conditions. The loess specimens collapsed after eight freeze–thaw cycles (192 h), but most stabilized loess specimens had no visible damage after all freeze–thaw cycles were completed. All of the stabilized loess samples underwent a much smaller volume change than the loess alone after the freeze–thaw cycles. Although surface porosity and equivalent diameter of stabilized loess samples increased, the stabilized loess can retain its microstructure during freeze–thaw cycles when the cement content was less than 6%. To ensure freeze–thaw resistance of stabilized loess subgrades, the mix proportions of the three additives was recommended to be 4 to 5% cement, 6% lime, and 10% fly ash.


2020 ◽  
Author(s):  
Xiaoqing Wang ◽  
Collin Tokheim ◽  
Binbin Wang ◽  
Shengqing Stan Gu ◽  
Qin Tang ◽  
...  

SUMMARYDespite remarkable clinical efficacies of immune checkpoint blockade (ICB) in cancer treatment, ICB benefits in triple-negative breast cancer (TNBC) remain limited. Through pooled in vivo CRISPR knockout (KO) screens in syngeneic TNBC mouse models, we found that inhibition of the E3 ubiquitin ligase Cop1 in cancer cells decreases the secretion of macrophage-associated chemokines, reduces tumor macrophage infiltration, and shows synergy in anti-tumor immunity with ICB. Transcriptomics, epigenomics, and proteomics analyses revealed Cop1 functions through proteasomal degradation of the C/ebpδ protein. Cop1 substrate Trib2 functions as a scaffold linking Cop1 and C/ebpδ, which leads to polyubiquitination of C/ebpδ. Cop1 inhibition stabilizes C/ebpδ to suppress the expression of macrophage chemoattractant genes. Our integrated approach implicates Cop1 as a target for improving cancer immunotherapy efficacy by regulating chemokine secretion and macrophage levels in the TNBC tumor microenvironment.HighlightsLarge-scale in vivo CRISPR screens identify new immune targets regulating the tumor microenvironmentCop1 knockout in cancer cells enhances anti-tumor immunityCop1 modulates chemokine secretion and macrophage infiltration into tumorsCop1 targets C/ebpδ degradation via Trib2 and influences ICB response


2020 ◽  
Author(s):  
Anik Banik ◽  
Md. Fuad Mondal ◽  
Md. Mostafigur Rahman Khan ◽  
Sheikh Rashel Ahmed ◽  
Md. Mehedi Hasan

AbstractThe locust problem is a global threat for food security. Locusts can fly and migrate overseas within a zip and creating a large-scale devastation to the diversified agro-ecosystem. GIS based analysis showed the recent movement of locusts, among them Schistocerca gregaria and Locusta migratoria are predominant in Indian subcontinent and are found more notorious and devastating one. This devastation needs to be stopped to save human race from food deprivation. In our study, we screened some commonly used agricultural pesticides and strongly recommended three of them viz. biphenthrin, diafenthiuron and silafluofen which might be potential to control the desert locusts based on their binding affinity towards the locust’s survival proteins. Our phylogenetic analysis reveals that these three recommended pesticides might also show potency to the other locust species as well as they are also way safer than the other commercially available pesticides. These proposed pesticide’s bioactive analogs from fungus and bacteria may also show efficacy as next generation controlling measures of locust as well as different kind of pests. These recommended pesticides are expected to be highly effective against locusts and needs to bring forward by the entomologists’ by performing experimental field trials.HighlightsGIS map unmasked the 2020 migratory pattern of locusts which now predominant towards Indian subcontinent.Biphenthrin, diafenthiuron and silafluofen showed maximum binding affinity.Biphenthrin and diafenthiuron were relatively safer than silafluofen.Bioactive analogs from fungus and bacteria could be an alternative to control locusts.Pesticides inhibition hotspots for desert locusts were unrevealed.


2019 ◽  
Author(s):  
Wojciech Michalak ◽  
Vasileios Tsiamis ◽  
Veit Schwämmle ◽  
Adelina Rogowska-Wrzesińska

AbstractWe have developed ComplexBrowser, an open source, online platform for supervised analysis of quantitative proteomics data that focuses on protein complexes. The software uses information from CORUM and Complex Portal databases to identify protein complex components. Based on the expression changes of individual complex subunits across the proteomics experiment it calculates Complex Fold Change (CFC) factor that characterises the overall protein complex expression trend and the level of subunit co-regulation. Thus up- and down-regulated complexes can be identified. It provides interactive visualisation of protein complexes composition and expression for exploratory analysis. It also incorporates a quality control step that includes normalisation and statistical analysis based on Limma test. ComplexBrowser performance was tested on two previously published proteomics studies identifying changes in protein expression in human adenocarcinoma tissue and during activation of mouse T-cells. The analysis revealed 1519 and 332 protein complexes, of which 233 and 41 were found co-ordinately regulated in the respective studies. The adopted approach provided evidence for a shift to glucose-based metabolism and high proliferation in adenocarcinoma tissues and identification of chromatin remodelling complexes involved in mouse T-cell activation. The results correlate with the original interpretation of the experiments and also provide novel biological details about protein complexes affected. ComplexBrowser is, to our knowledge, the first tool to automate quantitative protein complex analysis for high-throughput studies, providing insights into protein complex regulation within minutes of analysis.A fully functional demo version of ComplexBrowser v1.0 is available online via http://computproteomics.bmb.sdu.dk/Apps/ComplexBrowser/The source code can be downloaded from: https://bitbucket.org/michalakw/complexbrowserHighlightsAutomated analysis of protein complexes in proteomics experimentsQuantitative measure of the coordinated changes in protein complex componentsInteractive visualisations for exploratory analysis of proteomics resultsIn briefComplexBrowser is capable of identifying protein complexes in datasets obtained from large scale quantitative proteomics experiments. It provides, in the form of the CFC factor, a quantitative measure of the coordinated changes in complex components. This facilitates assessing the overall trends in the processes governed by the identified protein complexes providing a new and complementary way of interpreting proteomics experiments.


2021 ◽  
Author(s):  
Tanima Arora ◽  
Michael Simonov ◽  
Jameel Alausa ◽  
Labeebah Subair ◽  
Brett Gerber ◽  
...  

ABSTRACTBackgroundThe COVID-19 pandemic has led to an explosion of research publications spanning epidemiology, basic and clinical science. While a digital revolution has allowed for open access to large datasets enabling real-time tracking of the epidemic, detailed, locally-specific clinical data has been less readily accessible to a broad range of academic faculty and their trainees. This perpetuates the separation of the primary missions of clinically-focused and primary research faculty resulting in lost opportunities for improved understanding of the local epidemic; expansion of the scope of scholarship; limitation of the diversity of the research pool; lack of creation of initiatives for growth and dissemination of research skills needed for the training of the next generation of clinicians and faculty.ObjectivesCreate a common, easily accessible and up-to-date database that would promote access to local COVID-19 clinical data, thereby increasing efficiency, streamlining and democratizing the research enterprise. By providing a robust dataset, a broad range of researchers (faculty, trainees) and clinicians are encouraged to explore and collaborate on novel clinically relevant research questions.MethodsWe constructed a research platform called the Yale Department of Medicine COVID-19 Explorer and Repository (DOM-CovX), to house cleaned, highly granular, de-identified, continually-updated data from over 7,000 patients hospitalized with COVID-19 (1/2020-present) across the Yale New Haven Health System. This included a front-end user interface for simple data visualization of aggregate data and more detailed clinical datasets for researchers after a review board process. The goal is to promote access to local COVID-19 clinical data, thereby increasing efficiency, streamlining and democratizing the research enterprise.Expected OutcomesAccelerate generation of new knowledge and increase scholarly productivity with particular local relevanceImprove the institutional academic climate by:Broadening research scopeExpanding research capability to more diverse group of stakeholders including clinical and research-based faculty and traineesEnhancing interdepartmental collaborationsConclusionsThe DOM-CovX Data Explorer and Repository have great potential to increase academic productivity. By providing an accessible tool for simple data analysis and access to a consistently updated, standardized and large-scale dataset, it overcomes barriers for a wide variety of researchers. Beyond academic productivity, this innovative approach represents an opportunity to improve the institutional climate by fostering collaboration, diversity of scholarly pursuits and expanding medical education. It provides a novel approach that can be expanded to other diseases beyond COVID 19.


2021 ◽  
Vol 47 (1) ◽  
pp. 164-173
Author(s):  
Mohammad Mehdi Khabiri ◽  
Bahareh Ebrahimialavijeh

Improving the subgrade performance and increasing their efficiency can lead to improving the operation and increasing the life of the pavement. One of the common solutions to improve the resistance and engineering properties of the soils is using the stabilizing materials. Using the waste materials as a stabilizer in the soil can lead to a reduction in project costs and help the protection from the environment. In this study, emulsion bitumen and crushed waste tile are used to stabilize the sand dune which is soil with low bearing capacity and resistance properties. In the present study, the emulsion bitumen and crushed waste tile have been used. The effect of dimensions and percentage of crushed tile with different percentages of emulsion bitumen on the compressive pressure and bearing capacity as well as the compressive strength after applying freeze-thaw cycle. The results indicate that the addition of crushed waste tile increases the compression strength and bearing capacity and the tile with a higher dimension has shown more effectiveness. Applying the freeze-thaw cycle has reduced the compression strength and increasing the number of cycles has increased the resistance drop rate. Soil stabilized with coarse-grained tile has more resistance drop rate which increases by increasing the tile percentage. Then, the 3D graph and the recommended function related to each parameter investigated in the test were provided using the response surface analysis method.


2000 ◽  
Vol 1696 (1) ◽  
pp. 118-123 ◽  
Author(s):  
J. W. Gillespie ◽  
D. A. Eckel ◽  
W. M. Edberg ◽  
S. A. Sabol ◽  
D. R. Mertz ◽  
...  

Bridge 1.351 on Business Route 896 in Glasgow, Delaware, was replaced with one of the first state-owned all-composite bridges in the nation. Composites are lightweight construction materials that do not corrode, which results in benefits such as ease of construction and reduced maintenance costs. A summary of the design, large-scale testing, fabrication, erection, and monitoring of this bridge is presented. The bridge was designed to AASHTO load and resistance factor design specifications. A methodology was developed to incorporate the engineering properties of these unique composite materials into the design. The bridge consists of two 13 × 32 ft (3.96 × 9.75 m) sections joined by a unique longitudinal joint. The sections have sandwich construction consisting of a core [28 in. (71.12 cm) deep] and facesheets [0.4 to 0.6 in. (10.16 to 15.24 mm) thick] that provide shear and flexural rigidity, respectively. The composite bridge was fabricated with E-glass preforms and vinyl-ester resin, which offers excellent structural performance and long-term durability. Each of the sections was fabricated to near-net shape in a single step by a vacuum-assisted resin transfer molding process. The overall structural behavior has been accurately predicted with simple design equations based on sandwich theory for anisotropic materials. Large-scale testing of full-sized subcomponents was conducted to prove that the design satisfied deflection, fatigue, and strength limit states. A redundant longitudinal joint was designed that consisted of both an adhesively bonded vertical joint between sections and splice plates. Assembly procedures were developed, and transverse testing of the full-sized joint was conducted. Final bridge sections were proof-tested to the strength limit state. The construction phase included section positioning, joint assembly, and application of a latex-modified concrete wear surface. The bridge was reopened to traffic on November 20, 1998. Results from the long-term monitoring effort will be documented.


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